Abstract: A method of expanding tumor infiltrating lymphocytes (TILs) into a therapeutic population of TILs may include the steps of: (a) obtaining and/or receiving a first population of TILs from surgical resection, needle biopsy, core biopsy, small biopsy, or other means for obtaining a sample that contains a mixture of tumor and TIL cells from a cancer in the subject or patient; performing an initial expansion (or priming first expansion) of the first population of TILs in the first cell culture medium to obtain a second population of TILs, wherein the first cell culture medium comprises IL-2, optionally OKT-3 (anti-CD3 antibody), and optionally antigen presenting cells (APCs), performing a rapid second expansion of the second population of TILs in a second cell culture medium to obtain a third population of TILs; wherein the second cell culture medium comprises IL-2, OKT-3 (anti-CD3 antibody), and APCs; harvesting the third population of TILs; and genetically modifying TILs at any time prior to step (d) or after st

Abstract: Provided herein are compositions and methods for the treatment of cancers using modified TILs, wherein the modified TILs include one or more immunomodulatory agents (e.g., cytokines) associated with their cell surface. The immunomodulatory agents associated with the TILs provide a localized immunostimulatory effect that can advantageously enhance TIL survival, proliferation and/or anti-tumor activity in a patient recipient. As such, the compositions and methods disclosed herein provide effective cancer therapies.

Abstract: A customer premise equipment (CPE), a control method for the CPE, and a computer-readable storage medium. The CPE may include a WiFi access module (110), a rotating body (120), a base (130), and a control processing module (140), where the rotating body (120) is provided with a millimeter wave access module (121), the base (130) is provided with a rotary driving device (131) and a rotary shaft (132), and the rotary driving device (131) is connected to the rotating body (120) by means of the rotary shaft (132).

Abstract: A lighting apparatus includes a light source plate, a driver, an antenna base and an antenna module. The driver includes a wireless circuit. The antenna base unit includes a first plastic unit, a metal contact and a metal path. The antenna base is coupled to the light source plate. The metal contact is electrically coupled to the wireless circuit of the driver. The antenna module includes a metal antenna and a second plastic unit. The second plastic unit and the first plastic unit are two separate components. When the second plastic unit is coupled to the first plastic unit, the metal antenna is electrically coupled to the metal contact of the antenna base for receiving a wireless signal to the wireless circuit of the driver.

Abstract: The present invention provides a method of treating a cancer in a patient or subject in need thereof comprising administering a population of modified tumor infiltrating lymphocytes (TILs), wherein the population of TILs has been modified by adding an epigenetic reprogramming agent to the cell culture medium used for expanding the TILs.

Abstract: Provided herein are compositions and methods for the treatment of cancers using modified TILs, wherein the modified TILs include one or more immunomodulatory agents (e.g., cytokines) associated with their cell surface. The immunomodulatory agents associated with the TILs provide a localized immunostimulatory effect that can advantageously enhance TIL survival, proliferation and/or anti-tumor activity in a patient recipient. As such, the compositions and methods disclosed herein provide effective cancer therapies.

Abstract: Provided herein are compositions and methods for the treatment of cancers using modified TILs, wherein the modified TILs include one or more immunomodulatory agents (e.g., cytokines) associated with their cell surface. The immunomodulatory agents associated with the TILs provide a localized immunostimulatory effect that can advantageously enhance TIL survival, proliferation and/or anti-tumor activity in a patient recipient. As such, the compositions and methods disclosed herein provide effective cancer therapies.

Abstract: The present disclosure provides compositions and methods for engineered cellular compositions and methods of immunotherapy utilizing the same. Compositions of the present disclosure for immune cell regulation comprise a chimeric antigen receptor polypeptide, a T cell receptor polypeptide, and combinations thereof.

Abstract: Provided herein are compositions and methods for the treatment of cancers using modified TILs, wherein the modified TILs include one or more immunomodulatory agents (e.g. cytokines) associated with their cell surface. The immunomodulatory agents associated with the TILs provide a localized immunostimulatory effect that can advantageously enhance TIL survival, proliferation and/or anti-tumor activity in a patient recipient. As such, the compositions and methods disclosed herein provide effective cancer therapies.

Abstract: The disclosure relates to the technical field of computers, in particular to information display method and device, terminal and storage medium. The method provided by the embodiments of the disclosure comprises: acquiring a new target message associated with a user account currently logged in a client; displaying a first reminder view associated with a first new target message; displaying a message user interface containing the first new target message in response to an operation of triggering the first reminder view; and associating the first reminder view with a second new target message after the first reminder view is triggered.

Abstract: A mobile terminal assembly and a mobile terminal are disclosed. The mobile terminal assembly may include a housing, a card holder assembly and a first antenna module. The housing is provided with a card slot; the card holder assembly is located at the card slot and is configured to carry a memory; and the first antenna module is installed in the housing. The first antenna module is configured to be switched between a first position and a second position under the action of an external force. When the first antenna module is located at the first position, the card holder assembly is located in the housing, and the first antenna module is located between the card holder assembly and the card slot; and when the first antenna module is located at the second position, the holder assembly at least partially passes through the card slot to extend outside the housing.

Abstract: The present disclosure provides an information processing method and apparatus, a terminal, and a storage medium. The information processing method comprises: receiving input topic information and sending the topic information to a server; displaying the topic information in a preset topic format on a session interface of a session group, the preset topic format having a reply area; receiving reply information used for replying to the topic information; and displaying the reply information in the reply area of the topic information. According to the method of the present disclosure, information is displayed in the form of topic information and reply information, and reply information corresponding to the same topic is displayed corresponding to the same topic information, such that the display mode of information is more reasonable, and a user can conveniently and quickly find information of interest.

Abstract: The present invention provides compositions comprising chimeric receptors, including chimeric costimulatory receptors (CCRs), and/or chemokine receptors, methods for preparing CCRs and/or chemokine receptors, and therapeutic populations of tumor infiltrating lymphocytes, marrow infiltrating lymphocytes, and peripheral blood lymphocytes expressing CCRs and/or chemokine receptors with increased therapeutic performance and other advantages for the treatment of cancers, including solid tumor cancers.

Abstract: Embodiments of the present application relate to the technical field of photography, and disclose a photography apparatus and method, an electronic device, and a storage medium. The photography apparatus in the present application includes: an optical transmitting lens configured to transmit infrared light to a target object; and an optical receiving lens configured to receive first reflected infrared light and visible light reflected by the target object; where the visible light and the first reflected infrared light are configured for three-dimensional recognition of the target object. The optical transmitting lens includes a first floodlight irradiator, an infrared dot matrix projector, and a reflector. The first floodlight irradiator is configured to emit compensation infrared light. The infrared dot matrix projector is configured to emit dot matrix projection light. The reflector is arranged in a light emission path of the optical transmitting lens.

Abstract: Disclosed are a new AXL-targeting monoclonal antibody and antibody-drug conjugate. Also disclosed is a method for preparing said antibody and antibody-drug conjugate. The AXL antibody of the present invention can bind with purified human AXL protein and multiple AXL on tumor cell surface with high effectiveness and high specificity. Said humanized antibody also has high affinity and low immunogenicity. Said AXL antibody-drug conjugate has markable performance against tumors having high AXL expression.

Abstract: The present invention discloses a method for the design of complex-valued channel equalizer of digital communication systems, including: constructing a channel equalizer by using a complex-valued neural network; collecting the output signal y(n)=[y(n), y(n?1), . . . , y(n?m+1)]T of the nonlinear channel of the underlying digital communication system as the input of complex-valued neural network and s(n??) as the desired output, and taking the mean squared error as the loss function for the training of complex-valued neural network, which is optimized by the proposed adaptive complex-valued L-BFGS algorithm, and finally using it to implement the design of channel equalizer for digital communication systems. The present invention proposes the use of a multi-layer feedforward complex-valued neural network to construct complex-valued channel equalizer.

Abstract: The present disclosure provides an information processing method and apparatus, a terminal, and a storage medium. The information processing method comprises: receiving input topic information and sending the topic information to a server; displaying the topic information in a preset topic format on a session interface of a session group, the preset topic format having a reply area; receiving reply information used for replying to the topic information; and displaying the reply information in the reply area of the topic information. According to the method of the present disclosure, information is displayed in the form of topic information and reply information, and reply information corresponding to the same topic is displayed corresponding to the same topic information, such that the display mode of information is more reasonable, and a user can conveniently and quickly find information of interest.

Abstract: A camera system, a mobile terminal, and a three-dimensional image acquisition method are disclosed. The camera system may include, a first photographing device, a second photographing device, a photographing assistance device, and a processor; the photographing assistance device is configured to emit a first feature light to an object; the first photographing device is configured to collect a second feature light reflected by the object; the second photographing device includes a main camera configured to collect a first image of the object and a secondary camera configured to collect a second image of the object; and the processor is configured to acquire depth information of the object according to the second feature light, and perform feature fusion on the first and second images, and perform stereo registration on a result of feature fusion and the depth information, to acquire a 3D image of the object.

Abstract: The present invention discloses a method for the design of complex-valued channel equalizer of digital communication systems, including: constructing a channel equalizer by using a complex-valued neural network; collecting the output signal y(n)=[y(n), y(n?1), . . . , y(n?m+1)]T of the nonlinear channel of the underlying digital communication system as the input of complex-valued neural network and s(n??) as the desired output, and taking the mean squared error as the loss function for the training of complex-valued neural network, which is optimized by the proposed adaptive complex-valued L-BFGS algorithm, and finally using it to implement the design of channel equalizer for digital communication systems. The present invention proposes the use of a multi-layer feedforward complex-valued neural network to construct complex-valued channel equalizer.