Abstract: A display substrate has a display region and a peripheral region. The display substrate includes a substrate, a first dam, a second dam and a connection portion. The first dam and the second dam are located on a side of the substrate, and are located in the peripheral region. The second dam is farther from the display region than the first dam. A height of the second dam is greater than a height of the first dam. The connection portion is located between the first dam and the second dam. The connection portion connects the first dam and the second dam, and a height of the connection portion is less than the height of the first dam. At least a portion of the first dam, at least a portion of the connection portion and at least a portion of the second dam are of an integrative structure.

Abstract: Provided is a SARS-CoV-2 mRNA vaccine, and the preparation method and use thereof. The present invention provides an mRNA molecule capable of encoding a target polypeptide, wherein the target polypeptide comprises an NTD-RBD natural domain in the Spike (S) protein of SARS-CoV-2, and wherein the NTD-RBD natural domain comprises an NTD fragment and an RBD fragment, the NTD fragment and the RBD fragment being linked together via a natural amino acid sequence derived from the S protein as a linker. The present invention provides an mRNA encoding a NTD-RBD natural domain in the Spike protein of SARS-CoV-2, which achieves an immune effect against SARS-CoV-2 mutant strains and is widely applicable.

Abstract: A display substrate and a display device are disclosed. The display substrate includes a display area and a frame area, and the display substrate includes a substrate, a plurality of sub-pixels on a side of the substrate, the plurality of sub-pixels are configured to emit light in the display area, an encapsulation layer on a side of the plurality of sub-pixels away from the substrate, and a retaining wall located in the frame area, the retaining wall is located between the encapsulation layer and the substrate and includes a first sub-retaining wall, a second sub-retaining wall, and a transition area between the first sub-retaining wall and the second sub-retaining wall, the retaining wall includes at least one layer provided in the same layer, the at least one layer provided in the same layer continuously extends across the first sub-retaining wall, the second sub-retaining wall and the transition area.

Abstract: The disclosure claims a method of stimulating a conditional quantum master equation in a quantum transport process by a recurrent neural network, comprising the following steps of: establishing a recurrent neural network which is a long short term memory network (LSTM), wherein the LSTM comprises TLSTM cells arranged in chronological order, and each LSTM cell has an input value xt and an output value ht, and there is a parameter (W, b) in the LSTM cell; replacing the input value xt with a shot noise spectrum S(?) of the current obtained according to the conditional quantum master equation; replacing the output value ht with a trace of density matrices in the conditional quantum master equation; and replacing the parameter (W, b) with a connection between density matrices in the conditional quantum master equation at imminent moments.

Abstract: The present disclosure relates to the technical field of rapid detection of molecules, and specifically relates to a method for rapid fluorescent immunoassay (FIA) and chemiluminescent immunoassay (CLIA) based on electrokinetic acceleration. The method includes the following steps sequentially: S1. sample acceleration: applying an actuating signal to a chip on which a target molecule is dripped to obtain a chip binding to the target molecule, where the chip includes an electrode sheet and coating molecules is immobilized on the electrode sheet; and S2. secondary antibody acceleration: adding a secondary antibody for binding to the target molecule dropwise on the chip binding to the target molecule, and applying an actuating signal to the chip to obtain a chip binding to the secondary antibody. The method can effectively improve a rate of FIA and CLIA, and can speed up a detection process and meet the need for rapid point-of-care testing (POCT).

Abstract: A robotic garden tool including a deck, a blade motor configured to rotate a blade about a blade axis, and a mount axially movable with respect to the deck along the blade axis. The garden tool also includes a worm shaft mounted for rotation with respect to the deck about a worm axis, the work shaft forming a threaded interface with the mount such that rotation of the worm shaft about the worm axis causes the mount to move axially with respect to the deck. The garden tool also includes a manual actuator configured to move with respect to the deck in response to receiving a manual actuation force by an operator, where the manual actuator is in operable communication with the worm shaft such that movement of the manual actuator with respect to the deck causes the worm shaft to rotate about the worm axis.

Abstract: The present invention provides a mannose-based mRNA targeted delivery system and use thereof. The mRNA can encode one or more target polypeptides and contains at least one mannose modification. The technical solution of the present invention modifies the mRNA molecule with a mannose, so that the mRNA can be directly and efficiently coupled with the mannose, and the targeted delivery of the mRNA is realized without the need for a carrier.

Abstract: A data transmission method, a device, and a data transmission system implement local interaction between two terminals when the two terminals are served by different UPF entities. The method performed by a first user plane function entity includes receiving a data packet from a first terminal through an uplink path corresponding to the first terminal, where the data packet carries addressing information of a second terminal; determining path information of a second user plane function entity based on information about the uplink path corresponding to the first terminal and the addressing information of the second terminal; sending the data packet to the second user plane function entity based on the path information of the second user plane function entity; and sending the data packet to the second terminal through a downlink path corresponding to the second terminal.

Abstract: A display substrate has a display region and a peripheral region. The display substrate includes a substrate, a first dam, a second dam and a connection portion. The first dam and the second dam are located on a side of the substrate, and are located in the peripheral region. The second dam is farther from the display region than the first dam. A height of the second dam is greater than a height of the first dam. The connection portion is located between the first dam and the second dam. The connection portion connects the first dam and the second dam, and a height of the connection portion is less than the height of the first dam. At least a portion of the first dam, at least a portion of the connection portion and at least a portion of the second dam are of an integrative structure.

Abstract: The present application provides a separator, a secondary battery, a battery module, a battery pack and an electrical apparatus. The separator may sequentially include a first region, a main region and a second region in a first direction. At least one surface of the first region and/or at least one surface of the second region may be provided with a fluorescent coating. The fluorescent coating may be used to identify whether the separator is folded or not.

Abstract: The present disclosure relates to the technical field of rapid detection of molecules, and specifically relates to a method for rapid fluorescent immunoassay (FIA) and chemiluminescent immunoassay (CLIA) based on electrokinetic acceleration. The method includes the following steps sequentially: S1. sample acceleration: applying an actuating signal to a chip on which a target molecule is dripped to obtain a chip binding to the target molecule, where the chip includes an electrode sheet and coating molecules is immobilized on the electrode sheet; and S2. secondary antibody acceleration: adding a secondary antibody for binding to the target molecule dropwise on the chip binding to the target molecule, and applying an actuating signal to the chip to obtain a chip binding to the secondary antibody. The method can effectively improve a rate of FIA and CLIA, and can speed up a detection process and meet the need for rapid point-of-care testing (POCT).

Abstract: A 5?Cap analog having a Cap2 structure and a preparation method therefor. The molecular formula of the 5? Cap analog having a Cap2 structure is selected from any one of m7G(5?)ppp(5?)(2?OMeA)p(2?OMeG), m7G(5?)ppp(5?)(2?OMeG)p(2?OMeG), etc. The 5?Cap analog having a Cap2 structure has higher synthesis efficiency, higher capping efficiency, lower immunogenicity, and higher protein translation efficiency.

Abstract: A parameter configuration method includes that a service layer of an embedded device that can be applied to a vehicle such as an intelligent vehicle, a connected vehicle, or a new energy vehicle directly obtains a hardware resource parameter of a hardware layer, and sends the hardware resource parameter to an AUTomotive Open System ARchitecture (AUTOSAR) development tool such that the AUTOSAR development tool generates a configuration file and an executable file.

Abstract: Disclosed herein are an mRNA targeting molecule comprising an N-acetylgalactosamine binding polypeptide and a preparation method therefor. A plasmid vector containing a DNA fragment formed by sequentially connecting a promoter, a target gene, a specific protease cleavage sequence, and a polynucleotide sequence encoding a GBD capable of binding to N-acetylgalactosamine, is transcribed to obtain an mRNA, which is connected to a DNA-puromycin linker under the action of a T4 ligase. The resulting connection product is subjected to protein translation, followed by cleavage using a specific protease to obtain an mRNA-puromycin-GBD complex, which then binds to a GBD protein sequence under the action of an N-acetylgalactosamine transferase to form an mRNA-puromycin-GBD-GalNAc complex, thereby modifying the mRNA with GalNAc, thus achieving the purpose of precise administration in a process of mRNA drug delivery and increasing the efficacy of the mRNA drug molecule.

Abstract: Disclosed are a display panel, a manufacturing method thereof and display equipment. The display panel comprises a display area, the display area comprises a camera area and a peripheral area surrounding the camera area, the camera area is provided with a transparent first touch control structure, and the first touch control structure is arranged between a substrate and an organic luminescent layer.

Abstract: The present invention provides a mannose-based mRNA targeted delivery system and use thereof. The mRNA can encode one or more target polypeptides and contains at least one mannose modification. The technical solution of the present invention modifies the mRNA molecule with a mannose, so that the mRNA can be directly and efficiently coupled with the mannose, and the targeted delivery of the mRNA is realized without the need for a carrier.

Abstract: A data transmission method includes receiving, by a user plane function entity, a data packet from a first terminal through an uplink path corresponding to the first terminal, where the data packet carries addressing information of a second terminal; determining, by the user plane function entity based on information about the uplink path corresponding to the first terminal and the addressing information of the second terminal, a downlink path corresponding to the second terminal; and sending, by the user plane function entity, the data packet to the second terminal through the downlink path corresponding to the second terminal.

Abstract: The present disclosure provides a power supply device and a high-power illumination system. The power supply device includes: a housing, where the housing includes a first bottom plate having a first surface on which a first heat sink is provided and a second surface on which a thermal conductive potting layer is provided; and a printed circuit board, where the printed circuit board is located in the housing, the printed circuit board includes a circuit board body and multiple electronic components arranged on the circuit board body, at least part of the multiple electronic components is arranged facing the second surface of the first bottom plate, and the electronic component of the at least part of the multiple electronic components is partially immersed in the thermal conductive potting layer to conduct heat dissipated by the electronic component to the first heat sink for natural heat dissipation of the electronic component.

Abstract: Provided are a method for preparing an mRNA-GalNAc targeting molecule, an in vivo delivery system therefor and use thereof. The mRNA-GalNAc targeting molecule comprises an mRNA molecule that is linked to PolyA modified with an N-acetylgalactosamine at 3?-end, wherein a sequence of the mRNA molecule comprises a 5? cap and a target gene sequence. By directly linking the mRNA molecule expressing the target gene to the polyA sequence coupled with GalNAc, an mRNA molecule with GalNAc at 3?-end is synthesized to realize the aim of targeted drug delivery in liver. The method is simpler and more reliable, and solves existing problems in coupling between mRNA and N-acetylgalactosamine.