Abstract: The present invention belongs to the technical field of chemical pharmaceuticals, and relates to a compound represented by general formula (I) or formula (II) and a preparation method thereof. The compounds are biaryl derivatives with ROR?t activation activity. The biaryl derivatives disclosed in this invention can effectively activate the ROR?t protein receptor, and thereby promote the differentiation of Th17 cells and increasing the production of IL-17, which can be used as an immune modulator for the treatment of various cancers or viral infection-related diseases.

Abstract: A five-membered heterocyclic amide WNT pathway inhibitor having the following general structural formula: The five-membered heterocyclic amide WNT pathway inhibitor has a remarkable anti-tumor activity based on a target-based rational drug design, and can be used for the development of a new generation of Wnt pathway inhibitors, and has a great clinical application value and considerable market potential.

Abstract: The present application provides a device detection method and system, an electronic device, a cloud robot system. The method includes: in a first operating system, when a device detection instruction sent by a device detection program is detected, determining a driving program operation instruction corresponding to the device detection instruction, and transmitting the driving program operation instruction to a second operating system; in the second operating system, operating a corresponding driving program according to the driving program operation instruction, and feeding back an operation result to the first operating system; and in the first operating system, returning the operation result to the device detection program.

Abstract: The present disclosure discloses a biaryl urea ROR?t inhibitor, and specifically relates to a biaryl urea derivative, as represented by formula I, with an ROR?t inhibiting activity, and a preparation process thereof, and a pharmaceutical composition comprising the compound. Further disclosed is use of the compound for treating an ROR?t-related disease.

Abstract: The present invention discloses a compound for regulating protein kinase activity and used for treating or preventing diseases associated with protein kinases. Specifically, the present invention relates to a benzofuran pyrazole amine protein kinase inhibitor which belongs to compounds that regulate anaplastic lymphoma kinase (ALK), and provides a method of preparing such a compound and a pharmaceutical use of such a compound in the treatment or prevention of diseases associated with ALK. The inhibitor can solve the problem of the drug resistance of the first generation and the second generation of ALK inhibitors.

Abstract: The present invention discloses a biaryl urea ROR?t inhibitor, and specifically relates to a biaryl urea derivative, as represented by formula I, with an ROR?t inhibiting activity, and a preparation process thereof, and a pharmaceutical composition comprising the compound. Further disclosed is use of the compound for treating an ROR?t-related disease.

Abstract: The present invention belongs to the technical field of chemical pharmaceuticals, and relates to a compound represented by general formula (I) or formula (II) and a preparation method thereof. The compounds are biaryl derivatives with ROR?t activation activity. The biaryl derivatives disclosed in this invention can effectively activate the ROR?t protein receptor, and thereby promote the differentiation of Th17 cells and increasing the production of IL-17, which can be used as an immune modulator for the treatment of various cancers or viral infection-related diseases.

Abstract: The present invention provides a method and apparatus for simultaneously running multiple virtual machines, and an electronic device. The method includes: initiating a request of running a second operating system in Qemu; triggering abnormality to a Hypervisor of a currently running first operating system in a KVM module; storing a context of the Hypervisor of the first operating system in the Hypervisor of the first operating system, and loading the context of the Hypervisor of the second operating system; and storing the context of the first operating system in the Hypervisor of the second operating system, and loading the context of the second operating system. By adoption of the solution provided by the present application, multiple virtual machines can be run simultaneously, and the respective functions can be run independently.

Abstract: The present application provides a device detection method and system, an electronic device, a cloud robot system. The method includes: in a first operating system, when a device detection instruction sent by a device detection program is detected, determining a driving program operation instruction corresponding to the device detection instruction, and transmitting the driving program operation instruction to a second operating system; in the second operating system, operating a corresponding driving program according to the driving program operation instruction, and feeding back an operation result to the first operating system; and in the first operating system, returning the operation result to the device detection program.

Abstract: A first virtual machine of a device receives startup information and creates a startup identifier associated with the startup information. The device receives, a startup instruction for starting an application on a second virtual machine via the first virtual machine, then acquires startup information corresponding to the startup instruction, the startup information including information of the second virtual machine and information of the application on the second virtual machine. The device starts the second virtual machine according to the information of the second virtual machine; and starts the application on the second virtual machine according to the information of the application on the second virtual machine.

Abstract: A robot cooperation method includes: acquiring a team task, determining each robot in a robot team; determining a leader robot for the robot team; and determining whether any one robot in the robot team is the leader robot. If so, the any one robot generates and sends control instructions that respectively enable one or more robots in the robot team to cooperatively complete the team task; otherwise, it receives and executes a control instruction from the leader robot. Determination of the leader robot can include evaluating a leadership competence of each cooperating robot in the team, and assigning the robot with the highest leadership competence as the leader robot. A device in a robot to enable it to cooperatively work with other robots in a robot team, a robot having the device, and a robot system having more than one robot can employ the method.

Abstract: The present invention discloses a biaryl urea ROR?t inhibitor, and specifically relates to a biaryl urea derivative, as represented by formula I, with an ROR?t inhibiting activity, and a preparation process thereof, and a pharmaceutical composition comprising the compound. Further disclosed is use of the compound for treating an ROR?t-related disease.

Abstract: The present application provides a communication method and apparatus, and an electronic device and program product thereof. The method includes: acquiring a communication request of a first virtual machine application, packaging the communication request on a second virtual machine, and sending the packaged communication request to a communication component; and/or receiving communication data sent by a communication component, parsing the communication data on a second virtual machine, and sending the parsed communication data to a first virtual machine application. According to the present application, on the basis that a connection is established between the second virtual machine and the communication component, a connection between the first virtual machine and the communication component may be also established via the second virtual machine, further the first virtual machine may implement communication directly based on the connection relationship when necessary.

Abstract: The present invention discloses a compound for regulating protein kinase activity and used for treating or preventing diseases associated with protein kinases. Specifically, the present invention relates to a benzofuran pyrazole amine protein kinase inhibitor which belongs to compounds that regulate anaplastic lymphoma kinase (ALK), and provides a method of preparing such a compound and a pharmaceutical use of such a compound in the treatment or prevention of diseases associated with ALK. The inhibitor can solve the problem of the drug resistance of the first generation and the second generation of ALK inhibitors.

Abstract: Techniques are provided for controlling an order-picking, rack-transporting robot. More specifically, the robot is controlled to select a minimized number of movable racks storing ordered products identified in one or more orders for product deliveries, while still ensuring that all ordered products are included.

Abstract: Embodiments implement a minispace concept to dynamically manage layout of a robotics warehouse system. The warehouse space is divided into a plurality of equally sized minispaces, each corresponding to a standard rack footprint. Each minispace is identified by tagging with a unit location ID and attribute(s) such as coordinates. Minispaces may be referenced in a task planning process flow that initially comprises determining stock and rack, followed by determining a relevant workstation. The task is then assigned to an appropriate robot, and a travel route is planned (e.g., shortest path in minispace layout). Robot actions within the route are then planned and executed by the warehouse management system according to the minispace layout. Minispaces allow a robot to identify each minispace by the tagging, and to plan the next movement accordingly. The use of minispaces may facilitate collision avoidance by grouping actions together and allowing performance of minispace locking/checking procedures.

Abstract: Techniques are provided for controlling an order-picking, rack-transporting robot. More specifically, the robot is controlled to select a minimized number of movable racks storing ordered products identified in one or more orders for product deliveries, while still ensuring that all ordered products are included.

Abstract: A repairing apparatus for removal of metal residuals on a display substrate is provided. The apparatus includes a storage container, comprising at least a first container configured to store a metal etchant; an adsorption component, configured to be adsorbed on a surface to be repaired on the display substrate and to cooperate with the surface to be repaired to define collectively a closed chamber therebetween; and a circulating pipe assembly, arranged to be connected and in fluid communication between the storage container and the adsorption component. The repairing apparatus may include a first fluid circuit arranged to be connected and in fluid communication between the first container and the adsorption component and configured to guide the metal etchant within the first container to flow to the adsorption component and into the chamber and then back into the first container.

Abstract: The present application provides a communication method and apparatus, and an electronic device and program product thereof. The method includes: acquiring a communication request of a first virtual machine application, packaging the communication request on a second virtual machine, and sending the packaged communication request to a communication component; and/or receiving communication data sent by a communication component, parsing the communication data on a second virtual machine, and sending the parsed communication data to a first virtual machine application. According to the present application, on the basis that a connection is established between the second virtual machine and the communication component, a connection between the first virtual machine and the communication component may be also established via the second virtual machine, further the first virtual machine may implement communication directly based on the connection relationship when necessary.

Abstract: Embodiments implement a minispace concept to dynamically manage layout of a robotics warehouse system. The warehouse space is divided into a plurality of equally sized minispaces, each corresponding to a standard rack footprint. Each minispace is identified by tagging with a unit location ID and attribute(s) such as coordinates. Minispaces may be referenced in a task planning process flow that initially comprises determining stock and rack, followed by determining a relevant workstation. The task is then assigned to an appropriate robot, and a travel route is planned (e.g., shortest path in minispace layout). Robot actions within the route are then planned and executed by the warehouse management system according to the minispace layout. Minispaces allow a robot to identify each minispace by the tagging, and to plan the next movement accordingly. The use of minispaces may facilitate collision avoidance by grouping actions together and allowing performance of minispace locking/checking procedures.