Patents by Inventor Yong-Kang Zhang

Yong-Kang Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for treating medical dysfunctions and diseases using furan nitrone compounds
    Patent number: 6051571
    Abstract: Disclosed are methods for treating a patient with an acute central nervous system or cardiovascular disorder or a neurodegenerative, autoimmune or inflammatory disease using a pharmaceutical composition containing a pharmaceutically acceptable carrier and an effective amount of a furan nitrone compound.
    Type: Grant
    Filed: May 24, 1999
    Date of Patent: April 18, 2000
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: Judith A. Kelleher, Kirk R. Maples, Lowell David Waterbury, Hong Xu, Yong-Kang Zhang
  • .alpha.-aryl-N-alkylnitrones and pharmaceutical compositions containing the same
    Patent number: 6046232
    Abstract: Disclosed are novel .alpha.-aryl-N-alkylnitrone compounds and pharmaceutical compositions containing such compounds. The disclosed compositions are useful as therapeutics for preventing and/or treating neurodegenerative, autoimmune and inflammatory conditions in mammals and as analytical reagents for detecting free radicals.
    Type: Grant
    Filed: October 15, 1998
    Date of Patent: April 4, 2000
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: Judith A. Kelleher, Kirk R. Maples, Alina Dykman, Yong-Kang Zhang, Allan L. Wilcox, Julian Levell
  • Process for preparing furan nitrone compounds
    Patent number: 6040444
    Abstract: Disclosed are processes for preparing furan nitrone compounds using a furan carbonyl compound and a hydroxylamine compound.
    Type: Grant
    Filed: May 24, 1999
    Date of Patent: March 21, 2000
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: Allan L. Wilcox, Yong-Kang Zhang
  • Thiophene nitrone compounds
    Patent number: 6015831
    Abstract: Disclosed are novel thiophene nitrone compounds and pharmaceutical compositions containing such compounds. The disclosed compositions are useful as therapeutics for preventing and/or treating neurodegenerative, autoimmune and inflammatory conditions in mammals and as analytical reagents for detecting free radicals.
    Type: Grant
    Filed: January 14, 1999
    Date of Patent: January 18, 2000
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: Judith A. Kelleher, Kirk R. Maples, Yong-Kang Zhang
  • Thioether furan nitrone compounds
    Patent number: 5998469
    Abstract: Disclosed are novel thioether furan nitrone compounds and pharmaceutical compositions containing such compounds. The disclosed compositions are useful as therapeutics for preventing and/or treating neurodegenerative, autoimmune and inflammatory conditions in mammals and as analytical reagents for detecting free radicals.
    Type: Grant
    Filed: January 14, 1999
    Date of Patent: December 7, 1999
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: Judith A. Kelleher, Kirk R. Maples, Yong-Kang Zhang
  • Furansulfonic acid derivatives and pharmaceutical compositions containing the same
    Patent number: 5994396
    Abstract: Disclosed are furansulfonic acid derivatives and pharmaceutical compositions containing such derivatives. The disclosed compositions are useful for preventing and/or treating neurodegenerative, autoimmune and inflammatory conditions in mammals.
    Type: Grant
    Filed: August 13, 1998
    Date of Patent: November 30, 1999
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: Judith A. Kelleher, Kirk R. Maples, Yong-Kang Zhang
  • Furan nitrone compounds
    Patent number: 5942507
    Abstract: Disclosed are furan nitrone compounds and pharmaceutical compositions containing such compounds. The disclosed compounds are useful as analytical reagents for detecting free radicals and as therapeutics for treating a wide variety of medical dysfunctions and diseases.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: August 24, 1999
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: Judith A. Kelleher, Kirk R. Maples, Lowell David Waterbury, Allan L. Wilcox, Hong Xu, Yong-Kang Zhang
  • DMPO spin trapping compositions and methods of use thereof
    Patent number: 5681845
    Abstract: Spin trapping compositions in general have now been discovered to be effective in treating a variety of disorders, including disorders such as those arising from ischemia, infection, inflammation, exposure to radiation or cytotoxic compounds, not just of the central and peripheral nervous systems but of peripheral organ disease having a wide variety of etiologies. In the preferred embodiment, the compositions for treating tissue damage from ischemia (DMPO include 5,5-dimethyl pyrroline N-oxide (DMPO), and spin-trapping derivatives thereof, in a suitable pharmaceutical carrier for intravenous, oral, topical, or nasal/pulmonary administration. Many different disorders can be treated using these compounds, including diseases or disorders of the central and peripheral nervous systems, and disorders arising from ischemia, infection, inflammation, oxidation from exposure to radiation or cytotoxic compounds, as well as due to naturally occurring processes such as aging.
    Type: Grant
    Filed: February 1, 1993
    Date of Patent: October 28, 1997
    Assignee: Oklahoma Medical Research Foundation
    Inventors: Edward G. Janzen, Yong-Kang Zhang
  • Spin-trap molecules 2-trifluoromethyl- of 5,5-dimethyl-1-dyrroline-N-oxide
    Patent number: 5405967
    Abstract: Novel spin traps comprising 2-trifluoromethyl-1-DMPO or derivatives thereof have now been found. An effective synthesis method for these spin traps is also disclosed.
    Type: Grant
    Filed: October 22, 1993
    Date of Patent: April 11, 1995
    Assignee: Oklahoma Medical Research Foundation
    Inventors: Edward G. Janzen, Yong-Kang Zhang