Abstract: The present invention provides aspartyl-tRNA synthetase and Fc region conjugate polypeptides (DRS-Fc conjugates), such as DRS-Fc fusion proteins, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The DRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified DRS polypeptides.

Abstract: Methods and apparatuses for processing seismic data to generate images or determine properties of an interior section of the Earth. The seismic data is processed to filter coherent noise such as ground roll noise from seismic survey data. The noise is attenuated using 3D and/or 2D fan filters, which may have combined low-pass and band-pass filters derived from signal decomposition. The filters are designed with selected operator length, velocity bands of signals and noises and frequency range for a primary trace and adjacent traces within the operator length. The data is decomposed with the filters into signals and noises, and the noises are then filtered from the decomposed data. The process may be repeated for various frequencies and traces within the seismic data. The methods may be used for surveys that have either regular or irregular seismic receiver or seismic source positions.

Abstract: The present invention provides aspartyl-tRNA synthetase derived proteins (DRS polypeptides) with altered cysteine content, compositions comprising the same, and methods of using such polypeptides and compositions for treating or diagnosing a variety of conditions. The DRS polypeptides of the invention have immunomodulatory properties, and exhibit improved activity and stability.

Abstract: The present invention provides PEGylated tyrosyl-tRNA synthetase (YRS) polypeptides, compositions comprising the same, and methods of using such polypeptides and compositions for treating or diagnosing a variety of conditions. The PEGylated YRS polypeptides of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic properties compared to non-PEGylated YRS polypeptides.

Abstract: A method and a circuit component for suppressing crosstalk associated with the common voltage in a liquid crystal display are disclosed. In particular, in a liquid crystal display where the crosstalk is mainly caused by various control signals generated by a timing control circuit, one or more timing control signals are extracted from the timing control circuit and processed to become a compensation signal. The compensation signal is provided to display area of the liquid crystal display. The timing control signals generated by the timing control circuit include a start signal and a plurality of clock signals. The steps for processing these signals may include summing, inverting, high-pass filtering and amplitude adjustment, to be carried out in different orders and/or combinations. When the timing control signals are current signals, the steps for processing these signals may include current-to-voltage conversion, summing and inverting.

Abstract: Designing a multi-dimensional Finite Impulse Response FIR digital filter to attenuate the coherent noise while preserving reflection signals on seismic data, particular in land seismics, includes computing filter coefficients to minimize an l-norm function of differences between a response of a filter with the computed coefficients and a predetermined response which attenuates signals outside a predetermined range of slowness relative to signals within the predetermined range of slowness. Additional constraints may be imposed on the coefficients to improve the attenuation of signals outside the predetermined range of slowness of the desired reflection signals, and/or to improve uniformity within the desired range.

Abstract: Method and apparatus are provided to determine directional calibration parameters of an object. A method includes: disposing a tracking marker to the object, disposing the object on a calibration tool, rotating the object around its set linear axis while keeping the set linear direction unchanged, determining at least two three-dimensional rotation matrices of the tracking marker via a position tracking apparatus, and using the three-dimensional rotation matrices to determine the directional calibration parameters with the formula of two-point position relationship or rectilinear direction rotation relationship in the three-dimensional space. The action direction of the object is determined based on the determined directional calibration parameters and the current three-dimensional rotation matrix of the tracking marker.

Abstract: An integrated circuit device is disclosed. The integrated circuit device includes a semiconductor die fabricated by a front-end semiconductor process and having oppositely disposed planar surfaces. The semiconductor die is formed with semiconductor devices, power supply circuitry coupled to the semiconductor devices, decoupling capacitance circuitry, and through-vias. The through-vias include a first group of vias coupled to the power supply circuitry and a second group of vias coupled to the decoupling capacitance circuitry. Conductors are formed in a first metal layer disposed on the semiconductor die in accordance with a back-end semiconductor process. The conductors are configured to couple to the first and second groups of through-vias to establish conductive paths from the power supply circuitry to the decoupling capacitance circuitry.

Abstract: Disclosed are methods for preparation of two pharmaceutical intermediates (I, II) of Aliskiren, said intermediates are obtained by reacting compound of formula I or II and tribromophosphorus oxide. The method replaces the method in the prior art which is using column chromatopraphy to produce the compounds I and II, and overcomes the defect that the method in the prior art hardly carry out in a large-scale industrial production. The product can be purified by recrystallization or vacuum distillation, and the chemical purity of the product is good.

Abstract: Generating an image of an interior of the Earth from a seismic survey using multiple sources. The multiple sources may be fired simultaneously and the data received by seismic sensors in the seismic survey may be decomposed so that seismic data generated by each of the multiple sources may be determined. Decomposing of the received data may be performed using frequency diverse basis functions and converting the data separation problem into an optimization problem, which can be a one-norm or zero-norm optimization problem in frequency-space domain. The decomposed data may be used to generate the image of the Earth's interior.

Abstract: Adaptive filtering method to remove ground roll from seismic data. In an M channel adaptive filter, weights Wi are set using an adaptive algorithm based on seeking the minimum in the partial differential of cost function J. The cost function includes an expansion of the primary trace d into d=dg+?d (where: dg is ground roll contribution and ?d=dsig+dran, where dsig is the reflected signal component and dran is a random noise component) and a corresponding expansion of the reference x into x=xg+?x (where xg is ground roll contribution and ?x=xsig+xran; where xsig is a reflected signal component and xran is a random noise component). The delta components are included in the denominator of cost function J to provide an optimal solution of the filter coefficients biased by the reflection signal and random noise is removed.

Abstract: Designing a multi-dimensional Finite Impulse Response FIR digital filter to attenuate the coherent noise while preserving reflection signals on seismic data, particular in land seismics, comprises computing filter coefficients to minimise an l-norm function of differences between a response of a filter with the computed coefficients and a predetermined response which attenuates signals outside a predetermined range of slowness relative to signals within the predetermined range of slowness. Additional constraints may be imposed on the coefficients to improve the attenuation of signals outside the predetermined range of slowness of the desired reflection signals, and/or to improve uniformity within the desired range.

Abstract: Methods for treating landfill leachate taught herein comprise: (a) coagulatively settling leachate; (b) filtering the resultant supernatant liquid through multistage cartridges; (c) filtering the filtered liquid by reverse osmosis; and (d) treating the resultant liquid with chlorine-based oxidant. These methods provide the advantages of efficient wastewater treatment, compact equipment size, short process flow, and low startup and operational costs.

Abstract: Methods for treating landfill leachate taught herein comprise: (a) coagulatively settling leachate; (b) filtering the resultant supernatant liquid through multistage cartridges; (c) filtering the filtered liquid by reverse osmosis; and (d) treating the resultant liquid with chlorine-based oxidant. These methods provide the advantages of efficient wastewater treatment, compact equipment size, short process flow, and low startup and operational costs.

Abstract: The invention provides labeled proteins suitable for determining the presence of cAMP, other second messengers and organic molecules. The proteins are separately labeled with fluorochromes which, when in close spatial proximity, preferably, less than about 6 nm, interact through the transfer of energy from one fluorochrome to the other.A composition of matter, (S.sub.1.A).sub.n1 (S.sub.2.D).sub.n2 is provided wherein S.sub.1 and S.sub.2 are two proteins which are associated in one state and substantially disassociated in another, the equilibrium between which is controlled by the free concentration of an analyte, and A and D are fluorochromes, the emission wavelength of fluorochrome D overlapping the excitation wavelength of fluorochrome A and the distance between A and D being in sufficiently close proximity to allow the radiationless transfer of energy between the fluorochromes.