Abstract: A microfluidic exosome profiling platform integrating exosome isolation and targeted proteomic analysis is disclosed. This platform is capable of quantitative exosomal biomarker profiling directly from plasma samples with markedly enhanced sensitivity and specificity. Identification of distinct subpopulation of patient-derived exosomes is demonstrated by probing surface proteins and multiparameter analyzes of intravesicular biomarkers in the selected subpopulation. The expression of IGF-1R and its phosphorylation level in non-small cell lung cancer (NSCLC) patient plasma is assessed as a non-invasive alternative to the conventional biopsy and immunohistochemistry. Detection of ovarian cancer also is assessed. The microfluidic chip, which may be fabricated of a glass substrate and a layer of poly(dimethylsiloxane), includes a serpentine microchannel to mix a fluid and a microchamber for the collection and detection of exosomes.

Abstract: Expression vectors and therapeutic methods of using such vectors in the treatment of diseases of the eye resulting from failure to produce a specific protein in the eye, or the production of a non-functional protein in the eye.

Abstract: The present disclosure provides a precharge device and a frequency converter. The precharge device is applied in a flying capacitor type multi-level converter circuit, and the multi-level converter circuit includes: a flying capacitor, a bus capacitor, a first and second semiconductor components, wherein the first semiconductor component is electrically connected between a first end of the flying capacitor and a first end of the bus capacitor, and the second semiconductor component is electrically connected between a second end of the flying capacitor and a second end of the bus capacitor; and the precharge device includes: an AC source; and an auxiliary circuit electrically connected with the AC source, wherein the auxiliary circuit reuses the first and second semiconductor components, and the AC source charges the flying capacitor and the bus capacitor through the auxiliary circuit.

Abstract: A magnetic assembly includes a magnetic core and a winding. The magnetic core comprises an upper cover, a lower cover and at least one core column provided between the upper cover and the lower cover, the core column presents a prismatic shape and has at least two lateral surfaces, the lateral surfaces intersect with each other to form at least two longitudinal ridges, and the longitudinal ridge extends along the longitudinal direction of the core column. The winding, winding around the core column, a first semi-conductive component is provided between the core column and the winding at the position corresponding to the longitudinal ridge.

Abstract: A connector housing with heat dissipation structure includes a housing, a heat dissipation unit and a holding member. A first end part of the holding member is fixed to a top plate of the housing by using a first tongue piece engaged with a fastening piece, so an area of an opening of top plate is decreased and the EMI shielding effect is better. Two side arms of the holding member pass through the trenches inside the heat dissipation unit, such that the width of the heat dissipation unit is not limited and a heat dissipation area can be increased. The second end part of the holding member includes a second tongue piece plugged into a convex hull at a back cover, and an arrival end of the second end part withstands a stop part, so the holding member is not released easily and can endure an external force.

Abstract: The present disclosure discloses a power conversion system and a method for suppressing the common-mode voltage. The power conversion system comprises a grid-side converter, a motor-side converter, a bus capacitor, a first reactor, a second reactor, and a third reactor. The bus capacitor is electrically connected between the grid-side converter and the motor-side converter. The first reactor includes a first terminal and a second terminal, wherein the first terminal is electrically connected to the motor-side converter. The second reactor includes a first terminal and a second terminal, wherein the first terminal is electrically connected to the second terminal of the first reactor and the second terminal of the second reactor is electrically connected to a motor. The third reactor includes a first terminal and a second terminal, wherein the first terminal is electrically connected to a grid and the second terminal is electrically connected to the grid-side converter.

Abstract: Expression vectors and therapeutic methods of using such vectors in the treatment of diseases of the eye resulting from failure to produce a specific protein in the eye, or the production of a non-functional protein in the eye.

Abstract: The present disclosure provides a precharge device and a frequency converter. The precharge device is applied in a flying capacitor type multi-level converter circuit, and the multi-level converter circuit includes: a flying capacitor, a bus capacitor, a first and second semiconductor components, wherein the first semiconductor component is electrically connected between a first end of the flying capacitor and a first end of the bus capacitor, and the second semiconductor component is electrically connected between a second end of the flying capacitor and a second end of the bus capacitor; and the precharge device includes: an AC source; and an auxiliary circuit electrically connected with the AC source, wherein the auxiliary circuit reuses the first and second semiconductor components, and the AC source charges the flying capacitor and the bus capacitor through the auxiliary circuit.

Abstract: A capture device for capturing a biological substance can include: a substrate; a graphene-oxide layer on the substrate; at least one polydopamine polymer coupled with the graphene-oxide; and at least one targeting receptor coupled to the polydopamine(s), wherein the targeting receptor is capable of targeting/binding with a target biological substance. The graphene-oxide may be covalently coupled with the substrate and polydopamine, and the polydopamine may be covalently coupled with the targeting receptor. The targeting receptor can be an antibody or fragment thereof. The target biological substance can be an exosome. The substrate can be a particle (e.g., magnetic, such as magnetically responsive) or a surface in a microfluidic channel. The surface can be a top surface of a post, the post having a Y-shaped cross-sectional profile. In one aspect, the substrate is a particle. The capture device can include the target biological substance bound to the targeting receptor.

Abstract: In accordance with embodiments of the present disclosure, systems and methods for sensing and communicating sensed downhole parameters using a hybrid micro-structured fiber optic cable are provided. The micro-structured fiber optic cable may be used to communicate and/or amplify sensor signals indicative of the sensed downhole parameters. These sensed downhole parameters may include one or more of a downhole temperature, pressure, magnetic field, electromagnetic energy, radioactivity, telemetry signal, or some other downhole measurement. The micro-structured fiber optic cable may include opto-electronic circuitry built into the internal structure of the cable for modulating the optical signal based on the sensed parameters. The opto-electronic circuitry may include diodes, triodes, and other components that are communicatively coupled to external sensors used to measure downhole parameters.

Abstract: According to an example, a first terminal device uploads sharing information to a server, the server sends identification information related to the sharing information to the first terminal device according to the sharing information, and the first terminal device transforms the identification information into a sound signal, and plays the sound signal. a second terminal device receives the sound signal, parses the sound signal to obtain the identification information, and sends a download request comprising the identifier information to the server. The server sends the sharing information to the second terminal device according to the download request.

Abstract: A high-power conversion system includes a switching circuit and at least one reactor, the at least one reactor being electrically connected to the switching circuit, and the core of the at least one reactor being electrically connected to a potential point of the high-power conversion system.

Abstract: The present disclosure discloses a power conversion system and a method for suppressing the common-mode voltage. The power conversion system comprises a grid-side converter, a motor-side converter, a bus capacitor, a first reactor, a second reactor, and a third reactor. The bus capacitor is electrically connected between the grid-side converter and the motor-side converter. The first reactor includes a first terminal and a second terminal, wherein the first terminal is electrically connected to the motor-side converter. The second reactor includes a first terminal and a second terminal, wherein the first terminal is electrically connected to the second terminal of the first reactor and the second terminal of the second reactor is electrically connected to a motor. The third reactor includes a first terminal and a second terminal, wherein the first terminal is electrically connected to a grid and the second terminal is electrically connected to the grid-side converter.

Abstract: A high-power conversion system includes a switching circuit and at least one reactor, the at least one reactor being electrically connected to the switching circuit, and the core of the at least one reactor being electrically connected to a potential point of the high-power conversion system.

Abstract: Expression vectors and therapeutic methods of using such vectors in the treatment of diseases of the eye resulting from failure to produce a specific protein in the eye, or the production of a non-functional protein in the eye.

Abstract: Embodiments of the disclosure provide an ice crushing device and refrigerator The ice crushing device comprises an ice storage container, in which a rotatable ice knife assembly is provided, wherein the ice knife assembly includes a rotary shaft, a fixed ice knife, a movable ice knife and an ice cube separation structure, the rotary shaft is capable of driving the movable ice knife to rotate, the fixed ice knife and the ice cube separation structure are located at two sides of the rotary shaft separately, and the fixed ice knife and the ice cube separation structure are both fixed relative to the ice storage container.

Abstract: A sandwich structure for enhancement of photoluminescence (PL) from luminescent films and the corresponding preparation method are disclosed. The sandwich structure comprises a support, a luminescent film grown on the support, and a single-layer close-packed microsphere array deposited onto the luminescent film. The microspheres have high transmittance excitation light and emitted light, respectively. The low price of dielectric microspheres is beneficial to industrial applications. The stable chemical properties of dielectric microspheres make PL enhanced in a long term. Both metal and non-metal materials can be used as the support in the sandwich structure. These features significantly improve the technique of PL enhancement for luminescent films.

Abstract: A connector housing with heat dissipation structure includes a housing, a heat dissipation unit and a holding member. A first end part of the holding member is fixed to a top plate of the housing by using a first tongue piece engaged with a fastening piece, so an area of an opening of top plate is decreased and the EMI shielding effect is better. Two side arms of the holding member pass through the trenches inside the heat dissipation unit, such that the width of the heat dissipation unit is not limited and a heat dissipation area can be increased. The second end part of the holding member includes a second tongue piece plugged into a convex hull at a back cover, and an arrival end of the second end part withstands a stop part, so the holding member is not released easily and can endure an external force.

Abstract: In accordance with embodiments of the present disclosure, systems and methods for sensing and communicating sensed downhole parameters using a hybrid micro-structured fiber optic cable are provided. The micro-structured fiber optic cable may be used to communicate and/or amplify sensor signals indicative of the sensed downhole parameters. These sensed downhole parameters may include one or more of a downhole temperature, pressure, magnetic field, electromagnetic energy, radioactivity, telemetry signal, or some other downhole measurement. The micro-structured fiber optic cable may include opto-electronic circuitry built into the internal structure of the cable for modulating the optical signal based on the sensed parameters. The opto-electronic circuitry may include diodes, triodes, and other components that are communicatively coupled to external sensors used to measure downhole parameters.

Abstract: A microfluidic exosome profiling platform integrating exosome isolation and targeted proteomic analysis is disclosed. This platform is capable of quantitative exosomal biomarker profiling directly from plasma samples with markedly enhanced sensitivity and specificity. Identification of distinct subpopulation of patient-derived exosomes is demonstrated by probing surface proteins and multiparameter analyses of intravesicular biomarkers in the selected subpopulation. The expression of IGF-1R and its phosphorylation level in non-small cell lung cancer (NSCLC) patient plasma is assessed as a non-invasive alternative to the conventional biopsy and immunohistochemistry. Detection of ovarian cancer also is assessed. The microfluidic chip, which may be fabricated of a glass substrate and a layer of poly(dimethylsiloxane), includes a serpentine microchannel to mix a fluid and a microchamber for the collection and detection of exosomes.