Abstract: The present disclosure relates to use of a Clostridium ghonii spore combined with pembrolizumab in cancer treatment. It is found for the first time that the Clostridium ghonii spore combined with pembrolizumab can significantly improve a curative effect of colon cancer and reduce a dose of the pembrolizumab, and thus is efficient and low-toxic. Oncolysis by Clostridium ghonii can affect immunogenicity of a tumor microenvironment (TME) by various ways, converts an immunosuppressive state of the TME into an immune-activated state, adjusts the immunosuppressive TME, and breaks an immune tolerance. An optimal combination of the Clostridium ghonii spore and the pembrolizumab thoroughly removes about 20% of mouse tumor tissues. A benefit range of patients with tumors treated by a PD-1 antibody is expanded. The combination even has an obvious curative effect on patients failed the treatment by the PD-1 antibody.

Abstract: Methods and systems for managing memory usage in data learning operations. The method includes profiling one or more objects used for training in the data learning operation, in which the profiling includes determining an object size, a memory allocation timestamp, and a memory deallocation timestamp; and scheduling the memory usage. The scheduling includes grouping the one or more objects into the one or more groups based on the memory allocation and/or the memory deallocation timestamp of the one or more objects, and arranging the one or more objects in the one or more groups in descending order in a memory space. Two or more objects are provided in the descending order in the memory space, in which one of the objects having an earliest memory allocation timestamp is provided at a first value and the other object having a later memory allocation timestamp is provided at a second value.

Abstract: A cordycepin-based derived compound with an anti-tumor effect, and a structure of the compound is as shown in formula I; a cordycepin derivative and a pharmaceutical composition thereof provided by the invention have a good anti-tumor proliferation effect; compared with a parent drug, the cordycepin derivative has better affinity to cell membranes, so that a half-life period of in-vivo metabolism of the drug is longer, and in-vivo remaining time of the drug is longer; compared with other nucleoside anti-tumor drugs, the cordycepin derivative and the pharmaceutical composition thereof provided by the invention have wider types and action ranges of tumors, have excellent inhibition effects on a gastric cancer, a pancreatic cancer, a liver cancer, a small cell lung cancer, a colorectal cancer, melanoma, an ovarian cancer and the like, and have lower side effects and better curative effects.

Abstract: Embodiments of the disclosure provide a circuit, chip, system, and method for eliminating random perturbation. The circuit includes a weight calculating module for receiving digital signals and random perturbation digital quantity, using least mean square error algorithm to calculate weight deviation iteration coefficient based on digital signal and digital quantity, and updating perturbation weight in real-time according to weight deviation iteration coefficient; and a perturbation eliminating module for eliminating perturbation signal in output digital signal of quantizer according to perturbation weight updated in real-time and updating perturbation weight in real-time according to weight deviation iteration coefficient, and then calculating current perturbation weight in real time to realize self-calibration of perturbation weight.

Abstract: An industrial internet of things system for intelligent production control is provided, comprising: a user platform, a service platform, a management platform, a sensor network platform, and an object platform. The user platform modifies production line parameters based on an instruction of the user, generates a first instruction, and sends it to the management platform through the transformation of the service platform. The object platform collects production link data of each production link of products and transmits it to the management platform. The management platform modifies work order parameters based on a second instruction transformed by the service platform, generates a third instruction, and determines whether devices corresponding to the plurality of production links are abnormal based on the production link data.

Abstract: A flyback converter control architecture is provided in which primary-only feedback techniques are used to ensure smooth startup and detection of fault conditions. During steady-state operation, secondary-side regulation is employed. In addition, current limits are monitored during steady-state operation using primary-only feedback techniques to obviate the need for a secondary-side current sense resistor.

Abstract: The presently disclosed subject matter relates to multi-material electrical contacts, and methods of making multi-material electrical contact comprising a functionally graded monolithic structure, having a first metal and a second metal, an amount of the second metal as compared to an amount of the first metal increases with distance in the structure from a first surface to a second opposing surface of the structure such that the second metal content increases continuously or incrementally throughout the height of the electrical contact.

Abstract: The invention discloses a powder leakage monitoring device and a powder leakage monitoring method. The powder leakage monitoring device comprises light field camera, 3D PTZ (3-Dimensional Pan/Tilt/Zoom) and computer. Wherein, the light field camera records original light field images of monitored area; the 3D PTZ under the light field camera adjusts the shooting angle of the light field camera when it rotates according to the set direction; and the computer respectively connects to the light field camera and the 3D PTZ, which generates refocused images corresponding to the original light field images, and determines the spatial coordinates of the powder leakage point and the hazard range of the powder leakage in the monitored area according to the refocused images and the shooting angle. Therefore, the range and accuracy of powder leakage monitoring are both increased by using this invention.

Abstract: Disclosed is a device for efficiently recycling nickel from wastewater and a method. The device includes a housing, and an extraction unit and an electro-deposition unit which are respectively arranged inside the housing. The device is reasonable in overall structural design. An oscillating and floating component and a rotating component in an extraction cavity are used to fully and uniformly mix a solution to maximize the extraction strength. A mixing component in an electro-deposition cavity is used to accelerate ion dispersion, to better recycle nickel. The device is easy to operate, low in cost and suitable for mass promotion.

Abstract: The present disclosure provides a modified binder for use in an electrochemical cell that cycles lithium ions. The modified binder includes one or more agglomerates of polytetrafluoroethylene nanoparticles, where each of the polytetrafluoroethylene nanoparticles includes a polytetrafluoroethylene core and a polymeric shell that is disposed on exposed surfaces of the core. The polymeric shell can include a polymer selected from the group consisting of: polyethylene oxide, polyglycidyl methacrylate, polyvinylidene difluoride, fluoride-hexafluoropropylene, polypropylene oxide, polyacrylonitrile, polymethacrylonitrile, polymethyl methacrylate, derivatives and co-polymers, and combinations thereof, and in certain instances, also a humidity tolerant lithium salt.

Abstract: The present invention provides an energy absorbing foam material includes at least one shape memory polymer foam having a non-impact resistant configuration in a first force-application time, an impact resistant configuration in a second force-application time at a working temperature, a first glass transition temperature equal to or lower than a working temperature in the first force-application time, and a second glass transition temperature higher than a working temperature in the second force-application time. A second elastic modulus of the shape memory polymer foam in the second force-application time is at least 10 times than a first elastic modulus of the shape memory polymer form in the first force-application time at the working temperature.

Abstract: An electrode for display includes at least two display electrodes arranged at intervals along first direction, each including a body electrode and an end electrode; the at least two display electrodes include first and second display electrodes, body electrodes of the first and second display electrodes being parallel in first direction with a first preset pitch; among two side edges of the end electrode of the first display electrode opposite in first direction and two side edges of the end electrode of the second display electrode opposite in first direction, at least two side edges are unparallel; a minimum distance in first direction between one side edge of the end electrode of the first display electrode close to the second display electrode and one side edge of the end electrode of the second display electrode close to the first display electrode is greater than or equal to first preset pitch.

Abstract: A method, an apparatus for real-time multimedia communications using a software-defined network (SDN) are provided. The method includes receiving, in a periodic manner, a path metric associated with a first service node in the SDN and a second service node in the SDN, wherein the path metric comprises at least one of: a load status of at least one of the first service node or the second service node, or a transmission metric between the first service node and the second service node; and in response to receiving the path metric, updating a cascade network topology comprising an optimal path for transmitting multimedia data between a first edge node and a second edge node.

Abstract: A fetal Doppler (10) and a detection method, which relate to the technical field of medical devices. The fetal Doppler (10) comprises a housing (1, a fetal detection unit (20) and a maternal parameter detection unit (30), wherein the fetal detection unit (20) and the maternal parameter detection unit (30) are respectively used for collecting fetal physiological data and maternal physiological data; a controller (7) is arranged in an internal cavity of the housing (1); and the controller (7) is used for analyzing the collected fetal physiological data and maternal physiological data, so as to obtain a fetal heart rate and a maternal parameter. The same fetal Doppler (10) is used, such that the instrument cost is reduced; and maternal and fetal parameters can be acquired at the same time by directly using the same fetal Doppler (10), such that an instrument structure is simplified, and the detection efficiency of the maternal and fetal parameters is improved.

Abstract: Systems and methods here may be used for a setup of image capturing of a gemstone, such as a diamonds that are of high clarity grades. The present embodiments can provide methods to capture a diamond surface and internal clarity features from a diamond table and through and of other facets. Systems and methods may be used to convert gemstone dimension information into azimuth, slope, and distance information and adjust the motorized stage accordingly for surface imaging. Further, a calibration method can consider the offsets between design and actual system alignment. A calibration process can be used to compensate the offsets. Further, an additional conversion can be derived to compensate the offset caused by the geometry of the gemstone. The methods can automatically capture surface reflection images on facets of the gemstone and internal features taken through facets of the gemstone.

Abstract: A nitride-based semiconductor device includes a first nitride-based semiconductor layer, a second nitride-based semiconductor layer, a third nitride-based semiconductor layer, a passivation layer, a gate insulator layer, and a gate electrode. The first nitride-based semiconductor layer includes at least two doped barrier regions defining an aperture between the doped barrier regions. The second nitride-based semiconductor layer is disposed over first nitride-based semiconductor layer. The third nitride-based semiconductor layer is disposed on the second nitride-based semiconductor layer and has a bandgap higher than a bandgap of the second nitride-based semiconductor layer. The passivation layer is disposed over the third nitride-based semiconductor layer, in which a vertical projection of the passivation layer on the first nitride-based semiconductor layer is spaced apart from the aperture. The gate insulator layer is disposed over the third nitride-based semiconductor layer.

Abstract: The subject disclosure provides systems and methods for improved medium access for wireless communication. A wireless access point, on contending for and gaining medium access, may share a time and/or bandwidth channel resource with one or more other wireless access points and/or one or more client devices. The wireless access point can efficiently share the channel resource using buffer status information computed by the wireless access point and/or additional buffer status information computed by the one or more other wireless access points. In one or more implementations, latency information for buffered data can be provided from a client device to a wireless access point and/or from a satellite wireless access point to a control wireless access point.

Abstract: The invention provides a method for evaluating deep-buried tunnel blasting parameters, and belongs to the technical field of mine engineering. The method comprises: setting multiple diverse blasting schemes; selecting a plurality of test sections with the same geological characteristics, the number of the test sections corresponding to the number of the blasting schemes; blasting the test sections using the blasting schemes, and obtaining diversified monitoring data of each test section; and comparing the diversified monitoring data to select the optimal blasting schemes for the test sections. According to the method for evaluating the deep-buried tunnel blasting parameters, by implementing different blasting schemes in test sections with the same geological characteristics, diversified monitoring data of the test sections are obtained and compared to select the optimal blasting schemes for the test sections, so as to ensure the safety and quality of blasting excavation of deep-buried tunnels.

Abstract: The subject disclosure provides systems and methods for improved medium access for wireless communication. A wireless access point, on contending for and gaining medium access, may share a time and/or bandwidth channel resource with one or more other wireless access points and/or one or more client devices. The wireless access point can efficiently share the channel resource using buffer status information computed by the wireless access point and/or additional buffer status information computed by the one or more other wireless access points. In one or more implementations, latency information for buffered data can be provided from a client device to a wireless access point and/or from a satellite wireless access point to a control wireless access point.

Abstract: In order to eliminate the reliance of ultra-high bandwidth (UWB) standalone transceivers and narrow-band-assisted (NB-assisted) UWB transceivers on BLUETOOTH™ (BLE) usage, an NB radio may be used. The NB radio may be tightly coupled with the UWB radio, for example driven by the same time source, to enable leveraged use of ACP (Acquisition Packet) for discovery, session setup, and maintenance over UWB and/or NB-assisted UWB without the use of BLE. Rules for advertising ACP and scanning for ACP may be defined for two modes of operation. An ad-hoc discovery may be based on external acquisition triggers, while a managed discovery may be based on an ongoing discovery advertisement process. ACPs may thereby be transmitted over UWB and/or NB.