Abstract: This disclosure describes a user interface (UI) conceptual model and a data model for quickly and easily developing and managing a GUI. The present methods and systems described herein provide for defining one or more UI elements in the UI conceptual model. The one or more UI elements may further reference one or more model objects in the data model. The one or more model objects may include one or more tasks, which may each be mapped to one or more commands for performing each task, or one or more data items, which may each be mapped to rules or conditions for transforming data. According to embodiments, graphics or functionality of a GUI may be easily and efficiently modified by adding, deleting, or modifying UI elements in the UI conceptual model or by adding, deleting, or modifying referenced model objects in the data model, thereby reducing management and development costs.

Abstract: The invention relates generally to compounds that modulate the activity of TGF?R-1 and TGF?R-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

Abstract: The present invention relates to nitric oxide (NO)-releasing nail coating compositions, NO-releasing coatings, and methods of using the same, for example, to treat fungal infections of a nail. It is noted that aspects described with respect to one embodiment may be incorporated in different embodiments although not specifically described relative thereto. Provided according to embodiments of the invention are nitric oxide (NO)-releasing nail coating compositions and/or coatings.

Abstract: Graphene is used as an interfacial layer to grow Si and other semiconductors or crystalline materials including two-dimensional Si and other structures on any foreign substrate that can withstand the growth temperature without the limitation matching condition typically required for epitaxial growth.

Abstract: The present disclosure provides a shift register circuit, which includes a first switch unit connecting an input end to a first node when a positive-phase clock signal is at a first level; a second switch unit applying a negative-phase clock signal to an output end when the first node is at the first level; a positive feedback unit enabling the second node to be at a second level when the first node is at the first level and enabling the first node to be at the second level when the second node is at the first level; a third switch unit enabling a third node to be at the first level when the positive-phase clock signal is at the first level; a fourth switch unit connecting the second node to the third node when the negative-phase clock signal is at the first level; and a fifth switch unit.

Abstract: The present disclosure provides a thin film transistor, an array substrate, a display panel and a display device. The thin film transistor comprises a gate layer, a source and a drain located on the gate layer, and an active layer located on the source and the drain. The active layer is electrically connected to the source and the drain. The active layer comprises two sides arranged in parallel, and each side forms an acute angle of 45° with a face of the drain facing the source.

Abstract: Disclosed are a method of determining an HPV integration site in a genome of a human tissue sample and a system thereof. The method comprises: subjecting genome DNA of the human tissue sample to a first sequencing, to obtain a sequencing result; determining DNA fragments containing both HPV sequence and human genome sequence, based on the sequencing result; determining a pair of amplification primers based on the DNA fragments containing both HPV sequence and human genome sequence, subjecting the genome DNA of the human tissue sample to PCR amplification using the pair of amplification primers, to obtain PCR product; and subjecting the PCR product to a second sequencing, to determine the integration site in a genome of the human tissue sample. The method is easy to be operated with low cost, high efficiency and excellent repeatability, which may be used to detect all HPV genotypes one time, and may rapidly and accurately determine detailed sequence information and integration site.

Abstract: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).

Abstract: The invention provides compounds of the Formula (I) or a pharmaceutically acceptable salts thereof, wherein X, Y, Z, R1, R2, R4, Ra, and the subscripts m, p, and q are as described herein. The compounds or their pharmaceutically acceptable salts can modulate the body's production of cyclic guanosine monophosphate (“cGMP”), and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The invention also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose.

Abstract: A refrigerator has a storage compartment, a door for opening and closing the storage compartment, an ice-making machine and an ice storage compartment. The ice-making machine is used to produce an ice cube. The ice storage compartment is disposed below the ice-making machine, so as to accommodate an ice cube. The ice storage compartment has a discharge port. A movable blocking member and an ice-crushing cutter are located in the ice storage compartment. A distributor is located on the door and used to distribute the ice cube from the ice storage compartment to the outside. The ice storage compartment further includes an opening and closing mechanism for opening or closing the discharge port. Because the discharge port of the ice storage compartment can be closed, the ice-crushing cutter disposed above the discharge port will not be unconsciously touched, and a user is avoided from being hurt by the ice-crushing cutter.

Abstract: A display panel and a manufacturing method thereof and a display device are provided. The display panel includes an array substrate and an opposed substrate that are opposite to each other, and a liquid crystal layer located between the array substrate and the opposed substrate. The display panel includes a display area and a non-display area, a phase shift layer is disposed at the non-display area of the array substrate, and the phase shift layer is configured to shift a phase of light passing through the phase shift layer. The display panel is used to solve color cast problem when a TFT-LCD displays a pure color, which is caused by cross color when the display panel is viewed at a side angle.

Abstract: The present invention relates to a novel method for producing 2-(4-N,N-dialkylamino-2-hydroxybenzoyl) benzoates.

Abstract: The present document discloses an organosilicon modified photoinitiator represented by the general formula (I): wherein, R1 and R2 are each independently selected from the group consisting of C1-C20 alkyl, C2-C8 alkenyl, C5-C8 cycloalkyl, aryl C1-C3 alkyl; one of R3, R4, R5, R6, and R7 is SIL1-X, and the others are each independently selected from the group consisting of hydrogen, C1-C20 alkyl, C2-C8 alkenyl, C5-C8 cycloalkyl, aryl C1-C3 alkyl, and halogen; X is a direct bond or C1-C12 alkylene; and SIL1 and SIL2 are each independently represented by the formula —SiR8R9R10 or (R?SiO3/2)a(R?2SiO2/2)b(R??3SiO1/2)c, wherein R8, R9 and R10 are each independently selected from the group consisting of C1-C20 alkyl, C2-C8 alkenyl, C5-C8 cycloalkyl, aryl, and aryl C1-C3 alkyl, R?, R? and R?? each independently selected from the group consisting of C1-C20 alkyl, C2-C8 alkenyl, C5-C8 cycloalkyl, and phenyl C1-C3 alkyl, and a, b, and c are numbers that satisfy a?0, b?0, c>0, the ratio of a to c is from 0 to 10

Abstract: The invention relates to the technical field of data hiding, in particular to a data hiding method and a data hiding system. An image is used as a data carrier; after secret data is converted into a bit sequence by a sending end, the values of each bit in the bit sequence are hidden in the image; the image hidden with the secret data is obtained and is sent to a receiving end; and the receiving end can extract the hidden secret data from the image according to a corresponding secret key. During data hiding, each square image block can hide two-bit data through inverse number odd-even properties of a pixel gray value sequence of two diagonal lines of each square image block, so that the volume of data hidden in the image is twice of the number of the image blocks split by the image.

Abstract: Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).

Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).

Abstract: According to one aspect, an electronic device for detecting an audio accessory. The electronic device includes an audio jack having at least two detection terminals. The detection terminals are spaced apart and positioned within a socket of the audio jack so when an audio plug of the accessory is inserted into the socket of the audio jack, the detection terminals will be shorted. The presence of a short between the detection terminals is indicative that the audio accessory is present.

Abstract: The present disclosure relates to an array substrate, a display panel, a display device and a driving method. The array substrate includes a plurality of sub-pixel dot matrix units. In each of the plurality of sub-pixel dot matrix units, the sub-pixels in a same row are connected to data lines arranged on a same side of the sub-pixels respectively, the sub-pixels in the rows where the sub-pixels are arranged in a same sequence are connected to the data lines in a same direction, and two first base color sub-pixels in at least two adjacent rows are connected to a same data line.

Abstract: An individualized or individual customization system includes a plurality of collecting terminals and a server coupled to the plurality of collecting terminals. The server obtains at least one related group within the plurality of collecting terminals and information as to demand management relevant to the at least one related group. The demand management information is analyzed to determine a triggering event and a corresponding triggering result and to monitor whether information collected by a collecting terminal is in accord with a triggering event. A triggering result corresponding to the trigger event is executed when the information collected by a collecting terminal is in accord with the triggering event. An individual customization method is also provided.