Abstract: The present invention provides a medicinal composition having an excellent antitumor activity.

Abstract: The present invention provides a medicinal composition having an excellent antitumor activity.

Abstract: The present invention creates a novel antiangiogenic agent and provides an antitumor agent which shows high safety as compared with conventional antitumor agents, has a sure effect and is able to be administered for a long period. That is, it provides an indole compound represented by the following formula (I), its pharmacologically acceptable salt or hydrates thereof: In the formula, R1 represents hydrogen atom, a halogen atom or cyano group; R2 and R3 are the same as or different from and each represents hydrogen atom, a C1˜C4 lower alkyl group or a halogen atom; R4 represents hydrogen atom or a C1˜C4 lower alkyl group; and the ring A represents cyanophenyl group, aminosulfonylphenyl group, aminopyridyl group, aminopyrimidyl group, a halopyridyl group or cyanothiophenyl group, provided that the case where all of R1, R2 and R3 are hydrogen atoms, where both R2 and R3 are hydrogen atoms or where the ring A is aminosulfonyl group and both R1 and R2 are halogen atoms is excluded.

Abstract: A catalyst composition that is the combination of or the reaction product of ingredients comprising (a) an lanthanide compound, (b) an alkylating agent, (c) a nickel-containing compound, and optionally (d) a halogen-containing compound, with the proviso that the halogen-containing compound must be present where none of the lanthanide compound, the alkylating agent, and the nickel-containing compound contain a labile halogen atom.

Abstract: The present invention provides a sulfonamide- or sulfonylurea-containing heterocyclic compounds. Specifically, it provides a heterocyclic compound represented by the formula (I), a pharmacologically acceptable salt thereof or a hydrate of them.

Abstract: A process for forming a copolymer comprising the steps of (i) preparing a living polymer segment by using anionic polymerization techniques, (ii) modifying the living polymer by reacting it with an alkyl metal halide to form an organometallic polymeric intermediate, and (iii) preparing a second polymer segment from the organometallic polymeric intermediate by combining the intermediate, conjugated diene monomer, and a coordination catalyst that will polymerize the conjugated diene monomer.

Abstract: A styrene-butadiene copolymer having excellent low hysteresis loss characteristic, wet skid resistance, fracture characteristics, and abrasion resistance and a rubber composition comprising the copolymer are disclosed. The styrene-butadiene copolymer has a total styrene content in the range of 33 to 42% by weight of the styrene-butadiene copolymer; a content of styrene sequences having 4 to 20 styrene units in the range of 40 to 65% by weight of the total styrene content, as obtained by measurements by NMR and GPC; a content of styrene sequences having more than 20 styrene units in the range of 5% by weight or less of the total styrene content, as obtained by measurement by GPC; a content of vinyl unit in the range of 30% by mol or less of a butadiene part of the styrene-butadiene copolymer; a sum of the total styrene value and ½ of the content of vinyl units in the range of 46 to 52%; and an inner or end structure having, for example tin-carbon bond.

Abstract: The present invention creates a novel antiangiogenic agent and provides an antitumor agent which shows high safety as compared with conventional antitumor agents, has a sure effect and is able to be administered for a long period. That is, it provides an indole compound represented by the following formula (I), its pharmacologically acceptable salt or hydrates thereof. In the formula, R1 represents hydrogen atom, a halogen atom or cyano group; R2 and R3 are the same as or different from and each represents hydrogen atom, a C1˜C4 lower alkyl group or a halogen atom; R4 represents hydrogen atom or a C1˜C4 lower alkyl group; and the ring A represents cyanophenyl group, aminosulfonylphenyl group, aminopyridyl group, aminopyrimidyl group, a halopyridyl group or cyanothiophenyl group, provided that the case where all of R1, R2 and R3 are hydrogen atoms, where both R2 and R3 are hydrogen atoms or where the ring A is aminosulfonyl group and both R1 and R2 are halogen atoms is excluded.

Abstract: The present invention creates a novel antiangiogenic agent and provides an antitumor agent which shows high safety as compared with conventional antitumor agents, has a sure effect and is able to be administered for a long period. That is, it provides an indole compound represented by the following formula (I), its pharmacologically acceptable salt or hydrates thereof.

Abstract: The present invention creates a novel antiangiogenic agent and provides an antitumor agent which shows high safety as compared with conventional antitumor agents, has a sure effect and is able to be administered for a long period. That is, it provides an indole compound represented by the following formula (I), its pharmacologically acceptable salt or hydrates thereof.

Abstract: A process for polymerizing 1,3-butadiene into a low molecular weight high-cis polybutadiene is described using a catalyst system comprising: (a) a neodymium-containing compound, (b) an aluminoxane or a trialkyl aluminum compound, (c) an organoaluminum hydride, and (d) a halogen source. A blend of a high molecular weight high-cis polybutadiene and the low molecular weight high-cis polybutadiene is also disclosed for use in pneumatic tire treads. Desirably both the high and the low molecular weight polymers have high cis contents, with the low molecular weight polymer being at least 70 percent cis and the high molecular weight polymer being at least 92 percent cis. Desirably both polymers are made with a neodymium catalyst system. The blends provide a balance of properties including good snow traction, wet traction, and rolling resistance while providing a balance of good physical properties including tension at break, modulus etc.

Abstract: The purpose of the present invention is to efficiently separate and utilize the rapeseed germ. The present invention relates to a method for the production of a fraction containing a rapeseed germ as a main component, comprising crushing a rapeseed and separating said fraction. One of the specific products derived from rapeseed germ is the oil and fat prepared by extraction or expression of the rapeseed germ.

Abstract: A functionalized polymer prepared by a process comprising the steps of preparing a solution of a cyclic amine compound, an organolithium compound, and from 3 to about 300 equivalents, based upon one equivalent of lithium, of a monomer selected from the group including diene monomers, vinyl aromatic monomers, and mixtures thereof, where the cyclic amine compound is defined by the formula where R.sub.2 is selected from the group consisting of an alkylene, substituted alkylene, oxy- or N-alkylamino-alkylene group having from about 3 to about 16 methylene groups, N is a nitrogen atom, and H is a hydrogen atom, thereby forming a polymerization initiator having the formula where Li is a lithium atom, SOL is a divalent hydrocarbon group having from 3 to about 300 polymerized monomeric units, y is from 0.5 to about 3, and A is a cyclic amine radical derived from the cyclic amine, charging the solution containing (A)Li(SOL)y with from about 0.

Abstract: A functionalized polymer includes a polymer chain carrying at least one functional group selected from alkyl, dialkyl and cycloalkyl amine radicals having the general formula ##STR1## and cyclic amine radicals having the general formula ##STR2## where R.sub.1 is an alkyl, cycloalkyl or aralkyl having from 1 to about 12 carbon atoms, and R.sub.2 is an alkylene, substituted alkylene, oxy- or N-alkylamino-alkylene group having from about 3 to about 16 methylene groups. The invention also provides products based upon such polymers.

Abstract: An acyclic alkane soluble anionic polymerization initiator includes a mixture of from about 90 to about 10 parts by weight of a lithio amine having the general formula A.sub.1 Li and from about 10 to about 90 parts by weight of at least one other lithio amine having the general formula A.sub.2 Li. A.sub.1 and A.sub.2 are selected from the dialkyl, alkyl, cycloalkyl and dicycloalkyl amine radicals and cyclic amine radicals. There is also provided a method of forming a mixture of anionic polymerization initiators, a functionalized polymer and a method of forming a functionalized polymer.

Abstract: The present invention is directed toward anionic polymerization employing lithio amines mixed with an organic alkali metal compound and optionally, a chelating reagent. The lithio amines have the general formula (A)Li(SOL)y, where SOL is a solubilizing component, A is an alkyl, dialkyl, cycloalkyl or dicycloalkyl amine radical or a cyclic amine, and y is 0 or is from about 0.5 to about 3. The invention is also directed toward polymers and other products made using the initiator, and methods therefor. Further, the invention contemplates a polymer, a polymer composition and products therefrom, which include a functional group from the reaction product of an amine and an organolithium compound. The resulting polymers may be terminated with a terminating, coupling or linking agent, which may provide the polymer with a multifunctionality.

Abstract: Novel heterobicyclic sulfonamide and sulfonic ester derivatives represented by the following general formula (I), which exhibit an antitumor activity and are lowly toxic, and processes for the preparation thereof.A sulfonamide derivative and a sulfonic ester derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein variables A, W, X, B, C, Y, Z are as defined in the specification.

Abstract: An acyclic alkane soluble anionic polymerization initiator includes a mixture of from about 90 to about 10 parts by weight of a lithio amine having the general formula A.sub.1 Li and from about 10 to about 90 parts by weight of at least one other lithio amine having the general formula A.sub.2 Li. A.sub.1 and A.sub.2 are selected from the dialkyl, alkyl, cycloalkyl and dicycloalkyl amine radicals and cyclic amine radicals. There is also provided a method of forming a mixture of anionic polymerization initiators, a functionalized polymer and a method of forming a functionalized polymer.

Abstract: Novel heterobicyclic sulfonamide and sulfonic ester derivatives represented by the following general formula(I), which exhibit an antitumor activity and are lowly toxic, and processes for the preparation thereof.A sulfonamide derivative and a sulfonic ester derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein A represents a monocyclic or bicyclic aromatic ring which may be substituted; B represents a six-membered unsaturated hydrocarbon ring or a six-membered unsaturated heterocycle containing one nitrogen atom, each of which may be substituted; C represents a five-membered heterocycle containing one or two nitrogen atoms which may be substituted; W represents a single bond or a group represented by formula --CH.dbd.CH--; X represents a group represented by formula --N(R.sup.1)-- or oxygen; Y represents carbon or nitrogen; Z represents a group represented by formula --N(R.sup.2)-- or nitrogen; and R.sup.1 and R.sup.

Abstract: A polymer modified with an alkoxysilane is prepared by a reaction forming a bond between an alkoxysilane compound represented by General Formula (I) and at least one of end parts of a conjugated diene/vinylaromatic hydrocarbon copolymer obtained by copolymerization of a conjugated diene and a vinylaromatic hydrocarbon using a lithium compound as an initiator. An adhesive composition contains 3% by weight or more of the polymer modified with an alkoxysilane. The polymer is used for an adhesive composition, can be prepared by a simple process, has excellent adhesive property and durability so that an additive such as a tackifier is not always required, and has essentially enhanced adhesive property to inorganic materials, in particular. The adhesive composition in which the polymer is used has excellent adhesive property and durability.