Abstract: The present invention relates to novel 5-hydroxy pyridine-based compounds useful as P2X1 and P2X3 receptor antagonists and compositions comprising the same. The compounds according to the present invention have an activity of strongly antagonizing P2X1 and P2X3 receptors, and thus can be effectively used as a drug for treating or preventing chronic inflammatory diseases or neuropathic pain diseases caused by P2X1 and P2X3 receptor activity.

Abstract: A vent unit includes a bezel installed on a vehicle and formed in a ring shape with a flow hole at the center, and a spacer overlapping and coupled to the bezel and formed in a ring shape rotating relative to the bezel. The bezel has a plurality of first through-holes circumferentially spaced apart from one another, and the spacer has a plurality of second through-holes circumferentially spaced apart from one another such that conditioning air is discharged to an interior through the second through-holes and the first through-holes when the second through-holes are aligned with the first through-holes by circumferential rotation. The vent unit further includes a wing disposed in the flow hole of the bezel and coupled to the spacer through a hinge shaft. The wing controls discharge of conditioning air through the flow hole by axially rotating, and circumferentially relatively rotating together with the spacer.

Abstract: A cabin air state sensing system for a vehicle may include a divergence structure facilitating measurement of cabin air temperature and dust concentration in a cabin through suction of air using an air suction device and an operation method thereof.

Abstract: One embodiment relates to a stator unit and a motor comprising same, the stator unit comprising: a stator core; a coil wound around the stator core; and an insulator disposed between the stator core and the coil, wherein the stator core comprises a support part, and a coil winding part disposed on both side surfaces of the support part so as to protrude therefrom, wherein the support part and the coil winding part are disposed so as to form a cross shape. Accordingly, a coil space factor may be increased by using the cross-shaped stator core.

Abstract: A data storage device includes a nonvolatile memory device including a plurality of memory blocks and a controller for controlling the nonvolatile memory device. A plurality of management blocks includes first and second management blocks managed by the controller. The second management block stores start data and then stores integrity data. The first management block stores a storage location of the second management block. An integrity checker checks integrity of data associated with the first and second management blocks.

Abstract: A display device may include a substrate including a display area and a peripheral area adjacent to the display area, fan-out lines disposed in the peripheral area of the substrate, an insulation layer disposed on the fan-out lines, at least one first dam disposed on the insulation layer in the peripheral area, the at least one first dam surrounding the display area, a second dam disposed on the insulation layer in the peripheral area, the second dam surrounding the at least one first dam, and a blocking pattern disposed between the insulation layer and an edge of the second dam adjacent to the at least one first dam.

Abstract: The bioenvironmental simulation device according to an embodiment of the present invention includes at least one mounting unit on which cells to be measured are placed, a rotational force application unit configured to rotate the mounting unit so as to apply a rotational force to the cells to be measured placed on the mounting unit, and a culture liquid flow device through which a culture liquid flows across the mounting unit, wherein the culture liquid flows by the culture liquid flow device so as to apply a shear force to the cells to be measured.

Abstract: The present invention provides, among other things, compositions and methods for CNS delivery of Idursulfase-beta, a human recombinant iduronate-2-sulfatase protein, for effective treatment of Hunter Syndrome. The compositions and methods provided by the present invention effectively reduce symptoms not only in brain and spinal cord but also in peripheral tissues including heart, liver, spleen, lung, and kidney.

Abstract: A cleaner using a heating, ventilating, and air conditioning (HVAC) module is provided. The cleaner connects a ventilation fan for the HVAC module and a suction fan for vacuum cleaning to a single motor to independently drive the ventilation fan when the HVAC module is operated and to independently drive the suction fan when vacuum cleaning is performed. Accordingly, the number of components and production cost are reduced and, simultaneously, package assembly capability is improved.

Abstract: A new use of a cyclo histidine-proline (Cyclo His-Pro, CHP) is disclosed. A composition including cyclo histidine-proline (CHP) as an active ingredient has an excellent protective effect to protect kidney and liver cells from damage and/or toxicity induced by various causes. The composition is useful and effective in protecting kidney and/or liver cells/tissues and in treating a subject with kidney and/or liver diseases and/or damages.

Abstract: Disclosed herein are a touch panel and a touch-panel-integrated organic light-emitting display device that are capable of solving a retransmission problem while exhibiting excellent luminance and color viewing angle characteristics. The touch panel includes a plurality of first and second electrodes disposed on a substrate so as to intersect each other. Each first electrode includes a first touch electrode, the first touch electrode including a first metal mesh pattern having a lattice structure formed by a plurality of first and second line electrodes intersecting each other and a first floating unit disposed in the central part of the first metal mesh pattern, the first floating unit being electrically isolated from the first metal mesh pattern, the first floating unit being made of a transparent conductive material.

Abstract: Disclosed herein are a touch panel and a touch-panel-integrated organic light-emitting display device that are capable of solving a retransmission problem while exhibiting excellent luminance and color viewing angle characteristics. The touch panel includes a plurality of first and second electrodes disposed on a substrate so as to intersect each other. Each first electrode includes a first touch electrode, the first touch electrode including a first metal mesh pattern having a lattice structure formed by a plurality of first and second line electrodes intersecting each other and a first floating unit disposed in the central part of the first metal mesh pattern, the first floating unit being electrically isolated from the first metal mesh pattern, the first floating unit being made of a transparent conductive material.

Abstract: The present disclosure relates to a cell-protecting pharmaceutical composition including a cyclo histidine-proline (Cyclo His-Pro, CHP) as an active ingredient. The cell-protecting pharmaceutical composition including the present cyclo histidine-proline (CHP) as an active ingredient has an excellent protective effect to protect kidney and liver cells from toxicity. Thus, the composition may be useful for the prevention or treatment of kidney and liver diseases.

Abstract: The present invention relates to a composition for inducing cell reprogramming. The indazole derivative compound contained in the composition of the present invention shows an improved biological profile and at the same time can perform efficient cell reprogramming. In addition, unlike conventional compounds (e.g. riversine or BIO) for inducing low-molecular cell reprogramming, the indazole derivative compound of the present invention does not show cytotoxicity and thus is expected to have high growth in the market of cell therapy products when clinically applied. Conventional indazole derivative compounds have never known as a use for cell reprogramming. Compared with conventional indazole derivative compounds, the compound of the present invention has a great cell reprogramming ability while having no or little cytotoxicity.

Abstract: An air conditioner for a vehicle is provided and includes a dryer which is connected to an indoor air conditioner that adjusts the temperature and humidity within a vehicle. The air conditioner simultaneously dries a dry subject such as clothes, shoes or the like.

Abstract: A vehicle detector assembly for detecting solar radiation may include a housing, a fixed plate fixed to an upper surface of the housing in a flat form, a plurality of photo detectors bonded to a surface of the fixed plate, each being connected to a lead having a uniform one-directional inclination structure, and a detector cap fastened to the housing and transmitting sunlight.

Abstract: An air conditioner for a vehicle including a case body having a floor outlet, a roof outlet, an evaporator, and a heater core; a mode door adjusting an opening amount of each of the vents; and a temp door adjusting an opening amount of a cold-air passage and a hot-air passage, includes: an actuator lever connected to an actuator provided in the case body, and a main lever connected to the actuator lever to simultaneously control the mode door and the temp door.

Abstract: The present invention provides, among other things, compositions and methods for CNS delivery of Idursulfase-beta, a human recombinant iduronate-2-sulfatase protein, for effective treatment of Hunter Syndrome. The compositions and methods provided by the present invention effectively reduce symptoms not only in brain and spinal cord but also in peripheral tissues including heart, liver, spleen, lung, and kidney.

Abstract: A kit for diagnosing a renal disease or predicting prognosis of the renal disease from urine includes a binding molecule specifically bound to cMet protein contained in the urine. When a level of cMet protein in urine is higher than a normal group, this condition is diagnosed as the renal disease or predicted to have poor prognosis thereof. A screening method of a substance for treatment of renal disease includes first-measuring a level of cMet protein in urine of an object, injecting a sample to be analyzed into the object, and second-measuring the level of cMet protein in urine of the object. When the level of cMet protein in the second-measuring is lower than the level of cMet protein in the first-measuring, the sample to be analyzed is the substance for treatment of renal disease.

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating acute myeloid leukemia or metastatic breast cancer, comprising, as an active ingredient, an indirubin derivative. When the compound of the present invention is used, it can effectively inhibit the activity of FLT3 kinase and can be usefully used to prevent or treat acute myeloid leukemia or metastatic breast cancer.