Abstract: Compositions and method for stimulating and controlling arteriogenesis and lymphatic vasculature by preventing and/or reducing the cellular interaction between RAF1 and AKT have been developed. The compositions include molecules that increase the bioavailability of non-phosphorylated RAF1, for example, the RAF1 Ser259 to Ala259 mutant in (RAF1 S259A), and AKT1 inhibitory molecules. Defects, disorders or diseases of insufficient blood or lymphatic vasculature are treated by administering to a patient in need thereof, a pharmaceutical composition comprising a molecule specifically blocking RAF1-AKT crosstalk in a pharmaceutically acceptable carrier or excipient in an amount effective to enhance the growth of blood or lymphatic vasculature in the patient.

Abstract: A method for heat-treating a bainite steel rail is disclosed. The method includes: cooling a rolled steel rail naturally to lower a surface temperature of a rail head of the steel rail to 460° C. ?490° C.; cooling the steel rail forcely at a cooling rate of 2.0° C./s-4.0° C./s to lower the surface temperature of the rail head to 250° C.-290° C.; placing the steel rail in an ambient temperature until the surface temperature of the rail head is more than 300° C.; performing a tempering on the steel rail in a heating furnace at 300° C.-350° C. for 2 h-6 h; and air cooling the steel rail to the ambient temperature. Steel rails heat-treated by present method may have a stable retained austenite structure and a good mechanical performance.

Abstract: The present disclosure discloses a heat treatment method for a bainitic turnout rail, which includes: naturally cooling the turnout rail at a temperature in an austenite region after being finishing rolled to 450-480° C. at a tread center of a rail head of the turnout rail; accelerated cooling the naturally cooled turnout rail to 230-270° C. at the tread center of the rail head, a cooling rate at the tread center and a non-working side of the rail head being 1.5-5.0° C./s, a cooling rate at the working side of the rail head increasing by 0.1-1.0° C./s based on 1.5-5.0° C./s; continuously accelerated cooling the working side, the tread center and the non-working side of the rail head at a cooling rate of 0.05-0.25° C./s to decrease a temperature of the tread center of the rail head to 265-270° C.; and finally, naturally cooling the turnout rail to an ambient temperature.

Abstract: The present discloses a steel rail for high speed and quasi-high speed railways and a manufacturing method thereof. The steel rail having a superior rolling contact fatigue property can be obtained by reducing content of carbon in conjunction with controlled cooling after rolling. The steel rail includes 0.40-0.64% by weight of C, 0.10-1.00% by weight of Si, 0.30-1.50% by weight of Mn, less than or equal to 0.025% by weight of P, less than or equal to 0.025% by weight of S, less than or equal to 0.005% by weight of Al, more than 0 and less than or equal to 0.05% by weight of a rare earth element, more than 0 and less than or equal to 0.20% by weight of at least one of V, Cr, and Ti, and a remainder of Fe and inevitable impurities.

Abstract: An alignment device for aligning a second aperture in a second plate with a first aperture in a first plate and an alignment method of utilizing the same. The alignment device includes a main body, a first part extending from the main body, and a second part extending from the first part. The main body comprises a first linear dimension exceeding a width of the second aperture for disposing overlying the second plate. The first part comprises a second linear dimension for extending and fitting into the second aperture. The second part comprises a third linear dimension for extending and fitting into the first aperture.

Abstract: A high carbon content and high strength heat-treated steel rail including by weight 0.80-1.20% carbon, 0.20-1.20% silicon, 0.20-1.60% manganese, 0.15-1.20% chromium, 0.01-0.20% vanadium, 0.002-0.050% titanium, less than or equal to 0.030% phosphorus, less than or equal to 0.030% sulfur, less than or equal to 0.010% aluminum, less than or equal to 0.0100% nitrogen, and iron. The steel rail has excellent wear resistance and plasticity and can satisfy the requirement for overloading. A method for producing the steal rail by heating a slab to a heating temperature, multi-pass rolling, and accelerated cooling, wherein a maximum heating temperature (° C.) of said slab is equal to 1,400 minus 100[% C], [% C] representing the carbon content (wt. %) of said slab multiplied by 100.

Abstract: A method comprises supplying a dopant gas in an arc chamber of an ion source. A dilutant is supplied to dilute the dopant gas. The dilutant comprises about 98.5 wt. % xenon and about 1.5 wt. % hydrogen. An ion beam is generated from the diluted dopant gas using the ion source.

Abstract: The present invention provides a roofing product comprised of an asphalt coating on a nonwoven fiberglass mat. Enhanced tear strength for the roofing product, generally an asphalt shingle, is obtained by the presence of a release agent. The release agent can be a coating on the fiberglass mat, an additive in the mat binder, or present as an additive in the asphalt itself. Preferably, the release agent is a reactive polysiloxane which can react with any component within the roofing product, including the glass surface, sizing chemicals, binder chemicals, as well as the asphalt coating. The reaction can take place either during or after the polysiloxane is added or applied.

Abstract: A method comprises supplying a dopant gas in an arc chamber of an ion source. A dilutant is supplied to dilute the dopant gas. The dilutant comprises about 98.5 wt. % xenon and about 1.5 wt. % hydrogen. An ion beam is generated from the diluted dopant gas using the ion source.

Abstract: Non-steroidal androgen receptor modulating compounds of the general formula (I), their pharmaceutically acceptable salts, preparation process and pharmaceutically compositions containing the said compounds are disclosed. Such compounds of the general formula (I) or their pharmaceutically acceptable salts can be used for preparing non-steroidal medicines to treat and/or prevent conditions or diseases such as prostatic hyperplasia, prostate cancer, hirsutism, severe hormone-dependent alopecia or acne, etc. as a result of androgen receptor antagonistic activities.

Abstract: Non-steroidal androgen receptor modulating compounds of the general formula (I), their pharmaceutically acceptable salts, preparation process and pharmaceutically compositions containing the said compounds are disclosed. Such compounds of the general formula (I) or their pharmaceutically acceptable salts can be used for preparing non-steroidal medicines to treat and/or prevent conditions or diseases such as prostatic hyperplasia, prostate cancer, hirsutism, severe hormone-dependent alopecia or acne, etc. as a result of androgen receptor antagonistic activities.

Abstract: An alignment device for aligning a second aperture in a second plate with a first aperture in a first plate and an alignment method of utilizing the same. The alignment device includes a main body, a first part extending from the main body, and a second part extending from the first part. The main body comprises a first linear dimension exceeding a width of the second aperture for disposing overlying the second plate. The first part comprises a second linear dimension for extending and fitting into the second aperture. The second part comprises a third linear dimension for extending and fitting into the first aperture.

Abstract: A task scheduler system and method for managing tasks in an embedded system executes both unscheduled and scheduled tasks in their respective queues in a prescribed order without dependence on a Real Time Operating System (RTOS).