Abstract: The present invention belongs to the field of genetic engineering, and particularly relates to a genetically engineered dual-targeting chimeric antigen receptor. The present invention provides a genetically engineered dual-targeting chimeric antigen receptor and a host cell thereof in response to up-regulated expression of PD-L1 in tumor cells and immune cells after these cells are exposed to malignant serosal cavity effusion. The dual-targeting chimeric antigen receptor provided by the present invention competitively binds to PD-L1 to transform an inhibition signal of PD-L1 into an activation signal and to enhance the killing activity of T cells; meanwhile, 4-1BB introduced downstream thereof can promote proliferation and survival of T cells. In addition, the present invention also discloses a host cell expressing the above dual-targeting antigen receptor and a use thereof in preventing or treating solid tumors.

Abstract: The present application relates to the field of pharmaceutical chemistry, and specifically to cyclopropanecarboxamide-containing compounds of formula (I) and application thereof. The cyclopropanecarboxamide-containing compounds have great medical value and market potential for autoimmune diseases and myeloproliferative neoplasm diseases.

Abstract: The present application relates to the technical field of pharmaceutical chemistry, and particularly relates to compounds with ALK inhibitory activity and preparation method and use thereof. The compounds with ALK inhibitory activity provided by the present application are ALK inhibitors for treating diseases responsive to the inhibition of ALK kinase, can be used for treating ALK-positive diseases, such as tumors and cancers, and have broad application prospects.

Abstract: The present application provides an application method, system, medium and device of digital assets based on digital product. This method includes: receiving a request from a requester for the display of a digital asset; sending a first identity authentication instruction to the owner of the digital asset according to the display request; receiving a first identity verification instruction sent by the owner of the digital asset according to the first identity authentication instruction; displaying the digital asset to the requester according to the first identity verification instruction, and recording the display of the digital asset to the requester on a transaction block of the blockchain platform. The application can not only improve the security performance of the transaction, but also improve the user experience.

Abstract: The invention discloses A mechanical and electronic dual control water tap, including faucet group, control box and sensor, the sensor is arranged on the faucet group, and the faucet group is provided with a mixing valve; the mixing valve is internally arranged a cold water inlet, a hot water inlet, a first mixed water outlet and a second mixed water outlet are arranged; the second mixed water outlet is a normal water outlet channel; the control box includes a detection control unit, a first inflow runner, a second inflow runner and a mixed outlet channel; the first mixed water outlet is connected with the first inflow runner, and the second mixed water outlet is connected with the second inflow runner the first inflow runner and the second inflow runner are respectively provided with inductor and solenoid valves.

Abstract: The present invention discloses a shower apparatus, which comprises an upper body, a lower body and a mixing valve, the upper body and lower body are interconnected and fixed, the upper body is provided with a capacious space, the mixing valve is placed within the capacious space; the lower body comprises a cold water inlet channel, a hot water inlet channel and a mixing water outlet, the upper body comprises a cold water crossing channel, a hot water crossing channel and a mixing water crossing channel, the upper body comprises a cold water crossing channel, a hot water crossing channel and a mixing water crossing channel, the cold inlet channel, the hot inlet channel and the mixed water outlet are hermetically connected to the cold water crossing channel, the hot water crossing channel and the mixed water crossing channel, respectively.

Abstract: Disclosed is a method for preparing a high-entropy alloy composites reinforced by diamond particles, belonging to the technical field of metal composites preparation. A vacuum coating preparation equipment equipped with an in-situ heating sample stage is used to perform a treatment of high-entropy alloy metallizing coating on the surface of diamond particles to generate modified diamond particles, where the alloy of the coating includes any four, five or six elements among seven elements of Ti, Zr, Hf, Nb, Ta, W and Mo in an equal atomic proportion. The obtained coating generates carbide film in-situ with the surface layer of diamond particles, while the high-entropy alloy covers the carbide film, ensuring a strong bond with the diamond, and the high-entropy alloy composites reinforced by diamond particles are finally prepared.

Abstract: A radio-frequency ablation instrument (100) and a control method and a control apparatus (30) thereof, a system, an electronic device (90) and a storage medium are provided. The control method includes: acquiring at least one current ablation parameter (S701); calculating a power value needed to be outputted in a next cycle according to the current ablation parameter (S702); acquiring an input control voltage corresponding to the power value according to the power value needed to be outputted (S703); and controlling the radio-frequency energy output according to the input control voltage (S704).

Abstract: Disclosed is a method for preparing a high-entropy alloy composites reinforced by diamond particles, belonging to the technical field of metal composites preparation. A vacuum coating preparation equipment equipped with an in-situ heating sample stage is used to perform a treatment of high-entropy alloy metallizing coating on the surface of diamond particles to generate modified diamond particles, where the alloy of the coating includes any four, five or six elements among seven elements of Ti, Zr, Hf, Nb, Ta, W and Mo in an equal atomic proportion. The obtained coating generates carbide film in-situ with the surface layer of diamond particles, while the high-entropy alloy covers the carbide film, ensuring a strong bond with the diamond, and the high-entropy alloy composites reinforced by diamond particles are finally prepared.

Abstract: The present disclosure discloses a highly flexible stent which includes a plurality of annular supports arranged in an axial direction. The annular support is formed by a plurality of wave-shaped support units which are connected end to end. The support unit comprises a peak, a valley and a bar connected between the peak and the valley. In two adjacent annular supports, the peaks and the valleys of the support units of different annular supports are connected by first flexible connecting members. The first flexible connecting member further extends to and is wound onto at least one support unit to form a second flexible connecting member. The present disclosure provides a highly flexible stent having good compressibility, delivery compliance, and uniformity of expansion.

Abstract: The invention discloses a stent graft used for interventional treatment of abdominal aortic disease, comprising a tube body composed of a tubular covering and a plurality of annular stents, and the tube body comprises a first tube body and a second tube body that arranged in sequence from the proximal end to the distal end, wherein the diameter of the first tube body is greater than diameter of the second tube body; the first tube body and the second tube body are connected by a transition section as a whole; the diameter at central part of the transition section is smaller than the diameter of the proximal end of the transition section and the diameter of the distal end of the transition section; a plurality of fenestrations are disposed on the first tube body and the transition section.

Abstract: The present application provides an occluder, for use in occluding a defect in a vascular system. The occluder comprises a first occlusion disc, a second occlusion disc, and a tightening wire; the first occlusion disc and the second occlusion disc are used for covering different openings of a defect, respectively; a connector is provided on the first occlusion disc; the connector is provided with a wire passing hole; the tightening wire passes through the wire passing hole of the connector; two ends of the tightening wire pass through the second occlusion disc, and form an adjustment wire knot on the side of the second occlusion disc facing away from the first occlusion disc; the distance between the first occlusion disc and the second occlusion disc can be adjusted by the ends of the tightening wire. The present application also provides an occlusion system having the occluder.

Abstract: An ablation device and an ablation system provided with an ablation device, include an ablation assembly and an adjustment assembly provided at the proximal end of the ablation assembly. The adjustment assembly includes an outer catheter and an inner catheter which extend axially. The ablation assembly includes a supporting framework and an ablation member provided on the supporting framework. The supporting framework includes a positioning frame and a bearing frame. The positioning frame is provided at the distal end relative to the bearing frame, the distal end of the outer catheter is connected to the proximal end of the bearing frame, the distal end of the inner catheter is connected to the distal end of the positioning frame. During moving of the inner catheter relative to the outer catheter, the supporting framework deforms, and the deformation ratio of the positioning frame is less than that of the bearing frame.

Abstract: A vascular shunt frame with improved apposition including a main body tube; at least one end of the main body tube is provided with a sealing covering; the sealing covering is provided with a main blood flow opening; a shaping component is disposed at the edge of the main blood flow opening. When the main body stent is inserted into the main blood flow opening of the main body tube, the shaping component can be closely attached to the outer surface of the main body stent, such that the sealing covering closely fits the outer surface of the main body stent to prevent endoleaks. The present disclosure also provides a vascular stent provided with an apposition-improved vascular shunt frame.

Abstract: The present disclosure relates to systems, methods, and non-transitory computer-readable media for acquiring a virtual resource, including displaying an interactive interface of a second user in response to an access request of a first user for the interactive interface of the second user. A virtual resource state control is displayed on the interactive interface. A preview interface of a target multimedia resource posted by the second user is played in response to a trigger operation on the virtual resource state control by the first user in a case where the virtual resource state control indicates an available state. A preset quantity of virtual resources from virtual resources associated with the target multimedia resource is acquired in response to a trigger operation on the preview interface by the first user.

Abstract: A tool for replacing an escalator drive shaft comprises a first tool and a second tool. One side of the first tool is adapted to be assembled on an original shaft adapter, and the other side of the first tool is adapted to be assembled on a new shaft adapter. The second tool is adapted to be assembled on the first tool. A central axis of the first tool coincides with a central axis of the original shaft adapter, a central axis of the second tool coincides with the central axis of the first tool, and the central axis of the first tool coincides with a central axis of the new shaft adapter. A positioning reference of the original drive shaft is accurately transferred to the new drive shaft by the first and second tools, so that the new drive shaft may be accurately assembled to the position of the original drive shaft with respect to the truss after replacement.

Abstract: A multi-lumen stent graft including a tubular main body stent graft and a tubular connection stent graft; the main body stent graft includes a tubular main body stent; the main body stent includes a tubular main body covering and a main body support frame fixed on a wall of the main body covering; a main lumen and at least one sub lumen are separated axially by a separation covering within the main body stent; in a released state, a proximal end of the connection stent graft and the main lumen at a distal end of the tubular main body stent graft are fitted and connected together. The multi-lumen stent graft is not prone to endoleaks and displacement, which can simplify surgical operations, reduce the difficulty and risk of surgery, and has a wide range of applications.