Patents by Inventor Yoichi Makino
Yoichi Makino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210387194Abstract: A microfluidic device including a substrate having at least one droplet holder formed thereon, and a cover member facing the substrate with a space between the cover member and the substrate, and having a flow path formed in the space and connected to the droplet holder. The flow path has a height of more than 0 ?m and 30 ?m or less.Type: ApplicationFiled: August 27, 2021Publication date: December 16, 2021Applicant: TOPPAN PRINTING CO., LTD.Inventors: Keisuke GOTO, Yoichi MAKINO
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Patent number: 11142731Abstract: An analytical device includes a plate including a first substrate having a front surface and a back surface and a second substrate facing the back surface of the first substrate such that at least one detection space observable from outside is formed between the second substrate and the back surface of the first substrate, and an adapter. The first substrate has a first port having a through hole formed through the front surface and communicated with the detection space for delivering a liquid-containing substance into the detection space, the first substrate has a second port having a through hole formed through the front surface and communicated with the detection space for discharging a liquid-containing substance or a gas from the detection space, and the adapter is attachable to and detachable from the first port and the second port, and the front surface of the first substrate without the adapter is flat.Type: GrantFiled: December 26, 2017Date of Patent: October 12, 2021Assignee: TOPPAN PRINTING CO., LTD.Inventors: Tomoko Kunitomi, Yoichi Makino
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Patent number: 11097269Abstract: A microfluidic device includes: a base plate allowing an electromagnetic wave to pass therethrough and having no autofluorescence; a microwell array formed on the base plate and including a wall layer in which a plurality of through-holes are formed in a thickness direction; and a lid member disposed opposite to the base plate in a state of being separated from the wall layer, wherein microwells are formed by the base plate and the through-holes formed in the wall layer, and wherein the wall layer is formed of a material containing a colored component that absorbs an electromagnetic wave of a predetermined wavelength.Type: GrantFiled: April 4, 2018Date of Patent: August 24, 2021Assignee: TOPPAN PRINTING CO., LTD.Inventors: Keisuke Goto, Yoichi Makino, Akihiro Hoshino
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Patent number: 10894973Abstract: An array device including a base having wells, a cover positioned over the base with a gap from the base such that openings of the wells are covered by the cover with the gap in between, an injection port communicating with the gap, a discharge port communicating with the gap and positioned apart from the injection port, and a waste liquid vessel which collects liquid that flows from the gap via the discharge port and is positioned at a level different from the gap forming a channel. The discharge port is placed to discharge a surplus aqueous solution outside the wells from the discharge port by an oleaginous sealing liquid to be delivered from the injection port.Type: GrantFiled: May 4, 2017Date of Patent: January 19, 2021Assignee: TOPPAN PRINTING CO., LTD.Inventors: Yoichi Makino, Tomoyuki Ozawa, Shuichi Akashi, Tomoko Kunitomi
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Patent number: 10766073Abstract: After a chuck portion chucks a workpiece holding body which aligns and holds a plurality of workpieces on which components are to be placed, the posture of the workpieces held in the workpiece holding body is adjusted due to rotation mechanism by rotating the chuck portion around an axial line which extends in an aligning direction of the plurality of workpieces held in the workpiece holding body. Then, a placing head places the components on each of the plurality of workpieces which are subjected to posture adjustment.Type: GrantFiled: September 5, 2017Date of Patent: September 8, 2020Assignee: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.Inventor: Yoichi Makino
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Publication number: 20200270674Abstract: A method for detecting a target molecule, including supplying a liquid dispersion of a structural substance including a target molecule into a well array such that the structural substance is introduced into wells of the well array, supplying a sealing solution into the well array such that a layer of the sealing solution is formed on the liquid dispersion in the wells, and that the liquid dispersion is sealed in the wells, extracting the target molecule from the structural substance, and detecting the target molecule.Type: ApplicationFiled: May 12, 2020Publication date: August 27, 2020Applicant: TOPPAN PRINTING CO., LTD.Inventors: Takumi HIRASE, Yoichi MAKINO, Yosuke HORIUCHI
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Patent number: 10718776Abstract: A method of detecting a biological substance, including introducing a first substance dispersed in a solvent into a flow channel formed between a first substrate and a second substrate such that the first substance is placed in a first well formed in the first substrate, and detecting the first substance. The first well is formed such that the first well has an open side which faces downwards and is communicated with the flow channel, and the solvent has a specific gravity larger than a specific gravity of the first substance.Type: GrantFiled: March 7, 2018Date of Patent: July 21, 2020Assignee: TOPPAN PRINTING CO., LTD.Inventor: Yoichi Makino
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Publication number: 20200224253Abstract: A method of detecting a nucleic acid including mixing a fluid including a target nucleic acid with a detection reagent including a first enzyme for cleaving a first nucleic acid having a first flap and a second enzyme for cleaving a second nucleic acid such that the target nucleic acid, the first nucleic acid and the second nucleic acid form a complex as a first invasive structure, conducting a first reaction which causes the first enzyme to cleave the first flap of the first invasive structure and produces a third nucleic acid that forms a complex, as a second invasive structure, with a fourth nucleic acid having a second flap, and conducting a second reaction which causes the second enzyme to cleave the second flap of the second invasive structure and produces a cleaved product.Type: ApplicationFiled: January 31, 2020Publication date: July 16, 2020Applicant: TOPPAN PRINTING CO., LTD.Inventors: Masayuki Ogino, Yoichi Makino
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Patent number: 10668584Abstract: A plurality of workpieces on which components are to be placed are lined up in a row and held by a workpiece holding body, and the workpiece holding body is placed on a carrier and is transported to a working position using a transport conveyor. After the workpiece holding body is chucked by a chuck portion, the workpiece holding body is separated from the carrier by linking an operation of lifting and lowering the chuck portion using a lifting-lowering mechanism and an operation of moving the carrier in a transport direction. The chuck portion which chucks the workpiece holding body is rotated by a rotation mechanism, postures of the plurality of workpieces which are held in the workpiece holding body are adjusted, and then, the components are placed on component placing parts using a placing head.Type: GrantFiled: September 5, 2017Date of Patent: June 2, 2020Assignee: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.Inventor: Yoichi Makino
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Patent number: 10661401Abstract: When a workpiece holder holding a workpiece is rocked around a lateral rocking axis by a work stage of a mounter and the workpiece is positioned so that one mounting surface of the workpiece faces a predetermined direction to be worked, a component is mounted on the one mounting surface by a mounting head of the mounter. When a posture of the workpiece in the workpiece holder is changed by a posture changing head of a posture changer and thereafter the workpiece holder in which the posture of the workpiece is changed is rocked around the lateral rocking axis by the work stage of the mounter and the workpiece is positioned so that the other mounting surface of the workpiece faces a predetermined direction to be worked, a component is mounted on the other mounting surface by the mounting head of the mounter.Type: GrantFiled: February 5, 2018Date of Patent: May 26, 2020Assignee: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.Inventors: Seiji Mizuoka, Takahiro Endo, Yasuhiro Suzuki, Yoichi Makino
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Patent number: 10627327Abstract: A membrane vesicle recovery device includes: a liquid filler; and at least a fused membrane having a lipid bilayer membrane which covers at least a part of the outer periphery of the liquid filler, in which a content of a membrane vesicle is mixed into the liquid filler through fusing of the membrane vesicle and the fused membrane.Type: GrantFiled: April 22, 2016Date of Patent: April 21, 2020Assignee: TOPPAN PRINTING CO., LTD.Inventors: Yoichi Makino, Shinji Irie
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Publication number: 20200003691Abstract: A device including a well array including wells in which a target substance is detected based on a biochemical reaction thereof. Each of the wells has an aspect ratio of 1 or more as calculated by Formula (1) such that the biochemical reaction of the target substance is detected, Aspect ratio=Depth of each well/Diameter of largest circle among circles included in a region enclosed by a rim of each well??Formula (1).Type: ApplicationFiled: September 13, 2019Publication date: January 2, 2020Applicant: TOPPAN PRINTING CO., LTD.Inventors: Misaki NAGAHARA, Yoichi MAKINO, Akihiro HOSHINO, Takumi HIRASE, Tomoko KUNITOMI, Keisuke GOTO, Yusuke HORIUCHI
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Publication number: 20190241948Abstract: A biomolecule analysis method including: feeding a reagent into a reaction container which includes a plurality of wells and filing the reagent in the plurality of wells, the reagent being for causing an enzymatic reaction with regard to a target substance of analysis; feeding an oil sealing solution over the plurality of wells and sealing the reagent into the plurality of wells with the oil sealing solution so that the plurality of wells become a plurality of independent reaction containers; performing the enzymatic reaction by incubating the reaction container; and detecting a signal amplified by the enzymatic reaction.Type: ApplicationFiled: April 17, 2019Publication date: August 8, 2019Applicant: TOPPAN PRINTING CO., LTD.Inventors: Yoichi Makino, Tomoko Kunitomi
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Publication number: 20190085385Abstract: A method of detecting a target molecule including binding, to first target molecules, specific binding substances which are capable of recognizing different epitopes and labeled with nucleic acid fragments, respectively, detecting the specific binding substances based on fluorescence signals of different fluorescence wavelengths from the nucleic acid fragments, and detecting the first target molecules based on the fluorescence signals that correspond to the specific binding substances, respectively.Type: ApplicationFiled: November 19, 2018Publication date: March 21, 2019Applicant: TOPPAN PRINTING CO., LTD.Inventors: Yoichi Makino, Takumi Hirase, Noriaki Arai, Hiroyuki Noji
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Publication number: 20190060897Abstract: An analysis apparatus including a stage, an analysis device placed on the stage and including receiving sections which accommodate a sample and a reagent for biochemical reaction, and are communicated with one another through a flow path having an inlet and an outlet, a liquid introduction section which is connected to the inlet and supplies into the flow path the sample, the reagent, and an sealing liquid for sealing each of the receiving sections, and a waste liquid storage section which is connected to the outlet and stores as waste liquid an excess of the sample and the reagent and a part of the sealing liquid supplied to the flow path, an optical system which includes an objective lens, emits excitation light to the receiving sections and allows observation of fluorescence generated in the receiving sections by the excitation light, and a control unit that controls such that the sealing liquid and the excess of the sample and the reagent form an interface in the waste liquid storage section, and that theType: ApplicationFiled: October 29, 2018Publication date: February 28, 2019Applicant: TOPPAN PRINTING CO., LTD.Inventors: Yoichi MAKINO, Akihiro HOSHINO, Tomoko KUNITOMI, Keisuke GOTO, Yosuke HORIUCHI
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Publication number: 20190062821Abstract: A reaction container including a transparent base having a first surface having at least one region where recessed portions are formed and recessed from the first surface, and a cover member positioned such that the cover member forms a gap from the first surface inside the region and is welded to the transparent base outside the region. The cover member absorbs infrared light and transmits light having a wavelength within a range of visible light.Type: ApplicationFiled: October 26, 2018Publication date: February 28, 2019Applicant: TOPPAN PRINTING CO., LTD.Inventors: Masahiro MATSUKAWA, Yoichi MAKINO, Akihiro HOSHINO
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Patent number: 10165716Abstract: A substrate conveyance mechanism that includes conveyance units and a working area length change part to easily change the types of substrates to allow substrates of different lengths to be selected to mount electronic components onto the substrate. The conveyance units include a working area for substrates having different length that are conveyed from a stand-by area, an area length of the working area that is variable in accordance with the length of the substrate, and a stand-by unit corresponding to a stand-by area for the substrate to be carried in to the working area. The working area length change part changes an interval between a commonly used first pulley and one of a plurality of second pulleys selectively used in accordance with the area length of the working area by changing a belt winding path of a conveyance belt wound on the pulleys in the working unit.Type: GrantFiled: March 3, 2014Date of Patent: December 25, 2018Assignee: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.Inventors: Toshihiko Nagaya, Hiroyuki Fujiwara, Shigeo Ogata, Yoshinori Konda, Yoichi Makino, Shinji Yamamoto, Shuuichi Kubota, Kimio Iizuka, Koji Sakurai
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Publication number: 20180299380Abstract: A microfluidic device includes a substrate having an electromagnetic wave transmission property, a lid member facing the substrate and being separated from the substrate such that a flow channel is formed between the substrate and the lid member, a light absorption layer which is placed in the flow channel and absorbs an electromagnetic wave, and a microwell array formed on the substrate and having plural microwells that are open to the flow channel to receive a target of analysis.Type: ApplicationFiled: June 26, 2018Publication date: October 18, 2018Applicant: Toppan Printing Co., Ltd.Inventors: Yoichi Makino, Keisuke Goto
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Publication number: 20180243869Abstract: When a workpiece holder holding a workpiece is rocked around a lateral rocking axis by a work stage of a mounter and the workpiece is positioned so that one mounting surface of the workpiece faces a predetermined direction to be worked, a component is mounted on the one mounting surface by a mounting head of the mounter. When a posture of the workpiece in the workpiece holder is changed by a posture changing head of a posture changer and thereafter the workpiece holder in which the posture of the workpiece is changed is rocked around the lateral rocking axis by the work stage of the mounter and the workpiece is positioned so that the other mounting surface of the workpiece faces a predetermined direction to be worked, a component is mounted on the other mounting surface by the mounting head of the mounter.Type: ApplicationFiled: February 5, 2018Publication date: August 30, 2018Inventors: SEIJI MIZUOKA, TAKAHIRO ENDO, YASUHIRO SUZUKI, YOICHI MAKINO
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Publication number: 20180221877Abstract: A microfluidic device includes: a base plate allowing an electromagnetic wave to pass therethrough and having no autofluorescence; a microwell array formed on the base plate and including a wall layer in which a plurality of through-holes are formed in a thickness direction; and a lid member disposed opposite to the base plate in a state of being separated from the wall layer, wherein microwells are formed by the base plate and the through-holes formed in the wall layer, and wherein the wall layer is formed of a material containing a colored component that absorbs an electromagnetic wave of a predetermined wavelength.Type: ApplicationFiled: April 4, 2018Publication date: August 9, 2018Applicant: TOPPAN PRINTING CO., LTD.Inventors: Keisuke Goto, Yoichi Makino, Akihiro Hoshino