Patents by Inventor Yongchao Liang
Yongchao Liang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20200062966Abstract: Water soluble polymeric dyes and polymeric tandem dyes are provided. The polymeric dyes include a water solvated light harvesting multichromophore having a conjugated segment of aryl or heteroaryl co-monomers including branched non-ionic water soluble groups (WSG) comprising two or more water soluble polymers. In some cases, the branched non-ionic water soluble groups (WSG) of the present disclosure are capable of imparting solubility in water in excess of 50 mg/mL to the multichromophore. The polymeric tandem dyes further include a signaling chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. Also provided are aggregation-resistant labelled specific binding members that include the subject water soluble polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: October 29, 2019Publication date: February 27, 2020Inventors: Glenn P. Bartholomew, Yongchao Liang
-
Publication number: 20200048469Abstract: Polymeric tandem dyes are provided. The polymeric tandem dyes include a narrow emission fluorophore configured as a pendant acceptor in energy-receiving proximity to a donor water solvated light harvesting multichromophore. The narrow emission acceptor fluorophores of the present disclosure are capable of providing polymeric tandem dyes having a variety of narrow emission spectrums suitable for multiplexing. Also provided are compositions for multicolor fluorescent signal generation that include two or more polymeric tandem dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: July 26, 2019Publication date: February 13, 2020Inventors: Glenn Bartholomew, Yongchao Liang, Lucy Xiumin Zhao
-
Patent number: 10533092Abstract: Water soluble polymeric dyes and polymeric tandem dyes are provided. The polymeric dyes include a water solvated light harvesting multichromophore having a conjugated segment of aryl or heteroaryl co-monomers including branched non-ionic water soluble groups (WSG) comprising two or more water soluble polymers. In some cases, the branched non-ionic water soluble groups (WSG) of the present disclosure are capable of imparting solubility in water in excess of 50 mg/mL to the multichromophore. The polymeric tandem dyes further include a signaling chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. Also provided are aggregation-resistant labelled specific binding members that include the subject water soluble polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.Type: GrantFiled: December 11, 2017Date of Patent: January 14, 2020Assignee: BECTON, DICKINSON AND COMPANYInventors: Glenn P. Bartholomew, Yongchao Liang
-
Publication number: 20200002540Abstract: Water soluble light harvesting multichromophores having pendant chromophore groups are provided. The light harvesting multichromophore has a polymeric backbone including non-conjugated repeat units and a plurality of pendant donor chromophore groups linked to a non-conjugated repeat unit of the polymeric backbone. A pendant chromophore group can be a BODIPY group substituted with one or more water soluble groups. Polymeric tandem dyes based on the subject multichromophores are provided that further include an acceptor fluorophore linked to a non-conjugated repeat unit of the polymeric backbone and configured in energy-receiving proximity to a pendant donor chromophore group. Also provided are labelled specific binding members that include the subject polymeric tandem dyes. Methods of evaluating a sample for a target analyte and methods of labelling a target molecule in which the subject polymeric tandem dyes find use are provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: March 28, 2019Publication date: January 2, 2020Inventors: Glenn Bartholomew, Yongchao Liang, Brian Wall, David Moureau
-
Patent number: 10481161Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.Type: GrantFiled: March 20, 2019Date of Patent: November 19, 2019Assignee: SIRIGEN II LIMITEDInventors: Brent S. Gaylord, Glenn P. Bartholomew, Russell A. Baldocchi, Janice W. Hong, William H. Huisman, Yongchao Liang, Trung Nguyen, Lan T. Tran, Jean M. Wheeler, Adrian Charles Vernon Palmer, Frank Peter Uckert
-
Publication number: 20190346450Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.Type: ApplicationFiled: July 31, 2019Publication date: November 14, 2019Inventors: Brent S. GAYLORD, Glenn P. BARTHOLOMEW, Russell A. BALDOCCHI, Janice W. HONG, William H. HUISMAN, Yongchao LIANG, Trung NGUYEN, Lan T. TRAN, Jean M. WHEELER, Adrian Charles Vernon PALMER, Frank Peter UCKERT
-
Patent number: 10458989Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.Type: GrantFiled: March 20, 2019Date of Patent: October 29, 2019Assignee: SIRIGEN II LIMITEDInventors: Brent S. Gaylord, Glenn P. Bartholomew, Russell A. Baldocchi, Janice W. Hong, William H. Huisman, Yongchao Liang, Trung Nguyen, Lan T. Tran, Jean M. Wheeler, Adrian Charles Vernon Palmer, Frank Peter Uckert
-
Publication number: 20190293654Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.Type: ApplicationFiled: March 20, 2019Publication date: September 26, 2019Inventors: Brent S. GAYLORD, Glenn P. BARTHOLOMEW, Russell A. BALDOCCHI, Janice W. HONG, William H. HUISMAN, Yongchao LIANG, Trung NGUYEN, Lan T. TRAN, Jean M. WHEELER, Adrian Charles Vernon PALMER, Frank Peter UCKERT
-
Patent number: 10365285Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.Type: GrantFiled: September 27, 2017Date of Patent: July 30, 2019Assignee: Sirigen II LimitedInventors: Brent S. Gaylord, Glenn P. Bartholomew, Russell A. Baldocchi, Janice W. Hong, William H. Huisman, Yongchao Liang, Trung Nguyen, Lan T. Tran, Jean M. Wheeler, Adrian Charles Vernon Palmer, Frank Peter Uckert
-
Publication number: 20190204328Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.Type: ApplicationFiled: March 19, 2019Publication date: July 4, 2019Inventors: Brent S. Gaylord, Glenn P. Bartholomew, Russell A. Baldocchi, Janice W. Hong, William H. Huisman, Yongchao Liang, Trung Nguyen, Lan T. Tran, Jean M. Wheeler, Adrian Charles Vernon Palmer, Frank Peter Uckert
-
Publication number: 20190204329Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.Type: ApplicationFiled: March 20, 2019Publication date: July 4, 2019Inventors: Brent S. Gaylord, Glenn P. Bartholomew, Russell A. Baldocchi, Janice W. Hong, William H. Huisman, Yongchao Liang, Trung Nguyen, Lan T. Tran, Jean M. Wheeler, Adrian Charles Vernon Palmer, Frank Peter Uckert
-
Publication number: 20190194467Abstract: Water solvated polymeric dyes having a deep ultraviolet excitation spectrum are provided. The subject polymeric dyes include a light harvesting multichromophore having conjugation-modifying repeat units incorporated into the polymer backbone to provide segments of ?-conjugated co-monomers having limited ?-conjugation between segments. Polymeric tandem dyes are also provided that further include a signaling chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. Also provided are labelled specific binding members that include the subject water solvated polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: December 19, 2018Publication date: June 27, 2019Inventors: Yongchao Liang, Jonathan Hollinger, Brian Wall, David Moureau, Lucy Zhao, Glenn P. Bartholomew
-
Publication number: 20190170757Abstract: Water soluble light harvesting multichromophores that have an ultraviolet absorption maximum are provided. In some embodiments, the multichromophores include a conjugated segment including a fused 6-5-6 tricyclic co-monomer and a UV absorbance-modifying co-monomer. The multichromophores may include an acceptor chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. In some embodiments, a specific binding member is covalently linked to the multichromophore. Also provided are methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule using compositions including the light harvesting multichromophores. Kits and systems for practicing the subject methods are also provided.Type: ApplicationFiled: January 24, 2019Publication date: June 6, 2019Inventors: Yongchao Liang, Frank P. Uckert, Glenn P. Bartholomew, Barry E. Leonard, Brent S. Gaylord
-
Patent number: 10302648Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.Type: GrantFiled: September 27, 2017Date of Patent: May 28, 2019Assignee: SIRIGEN II LIMITEDInventors: Brent S. Gaylord, Glenn P. Bartholomew, Russell A. Baldocchi, Janice W. Hong, William H. Huisman, Yongchao Liang, Trung Nguyen, Lan T. Tran, Jean M. Wheeler, Adrian Charles Vernon Palmer, Frank Peter Uckert
-
Patent number: 10288620Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.Type: GrantFiled: October 31, 2017Date of Patent: May 14, 2019Assignee: SIRIGEN II LIMITEDInventors: Brent S. Gaylord, Glenn P. Bartholomew, Russell A. Baldocchi, Janice W. Hong, William H. Huisman, Yongchao Liang, Trung Nguyen, Lan T. Tran, Jean M. Wheeler, Adrian Charles Vernon Palmer, Frank Peter Uckert
-
Patent number: 10228375Abstract: Water soluble light harvesting multichromophores that have an ultraviolet absorption maximum are provided. In some embodiments, the multichromophores include a conjugated segment including a fused 6-5-6 tricyclic co-monomer and a UV absorbance-modifying co-monomer. The multichromophores may include an acceptor chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. In some embodiments, a specific binding member is covalently linked to the multichromophore. Also provided are methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule using compositions including the light harvesting multichromophores. Kits and systems for practicing the subject methods are also provided.Type: GrantFiled: June 21, 2017Date of Patent: March 12, 2019Assignee: Becton, Dickinson and CompanyInventors: Yongchao Liang, Frank P. Uckert, Glenn P. Bartholomew, Barry E. Leonard, Brent S. Gaylord
-
Patent number: 10228174Abstract: Provided is a compressor over-load protection control method. The method includes that: the state of a compressor is detected (S101); it is judged whether the compressor is under over-load protection (S102); and when the compressor is under the over-load protection, fluorine shortage protection is shielded (S103). A compressor over-load protection control apparatus includes: a detection unit (10), configured to detect the state of a compressor; a judgement unit (20), configured to judge whether the compressor is under over-load protection; and a shielding unit (30), configured to shield fluorine shortage protection when the compressor is under the over-load protection. Through the method and apparatus, the problem in the relevant art that a fluorine shortage false alarm is easily triggered is solved, thereby achieving the effect of preventing the fluorine shortage false alarm when the compressor is under the over-load protection.Type: GrantFiled: October 20, 2014Date of Patent: March 12, 2019Assignee: GREE ELECTRIC APPLIANCES, INC. OF ZHUHAIInventors: Wei Liu, Yongchao Liang, Peili Li, Ding Yu, Yuping Gao, Pengyu Chen, Yonghong Luo, Zuqing Chen, Qiyang Peng, Chun Wang, Jianqun Yang
-
Patent number: 10094838Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.Type: GrantFiled: August 17, 2016Date of Patent: October 9, 2018Assignee: Sirigen II LimitedInventors: Brent S. Gaylord, Glenn P. Bartholomew, Russell A. Baldocchi, Janice W. Hong, William H. Huisman, Yongchao Liang, Trung Nguyen, Lan T. Tran, Jean M. Wheeler, Adrian Charles Vernon Palmer, Frank Peter Uckert
-
Patent number: 10030883Abstract: A method and a system for monitoring an abnormality at an air outlet of a dehumidifier. The method comprises: identifying whether there is a blockage abnormality at the air outlet of the dehumidifier; after a blockage abnormality has been identified, starting a high wind-level operation of the dehumidifier or controlling air deflectors of the dehumidifier to be reset; after the high wind-level operation has run for a set time period or after the air deflectors are reset, identifying whether the blockage abnormality has been eliminated; and after it has been identified that the blockage abnormality has not been eliminated, controlling the dehumidifier to stop running, and sending out a fault cue. The method and system disclosed can avoid influences on the operation, service life and reliability of the dehumidifier due to a long-term blockage at the air outlet of the dehumidifier.Type: GrantFiled: September 9, 2014Date of Patent: July 24, 2018Assignee: GREE ELECTRIC APPLIANCES, INC. OF ZHUHAIInventors: Wei Liu, Yongchao Liang, Peili Li, Ding Yu, Yuping Gao, Pengyu Chen, Yonghong Luo, Zuqing Chen, Qiyang Peng, Chun Wang, Jianqun Yang
-
Publication number: 20180163054Abstract: Water soluble polymeric dyes and polymeric tandem dyes are provided. The polymeric dyes include a water solvated light harvesting multichromophore having a conjugated segment of aryl or heteroaryl co-monomers including branched non-ionic water soluble groups (WSG) comprising two or more water soluble polymers. In some cases, the branched non-ionic water soluble groups (WSG) of the present disclosure are capable of imparting solubility in water in excess of 50 mg/mL to the multichromophore. The polymeric tandem dyes further include a signaling chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. Also provided are aggregation-resistant labelled specific binding members that include the subject water soluble polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: December 11, 2017Publication date: June 14, 2018Inventors: Glenn P. Bartholomew, Yongchao Liang