Abstract: A method of producing a transdermal absorption sheet includes: filling needle-like recessed portions of a mold with a drug solution that is a polymer solution containing a drug; drying the drug solution filling the needle-like recessed portions to form a drug layer containing the drug; supplying a polymer layer forming solution to the mold, the mold provided with a step portion that has a height different from a height of a region in which the needle-like recessed portion is formed in a periphery of the region in which the needle-like recessed portion is formed in a range of equal to or greater than the step portion as seen from above, and then fixing a contact position of the polymer layer forming solution and the mold to the step portion while reducing the polymer layer forming solution; and drying the polymer layer forming solution to form a polymer layer.

Abstract: A method of producing a transdermal absorption sheet including: preparing a mold having needle-like recessed portions including tapered inlet portions; preparing a liquid feeder including an opening portion and a lip land portion; filling the needle-like recessed portions with a solution by feeding the solution to the mold and moving the liquid feeder in a traveling direction while bringing an upstream end of the lip land portion on an upstream side of the liquid feeder in the traveling direction into contact with the mold; and forming needle portions and a sheet portion using a polymer solution. In the filling of the solution, when the upstream end of the lip land portion on the upstream side aligns with an upstream side inlet surface of one of the needle-like recessed portions, the shortest distance from a downstream side inlet surface of the needle-like recessed portion to a surface of the lip land portion on the upstream side is 220 ?m or less.

Abstract: The method includes the steps of: preparing a mold and a liquid filling device; and filling needle-like recessed portions with a liquid medicine by repeating the following: a filling operation in which the liquid medicine is supplied to the mold from the liquid filling device and the needle-like recessed portions are filled with the liquid medicine while a nozzle tip is brought into pressed contact with a surface of the mold; and a moving operation in which a nozzle is relatively moved with respect to the mold while the nozzle tip and the surface of the mold are in contact with each other, wherein the nozzle is held in a Z-axis drive unit configured to vertically move the nozzle while an elastic body is provided in the Z-axis drive unit, while the nozzle tip is brought into pressed contact with the surface of the mold.

Abstract: Provided is a manufacturing method of a sheet having needle-like protrusions capable of individually manufacturing sheets on a mold. The manufacturing method of a sheet having needle-like protrusions includes, for a mold provided with needle-like recesses and an annular groove provided around a region where the needle-like recesses are formed, a first polymer solution supplying step of supplying a first polymer solution, which is to become a first layer, to the needle-like recesses; a second polymer solution supplying step of filling the needle-like recesses and the groove with a second polymer solution by supplying the second polymer solution, which is to become a second layer, to a surface of the mold; a drying step of forming a laminate of the first layer and the second layer by drying the first polymer solution and the second polymer solution; and a peeling step of peeling the laminate away from the mold.

Abstract: The method of producing a transdermal absorption sheet includes: preparing a mold having needle-like recessed portions and an angle of an inlet portion of 120° to 160°, and a liquid feeder including an opening portion and a lip land portion; filling the needle-like recessed portions with a solution by feeding the solution to the mold and moving the liquid feeder while bringing a rear end of a lip land portion on the secondary side of the liquid feeder into contact with the mold; and forming needle portions and a sheet portion using a polymer solution. In the filling of the solution, when the rear end of the lip land portion on the secondary side matches with a secondary side inlet of the needle-like recessed portion, the shortest distance from a primary side inlet of the needle-like recessed portion to a secondary side block is 220 ?m or less.

Abstract: A method of producing a transdermal absorption sheet includes: filling needle-like recessed portions of a mold with a drug solution that is a polymer solution containing a drug; drying the drug solution filling the needle-like recessed portions to form a drug layer containing the drug; supplying a polymer layer forming solution to the mold, the mold provided with a step portion that has a height different from a height of a region in which the needle-like recessed portion is formed in a periphery of the region in which the needle-like recessed portion is formed in a range of equal to or greater than the step portion as seen from above, and then fixing a contact position of the polymer layer forming solution and the mold to the step portion while reducing the polymer layer forming solution; and drying the polymer layer forming solution to form a polymer layer.

Abstract: The manufacturing method of the sheet having the needle-like protruding portions includes: preparing a mold including needle-like recessed portions, and a solution supply device including a slit-like opening formed at a nozzle distal end portion; supplying a solution from the solution supply device to the mold in a state that the nozzle distal end portion is pressed to a front surface of the mold, and filling the solution in the needle-like recessed portions; and moving the solution supply device relatively to the mold in a state that the nozzle distal end portion is brought into contact with the front surface of the mold, and, as a hardness distribution in a thickness direction of the mold, an average value of a Young's modulus at a part within 40 ?m from the front surface of the mold is 1.9 MPa or higher and 100 MPa or lower.

Abstract: The method includes the steps of: preparing a mold and a liquid filling device; and filling needle-like recessed portions with a liquid medicine by repeating the following: a filling operation in which the liquid medicine is supplied to the mold from the liquid filling device and the needle-like recessed portions are filled with the liquid medicine while a nozzle tip is brought into pressed contact with a surface of the mold; and a moving operation in which a nozzle is relatively moved with respect to the mold while the nozzle tip and the surface of the mold are in contact with each other, wherein the nozzle is held in a Z-axis drive unit configured to vertically move the nozzle while an elastic body is provided in the Z-axis drive unit, while the nozzle tip is brought into pressed contact with the surface of the mold.

Abstract: A die of a coating apparatus for applying a coating solution includes down- and upstream blocks in a feeding direction of a web, which respectively have a first lip and a second lip. A lip land of the first lip is shorter than a lip land of the second lip in the feeding direction so as to satisfy a predetermined condition. In assembling the coating apparatus, bottoms of down- and upstream blocks are fixed to a fixer with bolts. Between the fixer and the downstream block, a plate member is provided such that the first lip land protrudes from the second lip land.

Abstract: The mounting is formed by grinding an integrally molded material with accuracy of the ?m order. An upper portion of the mounting is an L-shaped holding portion on which a slot die is positioned. An upper face of the holding portion contacts a lower face of the slot die, and a side face of the holding portion contacts a rear face of the slot die. The lower and rear faces of the slot die and the upper and side faces of the holding portion are formed to have such a straightness for the total length that the unevenness thereof may be in 5 ?m. Thus the slot die can be held with high accuracy, and the clearance accuracy between the lips and a web can be increased.

Abstract: A die of a coating apparatus for applying a coating solution includes down- and upstream blocks in a feeding direction of a web, which respectively have a first lip and a second lip. A lip land of the first lip is shorter than a lip land of the second lip in the feeding direction so as to satisfy a predetermined condition. In assembling the coating apparatus, bottoms of down- and upstream blocks are fixed to a fixer with bolts. Between the fixer and the downstream block, a plate member is provided such that the first lip land protrudes from the second lip land.

Abstract: A die of a coating apparatus for applying a coating solution includes down- and upstream blocks in a feeding direction of a web, which respectively have a first lip and a second lip. A lip land of the first lip is shorter than a lip land of the second lip in the feeding direction so as to satisfy a predetermined condition. In assembling the coating apparatus, bottoms of down- and upstream blocks are fixed to a fixer with bolts. Between the fixer and the downstream block, a plate member is provided such that the first lip land protrudes from the second lip land.

Abstract: The mounting is formed by grinding an integrally molded material with accuracy of the ?m order. An upper portion of the mounting is an L-shaped holding portion on which a slot die is positioned. An upper face of the holding portion contacts a lower facer of the slot die, and a side face of the holding portion contacts a rear face of the slot die. The lower and rear races of the slot die and the upper and side faces of the holding portion are formed to have such a straightness for the total length that the unevenness thereof may be in 5 ?m. Thus the slot die can be held with high accuracy, and the clearance accuracy between the lips and a web can be increased.

Abstract: A die of a coating apparatus for applying a coating solution includes down- and upstream blocks in a feeding direction of a web, which respectively have a first lip and a second lip. A lip land of the first lip is shorter than a lip land of the second lip in the feeding direction so as to satisfy a predetermined condition. In assembling the coating apparatus, bottoms of down- and upstream blocks are fixed to a fixer with bolts. Between the fixer and the downstream block, a plate member is provided such that the first lip land protrudes from the second lip land.

Abstract: A die of a coating apparatus for applying a coating solution includes down- and upstream blocks in a feeding direction of a web, which respectively have a first lip and a second lip. A lip land of the first lip is shorter than a lip land of the second lip in the feeding direction so as to satisfy a predetermined condition. In assembling the coating apparatus, bottoms of down- and upstream blocks are fixed to a fixer with bolts. Between the fixer and the downstream block, a plate member is provided such that the first lip land protrudes from the second lip land.

Abstract: In a coating apparatus, a nozzle connects a feed pipe for feeding a coat solution to a manifold of a die with an opening of the manifold. The nozzle satisfies conditions: 1.5≦B/A≦5.0 and 0.8≦C/B≦8.0, when A is an equivalent diameter of an end of the nozzle to be connected with the tube, B is an equivalent diameter of another end of the nozzle to be connected with the opening, and C is a length of the nozzle. The coat solution fed from the feed pipe enters in the nozzle. In the nozzle, the coating solution diverges along with an inner wall of the nozzle to enter into the manifold. In the manifold the coating solution flows in a widthwise direction and flows out through a slit extending from the manifold to a lip of the die, such that a moving web is coated with the coating solution uniformly.

Abstract: A method to obtain and keep, at the time of actual coating, a uniform charge distribution on a web that is to be subsequently coated in order to establish stable high-speed coating provides a higher resistivity in a web edge area than that in a web central area by applying a subbing layer to the web central area while leaving the edge area free of the subbing layer.

Abstract: A curtain coating method which enables the formation of a uniform curtain of coating solution without accompanied by the sagging phenomenon in a range of high flowing-down rates of a coating solution per unit length in curtain breadth, thereby elevating the upper limit of coating speed, is disclosed. In this method, a coating solution as a freely falling curtain is made to impinge on the surface of a continuously moving web, and thereby the coating solution is coated on the web. Therein, the curtain of the coating solution is controlled so that the flowing-down rate thereof per unit length in curtain breadth is from 2.5 to 10 cc/cm/sec, and the web surface to be coated with the coating solution is controlled so as to have a temperature between 22° to 55° C. A curtain coating method which can prevent the air entrainment phenomenon from occurring at the start in the coating operation and enables the formation of uniform coating is also disclosed.

Abstract: A die of a coating apparatus for applying a coating solution includes down- and upstream blocks in a feeding direction of a web, which respectively have a first lip and a second lip. A lip land of the first lip is shorter than a lip land of the second lip in the feeding direction so as to satisfy a predetermined condition. In assembling the coating apparatus, bottoms of down- and upstream blocks are fixed to a fixer with bolts. Between the fixer and the downstream block, a plate member is provided such that the first lip land protrudes from the second lip land.

Abstract: In curtain coating for multiple layers consisting of lower most layer, uppermost layer and intermediate layer, using coating liquid having viscosity more than 300 mPas for one layer or more of multiple layers improves amazingly the curtain coating stability against disturbance such as passing spliced portion of running web. The one layer or more layers for which coating liquid having viscosity more than 300 mPas is to be used is selected from intermediate layer. The curtain coating stability is further improved by combining the high viscosity coating liquid for intermediate layer with other technologies such as electrifying web, heating web upstream of coating point and/or keeping web tension higher than some specified value.