Abstract: A horizontal continuous casting device including a mold horizontally mounted through an orifice plate on a front side of a tundish. A front portion of the orifice plate is exposed into the mold. A horizontally extending small gap is formed between an outer circumferential surface of the front portion of the orifice plate and an inner circumferential surface of the mold. A facing surface between the mold and the orifice plate is provided with an annular lubricating oil passage and a given number of radial grooves communicated from the lubricating oil passage to the gap.

Abstract: A monoclonal antibody specifically recognizes an epitope or an antigenic determinant represented by the following formula and specifically reacts therewith: ##STR1## The monoclonal antibody can be obtained by cultivating hybridoma cells which can be generated by a method comprising cell-fusing (A) B cells or lymphocytes obtained by immunizing an animal with a substance involving the epitope or the antigenic determinant represented by the foregoing formula and (B) myeloma cells. The monoclonal antibody shows high specificity to ganglioside GQ.sub.1b and ganglioside GT.sub.1a having a specific epitope and thus can detect the epitope in high sensitivity. Therefore, the antibody can be used for the elucidation of sugar chain's roles in cell functions and for studying the development of animals. Moreover, the monoclonal antibody would have various clinical applications.

Abstract: A hybridoma capable of producing a monoclonal antibody specific to a sialic acid containing glycolipid carrying N-acetylneuraminic acid residue having alpha 2.fwdarw.3 linkage is herein disclosed. The hybridoma can be generated by fusing (i) B cells or lymphocytes obtained by immunizing an animal with a sialic acid containing glycolipid carrying N-acetylneuraminic acid residue having alpha 2.fwdarw.3 linkage and (ii) myeloma cells. The monoclonal antibody produced by the hybridoma can be used for purifying gangliosides, for treating patients suffering from melanoma and for diagnosing sera.

Abstract: The present invention relates to a sodium salt of sialosyl cholesterol. The present compound has an excellent high water solubility, and therefore the compound is very useful as a medicine to be used for treating various diseases derived from lesions of peripheral or central nerves.

Abstract: A pharmaceutical composition containing serum thymic factor (FTS) and a method for using FTS containing compositions for treating a variety of immunodeficiencies and autoimmune diseases including multiple sclerosis, Guillain-Barre syndrome, inflammatory neuropathy, polyneuritis and other immunodemyelinating diseases.

Abstract: The present invention relates to a sodium salt of sialosyl cholesterol. The present compound has an excellent high water solubility, and therefore the compound is very useful as a medicine to be used for curing various diseases derived from lesions of peripheral or central nerves.

Abstract: A secondary cooling device for a horizontal continuous casting apparatus, comprising (1) a support rod horizontally disposed before a tundish and above a cooling mold, (2) a holder slidably mounted on the support rod and incorporating a worm and a pair of worm gears engageable with each other, (3) an arm extending downwardly from the end of each of the worm gears, (4) half-annular shaped cooling water pipes secured onto the lower ends of the respective arms, said half-annular shaped cooling water pipes being so designed as to form an annular shape when brought together, (5) half-annular shaped wipers secured to the respective cooling water pipes on the side facing the tundish, the wipers being positioned concentrically with respect to said resulting ingot and having a inner diameter smaller than the diameter of the resulting ingot and (6) cooling water nozzles secured to the cooling water pipes on the side away from the tundish.

Abstract: The shut-off device includes (1) a stopper capable of blocking a stream of melt flowing in the guide conduit which introduces the melt from a furnace into a tundish therethrough, if the occasion arises, and (2) a receiving plate disposed below a cooling mold so as to receive a leakage melt and having a heat sensor, the heat sensor being adapted to detect the heat of the leakage melt and communicating with a converter for transmitting an operation signals to the stopper. In such a specially designed structure, if the melt breaks out of the cooling mold, the leaked melt is received by the receiving plate and its heat is detected by the heat sensor. According to the detection of the heat, corresponding electric signals are instantly transmitted from the converter to the stopper and thereby the stopper is actuated so as to block the melt flow in the guide conduit.

Abstract: A monoclonal antibody specific to a sugar chain containing N-glycolylneuraminic acid and has an ability to bind at least to N-glycolyl GM.sub.2 ganglioside, and producing methods of a hybridomas which produce the monoclonal antibodies are disclosed. The antibodies are extremely useful for clarification of carcinogenesis mechanism, cancer diagnosis and therapy. The hybridomas are manufactured by using an animal with autoimmune disease.

Abstract: A sialic acid-bonded octapeptide represented by the following general formula (I): ##STR1## wherein R represents a hydrogen atom or an acetyl group; and R' represents a lower alkyl group, an aralkyl group, a hydrogen atom or an alkali metal atom, is herein disclosed. The peptide chain of the sialic acid-bonded octapeptide is constituted by 8 amino acid molecules on the C-terminus side of FTS and the compounds represented by formula (I) can be obtained by bonding sialic acid to the amino terminus of the peptide chain according to condensation. These octapeptides show excellent physiological activity comparable to FTS and a half life in blood longer than that of FTS and it is expected that the affinity of the peptide to lymphocytes is also enhanced. Thus they can effectively be used as medicines for treating the lowering and abnormality of functions of the thymus.

Abstract: Disclosed are a monoclonal antibody which recognizes specifically an O-acylsialic acid containing sugar chain and a method for preparing a hybridoma capable of producing the monoclonal antibody, which comprises using an autoimmune disease animal as the immunization animal and/or using a substance containing said sugar chain adsorbed on Salmonella minesota bacteria as the immunogen.The monoclonal antibody of the present invention capable of recognizing the above described sugar chain which may be considered to be antigens related with human cancer are very useful in diagnosis of cancer.

Abstract: A method for manufacturing a heat insulating shaped bar including a pair of spaced side walls and a heat insulating connecting portion formed by heat insulating material and connecting the pair of side walls together from an integrally extruded metal shaped bar having the pair of side walls and a connecting wall (or walls) extending and connecting between the side walls is disclosed. The connecting wall(s) includes on one surface thereof a recess having sloped sides and extending longitudinally of the metal shaped bar and the method includes a step of cutting the material of the connecting wall(s) from the other surface at the area of the recess.

Abstract: The invention provides a novel method for manufacturing a heat insulating sash bar comprising two face members connected together with two connecting members formed of a heat insulating material which is pourable and is cured or solidified after impregnating the space between the face members of a bar material of, for example, aluminum composed of two oppositely positioned face members connected together with at least one inner connecting part to have, for example, a H-wise cross section and provided with one or two pairs of inwardly extending flanges each on one of the face members.

Abstract: A method and an apparatus for continuously filling grooves in metal sash bars with heat insulating synthetic resin are disclosed. The method comprises the steps of closing the opposite ends of the groove of each of the metal sash bars by end caps each having an end wall with a thinned top edge; continuously moving the metal sash bars through a path below an injection device with the grooves facing upwardly and with at least the top edges of the end caps of one preceding sash bar and the succeeding sash bar in close contact with each other on the upstream of the injection device; and continuously injecting a solution of the heat insulating synthetic resin from the injecting device into the grooves of the sash bars at a constant injecting rate while continuously moving the sash bars.

Abstract: An endoscope comprising optical elements such as field lenses and relay lenses arranged in an outer tube without using tubular spacers so that the intensity of transmitted light becomes high.