Patents by Inventor Ying Hou

Ying Hou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11655231
    Abstract: The disclosure relates to etoricoxib solvates and a preparation method thereof. A solvent is a hydrogen bond donor solvent with a polarity value ?* ranging from 60 to 100 or a hydrogen bond acceptor solvent with a polarity value ?* ranging from 92 to 100. Solvents with a polarity value ?* within the above range all can form corresponding etoricoxib solvates with etoricoxib. The etoricoxib solvate can be prepared by cooling crystallization or suspension crystallization. A 1,2-propanediol solvate of etoricoxib and a dimethyl sulfoxide (DMSO) solvate of etoricoxib provided in the present disclosure have high thermal stability, unique crystal form, large size, concentrated distribution, and prominent flowability and is safe, pharmaceutically acceptable, and not easy to agglomerate. Compared with etoricoxib, the etoricoxib solvates exhibit significantly improved solubility.
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: May 23, 2023
    Assignee: Tianjin University
    Inventors: Ying Bao, Feng Zhang, Peihua Liang, Baohong Hou, Chuang Xie, Ting Zhang, Yinghui Chai
  • Publication number: 20220383062
    Abstract: An optimal control method for wastewater treatment process (WWTP) based on a self-adjusting multi-task particle swarm optimization (SA-MTPSO) algorithm belongs to the field of WWTP. To balance the relationship between the effluent water quality (EQ) and energy consumption (EC) and achieve optimization online quickly, the invention establishes a data-based multi-task optimization model for WWTP to describe the relationship between the control variables and EQ, EC. Then, the SA-MTPSO algorithm is adopted to solve the optimal set-points of the nitrate nitrogen and dissolved oxygen concentration for WWTP. The PID controller is used to track the optimal set-points, so as to reduce EC while ensuring EQ, and realize the online optimal control of WWTP.
    Type: Application
    Filed: February 23, 2022
    Publication date: December 1, 2022
    Inventors: Honggui Han, Xing Bai, Ying Hou, Hongyan Yang, Junfei Qiao
  • Publication number: 20220306617
    Abstract: The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the ctivity of TMEM16a. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including COPD, bronchiectasis, asthma, cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, cystic fibrosis, primary ciliary dyskinesia, respiratory tract infections (acute and chronic; viral and bacterial), lung carcinoma.
    Type: Application
    Filed: August 24, 2020
    Publication date: September 29, 2022
    Inventors: Claire ADCOCK, Jake AXFORD, Ying HOU, Hyungchul KIM, Yiping SHEN, Nichola SMITH, Catherine Fooks SOLOVAY, Moo Je SUNG, Megan LIGHTFOOT, Alessandro MAZZACANI, Emily STANLEY, Lewis WHITEHEAD
  • Publication number: 20210253578
    Abstract: The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.
    Type: Application
    Filed: September 16, 2020
    Publication date: August 19, 2021
    Inventors: Gilbert BESONG, Christopher Thomas BRAIN, Clinton A. BROOKS, Miles Stuart CONGREVE, Claudio DAGOSTIN, Guo HE, Ying HOU, Steven HOWARD, Yue LI, Yipin LU, Paul MORTENSON, Troy SMITH, Moo Je SUNG, Steven WOODHEAD, Wojciech WRONA, Bharat LAGU
  • Patent number: 10788473
    Abstract: A computing system is designed for measuring the A2/O effluent total phosphorus based on data-driven method. Several related variables are obtained by analyzing the relationship between effluent total phosphorus and other process variables. In addition, a hardware platform is designed and built to further analysis sample information of each variable. Finally, the computing system for measuring total phosphorus in effluent is developed by combining the hardware and software as provided in implementations herein.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: September 29, 2020
    Assignee: Beijing University of Technology
    Inventors: Junfei Qiao, Ying Hou, Honggui Han
  • Publication number: 20180155351
    Abstract: The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.
    Type: Application
    Filed: February 1, 2018
    Publication date: June 7, 2018
    Inventors: Gilbert Besong, Christopher Thomas Brain, Clinton A. Brooks, Miles Stuart Congreve, Claudio Dagostin, Guo He, Ying Hou, Steven Howard, Yue Li, Yipin Lu, Paul Mortenson, Troy Smith, Moo Je Sung, Steven Woodhead, Wojciech Wrona, Bharat Lagu
  • Publication number: 20170299565
    Abstract: A computing system is designed for measuring the A2/O effluent total phosphorus based on data-driven method. Several related variables are obtained by analyzing the relationship between effluent total phosphorus and other process variables. In addition, a hardware platform is designed and built to further analysis sample information of each variable. Finally, the computing system for measuring total phosphorus in effluent is developed by combining the hardware and software as provided in implementations herein.
    Type: Application
    Filed: July 11, 2016
    Publication date: October 19, 2017
    Inventors: Junfei Qiao, Ying Hou, Honggui Han
  • Publication number: 20170183352
    Abstract: The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.
    Type: Application
    Filed: August 8, 2016
    Publication date: June 29, 2017
    Applicants: Novartis AG, Astex Therapeutics Ltd.
    Inventors: Gilbert BESONG, Christopher Thomas BRAIN, Clinton A. BROOKS, Miles Stuart CONGREVE, Claudio DAGOSTIN, Guo HE, Ying HOU, Steven HOWARD, Yue LI, Yipin LU, Paul MORTENSON, Troy SMITH, Moo Je SUNG, Steven WOODHEAD, Wojciech WRONA, Bharat LAGU
  • Patent number: 9633307
    Abstract: An intelligent method is designed for predicting the effluent ammonia-nitrogen concentration in the urban wastewater treatment process (WWTP). The technology of this invention is part of advanced manufacturing technology, belongs to both the field of control engineering and environment engineering. In order to improve the predicting efficiency, a recurrent self-organizing neural network, which can adjust the structure and parameters concurrently to train the parameters, is developed to design this intelligent method. This intelligent method can predict the effluent ammonia-nitrogen concentration with acceptable accuracy and solve the problem that the effluent ammonia-nitrogen concentration is difficult to be measured online. Moreover, the online information of effluent ammonia-nitrogen concentration, predicted by this intelligent method, can enhance the quality monitoring level and alleviate the current situation of wastewater to strengthen the whole management of WWTP.
    Type: Grant
    Filed: March 25, 2015
    Date of Patent: April 25, 2017
    Assignee: BEIJING UNIVERSITY OF TECHNOLOGY
    Inventors: Junfei Qiao, Ying Hou, Honggui Han, Wenjing Li
  • Patent number: 9449961
    Abstract: A display device includes a substrate, at least one signal circuit, a ground protection circuit, and an auxiliary protection circuit. The substrate has a first surface, wherein the first surface includes an active area and a frame area surrounding the active area. The at least one signal circuit is disposed and extending along the frame area and electrically coupled to the active area. The ground protection circuit is disposed and extending along the frame area, wherein the ground protection circuit is positioned at a side of the signal circuit facing an edge of the substrate. The auxiliary protection circuit is disposed and extending along the frame area. The auxiliary protection circuit is disposed between the signal circuit and the ground protection circuit, wherein the auxiliary protection circuit respectively has a gap with the signal circuit and the ground protection circuit, and is electrically conductive.
    Type: Grant
    Filed: September 2, 2014
    Date of Patent: September 20, 2016
    Assignee: AU OPTRONICS CORPORATION
    Inventors: Hsiao-Ying Hou, Wen-Chi Chuang, Yi-Ling Lin
  • Patent number: 9416136
    Abstract: The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: August 16, 2016
    Assignees: Novartis AG, Astex Therapeutics, Ltd.
    Inventors: Gilbert Besong, Christopher Thomas Brain, Clinton A Brooks, Miles Stuart Congreve, Claudio Dagostin, Guo He, Ying Hou, Steven Howard, Yue Li, Yipin Lu, Paul Mortenson, Troy Smith, Moo Je Sung, Steven Woodhead, Wojciech Wrona, Bharat Lagu
  • Publication number: 20160140437
    Abstract: An intelligent method is designed for predicting the effluent ammonia-nitrogen concentration in the urban wastewater treatment process (WWTP). The technology of this invention is part of advanced manufacturing technology, belongs to both the field of control engineering and environment engineering. In order to improve the predicting efficiency, a recurrent self-organizing neural network, which can adjust the structure and parameters concurrently to train the parameters, is developed to design this intelligent method. This intelligent method can predict the effluent ammonia-nitrogen concentration with acceptable accuracy and solve the problem that the effluent ammonia-nitrogen concentration is difficult to be measured online. Moreover, the online information of effluent ammonia-nitrogen concentration, predicted by this intelligent method, can enhance the quality monitoring level and alleviate the current situation of wastewater to strengthen the whole management of WWTP.
    Type: Application
    Filed: March 25, 2015
    Publication date: May 19, 2016
    Inventors: JUNFEI QIAO, YING HOU, HONGGUI HAN, WENJING LI
  • Publication number: 20150092306
    Abstract: A display device includes a substrate, at least one signal circuit, a ground protection circuit, and an auxiliary protection circuit. The substrate has a first surface, wherein the first surface includes an active area and a frame area surrounding the active area. The at least one signal circuit is disposed and extending along the frame area and electrically coupled to the active area. The ground protection circuit is disposed and extending along the frame area, wherein the ground protection circuit is positioned at a side of the signal circuit facing an edge of the substrate. The auxiliary protection circuit is disposed and extending along the frame area. The auxiliary protection circuit is disposed between the signal circuit and the ground protection circuit, wherein the auxiliary protection circuit respectively has a gap with the signal circuit and the ground protection circuit, and is electrically conductive.
    Type: Application
    Filed: September 2, 2014
    Publication date: April 2, 2015
    Inventors: Hsiao-Ying Hou, Wen-Chi Chuang, Yi-Ling Lin
  • Publication number: 20140135485
    Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
    Type: Application
    Filed: October 7, 2013
    Publication date: May 15, 2014
    Applicant: ENANTA PHARMACEUTICALS, INC.
    Inventors: Yat Sun Or, Guoqiang Wang, Ly Tam Phan, Dequiang Niu, Nha Huu Vo, Yao-Ling Qiu, Yanchun Wang, Marina V. Busuek, Ying Hou, Yulin Peng, Heejin Kim, Tongzhu Liu, Jay Judson Farmer, Guoyou Xu
  • Patent number: 8685980
    Abstract: The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.
    Type: Grant
    Filed: August 20, 2009
    Date of Patent: April 1, 2014
    Assignees: Novartis AG, Astex Therapeutics, Ltd.
    Inventors: Gilbert Ebai Besong, Christopher Thomas Brain, Clinton Alan Brooks, Miles Stuart Congreve, Claudio Dagostin, Guo He, Ying Hou, Steven Howard, Yue Li, Yipin Lu, Paul Neil Mortenson, Troy D. Smith, Moo Je Sung, Steven John Woodhead, Wojciech Wrona, Bharat Lagu
  • Patent number: 8367687
    Abstract: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases, particularly pyrazole compounds and derivatives are described which inhibit protein kinases. The organic compounds are useful in treating proliferative disease.
    Type: Grant
    Filed: December 8, 2008
    Date of Patent: February 5, 2013
    Assignees: Novartis AG, Astex Therapeutics Ltd.
    Inventors: Christopher Thomas Brain, Moo Sung, Young Shin Cho, Ying Hou
  • Publication number: 20120035352
    Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
    Type: Application
    Filed: July 18, 2011
    Publication date: February 9, 2012
    Inventors: Yat Sun Or, Guoqiang Wang, Ly Tam Phan, Deqiang Niu, Nha Huu Vo, Yao-Ling Qiu, Yanchun Wang, Marina Busuek, Ying Hou, Yulin Peng, Heejin Kim, Tongzhu Liu, Jay Judson Farmer, Gouyou Xu
  • Publication number: 20100280033
    Abstract: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases, particularly pyrazole compounds and derivatives are described which inhibit protein kinases. The organic compounds are useful in treating proliferative disease.
    Type: Application
    Filed: December 8, 2008
    Publication date: November 4, 2010
    Inventors: Christopher Thomas Brain, Moo Sung, Young Shin Cho, Ying Hou
  • Publication number: 20090324577
    Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
    Type: Application
    Filed: June 29, 2009
    Publication date: December 31, 2009
    Inventors: Yat Sun Or, Wang Guoqiang, Ly Tam Phan, Deqiang Niu, Nha Huu Vo, Yao-Ling Qiu, Yanchun Wang, Marina Busuyek, Ying Hou, Yulin Peng, Heejin Kim, Tongzhu Liu, Jay Judson Farmer, Guoyou Xu
  • Patent number: 7414030
    Abstract: The present invention discloses compounds of formulaes I, II, III, or IV, or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
    Type: Grant
    Filed: January 5, 2005
    Date of Patent: August 19, 2008
    Assignee: Enanta Pharmaceuticals, Inc.
    Inventors: Nha Huu Vo, Guoqiang Wang, Guoyou Xu, Ying Hou, Ying Sun, Ly Tam Phan, Zhe Wang, Yat Sun Or