Abstract: The patent application pertains to compositions and methods for reducing Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) expression and for reducing serum cholesterol in mammalian subjects. The exemplary compositions comprise heat shock protein HSP27 or fragments thereof and/or a HSP25, or fragments thereof in a mixture with an adjuvant. The compositions may optionally comprise anti-HSP27 antibody. The method for reducing serum cholesterol relate to the use of the compositions to increase the subject's levels of serum HSP27 and/or anti-HSP27 antibodies.

Abstract: A rock specimen, including a rock body having the shape of a cylinder or a regular square prism. The rock body includes: an upper end face, a first circular groove, a first cylinder, a first circular body, a lower end face, a second circular groove, a second cylinder, and a second circular body. The first circular groove is disposed on the upper end face of the rock body and has a circle center coinciding with the center of the upper end face of the rock body. The second circular groove is disposed on the lower end face of the rock body and has a circle center coinciding with the center of the lower end face of the rock body. The outer diameter of the first circular groove is smaller than the inner diameter of the second circular groove, and the first circular groove and the second circular groove are staggered.

Abstract: A rock specimen, including a rock body. The rock body includes: an upper part, an upper end face, a first circular groove, a first cylinder, a first circular body, a lower part, a lower end face, a second circular groove, a second cylinder, and a second circular body. The first circular groove is disposed on the upper end face of the rock body and has a circle center coinciding with a center of the upper end face. A method for testing pure shear of the rock specimen, includes: 1) disposing the rock specimen on a test bench of a rock mechanics testing system, allowing the end face of the second circular body to contact the test bench; and 2) operating the rock mechanics testing system, loading a pressure on the rock specimen via the end face of the first cylinder and the end face of the second circular body.

Abstract: The present disclosure provides a gel electrolyte membrane and a method for forming the same, an electrode assembly, a gel polymer lithium-ion battery and an electric vehicle. The gel electrolyte membrane is located between the cathode and the anode, and has adhesion of solid electrolyte and electrical conductivity of ion of liquid electrolyte. The gel electrolyte membrane obtained in the present disclosure has a porous mesh structure, a wide film forming temperature, a short required time, a high level of liquid electrolyte in the gel polymer, a high conductivity of 3.4 to 6.3*10?3 S·cm1, a wide electrochemical window, a good compatibility with the cathode and the anode, and low requirements for the conditions of the synthesis. The gel polymer lithium-ion battery and electrode assembly and electric vehicle of the present disclosure has high safety, simple forming technique and low requirements for environment, thus is suitable for industrial production.

Abstract: The present disclosure provides a method for forming liquid electrolyte-containing gel electrolyte membrane and electrode assembly, and gel electrolyte cell and method for forming the same, and gel polymer lithium-ion battery. The method for forming the liquid electrolyte-containing gel electrolyte membrane, which includes the following steps, providing a cathode or an anode; forming a liquid mixture C and a liquid electrolyte D; forming a gel membrane on at least one surface of the cathode and/or the anode by the liquid mixture C; forming the liquid electrolyte-containing gel electrolyte membrane by the gel membrane absorbing the liquid electrolyte D. The electrode assembly, the gel electrolyte cell and the gel polymer lithium-ion battery obtained in the present disclosure have excellent liquid absorption performance of liquid electrolyte, a high electrolyte conductivity of 3 to 7*10?3S·cm?1, a wide electrochemical window.

Abstract: A device for fixing a rock sample, the device including: a lower clamp and an upper clamp. The lower clamp includes: a lower connector connected to a bottom loading base, a lower end cap for fixing samples, a lower chain connecting the lower connector and the lower end cap, a first spiral spring, a first central position-limit mechanism, and a second central position-limit mechanism. The lower end cap includes: a first sample fixing groove and a first connecting segment. The upper clamp includes: an upper connector connected to a top loading base, an upper end cap for fixing the samples, an upper chain connecting with the upper connector and the upper end cap, a second spiral spring, a third central position-limit mechanism, and a fourth central position-limit mechanism. The upper end cap includes a second sample fixing groove and a second connecting segment.

Abstract: A device for fixing a rock sample, the device including: a lower clamp and an upper clamp. The lower clamp includes: a lower connector connected to a bottom loading base, a lower end cap for fixing samples, a lower chain connecting the lower connector and the lower end cap, a first spiral spring, a first central position-limit mechanism, and a second central position-limit mechanism. The lower end cap includes: a first sample fixing groove and a first connecting segment. The upper clamp includes: an upper connector connected to a top loading base, an upper end cap for fixing the samples, an upper chain connecting with the upper connector and the upper end cap, a second spiral spring, a third central position-limit mechanism, and a fourth central position-limit mechanism. The upper end cap includes a second sample fixing groove and a second connecting segment.

Abstract: A rock specimen, including a rock body having the shape of a cylinder or a regular square prism. The rock body includes: an upper end face, a first circular groove, a first cylinder, a first circular body, a lower end face, a second circular groove, a second cylinder, and a second circular body. The first circular groove is disposed on the upper end face of the rock body and has a circle center coinciding with the center of the upper end face of the rock body. The second circular groove is disposed on the lower end face of the rock body and has a circle center coinciding with the center of the lower end face of the rock body. The outer diameter of the first circular groove is smaller than the inner diameter of the second circular groove, and the first circular groove and the second circular groove are staggered.

Abstract: A rock specimen, including a rock body. The rock body includes: an upper part, an upper end face, a first circular groove, a first cylinder, a first circular body, a lower part, a lower end face, a second circular groove, a second cylinder, and a second circular body. The first circular groove is disposed on the upper end face of the rock body and has a circle center coinciding with a center of the upper end face. A method for testing pure shear of the rock specimen, includes: 1) disposing the rock specimen on a test bench of a rock mechanics testing system, allowing the end face of the second circular body to contact the test bench; and 2) operating the rock mechanics testing system, loading a pressure on the rock specimen via the end face of the first cylinder and the end face of the second circular body.

Abstract: A sheetfed film scanning correction method includes: using a film holding member as a film feeding carrier, wherein the film holding member is fixed and does not move during film feeding, and wherein after the film holding member is inserted into a work position in a scanner, a scanning module of the scanner collects a first correction information under a filmless scanning state and corrects a subsequent scan result according to the first correction information; and setting sheet-feeding rollers of the scanner in idle running as if under a real film scanning state during or prior to collection of the first correction information.

Abstract: The utility model provides a baby stroller capable of be folded with one hand, which comprises a comprise a joint seat, an upper joint, a lower joint, an annular pressing block, a lock device being used in the lower joint and the upper joint to avoid rotating among the lower joint, a folding device being used to control the lock device for locking or releasing the upper joint and the lower joint, wherein the folding device comprises a connecting seat, a lever, a wire and a lifting belt; the connecting seat is provided with first release components to control and lock the lever in case of movement. The present invention can fold the baby stroller by one hand, and the operation is very convenient, flexible, and effortless.

Abstract: A scan assisting fixing device and a scanner using the same are provided. The fixing device is for fixing an object to be scanned, which includes a scanning portion and a holding portion. The fixing device includes an accommodation region, a scan window and a protrusion portion. When the holding portion is loaded in the accommodation region, the scanning portion correspondingly disposed in the scan window is retained and fixed by the protrusion portion, and the position of the holding portion in the fixing device is constant, so that the scanning portion is always within the range of the field depth of the scanner regardless of the specification of the positive film holder, and the clarity of the scanned image is assured.

Abstract: The present invention provides an isolated polynucleotide acid comprising a polynucleotide sequence having a substantial amount of sequence identity to the entire length of the polynucleotide sequence as set forth in SEQ ID NO: 1 or its complementary strand (SEQ ID NO: 2), the sequence is derived from RT domain of HBV polymerase gene. The present invention also provides a polypeptide and related compositions, as well as methods for using the same.

Abstract: An antenna with electromagnetic interference (EMI) shelter is disclosed, which comprises: an EMI shelter, mounted on a substrate while covering the same; a radiation unit; an induction current steering unit, disposed at a position between the EMI shelter and the radiation unit; and a signal feed-in unit, electrically connected with the radiation unit; wherein, the induction current generated by the radiation unit when it is activating is guided to the EMI shelter through the guidance of the induction current steering unit, and then to be feed into a ground connection (GND), thereby, preventing the operation of radio circuit elements that are mounted on the substrate from being interfered by the electric wave resulting from the induction current. With the aforesaid configuration, not only the EMI effect can be significantly suppressed and the overall manufacturing cost of the antenna can be effectively reduced, but also the signal transmission efficiency is improved.

Abstract: An antenna with electromagnetic interference (EMI) shelter is disclosed, which comprises: an EMI shelter, mounted on a substrate while covering the same; a radiation unit; an induction current steering unit, disposed at a position between the EMI shelter and the radiation unit; and a signal feed-in unit, electrically connected with the radiation unit; wherein, the induction current generated by the radiation unit when it is activating is guided to the EMI shelter through the guidance of the induction current steering unit, and then to be feed into a ground connection (GND), thereby, preventing the operation of radio circuit elements that are mounted on the substrate from being interfered by the electric wave resulting from the induction current. With the aforesaid configuration, not only the EMI effect can be significantly suppressed and the overall manufacturing cost of the antenna can be effectively reduced, but also the signal transmission efficiency is improved.

Abstract: A method of preventing or treating cardiovascular disease is provided. The method comprises administering heat shock protein 27 (HSP27), a co-factor, variant or analogue thereof. The cardiovascular disease can include atherosclerosis. A pharmaceutical composition comprising HSP27 for use in the prevention or treatment of cardiovascular disease is also provided.

Abstract: A method of reducing cholesterol in a subject is provided. The method may be used to decrease serum cholesterol and/or arterial wall cholesterol. The method comprises administering a therapeutically effective amount of heat shock protein 27 (HSP27), or a co-factor, variant or analogue thereof. The method may be used to treat, prevent or reverse cardiovascular disease (including atherosclerosis); to decrease atherosclerotic lesion formation or rupture; to decrease apoptosis within a plaque; to decrease macrophage accumulation; and/or to reverse the accumulation of atherosclerotic plaque mass in a subject. Kits and pharmaceutical compositions comprising HSP27 for preventing or treating of cardiovascular disease, such as atherosclerosis, are also provided.

Abstract: A scan assisting fixing device and a scanner using the same are provided. The fixing device is for fixing an object to be scanned, which includes a scanning portion and a holding portion. The fixing device includes an accommodation region, a scan window and a protrusion portion. When the holding portion is loaded in the accommodation region, the scanning portion correspondingly disposed in the scan window is retained and fixed by the protrusion portion, and the position of the holding portion in the fixing device is constant, so that the scanning portion is always within the range of the field depth of the scanner regardless of the specification of the positive film holder, and the clarity of the scanned image is assured.

Abstract: A method of reducing cholesterol in a subject is provided. The method may be used to decrease serum cholesterol and/or arterial wall cholesterol. The method comprises administering a therapeutically effective amount of heat shock protein 27 (HSP27), or a co-factor, variant or analogue thereof. The method may be used to treat, prevent or reverse cardiovascular disease (including atherosclerosis); to decrease atherosclerotic lesion formation or rupture; to decrease apoptosis within a plaque; to decrease macrophage accumulation; and/or to reverse the accumulation of atherosclerotic plaque mass in a subject. Kits and pharmaceutical compositions comprising HSP27 for preventing or treating of cardiovascular disease, such as atherosclerosis, are also provided.