Abstract: Described is a system, method, and computer program product to perform bi-directional mapping of hierarchical data (e.g. JSON, XML) to database object types (e.g., user defined database object types).

Abstract: In one aspect, providing recovery during active/active replication includes: creating, at a first storage device, a local snapset; waiting for inflight (input/output) IO operations (IOs) from the first device to a second device at the time snapset creation to complete; creating a recovery snapset; and waiting for inflight IOs from the second device to the first device, at the time of snapset creation to complete. Upon determining a failure event, an aspect includes identifying a most recent local snapset (Sk) and a most recent recovery snapset (Sk?) on the first and second devices, respectively, identifying predecessor snapsets (Sk?1) and (Sk?1?) on the first and second devices, respectively, creating a new recovery snapset (Sk?) using (Sk?1?), sending the delta of (Sk) and (Sk?1) from the first device to the second device; updating (Sk?) with the delta; and performing async-to-sync recovery to transfer a difference between the first and second devices.

Abstract: The present invention provides monoclonal antibodies that bind to the complement factor 5 (C5) protein, and methods of use thereof. In various embodiments of the invention, the antibodies are fully human antibodies that bind to C5 protein. In some embodiments, the antibodies of the invention are useful for inhibiting or neutralizing C5 activity, thus providing a means of treating or preventing a C5-related disease or disorder in humans. In some embodiments, the invention provides for an anti-C5 antibody that has improved pharmacokinetic and pharmacodynamic properties, e.g., a half-life of more than 10 days.

Abstract: The present invention provides monoclonal antibodies that bind to the complement factor 5 (C5) protein, and methods of use thereof. In various embodiments of the invention, the antibodies are fully human antibodies that bind to C5 protein. In some embodiments, the antibodies of the invention are useful for inhibiting or neutralizing C5 activity, thus providing a means of treating or preventing a C5-related disease or disorder in humans. In some embodiments, the invention provides for an anti-C5 antibody that has improved pharmacokinetic and pharmacodynamic properties, e.g., a half-life of more than 10 days.

Abstract: An apparatus in one embodiment comprises at least one processing device comprising a processor coupled to a memory. The processing device is configured to capture metadata from a metadata area of a storage system for checkpointing, and to store the captured metadata as checkpointed metadata in a user data area of the storage system in association with mapping information relating portions of the checkpointed metadata to particular storage locations in the user data area. The processing device in some embodiments is implemented within the storage system, and may comprise a storage controller of the storage system. The mapping information illustratively comprises a plurality of page location arrays each having a plurality of entries specifying respective locations of checkpointed metadata pages in the user data area.

Abstract: The invention provides methods to prepare protein conjugates from proteins having at least two cysteines. In one embodiment, a protein with a disulfide linkage is reduced to provide two free cysteines for reaction with a 1,3-dihaloacetone or similar reactant, linking the sulfur atoms of the two cysteines together. The ketone inserted between the sulfur atoms is then used to form a Schiff base to an aminated payload molecule, thus conjugating the protein to a payload. In another embodiment, two cysteine residues are tied together by reaction with a 1,3-dihaloacetone or similar reactant. The linkage between the sulfur atoms in each case holds the protein or peptide in a constrained conformation, while also providing a convenient place for attaching a payload with good specificity and efficiency.

Abstract: In one aspect, IO recovery mechanisms in active/active replication for storage clusters provide, for each write IO request: determining an extent of pages to be modified; acquiring a lock by a cluster local to the request and locally persisting data; atomically creating an entry in a local journal; and sending, by the local cluster, a data write request to a peer cluster. Upon receiving acknowledgement from the peer cluster of successful transmission, the replication journal entry is cleared, the extent is unlocked, and a notification is returned to the peer. In response to a failure event at the peer cluster after persisting the data at the local cluster and creating the journal entry at the local cluster, an aspect includes sending, to the peer cluster upon recovery of the peer cluster, the journal entry with respect to an extent corresponding to a time of the failure event.

Abstract: In one aspect, providing recovery during active/active replication includes: creating, at a first storage device, a local snapset; waiting for inflight (input/output) IO operations (IOs) from the first device to a second device at the time snapset creation to complete; creating a recovery snapset; and waiting for inflight IOs from the second device to the first device, at the time of snapset creation to complete. Upon determining a failure event, an aspect includes identifying a most recent local snapset (Sk) and a most recent recovery snapset (Sk?) on the first and second devices, respectively, identifying predecessor snapsets (Sk-1) and (Sk-1?) on the first and second devices, respectively, creating a new recovery snapset (Sk?) using (Sk-1?), sending the delta of (Sk) and (Sk-1) from the first device to the second device; updating (Sk?) with the delta; and performing async-to-sync recovery to transfer a difference between the first and second devices.

Abstract: In one aspect, adaptive replication modes in a storage system are provided. An aspect includes during an active replication session in which a first type of replication is performed at the storage system, monitoring write input/output (IO) operations, collecting data from the write IO operations, and determining, from the collected data, write IO latency. Upon determining that a threshold value has been met from the write IO latency, where the threshold value is defined for the first type of replication, an aspect includes automatically switching from the first type of replication to a second type of replication. The second type of replication is configured to compensate for operational deficiencies detected in response to the write IO latency.

Abstract: A high-resolution processing method for seismic data based on inverse multi-resolution singular value decomposition includes the steps of: step 1: obtaining a single-trace seismic signal X as a raw signal; step 2: decomposing the seismic signal by using MRSVD algorithm to obtain a series of detailed singular values and inversely recursing the detailed singular values layer by layer to obtain a new detailed signal and an approximate signal; and step 3: sequentially superimposing the new detailed signal on the raw signal, layer by layer, to compensate the high-frequency component of the seismic signal so as to obtain a high-resolution seismic signal.

Abstract: A method is disclosed comprising: generating a first snapshot of a first storage subsystem; detecting, by a management node, that all in-flight data storage requests recorded in drain tables of storage nodes in the first storage subsystem have been completed, the in-flight data storage requests recorded in the drain tables of the storage nodes being replicated in a second storage subsystem; causing, by the management node, each of the storage nodes to flip the respective designations of the tracking tables in the node's respective pair of tracking tables; and transmitting, from the management node to the second storage subsystem, an instruction which when received by the second storage subsystem causes the second storage subsystem to generate a second snapshot of the second storage subsystem.

Abstract: Hypertonic pharmaceutical compositions are disclosed. The hypertonic pharmaceutical compositions contain an anti-platinum chemoprotectant agent and a gelling agent. Also disclosed are methods of medical use of the hypertonic pharmaceutical compositions.

Abstract: A storage system comprises a storage device and metadata journal comprising metadata configured to store information associated with changes to information stored on the storage device. Dirty tree (DT) metadata pages, each corresponding to information written to the storage device from the metadata journal, are stored on the storage device. DT pages are read and scanned to detect if any DT metadata page comprises an entry having an invalid snap group ID associated with a given offset. For each detected DT metadata page comprising a respective invalid snap group ID, a corresponding fake journal entry is created in metadata journal and configured to point to the respective DT metadata page comprising the invalid snap group ID and given offset. The fake journal entry is configured so that, when the metadata journal is destaged to the storage device, the invalid snap group ID is reset to nonexistent.

Abstract: An aspect of resolving conflicts during recovery operations includes separating journal entries for first and second types of recovery operations into each of a first and second array. For each entry in the first array, an aspect includes taking a range lock of a designated number of the addresses and creating an entry in a table. For each entry in the second array, an aspect includes upon determining a corresponding sub-LUN has been locked for an entry in the first array, incrementing a count in the table. Upon determining the corresponding sub-LUN is not locked for the entry, an aspect includes taking the address lock for the entry in the second array. An aspect further includes opening gates for a corresponding address, performing a first recovery operation corresponding to the first type of recovery operation, and performing a second recovery operation corresponding to the second type of recovery operation.

Abstract: A storage system in one embodiment is configured to participate as a source storage system in a synchronous replication process with a target storage system. In conjunction with the synchronous replication process, the source storage system receives write requests from at least one host device. Responsive to a given write request being a multi-page write request, an entry is created in a first journal, where the first journal is utilized to ensure that the given write request is completed for all of the pages or for none of the pages. Responsive to the write request being a single-page write request, an entry is created in a second journal different than the first journal. An address-to-signature table is updated utilizing write data of the write request, and if the corresponding entry for the write request was created in the first journal, the entry is swapped from the first journal into the second journal, and the write data of the write request is sent to the target storage system.

Abstract: The invention provides methods to prepare protein conjugates from proteins having at least two cysteines. In one embodiment, a protein with a disulfide linkage is reduced to provide two free cysteines for reaction with a 1,3-dihaloacetone or similar reactant, linking the sulfur atoms of the two cysteines together. The ketone inserted between the sulfur atoms is then used to form a Schiff base to an aminated payload molecule, thus conjugating the protein to a payload. In another embodiment, two cysteine residues are tied together by reaction with a 1,3-dihaloacetone or similar reactant. The linkage between the sulfur atoms in each case holds the protein or peptide in a constrained conformation, while also providing a convenient place for attaching a payload with good specificity and efficiency.

Abstract: Described embodiments provide systems and methods for operating a storage system wherein an online consistent system checkpoint is generated. The checkpoint contains a point in time image of a system and is used for providing recovery of the system to a known good state. In one embodiment the checkpoint includes volume configuration data, logical volume space, a plurality of layers of metadata, and physical data storage.

Abstract: In one aspect, support for hash based xcopy replication for synchronous replication is provided. An aspect includes determining, in response to an xcopy command, whether a source logical unit (LU) and a target LU are in active synchronous replication to the same target site. Upon determining that the LUs are in active synchronous replication, increasing a count of a hash handle list, obtaining a unique full hash digest, and sending the digest with volume replication pairing identifier, offset, and length to the target. Upon receiving a request from the source, searching, by the target, for local hash handles of the digest; and upon determining the local hash handles exist in the digest, incrementing, the reference counter handle list, and sending corresponding hash handles from the source site to the target.

Abstract: Embodiments of the present application disclose a gesture-based interaction method and interaction apparatus, and a user equipment. The method comprising: acquiring touch information corresponding to a touch event on a touch sensing surface; and in response to that determining the touch event according to the touch information meets at least one set condition, performing an operation corresponding to the touch event, wherein the at least one set condition comprises: a first touch by a first finger on the touch sensing surface comprises a fingertip touch and a finger joint touch that occur in order. Technical solutions of the embodiments of the present application enrich a manner for interacting with an electronic device having a touch sensing surface.

Abstract: A method is disclosed comprising: generating a first snapshot of a first storage subsystem; detecting, by a management node, that all in-flight data storage requests recorded in drain tables of storage nodes in the first storage subsystem have been completed, the in-flight data storage requests recorded in the drain tables of the storage nodes being replicated in a second storage subsystem; causing, by the management node, each of the storage nodes to flip the respective designations of the tracking tables in the node's respective pair of tracking tables; and transmitting, from the management node to the second storage subsystem, an instruction which when received by the second storage subsystem causes the second storage subsystem to generate a second snapshot of the second storage subsystem.