Patents by Inventor Yongchao Liang
Yongchao Liang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10844228Abstract: Water soluble light harvesting multichromophores having pendant chromophore groups are provided. The light harvesting multichromophore has a polymeric backbone including non-conjugated repeat units and a plurality of pendant donor chromophore groups linked to a non-conjugated repeat unit of the polymeric backbone. A pendant chromophore group can be a BODIPY group substituted with one or more water soluble groups. Polymeric tandem dyes based on the subject multichromophores are provided that further include an acceptor fluorophore linked to a non-conjugated repeat unit of the polymeric backbone and configured in energy-receiving proximity to a pendant donor chromophore group. Also provided are labelled specific binding members that include the subject polymeric tandem dyes. Methods of evaluating a sample for a target analyte and methods of labelling a target molecule in which the subject polymeric tandem dyes find use are provided. Systems and kits for practicing the subject methods are also provided.Type: GrantFiled: March 28, 2019Date of Patent: November 24, 2020Assignee: Becton, Dickinson and CompanyInventors: Glenn Bartholomew, Yongchao Liang, Brian Wall, David Moureau
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Publication number: 20200292183Abstract: An indoor unit of an air conditioner includes: a bottom shell, at least two air passages (11) are provided abreast in the bottom shell (1); an air passage cover plate (2), provided on the at least two air passages (11) in a covering manner, flow guide openings (21) corresponding to the at least two air passages (11) are provided in the air passage cover plate (2) respectively; at least two centrifugal fans (3), provided in the at least two air passages (11) respectively and provided opposite to the corresponding flow guide openings (21); and an evaporator (4), provided on a side, far away from the bottom shell (1), of the air passage cover plate (2), each of the flow guide openings (21) is provided opposite to the evaporator (4).Type: ApplicationFiled: June 1, 2020Publication date: September 17, 2020Inventors: SHAOBO WU, WEIWEI PENG, CHANGCHUN ZHANG, SONG LI, JIANQUN YANG, YONGCHAO LIANG, JUNXIONG YOU, HUAXIANG XIONG, ANHUI LIAO, YUANJU XU, BAOBAO LIU, SONGPING TAN, XIUYING WU
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Publication number: 20200200761Abstract: Water soluble light harvesting multichromophores that have an ultraviolet absorption maximum are provided. In some embodiments, the multichromophores include a conjugated segment including a fused 6-5-6 tricyclic co-monomer and a UV absorbance-modifying co-monomer. The multichromophores may include an acceptor chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. In some embodiments, a specific binding member is covalently linked to the multichromophore. Also provided are methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule using compositions including the light harvesting multichromophores. Kits and systems for practicing the subject methods are also provided.Type: ApplicationFiled: February 19, 2020Publication date: June 25, 2020Inventors: Yongchao Liang, Frank P. Uckert, Glenn P. Bartholomew, Barry E. Leonard, Brent S. Gaylord
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Publication number: 20200181412Abstract: Water solvated polymeric dyes and polymeric tandem dyes are provided. The polymeric dyes include a water solvated light harvesting multichromophore having a conjugated segment of aryl or heteroaryl co-monomers linked via covalent bonds, vinylene groups or ethynylene groups. The polymeric tandem dyes further include a signaling chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. Also provided are labeled specific binding members that include the subject polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labeling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: February 19, 2020Publication date: June 11, 2020Inventors: Glenn P. Bartholomew, Yongchao Liang, Brent S. Gaylord
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Patent number: 10670280Abstract: An indoor unit of an air conditioner includes: a bottom shell, at least two air passages (11) are provided abreast in the bottom shell (1); an air passage cover plate (2), provided on the at least two air passages (11) in a covering manner, flow guide openings (21) corresponding to the at least two air passages (11) are provided in the air passage cover plate (2) respectively; at least two centrifugal fans (3), provided in the at least two air passages (11) respectively and provided opposite to the corresponding flow guide openings (21); and an evaporator (4), provided on a side, far away from the bottom shell (1), of the air passage cover plate (2), each of the flow guide openings (21) is provided opposite to the evaporator (4).Type: GrantFiled: May 6, 2016Date of Patent: June 2, 2020Assignee: GREE ELECTRIC APPLIANCES, INC. OF ZHUHAIInventors: Shaobo Wu, Weiwei Peng, Changchun Zhang, Song Li, Jianqun Yang, Yongchao Liang, Junxiong You, Huaxiang Xiong, Anhui Liao, Yuanju Xu, Baobao Liu, Songping Tan, Xiuying Wu
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Publication number: 20200141943Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.Type: ApplicationFiled: January 17, 2020Publication date: May 7, 2020Inventors: Brent S. GAYLORD, Glenn P. BARTHOLOMEW, Russell A. BALDOCCHI, Janice W. HONG, William H. HUISMAN, Yongchao LIANG, Trung NGUYEN, Lan T. TRAN, Jean M. WHEELER, Adrian Charles Vernon PALMER, Frank Peter UCKERT
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Patent number: 10641775Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.Type: GrantFiled: July 31, 2019Date of Patent: May 5, 2020Assignee: SIRIGEN II LIMITEDInventors: Brent S. Gaylord, Glenn P. Bartholomew, Russell A. Baldocchi, Janice W. Hong, William H. Huisman, Yongchao Liang, Trung Nguyen, Lan T. Tran, Jean M. Wheeler, Adrian Charles Vernon Palmer, Frank Peter Uckert
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Patent number: 10605813Abstract: Water soluble light harvesting multichromophores that have an ultraviolet absorption maximum are provided. In some embodiments, the multichromophores include a conjugated segment including a fused 6-5-6 tricyclic co-monomer and a UV absorbance-modifying co-monomer. The multichromophores may include an acceptor chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. In some embodiments, a specific binding member is covalently linked to the multichromophore. Also provided are methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule using compositions including the light harvesting multichromophores. Kits and systems for practicing the subject methods are also provided.Type: GrantFiled: January 24, 2019Date of Patent: March 31, 2020Assignee: BECTON, DICKINSON AND COMPANYInventors: Yongchao Liang, Frank P. Uckert, Glenn P. Bartholomew, Barry E. Leonard, Brent S. Gaylord
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Patent number: 10604657Abstract: Water solvated polymeric dyes and polymeric tandem dyes are provided. The polymeric dyes include a water solvated light harvesting multichromophore having a conjugated segment of aryl or heteroaryl co-monomers linked via covalent bonds, vinylene groups or ethynylene groups. The polymeric tandem dyes further include a signaling chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. Also provided are labeled specific binding members that include the subject polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labeling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.Type: GrantFiled: July 5, 2017Date of Patent: March 31, 2020Assignee: BECTON, DICKINSON AND COMPANYInventors: Glenn P. Bartholomew, Yongchao Liang, Brent S. Gaylord
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Publication number: 20200062966Abstract: Water soluble polymeric dyes and polymeric tandem dyes are provided. The polymeric dyes include a water solvated light harvesting multichromophore having a conjugated segment of aryl or heteroaryl co-monomers including branched non-ionic water soluble groups (WSG) comprising two or more water soluble polymers. In some cases, the branched non-ionic water soluble groups (WSG) of the present disclosure are capable of imparting solubility in water in excess of 50 mg/mL to the multichromophore. The polymeric tandem dyes further include a signaling chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. Also provided are aggregation-resistant labelled specific binding members that include the subject water soluble polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: October 29, 2019Publication date: February 27, 2020Inventors: Glenn P. Bartholomew, Yongchao Liang
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Publication number: 20200048469Abstract: Polymeric tandem dyes are provided. The polymeric tandem dyes include a narrow emission fluorophore configured as a pendant acceptor in energy-receiving proximity to a donor water solvated light harvesting multichromophore. The narrow emission acceptor fluorophores of the present disclosure are capable of providing polymeric tandem dyes having a variety of narrow emission spectrums suitable for multiplexing. Also provided are compositions for multicolor fluorescent signal generation that include two or more polymeric tandem dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: July 26, 2019Publication date: February 13, 2020Inventors: Glenn Bartholomew, Yongchao Liang, Lucy Xiumin Zhao
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Patent number: 10533092Abstract: Water soluble polymeric dyes and polymeric tandem dyes are provided. The polymeric dyes include a water solvated light harvesting multichromophore having a conjugated segment of aryl or heteroaryl co-monomers including branched non-ionic water soluble groups (WSG) comprising two or more water soluble polymers. In some cases, the branched non-ionic water soluble groups (WSG) of the present disclosure are capable of imparting solubility in water in excess of 50 mg/mL to the multichromophore. The polymeric tandem dyes further include a signaling chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. Also provided are aggregation-resistant labelled specific binding members that include the subject water soluble polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.Type: GrantFiled: December 11, 2017Date of Patent: January 14, 2020Assignee: BECTON, DICKINSON AND COMPANYInventors: Glenn P. Bartholomew, Yongchao Liang
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Publication number: 20200002540Abstract: Water soluble light harvesting multichromophores having pendant chromophore groups are provided. The light harvesting multichromophore has a polymeric backbone including non-conjugated repeat units and a plurality of pendant donor chromophore groups linked to a non-conjugated repeat unit of the polymeric backbone. A pendant chromophore group can be a BODIPY group substituted with one or more water soluble groups. Polymeric tandem dyes based on the subject multichromophores are provided that further include an acceptor fluorophore linked to a non-conjugated repeat unit of the polymeric backbone and configured in energy-receiving proximity to a pendant donor chromophore group. Also provided are labelled specific binding members that include the subject polymeric tandem dyes. Methods of evaluating a sample for a target analyte and methods of labelling a target molecule in which the subject polymeric tandem dyes find use are provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: March 28, 2019Publication date: January 2, 2020Inventors: Glenn Bartholomew, Yongchao Liang, Brian Wall, David Moureau
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Patent number: 10481161Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.Type: GrantFiled: March 20, 2019Date of Patent: November 19, 2019Assignee: SIRIGEN II LIMITEDInventors: Brent S. Gaylord, Glenn P. Bartholomew, Russell A. Baldocchi, Janice W. Hong, William H. Huisman, Yongchao Liang, Trung Nguyen, Lan T. Tran, Jean M. Wheeler, Adrian Charles Vernon Palmer, Frank Peter Uckert
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Publication number: 20190346450Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.Type: ApplicationFiled: July 31, 2019Publication date: November 14, 2019Inventors: Brent S. GAYLORD, Glenn P. BARTHOLOMEW, Russell A. BALDOCCHI, Janice W. HONG, William H. HUISMAN, Yongchao LIANG, Trung NGUYEN, Lan T. TRAN, Jean M. WHEELER, Adrian Charles Vernon PALMER, Frank Peter UCKERT
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Patent number: 10458989Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.Type: GrantFiled: March 20, 2019Date of Patent: October 29, 2019Assignee: SIRIGEN II LIMITEDInventors: Brent S. Gaylord, Glenn P. Bartholomew, Russell A. Baldocchi, Janice W. Hong, William H. Huisman, Yongchao Liang, Trung Nguyen, Lan T. Tran, Jean M. Wheeler, Adrian Charles Vernon Palmer, Frank Peter Uckert
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Publication number: 20190293654Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.Type: ApplicationFiled: March 20, 2019Publication date: September 26, 2019Inventors: Brent S. GAYLORD, Glenn P. BARTHOLOMEW, Russell A. BALDOCCHI, Janice W. HONG, William H. HUISMAN, Yongchao LIANG, Trung NGUYEN, Lan T. TRAN, Jean M. WHEELER, Adrian Charles Vernon PALMER, Frank Peter UCKERT
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Patent number: 10365285Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.Type: GrantFiled: September 27, 2017Date of Patent: July 30, 2019Assignee: Sirigen II LimitedInventors: Brent S. Gaylord, Glenn P. Bartholomew, Russell A. Baldocchi, Janice W. Hong, William H. Huisman, Yongchao Liang, Trung Nguyen, Lan T. Tran, Jean M. Wheeler, Adrian Charles Vernon Palmer, Frank Peter Uckert
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Publication number: 20190204329Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.Type: ApplicationFiled: March 20, 2019Publication date: July 4, 2019Inventors: Brent S. Gaylord, Glenn P. Bartholomew, Russell A. Baldocchi, Janice W. Hong, William H. Huisman, Yongchao Liang, Trung Nguyen, Lan T. Tran, Jean M. Wheeler, Adrian Charles Vernon Palmer, Frank Peter Uckert
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Publication number: 20190204328Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.Type: ApplicationFiled: March 19, 2019Publication date: July 4, 2019Inventors: Brent S. Gaylord, Glenn P. Bartholomew, Russell A. Baldocchi, Janice W. Hong, William H. Huisman, Yongchao Liang, Trung Nguyen, Lan T. Tran, Jean M. Wheeler, Adrian Charles Vernon Palmer, Frank Peter Uckert