Abstract: The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the ctivity of TMEM16a. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including COPD, bronchiectasis, asthma, cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, cystic fibrosis, primary ciliary dyskinesia, respiratory tract infections (acute and chronic; viral and bacterial), lung carcinoma.

Abstract: The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

Abstract: A computing system is designed for measuring the A2/O effluent total phosphorus based on data-driven method. Several related variables are obtained by analyzing the relationship between effluent total phosphorus and other process variables. In addition, a hardware platform is designed and built to further analysis sample information of each variable. Finally, the computing system for measuring total phosphorus in effluent is developed by combining the hardware and software as provided in implementations herein.

Abstract: The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

Abstract: A computing system is designed for measuring the A2/O effluent total phosphorus based on data-driven method. Several related variables are obtained by analyzing the relationship between effluent total phosphorus and other process variables. In addition, a hardware platform is designed and built to further analysis sample information of each variable. Finally, the computing system for measuring total phosphorus in effluent is developed by combining the hardware and software as provided in implementations herein.

Abstract: The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

Abstract: An intelligent method is designed for predicting the effluent ammonia-nitrogen concentration in the urban wastewater treatment process (WWTP). The technology of this invention is part of advanced manufacturing technology, belongs to both the field of control engineering and environment engineering. In order to improve the predicting efficiency, a recurrent self-organizing neural network, which can adjust the structure and parameters concurrently to train the parameters, is developed to design this intelligent method. This intelligent method can predict the effluent ammonia-nitrogen concentration with acceptable accuracy and solve the problem that the effluent ammonia-nitrogen concentration is difficult to be measured online. Moreover, the online information of effluent ammonia-nitrogen concentration, predicted by this intelligent method, can enhance the quality monitoring level and alleviate the current situation of wastewater to strengthen the whole management of WWTP.

Abstract: A display device includes a substrate, at least one signal circuit, a ground protection circuit, and an auxiliary protection circuit. The substrate has a first surface, wherein the first surface includes an active area and a frame area surrounding the active area. The at least one signal circuit is disposed and extending along the frame area and electrically coupled to the active area. The ground protection circuit is disposed and extending along the frame area, wherein the ground protection circuit is positioned at a side of the signal circuit facing an edge of the substrate. The auxiliary protection circuit is disposed and extending along the frame area. The auxiliary protection circuit is disposed between the signal circuit and the ground protection circuit, wherein the auxiliary protection circuit respectively has a gap with the signal circuit and the ground protection circuit, and is electrically conductive.

Abstract: The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

Abstract: An intelligent method is designed for predicting the effluent ammonia-nitrogen concentration in the urban wastewater treatment process (WWTP). The technology of this invention is part of advanced manufacturing technology, belongs to both the field of control engineering and environment engineering. In order to improve the predicting efficiency, a recurrent self-organizing neural network, which can adjust the structure and parameters concurrently to train the parameters, is developed to design this intelligent method. This intelligent method can predict the effluent ammonia-nitrogen concentration with acceptable accuracy and solve the problem that the effluent ammonia-nitrogen concentration is difficult to be measured online. Moreover, the online information of effluent ammonia-nitrogen concentration, predicted by this intelligent method, can enhance the quality monitoring level and alleviate the current situation of wastewater to strengthen the whole management of WWTP.

Abstract: A display device includes a substrate, at least one signal circuit, a ground protection circuit, and an auxiliary protection circuit. The substrate has a first surface, wherein the first surface includes an active area and a frame area surrounding the active area. The at least one signal circuit is disposed and extending along the frame area and electrically coupled to the active area. The ground protection circuit is disposed and extending along the frame area, wherein the ground protection circuit is positioned at a side of the signal circuit facing an edge of the substrate. The auxiliary protection circuit is disposed and extending along the frame area. The auxiliary protection circuit is disposed between the signal circuit and the ground protection circuit, wherein the auxiliary protection circuit respectively has a gap with the signal circuit and the ground protection circuit, and is electrically conductive.

Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

Abstract: The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

Abstract: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases, particularly pyrazole compounds and derivatives are described which inhibit protein kinases. The organic compounds are useful in treating proliferative disease.

Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

Abstract: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases, particularly pyrazole compounds and derivatives are described which inhibit protein kinases. The organic compounds are useful in treating proliferative disease.

Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

Abstract: The present invention discloses compounds of formulaes I, II, III, or IV, or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.