Abstract: Disclosed are a use of a methylacryloyl benzimidazolone derivative, an optical isomer or a pharmaceutically acceptable salt or prodrug thereof in the preparation of: (a) a pharmaceutical composition or reagent for down-regulating the activity of PI3K/Akt pathways; (b) a pharmaceutical composition or reagent for treating or inhibiting a tumour; and/or inhibiting tumour cell growth; and/or (c) a pharmaceutical composition or reagent for blocking the cell cycle. The compounds involved in the present invention can down-regulate the level of Akt phosphorylation in P13K/Akt signaling pathways, and the functional effects of the compounds are equivalent to those of a novel small-molecular targeting drug MK2206; while the research at the cellular level has found that the methylacryloyl benzimidazolone derivatives represented by FD1 have a good proliferation inhibiting effect on tumour cells. What is different from MK2206 is that FD1 has better effects on a PTEN deleted cell.

Abstract: A liquid crystal display device includes a first substrate, a second substrate, and a liquid crystal layer. The first substrate includes a first transparent substrate including a first surface and a second surface, a color filter layer formed on the first surface of the first transparent substrate, a first alignment film formed on the color filter layer, and a first electrode interlayered in the color filter layer. The second substrate includes a second transparent substrate comprising a third surface and a fourth surface, a second electrode and a third electrode formed on the third surface of the second transparent substrate sequentially, and a second alignment film is formed on the third electrode. The second electrode and the third electrode are arranged at different insulation layers respectively and electrically insulated with each other. The LCD device of the present invention has an improved transmittance and a fast response time.

Abstract: The present invention provides a method of making a proteinase-engineered cancer vaccine for treating a cancer patient, especially for cancer patient at advanced/metastatic stage. The cancer vaccine comprises dead cancer cells with unbroken plasma membrane wherein the extracellular proteins and extracellular portion of membrane proteins are cleaved by proteinase digestion. The cancer vaccine may be derived from cancer cell lines or patients' cancer cells. The present invention provides a method of treating a cancer patient by administrating an effective amount of the cancer vaccine to the patient. In a clinical trial with 35 cancer patients, the cancer vaccine therapy brings cancer-free lives (no detectable tumor, micro tumor or cancer cells after treatments of customized cancer vaccines) back to 40% of these patients. The present invention further provides a method of obtaining cancer-specific immune components from blood of individuals treated with the cancer vaccine.

Abstract: Disclosed are a use of a methylacryloyl benzimidazolone derivative, an optical isomer or a pharmaceutically acceptable salt or prodrug thereof in the preparation of: (a) a pharmaceutical composition or reagent for down-regulating the activity of PI3K/Akt pathways; (b) a pharmaceutical composition or reagent for treating or inhibiting a tumour; and/or inhibiting tumour cell growth; and/or (c) a pharmaceutical composition or reagent for blocking the cell cycle. The compounds involved in the present invention can down-regulate the level of Akt phosphorylation in P 13K/Akt signaling pathways, and the functional effects of the compounds are equivalent to those of a novel small-molecular targeting drug MK2206; while the research at the cellular level has found that the methylacryloyl benzimidazolone derivatives represented by FD1 have a good proliferation inhibiting effect on tumour cells. What is different from MK2206 is that FD1 has better effects on a PTEN deleted cell.

Abstract: The invention relates to a drug sustained-release composition, particularly a sustained-release composition comprising metoprolol and preparation method thereof. The invention also relates to a combination product comprising a sustained-release composition comprising metoprolol and a pharmaceutical composition comprising hydrochlorothiazide. The sustained-release composition comprising metoprolol according to the invention eliminates the phenomena of delayed release of such sustained-release compositions in the prior art, has a better drug release curve, and also have the advantages such as simple formula, easy operation, stable quality, strong controllability, and good reproducibility, and therefore have good application prospects.

Abstract: According to one embodiment, a technique is presented to dynamically adjust a sample period used at a presenter device for a screen content capture sharing function during a communication session. In another embodiment, a technique is provided to control how frames of screen capture content, e.g., in a desktop sharing function, are sent to attendee devices during an online conference session. According to a still another embodiment, a technique is provided to enable on-demand designation of frames as key-frames during a desktop sharing function of an online conference session.

Abstract: The disclosure provides a method and system for link switching. The method includes: acquiring a warning message, wherein the warning message is sent via broadcast or multicast by a line card where a failure of a link occurs; executing link switching according to the warning message. Through the technical solutions provided by the disclosure, the efficiency of the link switching in a distributed system is improved.

Abstract: According to one embodiment, a technique is presented to dynamically adjust a sample period used at a presenter device for a screen content capture sharing function during a communication session. In another embodiment, a technique is provided to control how frames of screen capture content, e.g., in a desktop sharing function, are sent to attendee devices during an online conference session. According to a still another embodiment, a technique is provided to enable on-demand designation of frames as key-frames during a desktop sharing function of an online conference session.

Abstract: Techniques are provided for delivering messages to users of client devices in a network. At a server device in a network, location information of each of a plurality of client devices is obtained. Each of the client devices runs a presence application for a user in the network and is configured to log-in with one or more resources. A message is received from a sender device in the network. The message is intended to be presented to the user via the presence application and one or more of the resources. Based on the location information of the client devices, one or more designated client devices are selected to which the message is to be sent such that the message is presented to the user via the presence application running on the one or more designated client devices and via one or more of the resources.

Abstract: In a sharing session between a presenter and several attendees, the presenter can share any type of document quickly and without substantial prior preparation. The presenter's device identifies an active document-sharing window within the desktop sharing environment, and detects if there is a shared document in the active window. The presenter's device creates a framework for any detected shared document that is transmitted to each of the attendee devices. The framework contains information about the pages in the shared document, such that an attendee device can request a specific page in the shared document. At least the first page of the shared document is rendered to a page image and transmitted to the attendee devices. Upon request from an attendee device, page images of any of the remaining pages may be sent to the attendee device, allowing each attendee to view a different page than the presenter.

Abstract: A method for identifying a lightning fault of an overhead transmission line (OTL) comprising determining a polarity of a travelling wave of each of three ABC phases subsequent to a single phase outage of the OTL. If the polarity of each phase is the same, the outage is a lightning fault and its type a back flashover; if not the same, proceed to the second step to determine a current change rate R of the fault phase. If R is larger than a threshold value, the outage is a lightning fault and its type a shielding failure; otherwise, the outage is a single-phase grounding fault. A system for identifying the lightning fault which comprises successively at least a group of fault detectors, a wireless communication module, a remote monitoring master station which adopts the above method to determine the fault type of the overhead transmission line.

Abstract: Provided by the present disclosure are a traffic statistics collection method and device. In the method, one and the same counter is adopted to set an input control parameter for each type of message in N types of messages respectively; N count values are acquired from the counter when a first preset moment is reached, wherein the N count values include: a total number count of the N types of messages and N?1 input control parameter counts, which are received by a preset port at the first preset moment; and statistics are collected for traffic, at the first preset moment, of the each type of message in the N types of messages through the N input control parameters and the N count values respectively, thereby saving counter resources.

Abstract: A method for detecting and locating faulty line on the distribution network circuit based on full waveform information, which uses the current data on the fault occurrence and whole-process operation of the compensation device to effectively solve such common problems as low fault current, poor reliability and low sensitivity in case of single-phase grounding fault to the low-current system through precise GPS synchronization. It improves the sensitivity and reliability of the grounding fault detection, which does not interfere with the system and is applicable to high-resistance grounding.

Abstract: In an example embodiment disclosed herein, there is described methods and a system for sharing of content in collaborative computing sessions. The methods and the system are operable to initiate a collaborative computing session between a plurality of participant devices, wherein at least one participant device operates as a presenter device to share data with at least one other participant viewer device. The methods and system are further operable to designate data to be shared with at least one viewer device. The methods and system are also operable to transmit the designated shared data to the at least one viewer device, render the shared data for display on at least one viewer device, wherein the shared data is rendered in accordance with display capabilities of the at least one viewer device, and display the rendered shared data on the at least one viewer device.

Abstract: In one example embodiment, a method is provided and includes monitoring a display status associated with a client device that is participating in a meeting being conducted over a network (wired, wireless, etc.). The method also includes reporting the display status to a server associated with the meeting. For example, the server could be responsible for controlling at least a portion of meeting resources for the client device (or the client device itself could include software to perform these management functions). The method also includes receiving reduced meeting resources based, at least in part, on the display status.

Abstract: The disclosure provides a method and system for link switching. The method includes: acquiring a warning message, wherein the warning message is sent via broadcast or multicast by a line card where a failure of a link occurs; executing link switching according to the warning message. Through the technical solutions provided by the disclosure, the efficiency of the link switching in a distributed system is improved.

Abstract: A proteinase therapy has been invented to eliminate solid tumors by destroying tumors' solid structure and killing cancer cells by cleaving vital extracellular matrix proteins C-terminally, N-terminally or both with cell membrane intact and limited adverse effects. The micro-scale intratumoral proteinase K therapy is tumor specific but not cancer type specific. Proteinase K therapy can be operated on multiple tumors on multiple occasions, if necessary. It may be employed to eliminate any solid tumor to prolong a cancer patient's life span.

Abstract: A liquid crystal display device includes a first substrate, a second substrate opposite to the first substrate, and a liquid crystal (LC) layer sandwiched between the two substrates. The first substrate includes gate lines and data lines, and the gate lines and the data lines data lines are intersected with each other to define pixel areas. Each of the pixel areas includes a pixel electrode and first common electrodes arranged at different layers, and the first common electrodes are electrically coupled to each other. The second substrate includes a second common electrode, and the LC layer comprises negative LC molecules.

Abstract: The present invention provides a method of making a proteinase-engineered cancer vaccine for treating a cancer patient, especially for cancer patient at advanced/metastatic stage. The cancer vaccine comprises dead cancer cells with unbroken plasma membrane wherein the extracellular proteins and extracellular portion of membrane proteins are cleaved by proteinase digestion. The cancer vaccine may be derived from cancer cell lines or patients' cancer cells. The present invention provides a method of treating a cancer patient by administrating an effective amount of the cancer vaccine to the patient. In a clinical trial with 35 cancer patients, the cancer vaccine therapy brings cancer-free lives (no detectable tumor, micro tumor or cancer cells after treatment) back to 40% of these patients. The cancer vaccine therapy for the first time brings the promise of cure to this deadly disease.

Abstract: In an example embodiment, a virtual conference is established with a server and a plurality of endpoint devices. One endpoint device, acting as a sender, may transfer a file to N other endpoint devices, acting as receivers. The sender divides the file in at least N segments and delivers one segment to each receiver. Receivers then request the next desired segment from one or more devices containing that segment. If devices hold the segment, the segment may be divided into parts, and one part may be requested from each device.