Abstract: Polymers, monomers, chromophoric polymer dots and related methods are provided. Highly fluorescent chromophoric polymer dots with narrow-band emissions are provided. Methods for synthesizing the chromophoric polymers, preparation methods for forming the chromophoric polymer dots, and biological applications using the unique properties of narrow-band emissions are also provided.

Abstract: An interface circuit and an electronic apparatus, including: a programmable current array (1), generating a first current and a second current transmitted to a common mode and differential mode generation circuit (2) according to an input code, and a third current and a fourth current transmitted to a driving bias generation circuit (3) according to the input code; the common mode and differential mode generation circuit (2), generating a common mode voltage according to the first current, and generating a high level voltage and a low level voltage according to the second current and the common mode voltage; a driving bias generation circuit (3), simulating a load according to the third and fourth currents, and generating a bias voltage based on the load and the low and high level voltages; an output driving circuit (4), converting an input signal into a differential signal in which the common mode voltage and a differential mode amplitude are configurable.

Abstract: A spiking neural network acceleration method includes constructing an approximate computation model according to a spiking neuron model and a spiking coding mode. The approximate computation model utilizes the characteristic that spiking frequency domain coding ignores the time semantics of a spiking sequence, compresses the distribution of spiking signals on a time step, and greatly reduces a spiking routing process and a subsequent neural computation process. The time-driven accelerator replans the computation process of the spiking neural network, sets a deduplication queue and a bitmap to solve the problem of spiking jitter, and realizes efficient support on the inhibitory spiking neural network.

Abstract: Antibody-drug conjugates, compositions thereof, and methods use. The antibody-drug conjugates include a fusion protein comprising an antibody covalently linked to an ADP-ribosyl cyclase protein via a peptide linker moiety at one or more of a C-terminus or N-terminus of a heavy or light chain of the antibody, a NAD or NMN analogue, and a payload such that the NAD or NMN analogue is conjugated to both the payload and the ADP-ribosyl cyclase protein.

Abstract: A sensor module, including a main body shell and a sensing device provided in the main body shell; the sensing device includes a sensor, an upper cover plate, a lower cover plate and a circuit plate; the sensor is mounted on the circuit plate; the upper cover plate and the lower cover plate are respectively mounted on the upper and lower sides of the circuit plate, and are configured to support the main body shell and fix the circuit plate; an accommodation cavity for storing an insulating fluid is provided between the upper cover plate and the circuit plate, between the upper cover plate and the sensor, and between the lower cover plate and the circuit plate; and a first acoustic window is provided at a portion of the upper cover plate located above the sensor. Further disclosed are a sensor assembly and an acoustic logging tool.

Abstract: Various embodiments of the teachings herein include methods for implementing communication conversion between a server-client system and a publish-subscribe (pub-sub) system. An example may include: receiving a message from the pub-sub system, wherein a topic of the message includes information related to a target service in the server-client system to which the message is to be sent, and a payload of the message includes identification information of a consumer in the pub-sub system, wherein the consumer is to receive a response message from the server-client system; parsing the message to determine a host and a service provider that provide the target service, and the consumer who is to receive the response message; sending a request message for the target service to the service provider on the determined host; receiving the response message; adding the identification information to the response message; and sending it to the pub-sub system.

Abstract: The present disclosure is related to a derivative of berberine, and the preparation method and applications thereof. The present derivative of berberine has a significant anti-myocardial ischemic effect, and its preparation route is feasible and reasonable with lower cost, less toxic and harmful reagents used, no environmental contamination, and is suitable for large-scale production. The cardioprotective derivative of berberine developed in the present disclosure and the preparation method thereof effectively provide a basis for developing novel cardioprotective medicaments, have a great economic benefit in the future, and bring a broad social benefit, leading to promising application prospects.

Abstract: Disclosed herein are immunoglobulin fusion proteins comprising a first antibody region, a first therapeutic agent, and a first connecting peptide; wherein the first therapeutic agent is attached to the first antibody region by the connecting peptide; and wherein the connecting peptide does not comprise a region having beta strand secondary structure. The connecting peptide may comprise an extender peptide. The extender peptide may have an alpha helical secondary structure. The connecting peptide may comprise a linker peptide. The linker peptide may not comprise any secondary structure. Also disclosed herein are compositions comprising the immunoglobulin fusion proteins and methods for using the immunoglobulin fusion proteins for the treatment or prevention of a disease or condition in a subject.

Abstract: A fingerprint detection array substrate is provided. The fingerprint detection array substrate includes a plurality of touch electrode blocks in a plurality of touch detection regions configured to detect a touch position, wherein touch electrode blocks in a respective one of the plurality of touch detection regions are inter-connected through bridges, forming a touch electrode unit, and the touch electrode unit is isolated from touch electrode blocks in adjacent touch detection regions of the plurality of touch detection regions; a plurality of touch signal lines configured to respectively transmit touch signals to a plurality of touch detection regions, wherein a respective one of the plurality of touch signal lines is electrically connected to the touch electrode unit limited in the respective one of the plurality of touch detection regions; and a fingerprint sensor configured to perform fingerprint sensing limited in a fingerprint scanning region.

Abstract: The present disclosure provides a substrate-enhanced comparator and electronic device, the comparator including: a cross-coupled latch, for connecting input signals to the gate of a cross-coupled MOS transistor to form a first input of the latch; output buffers, connected to the cross-coupled latch for amplifying output signals of the latch; AC couplers, connected to the output buffers for receiving and amplifying the output signals of the latch, coupling the output signals to substrates of the cross-coupled MOS transistors to form second inputs of the latch. The cross-coupled latch is also for output signal regenerative latching based on input signals sampled at the first inputs and input signals sampled at the second inputs. The present disclosure introduces additional substrate inputs to the cross-coupled structure of the conventional latch as the second inputs of the latch.

Abstract: The present disclosure provides a method for recognizing crackles, including: processing collected lung sound signal to extract moist rale component for a respiratory cycle; calculating a power spectrum of the moist rale component, and, calculating at least one of a ratio of power of each preset frequency band to total power of all preset frequency bands and the total power of all the preset frequency bands as a frequency domain parameter, and/or calculating at least one of a ratio of the number of occurrence of moist rale and a maximum amplitude of moist rale in the entire inspiratory phase as a time domain parameter; inputting the frequency domain parameter and/or the time domain parameter serving as a parameter feature into a classification model for recognition. The present disclosure further provides a system for recognizing crackles.

Abstract: The present invention relates to monobactam compounds of Formula I: and pharmaceutically acceptable salts thereof. The present invention also relates to compositions which comprise a monobactam compound of structural formula I or a pharmaceutically acceptable salt therof, and a pharmaceutically acceptable carrier. The invention further relates to methods for treating a bacterial infection comprising administering to the patient a therapeutically effective amount of a compound of structural formula I, either alone or in combination with a therapeutically effective amount of a second beta-lactam antibiotic.

Abstract: A method for displaying screen information includes obtaining visitor information of a visitor of a display device. Once a page to be visited by the visitor is determined, a current color scheme for at least one controllable element of the page to be visited is determined according to the visitor information and a page type of the page to be visited.

Abstract: The present invention proposes a coal and gangue separation device, including a first supporting seat, a guide part and multiple material bins. The guide part is hinged with the first supporting seat; the guide part rotates in a vertical direction; and inlets of the plurality of material bins are sequentially distributed on a rotation track of a movable end of the guide part. In the coal and gangue separation device of the present invention, the high-pressure airflow of a high-pressure nozzle does not directly act on the materials, but on grate bar driving mechanisms; and cantilever grate bars are driven to rotate by the grate bar driving mechanisms so as to directionally discharge the mineral aggregate. Therefore, the gangue can accurately enter a gangue collection bin; and the clean coal can accurately enter a clean coal collection bin.

Abstract: Various approaches are disclosed to virtualizing intrusion detection and prevention. Disclosed approaches provide for an embedded system having a hypervisor that provides a virtualized environment supporting any number of guest OSes. The virtualized environment may include a security engine on an internal communication channel between the guest OS and a virtualized hardware interface (e.g., an Ethernet or CAN interface) to analyze network traffic to protect the guest OS from other guest OSes or other network components, and to protect those network components from the guest OS. The security engine may be on a different partition than the guest OS and the virtualized hardware interface providing the components with isolated execution environments that protect against malicious code execution. Each guest OS may have its own security engine customized for the guest OS to account for what is typical or expected traffic for the guest OS.

Abstract: Provided are engineered transposable elements, gene transfer systems comprising the engineered transposable elements, as well as methods and kits for using the same. The compositions, systems, and methods are useful for inserting a heterologous nucleic acid into a target nucleic acid in vitro or in a cell.

Abstract: A time series data injection method is provided, including: receiving time series data, where the time series data includes at least one parameter identifying a data source that generates the time series data, an indicator indicating at least one attribute of the data source, and a timestamp indicating a time point when the indicator is generated; storing a first parameter group in a row storage format, where the first parameter group includes the at least one parameter identifying the data source that generates the time series data; and storing a second parameter group in a columnar storage format, where the second parameter group includes the indicator indicating the at least one attribute of the data source and the timestamp. In the method, the time series data is injected in a hybrid row-column storage manner.

Abstract: Antibody-drug conjugates, compositions thereof, and methods use. The antibody-drug conjugates include a fusion protein comprising an antibody covalently linked to an ADP-ribosyl cyclase protein via a peptide linker moiety at one or more of a C-terminus or N-terminus of a heavy or light chain of the antibody, a NAD or NMN analogue, and a payload such that the NAD or NMN analogue is conjugated to both the payload and the ADP-ribosyl cyclase protein.

Abstract: A leakage detection method for a long petroleum pipeline based on AFPSO-K-means includes: initializing a particle swarm, and defining an initial velocity and an initial position of each particle in the particle swarm; determining a fitness value of the each particle; traversing the fitness value of the each particle to obtain an optimal position corresponding to the fitness value of the each particle and a global optimal position in optimal fitness values of the particle swarm; iteratively updating a velocity and a position of the each particle based on the optimal position corresponding to the fitness value of the each particle; and when a distance from the position of the each particle to the global optimal position is less than a preset threshold or a number of iterations reaches a preset value, outputting a current iteration updated result to determine an actual leakage position of the petroleum pipeline.

Abstract: A high-pressure self-sealing butterfly valve, which comprises a valve body and a valve shaft, wherein a flow channel and a butterfly plate are arranged in the valve body, a pure metal sealing ring and a pure metal valve seat are sequentially arranged at a portion, on the outer side of the butterfly plate, of the flow channel, a piston cavity is further formed in a flow direction end face of the pure metal valve seat, and an upper valve shaft and a lower valve shaft are arranged at the upper end and the lower end of the valve shaft respectively; an upper end cover assembly and an upper self-sealing assembly are arranged between the end part of the upper valve shaft and the valve body, a lower sealing bottom cover and a lower self-sealing assembly are arranged between the end part of the lower valve shaft and the valve body.