Abstract: Methods for treating a solid tumor, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a solid tumor, determined to lack a p53 deactivation mutation, in a subject.

Abstract: Provided are a method and apparatus for providing a counseling service. A method of operating a counseling center server interworking with an instant messaging service includes providing a profile of at least one expert account for counseling linked to a channel of a second user to a terminal of a first user, identifying an initiation condition for a counseling ticket for counseling with a first expert account, creating a counseling ticket to be allocated to the first expert account, and transmitting counseling content through a chat room for counseling of the channel in which the first expert account and an account of the first user participate.

Abstract: Provided are a method and apparatus for providing a counseling service. A method of operating a counseling center server interworking with an instant messaging service includes activating a connection with a chatbot server linked to a channel in a chat room, calling a chatbot block corresponding to a specific task included in the chatbot server through the chat room, transmitting a message received from a terminal of a user connected to the chat room to the chatbot server as an input of the chatbot block, and transmitting an output of the chatbot block in response to the message received from the chatbot server to the terminal of the user.

Abstract: Compositions and methods for editing, e.g., introducing double-stranded breaks, within the TTR gene are provided. Compositions and methods for treating subjects having amyloidosis associated with transthyretin (ATTR), are provided.

Abstract: Compositions and methods for editing, e.g., introducing double-stranded breaks, within the TTR gene in combination with administration of a corticosteroid are provided. Compositions and methods for treating subjects having amyloidosis associated with transthyretin (ATTR), in which a guide RNA and a corticosteroid are administered, are provided.

Abstract: Provided are a method and apparatus for providing a counseling service. A method of operating a counseling center server interworking with an instant messaging service includes acquiring, based a search request for a message transmitted to a channel registered in the service, a search result of a chatbot server linked to the channel, providing an interface for inputting a value of at least one parameter included in the search result to a terminal of a counselor linked to the channel, acquiring an entity corresponding to the parameter based on the message, determining a value of the parameter based on at least one of the acquired entity and data input through the interface, and requesting, based on the determined value of the parameter, an instant messaging server configured to provide the service to transmit a response message corresponding to the search result.

Abstract: Provided are a method and apparatus for providing a counseling service. A method of operating a counseling center server interworking with an instant messaging service includes creating, based on an input of a first user requesting counseling for a channel registered in the service, a first counseling ticket corresponding to the channel, determining whether the first counseling ticket is created due to switch to manned counseling during unmanned counseling based on a type of the requested counseling and a second counseling ticket created before the first counseling ticket by a request of the first user, updating an indicator for a counseling status of the channel based on a result of the determination and counseling data stored in correspondence with the second counseling ticket, and providing the updated indicator for the counseling status to a terminal of a second user linked to the channel.

Abstract: An FPA includes a substrate; a plurality of spaced-apart implant regions deposited in the substrate; a plurality of supplemental metal contacts, one supplemental metal contact of the plurality of supplemental metal contacts electrically connected to one implant region of the plurality of implant regions; a plurality of metal conductors electrically connecting the plurality of supplemental metal contacts; and a primary metal contact, electrically connected to the plurality of supplemental metal contacts by at least one of the metal conductors of the plurality of metal conductors. The pixel can include an Indium bump electrically connected to the primary metal contact.

Abstract: In a crystal growth furnace having an array of vertically arranged heaters to provide controlled heating zones within a chamber, and a crucible for holding crystal material, wherein the crystal is grown vertically through the heating zones, the improvement includes a laser mounted outside the chamber which radiates a beam of energy to locally melt precipitates and inclusions. The furnace includes a mechanism to position the laser vertically to, at or near the interface between the formed crystal and crystal melt material above the formed crystal. The crystal material can be CdZnTe.

Abstract: A method and system for generating voltage and/or current oscillations in a single magnetic layer is provided. The method comprises applying a direct voltage/current to the layer in a longitudinal direction; and developing a longitudinal voltage between a pair of longitudinal voltage leads and/or a transverse voltage between a pair of transverse voltage leads. The magnetic layer comprises a ferrimagnetic or antiferrimagnetic material having a first and second magnetic sub-lattice, wherein the first sub-lattice is a dominant sub-lattice such that the charge carriers at the Fermi energy originate predominantly from the dominant sub-lattice and the charge carriers at the Fermi energy are spin polarised. In some embodiments, the dominant current carrying sub-lattice may lack inversion symmetry.

Abstract: Disclosed is an artificial nail. The artificial nail according to an embodiment of the present disclosure includes a nail body, a design layer attached to an upper surface of the nail body, and a 3-dimensional coating layer of an upwardly convex transparent dome shape on the design layer.

Abstract: The present disclosure discloses a method and a system for generating a composite PET-CT image based on a non-attenuation-corrected PET image. The method includes: constructing a first generative adversarial network and a second generative adversarial network; obtaining a mapping relationship between a non-attenuation-corrected PET image and an attenuation-corrected PET image by training the first generative adversarial network; obtaining a mapping relationship between the attenuation-corrected PET image and a CT image by training the second generative adversarial network; and generating the composite PET-CT image by utilizing the obtained mapping relationships. According to the present disclosure, a high-quality PET-CT image can be directly composited from a non-attenuation-corrected PET image, and medical costs can be reduced for patients, and radiation doses applied to the patients in examination processes can be minimized.

Abstract: Disclosed is a mobile device and a control method thereof. The mobile device includes a communication interface configured to perform communication via a network; a display configured to display an image; and a processor.

Abstract: An integrated circuit includes a multiplexer circuit coupled to receive a first clock signal and a second clock signal and coupled to provide an output clock signal to a channel. A protection circuit is coupled to receive a feedback signal from the channel. The protection circuit causes the multiplexer circuit to provide oscillations in the second clock signal to the output clock signal in response to the feedback signal indicating that the channel is idle to cause the channel to be in a protection mode that reduces degradation from bias temperature instability. The protection circuit causes the multiplexer circuit to provide oscillations in the first clock signal to the output clock signal in response to the feedback signal indicating that the channel is active.

Abstract: A Terahertz Source and Detector device is provided that includes a nanostructured metasurface configured to transmit fully into a layer of absorbing material below the metasurface to achieve transparent conductivity in the visible spectrum region, wherein the metasurface is composed of crystalline material with very high mobility. The crystalline material can be composed of HgCdTe. The HgCdTe material can have a bandgap of about 700 meV. The intrinsic carrier concentration can be 1012 cm?3 at 300K.

Abstract: Provided is a tool adapter mounted on a handle of a tool to be gripped by a robot hand, the tool adapter including: a fixing part including an opening in which the handle of the tool is inserted to be fixed to the fixing part; a grip part including contact surfaces which are installed on left and right sides of the fixing part to be gripped by the robot hand, and configured such that as at least one of the contact surfaces moves in accordance with a gripping force from the robot hand, a distance between the contact surfaces changes; and a power transmission structure connected to the grip part and configured to convert a movement of the at least one of the contact surfaces into a movement of pressing a switch installed at the handle of the tool.

Abstract: Embodiments of the disclosure can include systems and methods for formation fluid sampling. In one embodiment, a method can include monitoring a relationship between a first characteristic of a formation fluid extracted from a formation and a second characteristic of the formation fluid extracted from the formation, determining, based at least in part on the monitoring, that a linear trend is exhibited by the relationship between the first characteristic of the formation fluid extracted from the formation and the second characteristic of the formation fluid extracted from the formation, and determining a reservoir fluid breakthrough based at least in part on the identification of the linear trend, wherein the reservoir fluid breakthrough is indicative of virgin reservoir fluid entering a sampling tool.

Abstract: The invention relates to Cu-embedded masterbatches forming by a novel formulation and its production process. The novel formulation comprises a mixing powder prepared from Cu2O and ZnO. The mixing powder is milled in water to form slurry. Spray-dry the slurry at 130˜150° C. to get anti-bacterial powder. Add 12 wt. %˜15 wt. % of the anti-bacterial powder to plastic masterbatches and follow by pre-mixing, heating, stirring, melting, extruding, cooling and cutting process to obtain the Cu-embedded masterbatches.

Abstract: A lifting belt includes a lifter configured to generate a tractive force in a longitudinal direction of a spinal column by expansion, a left connector and a right connector respectively disposed on a left side and a right side of the lifter, and a central connector attachable to or detachable from the left connector and the right connector.