Patents by Inventor Yongliang Zhang
Yongliang Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10987430Abstract: Provided in the present invention are a di-substituted maleic amide linker conjugated to an antibody and a preparation method and use thereof. In particular, the present invention conjugates a strongly cytotoxic active substance to a biomacromolecule through a class of new linkers. The class of linkers can selectively act simultaneously with disulphide chains, so as to greatly improve the substance homogeneity of a conjugate. The conjugate prepared by the linker of the present invention has a high inhibitory activity on a cell strain expressing the corresponding antigen. Also provided is a method for preparing the above-mentioned conjugate and the use.Type: GrantFiled: November 24, 2017Date of Patent: April 27, 2021Assignees: Mabwell (Shanghai) Bioscience Co., Ltd., Jiangsu Mabwell Health Pharmaceutical R&D Co., Ltd.Inventors: Jingkang Shen, Tao Meng, Lanping Ma, Xin Wang, Hongli Peng, Yongliang Zhang, Ting Yu, Lin Chen, Zhiyan Du, Ying Wang
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Patent number: 10986318Abstract: An electronic apparatus, comprising: data and charging port, direct current charging port, data interface, power switch, charging management module, main processor, video receiver, and video processing module. The power switch detects whether data and charging port or direct current charging port is transferring electrical energy, and enables, according to detection result, conduction between the data and charging port or the direct current charging port and the charging management module. The charging management module employs, after becoming in conduction with the data and charging port or the direct current charging port, the data and charging port or the direct current charging port to charge battery. The main processor controls the video receiver to detect whether the data and charging port or the data interface is transmitting video data, and receives, according to detection result, one video data flow and sends the same to the video processing module for processing.Type: GrantFiled: September 18, 2016Date of Patent: April 20, 2021Assignee: ZTE CorporationInventor: Yongliang Zhang
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Publication number: 20200408757Abstract: Disclosed herein is a T-helper cell (“TH-GM” cell) that is regulated by IL-7/STAT5 and which secrete GM-CSF/IL-3. Also disclosed are methods and compositions for modulating TH-GM function for the treatment of, e.g., inflammatory disorders. Diagnostic and prognostic methods for specifically identifying TH-GM-mediated inflammatory disorders (e.g., rheumatoid arthritis), as distinct from and/or in addition to non-TH-GM-mediated (e.g., TNF-?-mediated) inflammatory disorders, are also provided.Type: ApplicationFiled: June 15, 2020Publication date: December 31, 2020Applicant: National University of SingaporeInventors: Xin-yuan FU, Wanqiang SHENG, Yongliang ZHANG, Fan YANG
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Publication number: 20200314398Abstract: An electronic apparatus, comprising: data and charging port, direct current charging port, data interface, power switch, charging management module, main processor, video receiver, and video processing module. The power switch detects whether data and charging port or direct current charging port is transferring electrical energy, and enables, according to detection result, conduction between the data and charging port or the direct current charging port and the charging management module. The charging management module employs, after becoming in conduction with the data and charging port or the direct current charging port, the data and charging port or the direct current charging port to charge battery. The main processor controls the video receiver to detect whether the data and charging port or the data interface is transmitting video data, and receives, according to detection result, one video data flow and sends the same to the video processing module for processing.Type: ApplicationFiled: September 18, 2016Publication date: October 1, 2020Inventor: Yongliang ZHANG
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Publication number: 20200255803Abstract: Provided are an immune cell capable of inducing the secretion of an anti-CD47 antibody when a CAR and/or an exogenous TCR is activated, a use thereof, and a preparation comprising the immune cell. Also provided are a preparation method of the immune cell and a kit for the preparation method.Type: ApplicationFiled: September 27, 2018Publication date: August 13, 2020Inventors: Yongliang ZHANG, Liping LIU, Wei CAO, Ling MA, Anyun MA, Jiaping HE, Lianjun SHEN, Xinxin Wang
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Patent number: 10690666Abstract: Disclosed herein is a T-helper cell (“TH-GM” cell) that is regulated by IL-7/STAT5 and which secrete GM-CSF/IL-3. Also disclosed are methods and compositions for modulating TH-GM function for the treatment of, e.g., inflammatory disorders. Diagnostic and prognostic methods for specifically identifying TH-GM-mediated inflammatory disorders (e.g., rheumatoid arthritis), as distinct from and/or in addition to non-TH-GM-mediated (e.g., TNF-?-mediated) inflammatory disorders, are also provided.Type: GrantFiled: September 25, 2015Date of Patent: June 23, 2020Assignee: NATIONAL UNIVERSITY OF SINGAPOREInventors: Fu Xin-Yuan, Wanqiang Sheng, Yongliang Zhang, Fan Yang
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Publication number: 20200086376Abstract: Provided is a method for performing an external pipe thread process on a hollow blank by at least twice rolling: firstly, the first rolling wheel group rolls the outer surface of the hollow blank into a threaded cylindrical surface or a threaded conical surface or a threaded cylindrical conical mixing surface, and secondly, the second rolling wheel group rolls again for the outer surface of the hollow blank which has processed in step 1, and rolling to form an external pipe thread; wherein the number of rolling wheels in a rolling wheel group, used in any two back-to-back rolling processes in a processing sequence, are different in parity. Further provided are various rolling head, module, apparatuses and production line for pipe thread, achieving the above processing method and having a simple structure, portability and practicality.Type: ApplicationFiled: December 13, 2017Publication date: March 19, 2020Inventors: Jun ZHOU, Yongliang ZHANG, Jianming YANG, Minjun YANG
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Publication number: 20190388555Abstract: Provided in the present invention are a di-substituted maleic amide linker conjugated to an antibody and a preparation method and use thereof. In particular, the present invention conjugates a strongly cytotoxic active substance to a biomacromolecule through a class of new linkers. The class of linkers can selectively act simultaneously with disulphide chains, so as to greatly improve the substance homogeneity of a conjugate. The conjugate prepared by the linker of the present invention has a high inhibitory activity on a cell strain expressing the corresponding antigen. Also provided is a method for preparing the above-mentioned conjugate and the use.Type: ApplicationFiled: November 24, 2017Publication date: December 26, 2019Inventors: Jingkang SHEN, Tao MENG, Lanping MA, Xin WANG, Hongli PENG, Yongliang ZHANG, Ting YU, Lin CHEN, Zhiyan DU, Ying WANG
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Patent number: 10432038Abstract: Provided are an electronic device and a wireless charging method and apparatus for an electronic device. In the wireless charging method, an environmental parameter transmitted by a wireless charging device is detected (S102); and a receiving antenna board within an electronic device is moved to a designated position according to the environmental parameter, wherein charging efficiency for charging the electronic device at the designated position is higher than charging efficiency for charging the electronic device at other positions (S104). The problems of wasting time and poor user experience caused by adjusting back and forth the electronic device in the process of wireless charging are solved. Free positioning of the antenna can be implemented, and time required by matching the electronic device and a wireless power supply device in the process of wireless charging can be greatly reduced.Type: GrantFiled: October 20, 2014Date of Patent: October 1, 2019Assignee: XI'AN Zhongxing New Software Co., LTD.Inventor: Yongliang Zhang
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Patent number: 10219410Abstract: The disclosure discloses a device for terminal heat dissipation and a mobile terminal, including: a heat source chip, a heat pipe, and a shield, wherein the shield is located between the heat source chip and the heat pipe, and is connected with the heat source chip and with the heat pipe via the same type of flexible thermal conductive solid; and a microporous array is arranged at a connection position between the flexible thermal conductive solids, which are in contact with the shield.Type: GrantFiled: November 10, 2014Date of Patent: February 26, 2019Assignee: XI'AN ZHONGXING NEW SOFTWARE CO., LTD.Inventor: Yongliang Zhang
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Publication number: 20170237278Abstract: Provided are an electronic device and a wireless charging method and apparatus for an electronic device. In the wireless charging method, an environmental parameter transmitted by a wireless charging device is detected (S102); and a receiving antenna board within an electronic device is moved to a designated position according to the environmental parameter, wherein charging efficiency for charging the electronic device at the designated position is higher than charging efficiency for charging the electronic device at other positions (S104). The problems of wasting time and poor user experience caused by adjusting back and forth the electronic device in the process of wireless charging are solved. Free positioning of the antenna can be implemented, and time required by matching the electronic device and a wireless power supply device in the process of wireless charging can be greatly reduced.Type: ApplicationFiled: October 20, 2014Publication date: August 17, 2017Inventor: Yongliang ZHANG
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Publication number: 20170238442Abstract: The disclosure discloses a device for terminal heat dissipation and a mobile terminal, including: a heat source chip, a heat pipe, and a shield, wherein the shield is located between the heat source chip and the heat pipe, and is connected with the heat source chip and with the heat pipe via the same type of flexible thermal conductive solid; and a microporous array is arranged at a connection position between the flexible thermal conductive solids, which are in contact with the shield. By means of the disclosure, the problem in the related art that heat cannot be quickly conducted to the h at pipe due to the back and forth conversion of the conductive medium in the thermal conductive path is solved, and h at can therefore be quickly conducted to the heat pipe, speeding up an effect of heat dissipation.Type: ApplicationFiled: November 10, 2014Publication date: August 17, 2017Applicant: ZTE CorporationInventor: Yongliang ZHANG
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Publication number: 20170219581Abstract: Disclosed herein is a T-helper cell (“TH-GM” cell) that is regulated by IL-7/STAT5 and which secrete GM-CSF/IL-3. Also disclosed are methods and compositions for modulating TH-GM function for the treatment of, e.g., inflammatory disorders. Diagnostic and prognostic methods for specifically identifying TH-GM-mediated inflammatory disorders (e.g., rheumatoid arthritis), as distinct from and/or in addition to non-TH-GM-mediated (e.g., TNF-?-mediated) inflammatory disorders, are also provided.Type: ApplicationFiled: September 25, 2015Publication date: August 3, 2017Applicant: National University of SingaporeInventors: Fu Xin-Yuan, Wanqiang Sheng, Yongliang Zhang, Fan Yang
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Patent number: 9467731Abstract: A method for controlling touch screens and a mobile terminal are disclosed. The method includes: a mobile terminal, connected with an HDMI device, requesting the HDMI device for obtaining a right of controlling a touch screen of the HDMI device; and after receiving a permission response message of the HDMI device, the mobile terminal performing a control operation on the touch screen of the HDMI device.Type: GrantFiled: May 9, 2012Date of Patent: October 11, 2016Assignee: ZTE CorporationInventor: Yongliang Zhang
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Patent number: 9283986Abstract: Disclosed are a follow-up steering control system for a multi-axle automobile crane and the multi-axle automobile crane. In a steering state of the multi-axle automobile crane, an output oil pressure of a first oil pressure output port is greater or less than that of a second oil pressure output port; a piston rod of a left-turning hydraulic cylinder is lengthened and a piston rod of a right-turning hydraulic cylinder is shortened, or the piston rod of the left-turning hydraulic cylinder is shortened and the piston rod of the right-turning hydraulic cylinder is lengthened; and a first knuckle arm and a second knuckle arm are driven to make a rear left steering wheel and a rear right steering wheel turn left or right.Type: GrantFiled: May 7, 2015Date of Patent: March 15, 2016Assignee: Xuzhou Heavy Machinery Co., Ltd.Inventors: Peilei Cao, Zhifang Wang, Guangguang Cao, Honggang Ding, Yongliang Zhang, Jiandong Wang
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Publication number: 20150239498Abstract: Disclosed are a follow-up steering control system for a multi-axle automobile crane and the multi-axle automobile crane. In a steering state of the multi-axle automobile crane, an output oil pressure of a first oil pressure output port is greater or less than that of a second oil pressure output port; a piston rod of a left-turning hydraulic cylinder is lengthened and a piston rod of a right-turning hydraulic cylinder is shortened, or the piston rod of the left-turning hydraulic cylinder is shortened and the piston rod of the right-turning hydraulic cylinder is lengthened; and a first knuckle arm and a second knuckle arm are driven to make a rear left steering wheel and a rear right steering wheel turn left or right.Type: ApplicationFiled: May 7, 2015Publication date: August 27, 2015Inventors: Peilei Cao, Zhifang Wang, Guangguang Cao, Honggang Ding, Yongliang Zhang, Jiandong Wang
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Publication number: 20150046945Abstract: A method for controlling touch screens and a mobile terminal are disclosed. The method includes: a mobile terminal, connected with an HDMI device, requesting the HDMI device for obtaining a right of controlling a touch screen of the HDMI device; and after receiving a permission response message of the HDMI device, the mobile terminal performing a control operation on the touch screen of the HDMI device.Type: ApplicationFiled: May 9, 2012Publication date: February 12, 2015Applicant: ZTE CORPORATIONInventor: Yongliang Zhang
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Patent number: 8891258Abstract: In one embodiment, a switch mode power supply comprising a switch and a control circuit is disclosed. The control circuit may comprise a multi-function pin configured to receive a first current sampling signal and a first voltage sampling signal. A first comparing signal may be provided by comparing the first voltage sampling signal with a first threshold signal when the switch is turned OFF, and a second comparing signal may be provided by comparing the first current sampling signal with a second threshold signal when the switch is turned ON. The control circuit may be configured to control the switch in accordance with the first comparing signal and the second comparing signal.Type: GrantFiled: May 10, 2012Date of Patent: November 18, 2014Assignee: Monolithic Power Systems, IncInventors: Yongliang Zhang, Xiaoyu Xi, Jiali Cai
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Patent number: 8380243Abstract: A dual-mode digital mobile communication terminal enabling Code Division Multiple Access (CDMA) and Global System for Mobile Communications (GSM) is disclosed, in which a processing module functions as a core; both CDMA and GSM wireless modules can be controlled; functions of high performance Bluetooth, camera, and FM receiver, etc. can be expanded; program downloading, debugging information printing and radio calibration, etc.Type: GrantFiled: April 9, 2010Date of Patent: February 19, 2013Assignee: ZTE CorporationInventors: Yongliang Zhang, Ran Qi, Lei Ma, Fangxi Hou
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Publication number: 20120287682Abstract: In one embodiment, a switch mode power supply comprising a switch and a control circuit is disclosed. The control circuit may comprise a multi-function pin configured to receive a first current sampling signal and a first voltage sampling signal. A first comparing signal may be provided by comparing the first voltage sampling signal with a first threshold signal when the switch is turned OFF, and a second comparing signal may be provided by comparing the first current sampling signal with a second threshold signal when the switch is turned ON. The control circuit may be configured to control the switch in accordance with the first comparing signal and the second comparing signal.Type: ApplicationFiled: May 10, 2012Publication date: November 15, 2012Applicant: Chengdu Monolithic Power Systems Co., Ltd.Inventors: Yongliang Zhang, Xiaoyu Xi, Jiali Cai