Abstract: In a chemical analysis apparatus for extracting a specific substance, such as nucleic acid, from a sample containing a plurality of chemical substances, solutions remaining in valves are prevented so that a reagent in an earlier step does not contaminate the subsequent steps. Predetermined quantities of solutions are carried and supplied by centrifugal force without providing valves for controlling the flow of the solutions. After perforating the lids of ventilation holes 272, 273, 274 communicated with a detection container 450 and disposal containers 460 and 470 in an analysis disc 2, the analysis disc 2 is rotated to supply and carry a predetermined quantity of the sample.

Abstract: The flow rate of a solvent is reduced as a separation column and the separation performance is improved even under high-pressure conditions. There is provided a separation column including a monolith rod into which a sample and a mobile phase flow, the separation column comprising: a coating material coated on the outer circumference of a monolith rod; a support member into which the monolith rod coated with the coating material is inserted, and a rod fixing material fitted into or filled a gap between the coating material and the support member; wherein the upper end face of the rod fixing material is sealed, the upper end face being the inflow-side end when the separation column is assembled.

Abstract: A nucleic acid refining apparatus, being ease in automation thereof, keeping high in contacting frequency between nucleic acid within a sample and a solid phase during nucleic acid capture processing, thereby proving high capturing rate, comprises: means for separating a liquid containing the nucleic acid therein from said sample through centrifugal force; means for transferring a reagent through the centrifugal force; means for producing a mixture liquid of said reagent transferred through the centrifugal force and a solution containing said nucleic acid therein; a carrier for capturing said nucleic acid; means for transferring said mixture liquid to said carrier through the centrifugal force; heating means for heating said carrier; and a holding means for separating and holding the reagent containing said nucleic acid eluting from said carrier, separating from other reagent, through different centrifugal.

Abstract: An analysis cartridge for use in a chemical analysis device comprises a reagent cartridge having a plurality of reagent containers formed therein to be able to contain reagents, and a reaction cartridge connected to the reagent cartridge and having a reaction container formed therein. The reagent cartridge and the reaction cartridge are each made up of a base plate and a cover covering recesses formed in a surface of the base plate. Channels for interconnecting the plurality of reagent containers and the reaction container are formed in the reagent cartridge and the reaction cartridge. The channels are formed inside the base plates of the reagent cartridge and the reaction cartridge in their connected portions. The structure of the analysis cartridge for mixing and reacting a specimen and reagents can be simplified.

Abstract: A chemical analyzer has a rotatable holding disk, test cartridges disposed thereon, and a detector. The test cartridge includes a base plate having vessels and flow channels. The base plate is covered with a cover for covering the vessels and flow channels. The holding disk is rotated to generate centrifugal force, causing a fluid to be moved from one vessel at the inner peripheral side with respect to a rotation axis of the holding disk to another vessel at the outer peripheral side with respect to the rotation axis via the flow channel. In the test cartridge, at least one reagent port is formed in the base plate, and a closed vessel containing a reagent is placed in the reagent port. The closed vessel is a microcapsule, a plastic closed vessel, or a screw-in closed vessel, for example.

Abstract: A chemical analysis device has a motor, a holder disk to be rotated by the motor, a plurality of inspection cartridges, a penetrator for penetrating the inspection cartridges, a heater and a detector. The inspection cartridge has a substrate including containers formed as recesses and a flow path, and a cover is mounted on the substrate to cover the containers and flow path. By a centrifugal force generated by a rotation of the holder disk, a liquid is moved through the flow path from the container at a radially inner side with respect to a rotational axis to the container at a radially outer side with respect to the rotational axis.

Abstract: The invention provides a chemical analysis apparatus which easily agitates and warms up. A chemical analysis apparatus has a motor, a retaining disc which can be rotated by the motor, a plurality of inspection cartridges which are arranged on the retaining disc, a punching machine for punching the inspection cartridges, a warming apparatus and a detection apparatus. The inspection cartridge includes a container formed by a concave portion and a base plate having a flow path. A cover covering the container and the flow path is installed to the base plate. A liquid solution is moved to the container in an outer peripheral side with respect to a rotation axis from the container in an inner peripheral side with respect to the rotation axis via the flow path, by utilizing a centrifugal force generated on the basis of the rotation of the retaining disc.

Abstract: A chemical analysis apparatus comprises a motor, a holding disk that can be rotated by the motor, a plurality of examination cartridges arranged on the holding disk, a perforator that perforates the examination cartridges, a heating device, and a detection device. The examination cartridge comprises a substrate including a vessel and a flow channel, which are defined by recesses, and a cover that covers the vessel and the flow channel. A centrifugal force generated by rotation of the holding disk is made use of to move a solution from a vessel on an inner peripheral side relative to an axis of rotation to a vessel on an outer peripheral side relative to the axis of rotation through the flow channel.

Abstract: A chemical analyzing apparatus accommodates therein a structure for retaining a sample and reagents. A detecting mechanism detects the sample after reaction with a reagent. After or during extraction of a biological substance from the sample in the structure, a temperature of a fluid in a space around the structure is controlled to a value which is suitable for enzyme.

Abstract: In a chemical analyzer, an accommodation part accommodates a structure that stores a reagent being caused to react with a sample and has a reaction region, in which the sample and the reagent react with each other. Further, a detection mechanism detects the sample after reaction. The structure is formed with a reagent cartridge that stores a reagent, and an analysis cartridge comprising a connection part, to which the reagent cartridge is connected, a reagent flow path, through which the reagent flows, a sample flow path, through which the sample flows, and a reaction region communicated to the reagent flow path and the sample flow path. A side surface of the reagent cartridge and a side surface of the analysis cartridge are arranged in opposite to each other and connected to each other through the connection part.

Abstract: The invention is achieved by feeding a reagent using centrifugal force, without providing a valve for controlling the flow rate of the reagent in the reagent flow path. A chemical analyzer is used which comprises a structure that is supported so as to be rotatable, said structure comprising a capturing section for capturing specific chemical substances from a specimen, specimen containers and reagent containers including washing solution containers.

Abstract: A nucleic-acid amplifying apparatus comprising: a flow passage, through which a reaction fluid containing a sample containing a nucleic acid and a reagent flows, said flow passage including, a flow passage branch portion, at which the flow passage branches into a plurality of branch flow passages, a junction portion, at which the plurality of branch flow passages join, and a joined flow passage, through which the reaction fluid as joined is conducted; and a heating mechanism having a plurality of set temperature zones provided on the branch flow passages.

Abstract: An analyzer and a structure for analysis with high performance are provided which can reduce contamination between the reagents when the valve components or a plurality of reagents are included.

Abstract: A nucleic acid refining apparatus, being ease in automation thereof, keeping high in contacting frequency between nucleic acid within a sample and a solid phase during nucleic acid capture processing, thereby proving high capturing rate, comprises: means for separating a liquid containing the nucleic acid therein from said sample through centrifugal force; means for transferring a reagent through the centrifugal force; means for producing a mixture liquid of said reagent transferred through the centrifugal force and a solution containing said nucleic acid therein; a carrier for capturing said nucleic acid; means for transferring said mixture liquid to said carrier through the centrifugal force; heating means for heating said carrier; and a holding means for separating and holding the reagent containing said nucleic acid eluting from said carrier, separating from other reagent, through different centrifugal.

Abstract: In a fluidal machine with an impeller rotating to urge a fluid radially outwardly by a centrifugal force, a vane guiding the fluid discharged from the impeller, a vane member which includes a front end of the vane facing to the impeller so that the fluid discharged from the impeller strikes against the front end and which is prevented from contacting the atmosphere, and a casing surrounding the vane member and contacting the atmosphere, the vane member is discrete from the casing, a vibration propagation between the vane member and the casing is prevented or restrained, and a vibration of a pipe extending from the casing is absorbed.

Abstract: In a chemical analysis apparatus for extracting a specific substance, such as nucleic acid, from a sample containing a plurality of chemical substances, solutions remaining in valves are prevented so that a reagent in an earlier step does not contaminate the subsequent steps. Predetermined quantities of solutions are carried and supplied by centrifugal force without providing valves for controlling the flow of the solutions. After perforating the lids of ventilation holes 272, 273, 274 communicated with a detection container 450 and disposal containers 460 and 470 in an analysis disc 2, the analysis disc 2 is rotated to supply and carry a predetermined quantity of the sample.

Abstract: In a fluidal machine with an impeller rotating to urge a fluid radially outwardly by a centrifugal force, a vane guiding the fluid discharged from the impeller, a vane member which includes a front end of the vane facing to the impeller so that the fluid discharged from the impeller strikes against the front end and which is prevented from contacting the atmosphere, and a casing surrounding the vane member and contacting the atmosphere, the vane member is discrete from the casing, a vibration propagation between the vane member and the casing is prevented or restrained, and a vibration of a pipe extending from the casing is absorbed.

Abstract: In a fluidal machine with an impeller rotating to urge a fluid radially outwardly by a centrifugal force, a vane guiding the fluid discharged from the impeller, a vane member which includes a front end of the vane facing to the impeller so that the fluid discharged from the impeller strikes against the front end and which is prevented from contacting the atmosphere, and a casing surrounding the vane member and contacting the atmosphere, the vane member is discrete from the casing, a vibration propagation between the vane member and the casing is prevented or restrained, and a vibration of a pipe extending from the casing is absorbed.

Abstract: An automatically analyzing apparatus includes a plurality of reaction containers for reacting a sample with a reagent, and a reaction container washing unit for washing the reaction containers through a plurality of washing steps. The reaction container washing unit includes a plurality of storage parts in each of which washing liquid containing therein reacted substance is reserved. The plurality of storage parts are sorted with different reacted substance concentrations. A supply part of the reaction container washing unit selects washing liquid of a desired reacted substance concentration among the plurality of storage parts in accordance with respective washing conditions of the reaction containers and supplies the selected washing liquid into the reaction containers for washing the respective reaction containers.

Abstract: At a vaned diffuser or a volute casing of a centrifugal fluid machine, pressure pulsation and vibrating forces acting upon the diffuser or the volute casing are mitigated or cancelled so as to abate the noise from the centrifugal fluid machine. The fluid machine having an impeller 3 rotating about a rotating shaft 2 within a casing 1 and having a vaned diffuser 4 or volute 12 fixed to the casing 1 is constructed such that radius of the vane trailing edge of the impeller 3 and radius of the vane leading edge of the diffuser 4 or radius of the volute tongue is varied in the direction of axis of rotation and inclinations, on a meridional plane, of the vane trailing edge of the impeller 3 and the vane leading edge of the diffuser 4 or the volute tongue are set in the same orientation, thereby reduction in head and efficiency or occurrence of an axial thrust may be restrained to the extent possible to optimally abate the noise and pressure pulsation of the centrifugal fluid machine.