Abstract: Aspects of the disclosure provide a method for fabricating semiconductor device. The method includes characterizing an etch process that is used to etch channel holes and dummy channel holes in a stack of alternating sacrificial gate layers and insulating layers upon a substrate of a semiconductor device. The channel holes are in a core region and the dummy channel holes are in a staircase region. The stack of alternating sacrificial gate layers and insulating layers extend from the core region into in the staircase region of a stair-step form. The method further includes determining a first shape for defining the dummy channel holes in a layout based on the characterization of the etch process. The first shape is different from a second shape for defining the channel holes.

Abstract: Compositions and methods for reducing HLA-A protein expression in a cell comprising genetically modifying HLA-A for use e.g., in adoptive cell transfer therapies.

Abstract: The present disclosure discloses recycling treatment equipment for recycling heavy metals from complexed heavy metal wastewater, and belongs to the technical field of wastewater treatment. The recycling treatment equipment includes a wastewater separation and concentration component, an oxidization and decomplexing component, an electrolytic recovery component, and an intelligent detection component. Wastewater containing complexed heavy metals is divided into fresh water and concentrated water by performing microfiltration, nanofiltration, and reverse osmosis purification pretreatment, and the fresh water is then recycled in a targeted manner, so that the equipment has energy conservation and discharge reduction effects, can decomplex and recycle heavy metals in the concentrated water, and also synchronously purifies the fresh water. The whole process has the advantages of simple operation, zero sludge, and low treatment cost, so that the equipment is suitable for being greatly promoted.

Abstract: This application discloses a method for displaying a virtual environment picture performed by a computer device. The method includes: displaying a first virtual environment picture obtained by observing a virtual environment by using a first observation position; displaying, in response to receiving a first directional instruction generated by a first directional operation, a directional skill indicator pointing to a first direction; and in accordance with a determination that a length of the directional skill indicator is greater than a distance threshold in the first virtual environment picture, displaying a second virtual environment picture obtained by observing the virtual environment by using a second observation position, the second virtual environment picture including the directional skill indicator, and the second observation position being in the first direction of the first observation position or in a surrounding region in the first direction.

Abstract: Disclosed are a method for the synthesis of roxadustat and an intermediate thereof, and an intermediate thereof. In particular, disclosed is a method for the synthesis of compound M1, the method comprising the following steps: carrying out a reaction as shown below between compound SM and compound SM-A under the action of an oxidizing agent. The method of the present invention uses cheap and easily available raw materials, has short reaction steps, produces a high yield, has simple and convenient post-treatment procedures, and is suitable for industrial production.

Abstract: Embodiments of the present disclosure provide a distributed storage method and a distributed storage device. The method includes offline merging, by a first thread service of a distributed storage system, M small files in a file system, generating, by the first thread service, M pieces of metadata in the offline merging process, loading, by a second thread service of the distributed storage system, the M pieces of metadata into a metadata set, searching, by the second thread service, the metadata set for metadata of a first small file when the second thread service receives a first instruction, and performing, by the second thread service, the operation corresponding to the first instruction when the second thread service finds the metadata of the first small file in the metadata set.

Abstract: Compositions and methods for reducing MHC class II protein expression in a cell comprising genetically modifying CIITA for use e.g., in adoptive cell transfer therapies.

Abstract: Provided are ophthalmic devices comprised of a reaction product of a composition comprising: (i) a crosslinked substrate network containing covalently bound activatable free radical initiators; and (ii) a grafting composition containing one or more ethylenically unsaturated compounds. Also provided are processes for making ophthalmic devices.

Abstract: Various embodiments of the teachings herein include methods for implementing communication conversion between a server-client system and a publish-subscribe (pub-sub) system. An example may include: receiving a message from the pub-sub system, wherein a topic of the message includes information related to a target service in the server-client system to which the message is to be sent, and a payload of the message includes identification information of a consumer in the pub-sub system, wherein the consumer is to receive a response message from the server-client system; parsing the message to determine a host and a service provider that provide the target service, and the consumer who is to receive the response message; sending a request message for the target service to the service provider on the determined host; receiving the response message; adding the identification information to the response message; and sending it to the pub-sub system.

Abstract: A type of high-strength and ductile multicomponent precision resistance alloys and fabrication methods thereof are provided. The alloys are composed of the following components by atomic percentage: Ni 45-60%, Cr 15-30%, Fe 5-20%, Al 5-15%, Mn 3-5%, Cu 0.2-3%, Si 1-5%. Particularly, the sum of the atomic percentages of Mn, Cu and Si is ?13% and ?4.2%, the sum of the atomic percentages of Ni, Cr, Fe and Al is ?70% and ?95.8%, and the sum of the atomic percentages of all the components is 100%. The multicomponent alloys prepared by the methods exhibit face-cantered cubic matrix and possess high strength and good ductility; further, they have high resistivity and excellent resistivity stability in wide temperature ranges below 773 K.

Abstract: A computer device obtains a first face image (IMA) and a second face image (IFA). The device obtains M first image blocks corresponding to facial features from the first face image (IMA), and obtains N second image blocks corresponding to facial features from the second face image (IFA). The device transforms the M first image blocks and the N second image blocks to a feature space to generate M first feature blocks and N second feature blocks. The device selects a subset of the first feature blocks and a subset of the second feature blocks according to a specified control vector. The device generates a first composite feature map based the selected subset of the first feature blocks and the selected subset of the second feature blocks. The device inversely transforms the first composite feature map back to an image space to generate a third face image.

Abstract: Methods, systems and apparatus for identifying advertisements previously presented when processing related search queries related to a submitted search query, and providing the advertisements identified from the related search queries for presentation on a search results page for the submitted search query.

Abstract: This application discloses a method for operating virtual characters within a virtual environment performed by a computer device. The method includes: displaying a first virtual environment picture of a virtual environment, the first virtual environment picture including a first region obtained by using a first observation position and a master virtual character located in the virtual environment; displaying, in response to receiving an aiming operation, a regional skill indicator configured to select a target region in the virtual environment where the master virtual character releases a skill; and displaying a second virtual environment picture including a second region obtained by observing the virtual environment by using a second observation position, the second observation position being a position that is offset relative to the first observation position, and the second region including the target region, thereby improving the accuracy of aiming at a target.

Abstract: A coal and gangue identification device is disclosed. The device includes a rotary supporting frame, a water injection unit, a weighing unit, a liquid level detection device and a processing module. The rotary supporting frame is provided with a loading unit used to load a mineral aggregate. The rotary supporting frame is used to drive the loading unit to rotate on a horizontal plane. In the rotating process of the rotary supporting frame, the loading unit cyclically passes through a water injection region, a material adding region, a volume measurement region and an unloading region which are sequentially disposed on a rotation trajectory of the rotary supporting frame. The water injection unit is used to inject water to the loading unit of the water injection region.

Abstract: Provided are ophthalmic devices comprised of a reaction product of a composition comprising: (i) a crosslinked substrate network containing covalently bound activatable free radical initiators; and (ii) a grafting composition containing one or more ethylenically unsaturated compounds. Also provided are processes for making ophthalmic devices.

Abstract: A machine learning model is learned using secure vertical federated learning by receiving, by a network machine learning model, from a plurality of private machine learning models, a set of private machine learning model outputs. The set of private machine learning model outputs is based on data owned exclusively by each of the plurality of private machine learning models. The set of private machine learning model machine learning outputs is aligned based on sample IDs of the data. The network machine learning model, a prediction, the prediction being the output of the network model based on the set of private machine learning model outputs. Transmitting, by the network model, the prediction, to one of the plurality of private machine learning models, the one of the plurality of private machine learning models comprising labels.

Abstract: This disclosure provides a method of synthesis of 4?-thioribose NAD+ and analogues thereof, using an efficient chemoenzymatic approach. Also provided are methods of inhibiting the CD38 enzyme and compounds including 4?-thioribose NAD+ and compounds related thereto.

Abstract: The present disclosure provides a puncture guiding needle. The puncture guiding needle includes a needle guard, a needle seat assembly, a first spring and a support, wherein the needle seat assembly and the first spring are disposed inside the needle guard; one end of the needle guard is detachably connected to the support; the needle guard is provided with a first clamping structure; a pressing portion is connected to the first clamping structure; the pressing portion is located outside the needle guard; the needle seat assembly is provided with a second clamping structure which is in clamping connection with the first clamping structure; a needle tube is disposed at one end of the needle seat assembly close to the support; the first spring is sandwiched between the needle guard and the end of the needle seat assembly away from the support.

Abstract: A method of combinatorial optimization using hybrid temporo-attentional branching. Variable embeddings for the variable features, constraint embeddings for constraint features and edge embeddings for edge features are generated for each mixed integer linear program (MILP) sample in a dataset. The constraint embeddings are updated by a first graph attention network (GAT) of a neural network based on an attention of neighbouring nodes using the variable embeddings, constraint embeddings and edge embeddings. The variable embeddings are updated by a second GAT of the neural network based on an attention of neighbouring nodes using the variable embeddings, updated constraint embeddings and edge embeddings. A Gated Recurrent Unit (GRU) of the neural network generates a representation vector based on the updated variable embeddings for an input sequence consisting of all MILP samples in the dataset. Variables for a first MILP sample are selected from the representation vector in accordance with a branching policy.

Abstract: Methods, systems and media for explaining a basis for a binary inference task performed by a neural network. Binary relationships are identified between features detected by the trained neural network and data samples in which those features are detected. Sets of features providing an inference context are then identified in tandem with sets of features providing the inference basis within a given inference context. Each context, basis pair potentially provides an explanation for the inference behavior of the neural network. Human perceptible representations of such pairs are generated to explain the inference behavior of the neural network, including automatically identifying similar samples sharing both the context and basis, and automatically identifying likely alternative samples sharing the context but not the basis.