Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts and esters thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which is associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

Abstract: A cleaning device includes a base, a positioning component, and a cleaning component, all mounted on the base. The positioning component includes a fixture and a side pushing member, the side pushing member located alongside the fixture. The side pushing member is used to push a workpiece into a limiting area of the fixture, where the fixture secures the workpiece in place. The cleaning component includes an exhaust member and a suction member. The exhaust member blows gas into contaminated holes, the gas is then sucked by the suction member.

Abstract: A power supply mechanism for a long-stroke seat has a wire harness accommodation box having at least one accommodation space and at least one opening; a drag chain bent and accommodated in the accommodation space, where a first end of the drag chain is relatively fixed to the wire harness accommodation box, and a second end of the drag chain passes through the opening and is slidably disposed in a slideway of a lower slide rail of the seat; a wire harness threaded in the drag chain, where a first end of the wire harness passes through a first end of a wire harness channel and the opening to be connected to a power supply, and a second end of the drag chain passes through a second end of the wire harness channel to be connected to an upper slide rail of the seat.

Abstract: Various embodiments may relate to a liquid cooling module. The liquid cooling module may include a main body. The main body may include a cooling core including a microfluidic structure configured to carry a cooling liquid. The main body may also include a plurality of slots. The liquid cooling module may further include a sealing pad configured to transmit heat from an electronic device to the cooling core. The liquid cooling module may additionally include a plurality of fins extending from the main body, each of the plurality of fins including an internal circulating liquid duct such that the liquid cooling module includes a plurality of internal circulating liquid ducts in fluidic communication with the microfluidic structure.

Abstract: An apparatus for controlling a pointer on a screen of an electronic device may include a receiver device and a wireless input device. The input device may include a sensing unit configured to detect the input device's movement; a position determination unit configured to determine the input device's current position based on the detected movement; a prediction unit configured to predict the input device's current position; a comparison unit configured to determine a difference between the determined and predicted positions, and whether the difference is greater than a similarity threshold; and a transmitting unit configured to transmit the determined position to the receiver device in response to determining that the difference is greater than the similarity threshold. The receiver device may include a receiving unit configured to receive the determined current position and a communication unit configured to communicate this received position to the electronic device to control the pointer.

Abstract: An audio device includes a first earbud and a second earbud, each of which is configured to establish respective first and second wireless links with an audio source, and receive, from the audio source, audio information over the respective first and second wireless links. The first earbud and the second earbud are further configured to communicate with one another over a third wireless link. At least one of the first earbud and the second earbud includes a measurement circuit configured to measure respective signal strengths of the first, second and third wireless links, a computation circuit configured to compute a difference in signal strengths of the first and second wireless links, and a determination circuit configured to determine an operating environment of the audio device based on the computed difference and further based on the signal strength of the third wireless link.

Abstract: An inductor device including a frame portion, a first winding set, a second winding set and a first common magnetic core I piece is provided. The first winding set, the second winding set and the first common magnetic core I piece are disposed in the frame portion. The first common magnetic core I piece substantially connects the first winding set and the second winding set and the frame portion. The material of the two winding sets is different from that of the first common magnetic core I piece.

Abstract: Provided an electrostatic protection circuit. The electrostatic protection circuit includes: at least one first transistor and at least one second transistor. A gate electrode and a first electrode of the first transistor are connected to a first signal line, and a second electrode of the first transistor is connected to a second signal line. A gate electrode and a first electrode of the second transistor are connected to the second signal line, and a second electrode of the second transistor is connected to the first signal line. Orthographic projection(s) of a channel and/or a first electrode of the first transistor on a main surface of the array substrate is/are within an orthographic projection of the first signal line on the main surface of the array substrate.

Abstract: A path establishment method and a controller are disclosed. The method includes: when detecting a path establishment request for establishing P2MP TE, computing a P2MP TE path by using head node information and tail node information included in the path establishment request; identifying a target branch node in the P2MP TE path, and obtaining a label of the target branch node; and when a third node corresponding to the head node information and the target branch node are not a same node, sending first information to the third node, and sending second information to the target branch node, where the second information is used to instruct the target branch node to generate a multicast forwarding entry. Embodiments of this application can reduce complexity of establishing the P2MP TE path.

Abstract: A quick fitting and protection mechanism for a wire harness in a slide rail has a drag chain for the wire harness to be threaded through; a drag chain towing support connected to an upper slide rail and slidable in a slideway of a lower slide rail with the upper slide rail, where the drag chain towing support has a drag chain port, a wire harness outlet, and a first channel affording communication between the drag chain port and the wire harness outlet, where one end of the drag chain is connected to the drag chain port; a wire harness guide support having a wire harness entry, a wire harness exit, and a second channel affording communication between the wire harness entry and the wire harness exit, where the wire harness entry is in rotatable communication with the wire harness exit.

Abstract: A path establishment method and a controller are disclosed. The method includes: when detecting a path establishment request for establishing P2MP TE, computing a P2MP TE path by using head node information and tail node information included in the path establishment request; identifying a target branch node in the P2MP TE path, and obtaining a label of the target branch node; and when a third node corresponding to the head node information and the target branch node are not a same node, sending first information to the third node, and sending second information to the target branch node, where the second information is used to instruct the target branch node to generate a multicast forwarding entry. Embodiments of this application can reduce complexity of establishing the P2MP TE path.

Abstract: A transformer includes iron cores and a winding structure. The iron cores are stacked on each other at intervals, and iron core gaps are formed between the iron cores, wherein relative positions between the iron core gaps are fixed. The winding structure is disposed around the iron cores and includes a plurality of coils. A position of at least one of the iron core gaps corresponds to a position of at least one of coils.

Abstract: A path establishment method and a controller are disclosed. The method includes: when detecting a path establishment request for establishing P2MP TE, computing a P2MP TE path by using head node information and tail node information included in the path establishment request; identifying a target branch node in the P2MP TE path, and obtaining a label of the target branch node; and when a third node corresponding to the head node information and the target branch node are not a same node, sending first information to the third node, and sending second information to the target branch node, where the second information is used to instruct the target branch node to generate a multicast forwarding entry. Embodiments of this application can reduce complexity of establishing the P2MP TE path.

Abstract: An adjustable leakage inductance transformer includes a magnetic core, a primary side coil and a secondary side coil. The magnetic core includes a magnetic core column structure, which has a central column, a first outer column and a second outer column. The primary side coil is wound on the first outer column and the second outer column by a first primary side coil loop number and a second primary side coil loop number, respectively. The secondary side coil is wound on the first outer column and the second outer column by a first secondary side coil loop number and a second secondary side coil loop number, respectively, the first primary side coil loop number is not equal to the first secondary side coil loop number, and the second primary side coil loop number is not equal to the second secondary side coil loop number.

Abstract: Disclosed are a display module, a display device and a viewing-angle switching method. The display module includes a backlight module, a display panel, a lower polarizer sheet, a viewing-angle switching element and a transparent cover plate; the viewing-angle switching element and the transparent cover plate are arranged between the display panel and the lower polarizer sheet, and the transparent cover plate is arranged on a side of the viewing-angle switching element that is close to the lower polarizer sheet; the backlight module is configured to supply light that meets a preset condition, the viewing-angle switching element is configured to switch viewing-angle modes of the display module; the viewing-angle modes include; a first viewing-angle mode and a second viewing-angle mode; and a viewing-angle range of the first viewing-angle mode is smaller than a viewing angle range of the second viewing-angle mode.

Abstract: The present application discloses a circuit for providing a temperature-dependent common electrode voltage. The circuit includes a sensing sub-circuit coupled between a power-supply terminal and a ground terminal and configured to generate a first voltage for controlling a switching sub-circuit to connect the power-supply terminal to a first node. The circuit further includes a compensation sub-circuit coupled between the first node and the ground terminal and be enabled, when the first voltage decreases below a threshold as temperature increases above a threshold temperature, to output a temperature-dependent second voltage proportional to the temperature to a second node.

Abstract: A power supply mechanism for a long-stroke seat has a wire harness accommodation box having at least one accommodation space and at least one opening; a drag chain bent and accommodated in the accommodation space, where a first end of the drag chain is relatively fixed to the wire harness accommodation box, and a second end of the drag chain passes through the opening and is slidably disposed in a slideway of a lower slide rail of the seat; a wire harness threaded in the drag chain, where a first end of the wire harness passes through a first end of a wire harness channel and the opening to be connected to a power supply, and a second end of the drag chain passes through a second end of the wire harness channel to be connected to an upper slide rail of the seat.

Abstract: A quick fitting and protection mechanism for a wire harness in a slide rail has a drag chain for the wire harness to be threaded through; a drag chain towing support connected to an upper slide rail and slidable in a slideway of a lower slide rail with the upper slide rail, where the drag chain towing support has a drag chain port, a wire harness outlet, and a first channel affording communication between the drag chain port and the wire harness outlet, where one end of the drag chain is connected to the drag chain port; a wire harness guide support having a wire harness entry, a wire harness exit, and a second channel affording communication between the wire harness entry and the wire harness exit.

Abstract: The disclosure discloses a display control method and apparatus, a computer readable storage medium, and a computer device, where the display control method includes: receiving data of a frame of image to be displayed; determining proportions of numbers of sub-pixels in respective colors at nonzero grayscales in the frame of image to be displayed, according to the data of the frame of image to be displayed; determining a target common voltage value according to the determined proportions; and outputting the target common voltage value to a common electrode to display the image.

Abstract: A transformer includes a magnetic core, a primary side winding and a plurality of secondary side windings. The magnetic core includes a first outer column, a second outer column, an upper cover and a lower cover. The first outer column and the second outer column are disposed between the upper cover and the lower cover. The primary side winding is disposed on the first outer column and the second outer column, and the plurality of secondary side windings are disposed on the first outer column and the second outer column. Each of the secondary windings has one end passing through a region between the first outer column and the second outer column.