Abstract: The semiconductor device includes a first conductivity-type semiconductor structure comprising a first stack and a second stack, wherein the first stack comprises alternate first layers and second layers, the second stack comprises alternate third layers and fourth layers. The semiconductor device includes a second conductivity-type semiconductor structure on the first conductivity-type semiconductor and includes an active structure between the first conductivity-type semiconductor structure and the second conductivity-type semiconductor structure. The first stack is between the active structure and the second stack, and a first difference between a maximum of the first doping concentration of one of the first layers and a minimum of the second doping concentration of one of the second layers is less than a second difference between a maximum of the third doping concentration of one of the third layers and a minimum of the fourth doping concentration of one of the fourth layers.

Abstract: Described embodiments provide systems and methods for online system recovery orchestration. Embodiments may include receiving a request to recover a system management process from a checkpoint. The system management initialization parameter file is updated by setting a flag to start from the checkpoint. A system management process is started with the updated initialization parameter and a copy of the system management repository is loaded. Volumes are recovered before data path module activation. Data modules are then activated with checkpoint offset information and data module journals are reformatted. Control modules are then activated with recovered volume configuration and control module journals are reformatted. Defragmentation mode is set to rollback mode and data on checkpoint stripes that were written after checkpoint creation are deleted. After waiting for the defragmentation rollback to complete the host IO direction is set to checkpoint stripes.

Abstract: Some embodiments of the disclosure provide a sample rack scheduling control method. The method includes the following steps: respectively obtaining a state of each position node on each preset delivery path, wherein the state of each position node includes an available state and an occupancy state; and for each of the delivery paths, if a target position node on the delivery path and position nodes between the target position node and a start position node all are in the available state, marking the target position node on the delivery path and the position nodes between the start position node and the target position node all as the occupancy state, and controlling a current sample rack at the start position node to move to the target position node. The present disclosure further provides a sample rack scheduling control system and a medical detection device.

Abstract: This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments, particularly antibody drug conjugates comprising anti-P-cadherin antibodies conjugated to auristatin analogs. The invention also relates to methods of treating cancer using the antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

Abstract: A body fat measuring apparatus, system and pairing method thereof are provided. The body fat measuring apparatus and system include: a measuring unit provided for determining a current body weight and a current impedance of a user, and the current body weight and the current impedance used as a current analysis data set; a storage unit provided for cumulatively storing a user name, a user characteristic information related to the user name, and a plurality of recorded analysis data sets corresponding to the user names; and a processor provided for pairing the user name, reading the user characteristic information related to the user name, and obtaining a body fat information by calculating with the current body weight and the current impedance of the user.

Abstract: The present invention provides antibodies that bind specifically to TrkB and methods of using the same. According to certain embodiments, the antibodies of the invention are agonist antibodies that are neuroprotective, as shown by their effect on enhancing the survival of retinal ganglion cells in vitro. As such, these agonist antibodies may be used to treat diseases or disorders of the eye, such as, but not limited to glaucoma. In addition, other neuronal diseases or disorders may benefit from treatment with these agonist antibodies, including any disease or disorder characterized in part by neuronal damage. In certain embodiments, the invention includes antibodies that bind TrkB and mediate cell signaling. The antibodies of the invention may be fully human, non-naturally occurring antibodies.

Abstract: Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized TRKB locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized TRKB locus express a human TRKB protein or a chimeric transthyretin protein, fragments of which are from human TRKB. Methods are provided for using such non-human animals comprising a humanized TRKB locus to assess in vivo efficacy of human-TRKB-targeting reagents such as nuclease agents designed to target human TRKB.

Abstract: Polyvinyl chloride compositions and films formed therefrom are described which exhibit improved printability and resistance to weathering. The compositions generally comprise polyvinyl chloride, at least one plasticizer, at least one heat stabilizer, certain UV stabilizer(s), and print additives and/or other agents. In particular versions, the compositions utilize a combination of polyvinyl chloride resins. Also described are various vinyl-based laminates using the films which can be for example reflective products. Also described are methods of producing the noted laminates.

Abstract: A method for establishing data connections on a mobile network, a mobile network, and a policy control entity are disclosed. The method includes: establishing a data channel between a user equipment (UE) and a gateway (GW), and allocating an Internet Protocol (IP) address to the UE according to an address allocation request or a data channel setup request sent from the UE; and triggering the policy control entity to establish or update a policy control session according to the IP address. By using the mobile network and the policy control entity under the present disclosure, after the data channel is established between the UE and the GW, the GW may trigger the policy control entity to establish or update a policy control session.

Abstract: An apparatus in one embodiment comprises at least one processing device comprising a processor coupled to a memory. The processing device is configured to capture metadata from a metadata area of a storage system for checkpointing, and to store the captured metadata as checkpointed metadata in a user data area of the storage system in association with mapping information relating portions of the checkpointed metadata to particular storage locations in the user data area. The processing device in some embodiments is implemented within the storage system, and may comprise a storage controller of the storage system. The mapping information illustratively comprises a plurality of page location arrays each having a plurality of entries specifying respective locations of checkpointed metadata pages in the user data area.

Abstract: A storage system comprising a processor in operable communication with a storage device is configured to have first, second, and third tables and first, second, and third respective metadata journals storing time-based information associated, respectively, with the first, second, and third tables. The first table maps logical addresses associated with LUNs associated with the storage device to respective hash digests computed based on data residing at respective logical addresses. The second table maps a range of hash digests to respective associated physical locations on the storage device. The third table maps disk block allocation on the storage device. An online system checkpoint is created, comprising information relating to the state of the storage system at a point in time, where the first, second, and third, metadata journals are destaged in order so as to destage information stored in the respective journal up to the point in time.

Abstract: The invention provides methods to prepare protein conjugates from proteins having at least two cysteines. In one embodiment, a protein with a disulfide linkage is reduced to provide two free cysteines for reaction with a 1,3-dihaloacetone or similar reactant, linking the sulfur atoms of the two cysteines together. The ketone inserted between the sulfur atoms is then used to form a Schiff base to an aminated payload molecule, thus conjugating the protein to a payload. In another embodiment, two cysteine residues are tied together by reaction with a 1,3-dihaloacetone or similar reactant. The linkage between the sulfur atoms in each case holds the protein or peptide in a constrained conformation, while also providing a convenient place for attaching a payload with good specificity and efficiency.

Abstract: An apparatus in one embodiment comprises a storage system having a plurality of storage devices and an associated storage controller. The storage devices are configured to provide a metadata area and a user data area, the user data area being separated into pages. The storage controller is configured to initiate generation of one or more checkpoints in the storage system. In conjunction with the generation of a given one of the one or more checkpoints in the storage system, the storage controller causes checkpointed metadata from the metadata area to be stored in the user data area. The storage controller further stores mapping information relating portions of the checkpointed metadata to respective pages of the user data area that store those portions of the checkpointed metadata. The mapping information illustratively comprises page location arrays and array location arrays, and in some embodiments further comprises one or more higher-level location arrays.

Abstract: The invention provides improved methods to prepare protein conjugates from a ketone-modified protein. In one embodiment, the protein is prepared by linking two free cysteines by reaction with a 1,3-dihaloacetone or similar ketone-containing reactant, linking the sulfur atoms of the two cysteines together. The ketone inserted between the sulfur atoms is then used to form an oxime, thus conjugating the protein to a payload. In another embodiment, two cysteine residues are tied together by reaction with a 1,3-dihaloacetone or similar reactant, and the new ketone is used to form an oxime with a suitable payload molecule, thus conjugating the protein to a payload. The method provides improved reaction conditions for the oxime formation, whereby higher yields and improved product homogeneity are achieved.

Abstract: A method for establishing data connections on a mobile network, a mobile network, and a policy control entity are disclosed. The method includes: establishing a data channel between a user equipment (UE) and a gateway (GW), and allocating an Internet Protocol (IP) address to the UE according to an address allocation request or a data channel setup request sent from the UE; and triggering the policy control entity to establish or update a policy control session according to the IP address. By using the mobile network and the policy control entity under the present invention, after the data channel is established between the UE and the GW, the GW may trigger the policy control entity to establish or update a policy control session.

Abstract: A computer-implemented method is provided for a storage system comprising a processor in operable communication with a storage device that is configured into a plurality of respective regions of storage space. A first defragmentation process is performed on at least a first region of the plurality of respective regions of storage space to free a first portion of storage space in the a respective first region, where the freed first portion is reserved for user data and metadata associated with I/O requests to the storage system that are generated during a first operation running on the storage system. The storage system is configured to ensure that, during the first operation, user data and metadata are routed towards the first freed portion and kept separate from a set of system checkpoint information, associated with a first state of the storage system, stored in a protected portion of storage space.

Abstract: A method for managing data storage. The method included a processor identifying a plurality of first utilization values for data within a first data storage system, wherein the data includes a plurality of extents and the plurality of first utilization values corresponds to the plurality of extents are included in the data. The method further includes a processor transferring the data from the first data storage system to a second data storage system, wherein the second data storage system includes a plurality of solid-state drives (SSDs). The method further includes a processor storing the transferred data among the plurality of SSDs based, at least in part on, the plurality of first utilization values.

Abstract: Non-human animals comprising a human or humanized C3 and/or C5 nucleic acid sequence are provided as well as methods for using the same to identify compounds capable of modulating the complement system. Non-human animals that comprise a replacement of the endogenous C5 gene and/or C3 gene with a human or humanized C5 gene and/or C3 gene, and methods for making and using the non-human animals, are described. Non-human animals comprising a human or humanized C5 gene under control of non-human C5 regulatory elements is also provided, including non-human animals that have a replacement of non-human C5-encoding sequence with human C5-encoding sequence at an endogenous non-human C5 locus. Non-human animals comprising a human or humanized C3 gene under control of non-human C3 regulatory elements is also provided, including non-human animals that have a replacement of non-human C3 protein-encoding sequence with human or humanized C3 protein-encoding sequence at an endogenous non-human C3 locus.

Abstract: The semiconductor device includes a first conductivity-type semiconductor structure comprising a first stack and a second stack, wherein the first stack comprises alternate first layers and second layers, the second stack comprises alternate third layers and fourth layers. The semiconductor device includes a second conductivity-type semiconductor structure on the first conductivity-type semiconductor and includes an active structure between the first conductivity-type semiconductor structure and the second conductivity-type semiconductor structure. The first stack is between the active structure and the second stack, and a first difference between a maximum of the first doping concentration of one of the first layers and a minimum of the second doping concentration of one of the second layers is less than a second difference between a maximum of the third doping concentration of one of the third layers and a minimum of the fourth doping concentration of one of the fourth layers.

Abstract: A computer-implemented technique performs block deduplication. The technique involves generating a list of candidate blocks and adding classifications to the list of candidate blocks. The classifications classify the candidate blocks on the list into different categories based on a set of block sequence matching criteria. The technique further involves performing, based on the classifications added to the list of candidate blocks, further block deduplication processing on first candidate blocks having a first classification while not performing further block deduplication processing on second candidate blocks having a second classification. Examples of the categories include an “exact long match” category, a “disrupted long match” category, a “loosely long match” category, and a “short match” category.