Abstract: A vascular shunt stent includes a main body tube and at least one branch tube axially inserted into an inner lumen of the main body tube. The main body tube includes a tubular main membrane. At least one branch tube includes a tubular branch membrane, which is accommodated in an inner lumen of the main membrane. A first sealing film is arranged between a distal end of the main membrane and a distal end of the branch membrane to separate the inner lumen of the main membrane into a main opening and at least one first sub-opening, the first sub-opening is in sealed connection with the distal end of the branch membrane. An included angle between a plane defined by the first sub-opening is not parallel with a plane defined by the main opening.

Abstract: A left atrial appendage occluder for improving sealing effect and a manufacturing method thereof are provided. The left atrial appendage occluder includes a sealing portion and an anchoring portion coupled to the sealing portion. The sealing portion and the anchoring portion abut against each other. A tight connection between the sealing portion and the anchoring portion can be achieved by applying a pre-tightening force, such that the left atrial appendage occluder can be better attached to and occlude the left atrial appendage after being release.

Abstract: Provided is a segmented covered stent (100), which includes a covering membrane (120) and a support frame (110) fixed to the covering membrane (120). The support frame (110) comprises an annular structure (1200) and a spiral structure (1300), wherein the annular structure (1200) is formed by a plurality of first wave-shaped units (1100) connected end to end; and the spiral structure (1300) is a tubular structure formed by a plurality of second wave-shaped units (1400) connected end to end and arranged in a continuous spiral manner, and the overall extension direction of the spiral structure (1300) is parallel to the support frame (110). A method for preparing the segmented covered stent (100) is further provided.

Abstract: Disclosed is an occluder for occluding a defect in a vasculature. The occluder includes: two occluding disks and a tightening element. The two occluding disks is configured for covering different openings of the defect; wherein the tightening element includes a tightening thread, the tightening thread passing through the defect and being connected to the two occluding disks, the tightening thread has a length between the two occluding disks and the length is adjustable by means of a free end of the tightening thread. Further provided are an occluding system provided with the occluder, a knotting method for the tightening element of the occluder and a method for occluding an oval foramen with the occluder.

Abstract: A venous valve replacement device includes a stent with a blood flow channel and two leaflets connected to the stent, wherein one side of each leaflet is configured as a fixed edge connected with the stent, and the other side is configured as a movable edge, and wherein the movable edges of the two leaflets cooperates with each other to open or close the blood flow channel, and the movable edges of the two leaflets are provided with flaps that attach to each other in a closed configuration.

Abstract: Disclosed are a stent delivery and release device and a stent delivery and release system. The stent delivery and release device (20) includes a stent proximal end release assembly provided at a proximal end of the stent delivery and release device, a guide head provided at a distal end of the stent delivery and release device, and a control member, wherein an external stent is configured to be loaded between the guide head and the stent proximal end release assembly; a proximal end of the control member is connected to the stent proximal end release assembly, and at least part of a distal end of the control member is wound around the stent and is detachably connected to the guide head; and the stent proximal end release assembly folds or releases the stent by controlling the axial length of the control member.

Abstract: A vascular stent, including a plurality of wave-shaped supporters connected in an axial direction. The tubular stent includes a proximal support mechanism, a middle support mechanism, and a differential support mechanism connected in sequence; the middle support mechanism and the distal support mechanism are respectively closed-loop structure; the proximal support mechanism includes a first support portion connected to the middle support mechanism and a second support portion provided at the proximal end of the first support portion; the first support portion is a closed-loop structure; the second support portion is an open-loop structure, and the end surface of the proximal end of the second support portion is an uneven structure to provide local support in the circumferential direction.

Abstract: The present disclosure relates to systems, methods, and non-transitory computer-readable media for acquiring a virtual resource, including displaying an interactive interface of a second user in response to an access request of a first user for the interactive interface of the second user. A virtual resource state control is displayed on the interactive interface. A preview interface of a target multimedia resource posted by the second user is played in response to a trigger operation on the virtual resource state control by the first user in a case where the virtual resource state control indicates an available state. A preset quantity of virtual resources from virtual resources associated with the target multimedia resource is acquired in response to a trigger operation on the preview interface by the first user.

Abstract: The present disclosure relates to systems, methods, and non-transitory computer-readable media for acquiring a virtual resource, including displaying an interactive interface of a second user in response to an access request of a first user for the interactive interface of the second user. A virtual resource state control is displayed on the interactive interface. A preview interface of a target multimedia resource posted by the second user is played in response to a trigger operation on the virtual resource state control by the first user in a case where the virtual resource state control indicates an available state. A preset quantity of virtual resources from virtual resources associated with the target multimedia resource is acquired in response to a trigger operation on the preview interface by the first user.

Abstract: Disclosed are a nitrogen-containing heterocyclic derivative regulator, a preparation method therefor and an application thereof. In particular, disclosed are a compound as represented by general formula (I), a preparation method for the compound and a pharmaceutical composition containing the compound, and the use thereof as a KRAS G12C mutation inhibitor in treatment of diseases or symptoms such as leukemia, neuroblastoma, melanoma, breast cancer, lung cancer and colon cancer, wherein the definitions of substituents in general formula (I) are the same as those in the description.

Abstract: The present invention belongs to the field of genetic engineering, and particularly relates to a genetically engineered dual-targeting chimeric antigen receptor. The present invention provides a genetically engineered dual-targeting chimeric antigen receptor and a host cell thereof in response to up-regulated expression of PD-L1 in tumor cells and immune cells after these cells are exposed to malignant serosal cavity effusion. The dual-targeting chimeric antigen receptor provided by the present invention competitively binds to PD-L1 to transform an inhibition signal of PD-L1 into an activation signal and to enhance the killing activity of T cells; meanwhile, 4-1BB introduced downstream thereof can promote proliferation and survival of T cells. In addition, the present invention also discloses a host cell expressing the above dual-targeting antigen receptor and a use thereof in preventing or treating solid tumors.

Abstract: A left atrial appendage occluder with advanced connection manner and a manufacturing method thereof are provided. The left atrial appendage occluder includes a sealing portion and an anchoring portion. Each of the sealing portion and the anchoring portion is provided with a connection part formed by converging a corresponding shape of the sealing portion or the anchoring portion respectively. The connection parts of the sealing portion and the anchoring portion extend toward each other to be fixed and misaligned with each other.

Abstract: The present disclosure provides a temporally-resolved and spatially-resolved pump-probe control system and a method. The system includes an ultrafast femtosecond laser device, an optical parametric oscillator, a displacement delay module, a micro-drive rotation module, an objective lens, a sample stage, a coupled photoelectric amplifier and a computer terminal. The control system of the present disclosure integrates a temporally-resolved pump-probe function and a temporally-resolved and spatially-resolved pump-probe function. The present disclosure can realize pump-probe temporally-resolved scanning, one-dimensional temporally-resolved and spatially-resolved scanning, and two-dimensional temporally-resolved and spatially-resolved scanning under full-automatic control, and real-time data is visualized and synchronously written into batch files.

Abstract: An atrial septostomy device (20) includes a support frame (21) for propping a puncture hole in the atrial septum. The support frame (21) includes an expansion portion (23) for propping the puncture hole, a connecting portion (27) connected to a proximal end of the expansion portion (23), and an extension portion (25) connected to a distal end of the expansion portion (23). A distal end of the extension portion (25) has a converged portion (250) that is parallel to the axis of the support frame (21) or extends towards the axis of the support frame (21). The support frame (21) is provided with an ablation electrode (60) for ablating tissues surrounding the puncture hole.

Abstract: A tool for replacing an escalator drive shaft comprises a first tool and a second tool. One side of the first tool is adapted to be assembled on an original shaft adapter, and the other side of the first tool is adapted to be assembled on a new shaft adapter. The second tool is adapted to be assembled on the first tool. A central axis of the first tool coincides with a central axis of the original shaft adapter, a central axis of the second tool coincides with the central axis of the first tool, and the central axis of the first tool coincides with a central axis of the new shaft adapter. A positioning reference of the original drive shaft is accurately transferred to the new drive shaft by the first and second tools, so that the new drive shaft may be accurately assembled to the position of the original drive shaft with respect to the truss after replacement.

Abstract: An occluder includes a proximal occlusion portion. The proximal occlusion portion has a proximal end provided with a first converged member, and is provided with a conical guide structure on an outer periphery of the first converged member. The guide structure has an inner diameter gradually decreasing from a distal end to a proximal end. The guide structure provides a guiding performance to facilitate the occluder to be withdrawn into the sheath easily. An occluder fastening system is used in cooperation with the occluder.

Abstract: Disclosed are an occluder, an occluder fastening system and a fastening method therefor. The occluder includes a first occluding portion and a second occluding portion. A distal end of the first occluding portion is provided with a connecting bolt extending towards the second occluding portion, and a first external thread is provided on a side wall of the connecting bolt. A protrusion portion is provided at a proximal end of the second occluding portion with a through hole provided therein, and a second external thread is provided on a side wall of the protrusion portion. The thread direction of the first external thread is opposite to the thread direction of the second external thread, and a proximal end of the connecting bolt can extend through the through hole and is screwed to a nut. In cooperation with a pushing device, such designed occluder (10) achieves high-efficiency, stable and reliable fastening.

Abstract: A marker for use in the lung of patients for marking the position of a lesion in the lung, wherein the marker comprises a self-expandable structure capable of self-expanding when released from a constricting device so as to implement marking function. Because the marker for use in the lung of a patient employs the self-expandable structure, when the position of a lesion is detected during a lung examination, the marker can be delivered to the position of the lesion via a catheter or a delivering device and substantively pressed and fixed by the lung when expanded at the lesion positions; as such, the lesion position can be located quickly by a surgeon during a surgery, the surgery time is shortened, the area of resection is reduced, and the post-surgery quality of life is improved for a patient.