Abstract: Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) presented in the context of an HLA-Cw*0802 molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

Abstract: An orthodontic appliance may include an archwire and multiple orthodontic brackets. The archwire may fit within a human mouth and contain multiple male connectors. Each orthodontic bracket may have a configuration that facilitates attaching the orthodontic bracket to a single tooth. Each orthodontic bracket may allow one of the male connectors to be locked into the orthodontic bracket with a snapping action. The male connector may be unable to slide with respect to the orthodontic bracket after being locked in the orthodontic bracket. A manual unlocking action may allow the male connector to disengage from the orthodontic bracket.

Abstract: The present invention relates to the fields of automobile maintenance and device calibration technologies and discloses an automobile calibration device. The automobile calibration device includes: a stand apparatus; a supporting assembly, mounted at the stand apparatus and movable in a vertical direction with respect to the stand apparatus; and a drive assembly, configured to drive the supporting assembly to move in the vertical direction with respect to the stand apparatus. In the foregoing manner, the supporting assembly can automatically ascend or descend and manual adjustment of the supporting assembly is avoided.

Abstract: The present disclosure is directed to a package that includes openings that extend into the package. The openings are filled with a conductive material to electrically couple a first die in the package to a second die in the package. The conductive material that fills the openings forms electrical interconnection bridges between the first die and the second die. The openings in the package may be formed using a laser and a non-doped molding compound, a doped molding compound, or a combination of doped or non-doped molding compounds.

Abstract: Embodiments of the present disclosure relate to methods, apparatuses and computer program products for signal detection in a wireless communication system. A method implemented at a receiver device includes obtaining a set of received signals; determining a channel on which the set of received signals are transported; and detecting a set of transmitted signals from the set of received signals in an iterative manner based on the determined channel, a modulation mode for the set of transmitted signals, and the set of received signals, by using a gradient descent (GD) algorithm. Embodiments of the present disclosure may reduce computation complexity required in signal detection and/or improve detection performance.

Abstract: An orthodontic appliance may include an archwire and multiple orthodontic brackets. The archwire may fit within a human mouth and contain multiple male connectors. Each orthodontic bracket may have a configuration that facilitates attaching the orthodontic bracket to a single tooth. Each orthodontic bracket may allow one of the male connectors to be locked into the orthodontic bracket with a snapping action. The male connector may be unable to slide with respect to the orthodontic bracket after being locked in the orthodontic bracket. A manual unlocking action may allow the male connector to disengage from the orthodontic bracket.

Abstract: Provided are a cleaning device and a control method thereof. The cleaning device includes: a main body, including a suction unit generating a suction air flow, used for collecting an object to be cleaned up through the suction air flow; an interaction element, arranged on the main body and exposed outside, and used for generating, in response to an interaction event triggered by a user, an indication signal based on an interaction gesture sensed in the interaction event; and a second controller, arranged in the main body and coupled with the interaction element, and used for acquiring the indication signal and sending, according to the indication signal, a corresponding given signal to the suction unit such that the suction unit works according to the given signal.

Abstract: A pixel circuit, a driving method thereof, and a display panel are provided. The pixel circuit includes a first thin film transistor, a second thin film transistor, a first storage capacitor, a second storage capacitor, and an organic light-emitting diode. By adding a storage capacitor to a two-thin film transistors one-capacitor (2T1C) pixel circuit and electrically connected to a control signal, and further lowing a gate voltage of a second thin film transistor. As a result, a current of the pixel circuit under a same data signal voltage is greatly increased.

Abstract: An orthodontic appliance may include an archwire and multiple orthodontic brackets. The archwire may fit within a human mouth and contain multiple male connectors. Each orthodontic bracket may have a configuration that facilitates attaching the orthodontic bracket to a single tooth. Each orthodontic bracket may allow one of the male connectors to be locked into the orthodontic bracket with a snapping action. The male connector may be unable to slide with respect to the orthodontic bracket after being locked in the orthodontic bracket. A manual unlocking action may allow the male connector to disengage from the orthodontic bracket.

Abstract: Methods, systems, and apparatus for multi-scale stereolithography. The apparatus includes a light source for providing a laser beam having a first shape and a first size. The apparatus includes a dynamic aperture having multiple apertures that are of the same or different sizes or shapes. The dynamic aperture is configured to receive the laser beam and modify at least one of the shape or the size of the laser beam. The apparatus includes a platform for holding an object to be printed. The apparatus includes a processor connected to at least one of the light source, the dynamic aperture or the platform. The processor is configured to move the platform to direct the laser beam or direct the laser beam to cure resin onto the object to be printed using a first aperture of the multiple apertures to form the object.

Abstract: Embodiments of the present disclosure provide an image processing method based on artificial intelligence (AI) and an image processing system. The method includes: obtaining a feature recognition result of an image by performing image processing on the image to recognize a feature of the image and the image being obtained by performing image acquisition on a section of a patient using a digital slide scanner to generate a whole slide image (WSI) as the image; determining an imaging area of the section within a field of view of an eyepiece of a microscope with which real-time imaging is performed on the section; determining, within the image, an image area corresponding to the imaging area of the section and acquiring, from the feature recognition result of the image, a target feature recognition result of the image area; and superimposing the target feature recognition result on the imaging area of the section.

Abstract: Methods, systems, and devices including a light guide tool for multi-axis additive manufacturing. The light guide tool includes a tubular light guide. The tubular light guide may be made from an optically transmissive material enclosed by one or more reflective side walls that are interposed between opposing optically transmissive ends. The light guide tool includes an optical coupling fixed to a first end of the optically transmissive ends of the tubular light guide. The optical coupling is configured to couple to a lens. The light guide tool includes a transparent non-stick coating. The transparent non-stick coating is adhered over a second end of the optically transmissive ends of the tubular light guide. The light guide tool includes a lens. The lens is coupled to the optical coupling and configured to emit a two-dimensional light pattern.

Abstract: Synaptic resistors (synstors), and their method of manufacture and integration into exemplary circuits are provided. Synstors are configured to emulate the analog signal processing, learning, and memory functions of synapses. Circuits incorporating synstors are capable of performing signal processing and learning concurrently in parallel analog mode with speed, energy efficiency, and functions superior to computers.

Abstract: Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) presented in the context of an HLA-Cw*0802 molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

Abstract: The present invention relates to the technical field of automobile maintenance and device calibration, and discloses a calibration device of an automobile assistance system, the radar calibration device including a support assembly, a beam assembly, and a sliding member. The beam assembly is mounted to the support assembly and may move relative to the support assembly along a vertical direction. The sliding member is mounted to the beam assembly and may move relative to the beam assembly along a horizontal direction.

Abstract: A three-dimensional cell culture scaffold and preparation method thereof. The preparation method comprises the following steps: designing, according to a shape of a cell culture device, a shape of the three-dimensional cell culture scaffold; printing once by a 3D printer to form the three-dimensional cell culture scaffold; performing a surface treatment, by a surface treating agent, on the three-dimensional cell culture scaffold manufactured by 3D printing to obtain a resultant three-dimensional cell culture scaffold. By adopting a three-dimensional printing technology to manufacture a three-dimensional fibrous cell culture scaffold having a three-dimensional fibrous network structure, raw materials and a manufacturing time can be saved, reducing production costs, increasing production efficiency, decreasing power consumption, preventing a flaw in the conventional manufacturing technique, and facilitating large-scale intelligent manufacturing.

Abstract: An orthodontic appliance may include an archwire and multiple orthodontic brackets. The archwire may fit within a human mouth and contain multiple male connectors. Each orthodontic bracket may have a configuration that facilitates attaching the orthodontic bracket to a single tooth. Each orthodontic bracket may allow one of the male connectors to be locked into the orthodontic bracket with a snapping action. The male connector may be unable to slide with respect to the orthodontic bracket after being locked in the orthodontic bracket. A manual unlocking action may allow the male connector to disengage from the orthodontic bracket.

Abstract: A method and system for preparing high-purity taurine and salt by reacting ethylene oxide with bisulfite to generate isethionate, performing an ammonolysis reaction on the isethionate and ammonia as well as a metal salt, evaporating the reaction solution to obtain a taurine salt concentrated solution, subjecting the concentrated solution to ion exchange in an ion exchange system to obtain an adsorption solution with a main ingredient of taurine, separately collecting the adsorption solution, extracting the taurine from the adsorption solution, eluting adsorbed metal cations from the ion exchange system by an acid, separately collecting the eluate, and extracting salt from the eluate or directly using the eluate as a salt solution product.

Abstract: A fault handling method and apparatus for a wind power generator set, and a computer readable storage medium. The fault handling method comprises: dividing faults of a wind power generator set into groups according to a target protection object, each group of faults including a plurality of process faults associated with the target protection object and a target fault of the target protection object (101); if any one of the plurality of process faults in the same group as the target fault satisfies a corresponding process fault trigger condition and the target fault does not satisfy the corresponding target fault trigger condition, performing a fault-tolerant operation on the wind power generator set (102); if the target fault satisfies the corresponding target fault trigger condition, selecting, from the triggered process faults in the same group as the target fault, the process fault having the highest degree of association as a real fault that has caused shut-down of the wind power generator set (202).