Abstract: A drug injection control device allows a structure in which a piston rod moving with a rod guide makes a linear motion to stably inject a drug set through a dose dial. When an injection amount of drug is preset through an injection amount setting module configured to make a rotational motion with the dose dial in a housing to set the amount of drug to be injected by storing the twisting moment in a torsion spring, in actuating a drug delivery module switchably coupled to the injection amount setting module by an injection button on top of the drug injection control device, the rod guide is connected to the inside of the piston rod through a reset tube movably coupled to the injection button to allow a sub-linear motion of the piston rod.

Abstract: A drug injection control device includes a housing, a dose dial rotatably coupled to the housing, a cartridge holder coupled to an opposite side of the housing, an injection button, a spring base non-rotatably coupled to the housing, an injection amount setting module to set an amount of the drug to be injected by storing a twisting moment in a torsion spring in the housing, and a drug delivery module to deliver a drug from the cartridge embedded in the cartridge holder by moving through the release of the twisting moment. The spring base includes a ratchet to engage with ratchet protrusions in the dose dial during the rotation of the dose dial, and feedback on the set injection amount of the drug is provided through generating a sound by sequential contact between the ratchet and the ratchet protrusions radially formed along a radial direction on the dose dial.

Abstract: A drug injection control device has a structure in which a rod lock screw-coupled to an outer circumferential surface of a piston rod can only make a linear motion under restricted rotation in a rod holder with the rotation of a rod guide and the sub-linear motion of the piston rod. When an injection amount of drug is preset through an injection amount setting module configured to make a rotational motion with a dose dial in a housing to set the amount of drug to be injected by storing the twisting moment in a torsion spring, a button plate is fixed and positioned in the dose dial to perform a function of supporting a button spring, and an injection button is slidably coupled through the button plate, so the injection button rotates simultaneously with the rotation of the dose dial, but allows a stable pushing operation through the button plate.

Abstract: A drug injection control device has a structure in which a rod lock screw-coupled to a piston rod can make a linear motion under restricted rotation within a rod holder with the rotation of a rod guide and the sub-linear motion of the piston rod. When the injection amount of drug is preset through an injection amount setting module to make a rotational motion with a dose dial in a housing to set the amount of drug to be injected by storing the twisting moment in a torsion spring, in actuating a drug delivery module switchably coupled to the injection amount setting module, the rod lock can make a linear motion by the sliding motion of a lock protrusion through a lock guide formed through the rod holder along the lengthwise direction on the rotation of the rod guide and the sub-linear motion of the piston rod.

Abstract: The present invention provides a crack repair material of a concrete vacuum tube segment using ultra-high performance concrete (UHPC) for a hyper-speed transportation system and a crack repairing method for the same capable of, in a case in which a vacuum tube segment of a hyper-speed transportation system, such as the Hyperloop, is manufactured using UHPC, repairing cracks formed in the UHPC vacuum tube segment easily and conveniently using a crack growth prevention material and a patch repair material and capable of immediately repairing cracks formed in the UHPC vacuum tube segment to secure airtightness so that operation of a vacuum pump is minimized and overload of the vacuum pump is prevented.

Abstract: The present invention provides a concrete vacuum tube segment for a hyper-speed transportation system using ultra-high performance concrete (UHPC) and a manufacturing method thereof. A concrete vacuum tube segment for a hyper-speed transportation system can be easily manufactured using UHPC, in which shrinkage and structural cracking do not occur due to mixing a binder and a short fiber to secure airtightness on the basis of a maximum fill theory, and accordingly, shrinkage of the concrete vacuum tube segment can be reduced even in a partial-vacuum state in which the magnitude of drying shrinkage is very small and quick drying occurs; when mixing the UHPC, an antifoaming agent is mixed and a circular vacuum pump is used to remove generated entrapped air to minimize the entrapped air; and a capsule-type crack healing material, which is able to repair fine cracks, is compacted to secure airtightness of the concrete vacuum tube segment.

Abstract: The present disclosure relates to ultra-high density concrete composite containing super-absorbent polymer (SAP)-Attached Fibers, suitable for making a near-vacuum tube for hyperloop transportation system, a method for manufacturing the ultra-high density concrete composite, a method for manufacturing a concrete member using the ultra-high density concrete composite and an ultra-high density concrete member manufactured by the method.

Abstract: The present invention provides a crack repair material of a concrete vacuum tube segment using ultra-high performance concrete (UHPC) for a hyper-speed transportation system and a crack repairing method for the same capable of, in a case in which a vacuum tube segment of a hyper-speed transportation system, such as the Hyperloop, is manufactured using UHPC, repairing cracks formed in the UHPC vacuum tube segment easily and conveniently using a crack growth prevention material and a patch repair material and capable of immediately repairing cracks formed in the UHPC vacuum tube segment to secure airtightness so that operation of a vacuum pump is minimized and overload of the vacuum pump is prevented.

Abstract: Disclosed is a method for body fluid-based neurodegenerative disease diagnosis through high-sensitive immunoassay of aggregated proteins by photooxidation-induced amplification. The method according to the present disclosure provides an effect of quantitatively analyzing aggregated proteins in the form of oligomers or monomers which are present in trace amounts in a body fluid and measures normal or abnormal protein aggregation by detecting the aggregated proteins in the form of oligomers or monomers with high sensitivity by reaction of antibody-conjugated enzymes selectively bound to the aggregated proteins with substrates and photooxidation-induced amplification, thereby allowing accurate diagnosis of a neurodegenerative disease.

Abstract: The biosensor includes a substrate, an electrode pattern positioned on the substrate, a passivation layer which is formed with a plurality of holes spaced apart from each other, and a bead positioned at one or more holes among the plurality of holes, and to which an antibody is attached, the electrode pattern includes a first electrode pattern part and a second electrode pattern part spaced apart from the first electrode pattern part, which has a same height as a height of the first electrode pattern part, and forms an electric field with the first electrode pattern part.

Abstract: A vertical memory device includes a substrate including a cell array region and a connection region adjacent to the cell array region, a plurality of gate electrode layers stacked on the cell array region and the connection region of the substrate, a channel structure on the cell array region and extending in a direction perpendicular to an upper surface of the substrate while penetrating through the plurality of gate electrode layers, a dummy channel structure on the connection region and extending in the direction perpendicular to the upper surface of the substrate while penetrating through at least a portion of the plurality of gate electrode layers, and a support insulating layer between a portion of the plurality of gate electrode layers and the dummy channel structure. The plurality of gate electrode form a stepped structure on the connection region.

Abstract: Disclosed is a method of quantifying a biomarker with high sensitivity using photo-oxidation induced amplification. The method includes performing an enzyme-substrate reaction of a measurement sample including an enzyme labeled on any one selected from among an antibody, an aptamer, and a nucleic acid specifically bound to the biomarker, optically measuring one or more optical properties selected from among amounts of color formation, light emission, and fluorescence of a product during a photo-oxidation induced amplification process while the product resulting from the enzyme-substrate reaction is continuously exposed to light to thus perform the photo-oxidation induced amplification process, indexing a time-varying pattern of the measured optical properties, and quantifying a concentration of the biomarker included in the measurement sample by comparing an index extracted during the indexing with an index of a reference sample.

Abstract: A photoacoustic, noninvasive, and continuous blood glucose measurement device includes: a diode laser for irradiating a living body with a pulsed laser signal having a specific wavelength; and an ultrasound transducer for measuring a photoacoustic signal in a form of ultrasonic waves generated by a reaction of the living body with the pulsed laser signal.

Abstract: A vertical memory device includes a substrate including a cell array region and a connection region adjacent to the cell array region, a plurality of gate electrode layers stacked on the cell array region and the connection region of the substrate, a channel structure on the cell array region and extending in a direction perpendicular to an upper surface of the substrate while penetrating through the plurality of gate electrode layers, a dummy channel structure on the connection region and extending in the direction perpendicular to the upper surface of the substrate while penetrating through at least a portion of the plurality of gate electrode layers, and a support insulating layer between a portion of the plurality of gate electrode layers and the dummy channel structure. The plurality of gate electrode form a stepped structure on the connection region.

Abstract: The present invention relates to a method for isolating extracellular vesicles comprising: preparing a microfluidic chip in which at least two microfluidic channels are formed and inlets and outlets are formed at both ends of the channels, respectively; injecting at least one aqueous solution into the inlet of the microfluidic chip to form a microfluid; injecting a sample containing extracellular vesicles into the inlet of the microfluidic chip; and recovering the fluid from the outlet of the microfluidic chip.

Abstract: A vertical memory device includes a substrate including a cell array region and a connection region adjacent to the cell array region, a plurality of gate electrode layers stacked on the cell array region and the connection region of the substrate, a channel structure on the cell array region and extending in a direction perpendicular to an upper surface of the substrate while penetrating through the plurality of gate electrode layers, a dummy channel structure on the connection region and extending in the direction perpendicular to the upper surface of the substrate while penetrating through at least a portion of the plurality of gate electrode layers, and a support insulating layer between a portion of the plurality of gate electrode layers and the dummy channel structure. The plurality of gate electrode form a stepped structure on the connection region.

Abstract: A method for providing information relevant to the diagnosis of a neurodegenerative disorder. The method includes (i) obtaining a biological sample containing vesicles from a subject, (ii) measuring the level of amyloid beta in the biological sample using an antibody specific for the N-terminus of amyloid beta, and (iii) comparing the measured level of amyloid beta in the biological sample with the level of amyloid beta in a previously prepared control sample.

Abstract: The present disclosure relates to a system for monitoring post-translational modification of protein using a biosensor with a gap, which performs with high reliability a diagnosis of a disease associated with a target protein for which impedance is measured, by measuring an impedance of a sample introduced into a sensor and calculating a change rate of the measured impedance, and to a method of manufacturing the biosensor used for the system.

Abstract: According to a method for monitoring post-translational modifications of protein is provided, a first microbead by binding a protein antibody to a base bead is provided. A second microbead by binding a target protein having a first post-translational modification or a second post-translational modification, which are inversely proportional to each other, to the protein antibody of the first microbead, is provided. A third microbead by binding the second microbead to a first post-translational modification antibody is provided. A fourth microbead by binding the second microbead to a second post-translational modification antibody is provided. Impedances of the third and fourth microbeads are measured. A ratio of a first difference, between the impedances of the third microbead and a reference impedance, to a second difference, between the impedances of the fourth microbead and the reference impedance, is obtained.

Abstract: The present invention relates to a method for diagnosing a disease using an analysis of oligomer of an abnormal aggregated protein includes: (1) preparing a body fluid sample including at least one of blood, blood plasma, blood serum, saliva, urine, tear, and mucus; (2) making a dilution of the body fluid sample; (3) using a biosensor to measure and detect an aggregated protein in the diluted body fluid sample; (4) analyzing a signal change of the biosensor caused by the dilution of the aggregated protein to determine a slope according to the dilution from the measurements; and (5) analyzing a proportion of the oligomer from the slope according to the dilution to make a diagnosis. The method uses a biosensor to measure the impedance and the protein concentration of blood and detects the slope according to the numerical value of the monomer and the oligomer to diagnose normal or abnormal protein aggregation or the associated diseases with more accuracy.