Abstract: A shower device has a fixing portion, an outlet portion and a switch portion. The fixing portion is disposed with an inlet waterway and at least two diversion waterways connected to the inlet waterway, the outlet portion is rotatable with respect to the fixing portion such to change the outlet direction, the outlet portion is disposed with outlet chambers corresponding to the diversion waterways one-to-one. The switch portion is disposed at the fixing portion and is coupled to the inlet waterway and the diversion waterways; before water flows to the outlet portion, the diversion waterways are switched to connect to the inlet waterway by movement of the switch portion relative to the fixing portion.

Abstract: A top spraying shower head with reset function comprises a shower head main body having: a waterway switch valve, an inlet passage, a first outlet hole, and a second outlet hole concentrically arranged in the direction of the inlet passage. The inlet passage with the first outlet hole or the second outlet hole form a first outlet passage and a second outlet passage respectively. The waterway switch valve comprises: a valve body having a slidable valve body that moves between a first position and a second position to close the first outlet passage or the second outlet passage; a sealing element which can open the first and second outlet passage; an elastic element abutting between one end of the valve spindle and the inner wall of the valve body; and a W-shaped camshaft rotatably assembled in the valve body.

Abstract: Novel fluorinated compounds, their method of preparation and use are disclosed, as well as the incorporation of new and old fluorinated compounds in controlled radical polymerization processes to efficiently produce polymer compositions with unique and enhanced properties. Various cure mechanisms and types of end-uses are disclosed.

Abstract: A top spraying shower head with reset function comprises a shower head main body having: a waterway switch valve, an inlet passage, a first outlet hole, and a second outlet hole concentrically arranged in the direction of the inlet passage. The inlet passage with the first outlet hole or the second outlet hole form a first outlet passage and a second outlet passage respectively. The waterway switch valve comprises: a valve body having a slidable valve body that moves between a first position and a second position to close the first outlet passage or the second outlet passage; a sealing element which can open the first and second outlet passage; an elastic element abutting between one end of the valve spindle and the inner wall of the valve body; and a W-shaped camshaft rotatably assembled in the valve body.

Abstract: With the rise in resistance to antibiotics such as methicillin, there is a need for new drugs. The invention provides small molecules that inhibit cellular drug targets such as UPPS and FPPS by interacting with binding pockets, thereby preventing enzyme function. Compounds described herein are also active against Staphylococcus aureus (MIC90˜0.25 ?g/mL), can potently synergize with methicillin (fractional inhibitory concentration index=0.25), and are protective in a mouse infection model. The invention therefore provides numerous compounds for anti-bacterial treatments and for restoring sensitivity to drugs such as methicillin, using combination therapies.

Abstract: The present invention provides a method for resource information backup operation based on peer to peer network, comprising: an initiating node sending an out-of-domain backup node determining request to a connecting node in backup domain, and said out-of-domain backup node determining request including the resource global identifier of said resource information to be backed up, and the connecting node in said backup domain and said host node in which the resource information is saved have different domain identifiers; the connecting node in said backup domain determining an out-of-domain backup node according to information of said resource global identifier and out-of-domain backup rules, and sending routing information of said out-of-domain backup node to said initiating node; and said initiating node sending an out-of-domain backup operation request to said out-of-domain backup node according to said routing information, and said out-of-domain backup node implementing corresponding processing according to

Abstract: Novel fluorinated compounds, their method of preparation and use are disclosed, as well as the incorporation of new and old fluorinated compounds in controlled radical polymerization processes to efficiently produce polymer compositions with unique and enhanced properties. Various cure mechanisms and types of end-uses are disclosed.

Abstract: A packet loss rate detection method, apparatus, and system relating to a Packet Switching Network (PSN) are provided, and the method includes: transmitting, by a transmitting end, data packets and Operation, Administration, and Maintenance (OAM) packets, and writing a counting value of the data packets into the subsequent OAM packets after a time delay, and receiving, by a receiving end, the data packets and the OAM packets, counting a number of the received data packets, and calculating a packet loss rate based on the number of the practically received data packets and the counting value carried in the OAM packets.

Abstract: The invention provides compounds, compositions, and methods for studying the Rohmer pathway and for treating bacterial infections or parasitic infections. The parasitic infection can be a protozoan infection, such as malaria. The compounds and compositions can also be used as antibiotics, for example, to kill bacteria or parasites, or to inhibit bacterial or parasite growth. The invention further provides inhibitors of isoprenoid biosynthesis enzymes, and methods of inhibiting the activity of isoprenoid biosynthesis enzymes. The compounds can be, for example, alkynes or allenes that bind to a unique Fe of an Fe4S4 cluster of an isoprenoid biosynthesis enzyme.

Abstract: The invention provides compounds, compositions, and methods for studying the Rohmer pathway and for treating bacterial infections or parasitic infections. The parasitic infection can be a protozoan infection, such as malaria. The compounds and compositions can also be used as antibiotics, for example, to kill bacteria or parasites, or to inhibit bacterial or parasite growth. The invention further provides inhibitors of isoprenoid biosynthesis enzymes, and methods of inhibiting the activity of isoprenoid biosynthesis enzymes. The compounds can be, for example, alkynes or allenes that bind to a unique Fe of an Fe4S4 cluster of an isoprenoid biosynthesis enzyme.

Abstract: Methods for modulated degenerative transfer living polymerization and isotactic-atactic stereoblock and stereogradient poly(olefins) thereby Abstract A method of producing a multiblock, stereoblock polyolefin having substantially uniform microstructure is disclosed. The method includes contacting a Ziegler-Natta pre-catalyst with a co-catalyst and an olefin to polymerize the olefin and form a first stereoblock, adding a methyl donator that changes the stereoregularity of the polymerization, and polymerizing the olefin to form a second stereoblock. The methods of the present invention allow for the production of poly(olefin)s having predictable degrees of incorporation of stereoerrors of a known type. The methods allows for the production of a variety of poly(olefin) microstructures, ranging from stereoblock to stereogradient poly(olefin)s and poly(olefin)s having fully isotactic to fully atactic microstructures.

Abstract: The invention provides compounds, compositions, and methods for studying the Rohmer pathway and for treating bacterial infections or parasitic infections. The parasitic infection can be a protozoan infection, such as malaria. The compounds and compositions can also be used as antibiotics, for example, to kill bacteria or parasites, or to inhibit bacterial or parasite growth. The invention further provides inhibitors of isoprenoid biosynthesis enzymes, and methods of inhibiting the activity of isoprenoid biosynthesis enzymes. The compounds can be, for example, alkynes or allenes that bind to a unique Fe of an Fe4S4 cluster of an isoprenoid biosynthesis enzyme.

Abstract: The present invention provides a method for resource information backup operation based on peer to peer network, comprising: an initiating node sending an out-of-domain backup node determining request to a connecting node in backup domain, and said out-of-domain backup node determining request including the resource global identifier of said resource information to be backed up, and the connecting node in said backup domain and said host node in which the resource information is saved have different domain identifiers; the connecting node in said backup domain determining an out-of-domain backup node according to information of said resource global identifier and out-of-domain backup rules, and sending routing information of said out-of-domain backup node to said initiating node; and said initiating node sending an out-of-domain backup operation request to said out-of-domain backup node according to said routing information, and said out-of-domain backup node implementing corresponding processing according to

Abstract: Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as Leishmania major farnesyl diphosphate synthase (FPPS) inhibition, Dictyostelium discoideum growth inhibition, human gamma delta T cell activation, and bone resorption. The applicability of bisphosphonate compounds in the context of parasitic infections, for example against trypanosomes, is disclosed. Further potential applications of the invention are disclosed regarding the treatment of one or more conditions such as bone resorption disorders, cancer, bone pain, infectious diseases, and in immunotherapy.

Abstract: The disclosure provides, inter alia, novel bisphosphonate compounds and methods of making and using such compounds. In certain embodiments, compounds of the invention include bisphosphonates that are capable of selectively inhibiting one or more of farnesyl diphosphate synthase (FPPS), geranylgeranyl diphosphate synthase (GGPPS), and decaprenyl pyrophosphate synthase (DPPS). In preferred embodiments, compounds of the invention are capable of selectively inhibiting two or more of FPPS, GGPPS, and DPPS. In embodiments, compounds and methods of the invention demonstrate superior activity levels, such as in the anti-cancer context, immunostimulation context, and other contexts, which in several cases exceed the activity levels of previous generation bisphosphonate drugs by orders of magnitude. In embodiments, the invention provides compounds and methods in connection with research and therapeutic applications, e.g.

Abstract: A packet loss rate detection method, apparatus, and system relating to a Packet Switching Network (PSN) are provided, and the method includes: transmitting, by a transmitting end, data packets and Operation, Administration, and Maintenance (OAM) packets, and writing a counting value of the data packets into the subsequent OAM packets after a time delay, and receiving, by a receiving end, the data packets and the OAM packets, counting a number of the received data packets, and calculating a packet loss rate based on the number of the practically received data packets and the counting value carried in the OAM packets.

Abstract: Methods for modulated degenerative transfer living polymerization and isotactic-atactic stereoblock and stereogradient poly(olefins) thereby Abstract A method of producing a multiblock, stereoblock polyolefin having substantially uniform microstructure is disclosed. The method includes contacting a Ziegler-Natta pre-catalyst with a co-catalyst and an olefin to polymerize the olefin and form a first stereoblock, adding a methyl donator that changes the stereoregularity of the polymerization, and polymerizing the olefin to form a second stereoblock. The methods of the present invention allow for the production of poly(olefin)s having predictable degrees of incorporation of stereoerrors of a known type. The methods allows for the production of a variety of poly(olefin) microstructures, ranging from stereoblock to stereogradient poly(olefin)s and poly(olefin)s having fully isotactic to fully atactic microstructures.

Abstract: Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as Leishmania major farnesyl diphosphate synthase (FPPS) inhibition, Dictyostelium discoideum growth inhibition, human gamma delta T cell activation, and bone resorption. The applicability of bisphosphonate compounds in the context of parasitic infections, for example against trypanosomes, is disclosed. Further potential applications of the invention are disclosed regarding the treatment of one or more conditions such as bone resorption disorders, cancer, bone pain, infectious diseases, and in immunotherapy.

Abstract: Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as Leishmania major farnesyl diphosphate synthase (FPPS) inhibition, Dictyostelium discoideum growth inhibition, human gamma delta T cell activation, and bone resorption. The applicability of bisphosphonate compounds in the context of parasitic infections, for example against trypanosomes, is disclosed. Further potential applications of the invention are disclosed regarding the treatment of one or more conditions such as bone resorption disorders, cancer, bone pain, infectious diseases, and in immunotherapy.

Abstract: The invention provides, inter alia, novel bisphosphonate compounds and methods of making and using. In embodiments, the invention provides compounds and methods in connection with research and therapeutic applications, e.g., for tumor cell growth inhibition, activation of gammadelta T cells, inhibition of farnesyldiphosphate (FPPS) and/or undecaprenyldiphosphate synthase enzymes, bone resorption diseases, cancer, immune disorders, immunotherapy, and infectious diseases. In regards to certain embodiments, a surprising advance has been the recognition that certain structural features can significantly enhance the activity of the compounds. For example, the presence of particular cationic species e.g., phosphonium, sulfonium, and arsonium moieties can contribute to desirable functional activity when positioned near a bisphosphonate moiety. In other embodiments of non-nitrogen containing bisphosphonates, terphenyl and benzyl bisphosphonate compounds and methods are provided. Further variations are also provided.