Abstract: A method for preparing a functionalized polymer, the method comprising the steps of preparing a reactive polymer, and reacting the reactive polymer with a halosilane compound containing an amino group.

Abstract: This invention relates to a rubber composition being excellent in the low heat buildup and fracture properties (resistance to crack growth). and more particularly to a rubber composition, characterized by compounding 10-100 parts by mass of an inorganic filler and/or carbon black based on 100 parts by mass of a rubber component including not less than 10 mass % of a modified conjugated diene-based polymer having a cis-1,4 bond content of not less than 90% and a vinyl bond content of not more than 1.2% and a primary amino group. In this case, the modified conjugated diene-based polymer is obtained by (1) reacting the predetermined conjugated diene-based polymer having an active terminal with a compound having two or more predetermined functional groups and (2) further reacting the resulting product with a compound having a primary amino group.

Abstract: The present invention relates to pharmaceutical compositions comprising a sulfonamide-including compound in combination with an angiogenesis inhibitor.

Abstract: This invention relates to a rubber composition being excellent in the low heat buildup and fracture properties (resistance to crack growth). and more particularly to a rubber composition, characterized by compounding 10-100 parts by mass of an inorganic filler and/or carbon black based on 100 parts by mass of a rubber component including not less than 10 mass % of a modified conjugated diene-based polymer having a cis-1,4 bond content of not less than 90% and a vinyl bond content of not more than 1.2% and a primary amino group. In this case, the modified conjugated diene-based polymer is obtained by (1) reacting the predetermined conjugated diene-based polymer having an active terminal with a compound having two or more predetermined functional groups and (2) further reacting the resulting product with a compound having a primary amino group.

Abstract: In general the present invention provides a functionalized polymer prepared by a process comprising the steps of preparing a pseudo-living polymer by polymerizing conjugated monomer with a lanthanide-based catalyst, and reacting the pseudo-living polymer with a functionalizing agent defined by the formula (I) A-R1—Z??(I) where R1 is a divalent bond or divalent organic group comprising from 0 to about 20 carbon atoms, A is a substituent that will undergo an addition reaction with a pseudo-living polymer, and Z is a substituent that will react or interact with silica or carbon black reinforcing fillers, with the proviso that A, R1, and Z are substituents that will not protonate a pseudo-living polymer.

Abstract: A process for simply and inexpensively producing a conjugated diene polymer with a narrow molecular weight distribution and a high cis-bond content at a low cost is provided. The process comprises a polymerization step, wherein a conjugated diene polymer having a cis-1,4-bond content of 98.5 mass % or more and a ratio (Mw/Mn) of the weight average molecular weight (Mw) to the number average molecular weight (Mn) measured by gel permeation chromatography of 2.5 or less is obtained by carrying out a polymerization reaction in conjugated diene compounds using a catalyst composition containing a rare earth element-containing compound or a reaction product of the rare earth element-containing compound with a Lewis base, an aluminoxane and/or organoaluminum compound, and an iodine-containing compound.

Abstract: This invention relates to an aromatic vinyl compound-conjugated diene compound copolymer capable of giving excellent wear resistance and resistance to wet skid to a tire, and more particularly to an aromatic vinyl compound-conjugated diene compound copolymer obtained by an addition polymerization of an aromatic vinyl compound and a conjugated diene compound in the presence of a polymerization catalyst composition comprising at least one specified metallocene complex selected from the group consisting of a metallocene complex represented by the following general formula (I): (wherein M is a lanthanoid element, scandium or yttrium, and CpR is independently a non-substituted or substituted indenyl, and Ra to Rf are independently an alkyl group having a carbon number of 1-3 or a hydrogen atom, and L is a neutral Lewis base, and w is an integer of 0-3) and so on, wherein a content of cis-1,4 bond in a conjugated diene compound portion is not less than 80%.

Abstract: A method for preparing a functionalized polymer comprising the steps of preparing a polymer by polymerizing conjugated diene monomer with a lanthanide-based catalyst, wherein the lanthanide-based catalyst comprises (a) a lanthanide compound, (b) an alkylating agent, and (c) a source of halogen, and reacting the pseudo-living polymer with at least one amide-containing functionalizing agent.

Abstract: A method for preparing a functionalized polymer comprising the steps of preparing a polymer by polymerizing conjugated diene monomer with a lanthanide-based catalyst, wherein the lanthanide-based catalyst comprises (a) a lanthanide compound, (b) an alkylating agent, and (c) a source of halogen, and reacting the pseudo-living polymer with at least one amide-containing functionalizing agent.

Abstract: A method for preparing a functionalized polymer, the method comprising the steps of preparing a reactive polymer, and reacting the reactive polymer with a halosilane compound containing an amino group.

Abstract: An object of the present invention is to provide a rubber composition which not only realizes sufficiently low heat generation properties but also exhibits more excellent crack growth resistance than the conventional rubber composition. The rubber composition contains in 100 mass % of rubber components thereof: 20-80 mass % of natural rubber in which the total nitrogen content in natural rubber latex is in the range of 0.1 mass % to 0.4 mass % (exclusive of 0.1 mass % and inclusive of 0.4 mass %); and butadiene-based polymer having cis content of 90% or higher.

Abstract: A method for preparing a functionalized polymer, the method comprising the steps of preparing a reactive polymer, and reacting the reactive polymer with a halosilane compound containing an amino group.

Abstract: A functionalized polymer includes a polymer chain and a terminal functionality that includes at least one disilylamino group. The polymer can be the reaction product of a terminally active polymer chain and a compound that includes at least one disilylamino group and a group capable of reacting with terminally active polymers. Methods for making and using such polymers also are provided, as are compositions containing the polymer and one or more types of filler particles as well as vulcanizates provided from such compositions.

Abstract: There are provided a rubber composition simultaneously improving low loss factor and wear resistance as compared with the conventional ones as well as a tire using such a rubber composition. The invention lies in a rubber composition using a modified conjugated diene rubber and being excellent in the low loss factor and wear resistance as well as a tire. The rubber composition of the invention is formed by compounding a filler to a rubber component containing (A) a modified conjugated diene rubber having a cis-bond content in conjugated diene portion of not less than 87% and a vinyl bond content of not more than 2% and containing a functional group reactive with a filler and (B) a modified polymer having a modifying functional group number per 1 molecule of an unmodified polymer of not less than 0.6.

Abstract: The present invention relates to a polymer composition containing (A) an elastomer that has a reactive functional group on a main chain, (B) an inorganic filler, and (C) a coupling agent that has one or less on average per molecule of a modification functional group having binding reactivity with the reactive functional group on the main chain of the elastomer as the component (A), and has a functional group having affinity with the component (B) or being capable of being bonded to the component (B), a rubber composition containing the polymer composition, and a tire containing the rubber composition, and provides a polymer composition that provides a rubber composition capable of enhancing fuel consumption efficiency of a tire and imparting sufficient wear resistance and rupture resistance to a tire, a rubber composition that has the aforementioned properties, containing the polymer composition, and a tire containing the rubber composition.

Abstract: A process for simply and inexpensively producing a conjugated diene polymer with a narrow molecular weight distribution and a high cis-bond content at a low cost is provided. The process comprises a polymerization step, wherein a conjugated diene polymer having a cis-1,4-bond content of 98.5 mass % or more and a ratio (Mw/Mn) of the weight average molecular weight (Mw) to the number average molecular weight (Mn) measured by gel permeation chromatography of 2.5 or less is obtained by carrying out a polymerization reaction in conjugated diene compounds using a catalyst composition containing a rare earth element-containing compound or a reaction product of the rare earth element-containing compound with a Lewis base, an aluminoxane and/or organoaluminum compound, and an iodine-containing compound.

Abstract: A process for simply and inexpensively producing a conjugated diene polymer with a narrow molecular weight distribution and a high cis-bond content at a low cost is provided. The process comprises a polymerization step, wherein a conjugated diene polymer having a cis-1,4-bond content of 98.5 mass % or more and a ratio (Mw/Mn) of the weight average molecular weight (Mw) to the number average molecular weight (Mn) measured by gel permeation chromatography of 2.5 or less is obtained by carrying out a polymerization reaction in conjugated diene compounds using a catalyst composition containing a rare earth element-containing compound or a reaction product of the rare earth element-containing compound with a Lewis base, an aluminoxane and/or organoaluminum compound, and an iodine-containing compound.

Abstract: A combination therapy for tumor is provided. Disclosed is a method of treating tumor, the method comprises administering to a patient, a compound or pharmaceutically acceptable salt thereof represented by Formula (I) and everolimus represented by Formula (II): wherein R1 is C1-6 alkyl or C3-8 cycloalkyl; R2 is a hydrogen atom or C1-6 alkoxy; and R3 is a hydrogen atom or a halogen atom.

Abstract: The present invention aims to provide a pneumatic tire which does not cause air accumulation or film damage even without application of a mold release agent to an inner face of the pneumatic tire in vulcanizing and molding by use of a bladder. According to the present invention, the pneumatic tire has an inner liner including one or more film layers on an inner face of the pneumatic tire. A gelation rate of an innermost layer of the one or more film layers on an innermost side of the pneumatic tire is 10.0-99.0% before vulcanization. Here, it is preferred that the one or more film layers is formed of a single or multiple resin film layers.

Abstract: This invention relates to a method for producing functionalized cis-1,4-polydienes having a combination of a high cis-1,4-linkage content and a high functionality, the resulting polymers and the vulcanized products containing the polymers. The functionalized cis-1,4-polydienes of the present invention are produced by a method comprising the steps of: (1) preparing a reactive polymer by polymerizing conjugated diene monomer with a lanthanide-based catalyst in the presence of less than 20% by weight of organic solvent based on the total weight of monomer, organic solvent, and resulting polymer, where the lanthanide-based catalyst is the combination of or reaction product of (a) a lanthanide compound, (b) an aluminoxane, (c) an organoaluminum compound other than an aluminoxane, and (d) a halogen-containing compound; and (2) contacting the reactive polymer with a functionalizing agent.