Abstract: The present invention relates to rigid structures and composite materials thereof for providing radiation attenuation/shielding. Some embodiments pertain to a radiation shielding apparatus including: a plurality of positionable radiation-shielding stacks of tiles. The stacks are subsequently and adjacently arranged in a contiguous configuration. A tile positioning mechanism allows movement of tiles within a stack between a stacked (retracted) position and an extended position. In the extended position, the tiles of each of the plurality of radiation shielding stacks at least partially overlap tiles of subsequent and adjacent tile stack at corresponding opposing side-margins thereof.

Abstract: A surgical robot system whose robotic arm is divided into two parts, and is connected to the patient at the junction of the two parts, by means of a bone connector. The section between the bone connector and the robotic base has a predetermined level of flexibility, enabling the bone connector limited movement. Consequently, the patient's body can also move without the bone connector exerting excess forces on the patient, and without detachment from the patient. The arm section between the bone connection link and the end actuator has high rigidity, such that the pose of the end actuator relative to the patient is accurately maintained. As the patient undergoes small movements, such as in breathing or coughing, the bone connector and base connection arm section, move together with motion of the patient's bone, while the pose of the end actuator relative to the patient is accurately maintained.

Abstract: A system is disclosed for inserting a pharmaceutical cartridge into a delivery device. Optionally the cartridge is inserted in an arbitrary orientation. Optionally, the system reorients the cartridge to a locked orientation. For example, a driver applies a torque to the cartridge to cause the reorienting. For example, said torque rotates the cartridge around an axis thereof until the cartridge reaches the locked orientation. Optionally, when the cartridge reaches the locked orientation an interference element on the cartridge interlocks with a complementary interference element on the delivery device to lock the cartridge in the locked orientation. Optionally when the cartridge is locked in the second orientation, the torque causes discharge the pharmaceutical.

Abstract: In some embodiments a system and method are described for safeguarding a hazard, the hazard, for example a needle point, may be moved between a protected retracted position, an active extended position and/or an intermediate position. Optionally in the retracted position, the hazard may be protected inside a housing. Optionally in the extended position, the hazard may be exposed. Optionally, in the intermediate position the hazard may be partially protected and/or concealed, for example by a shield and/or in an indentation. In some embodiments, compromising a shield causes the hazard to be retracted to the retracted position.

Abstract: An injector includes an injector housing and a cartridge door movably mounted to the injector housing between a fully closed position and an open position. A latching mechanism is movable between a latched position, locking the cartridge door to the injector housing in the fully closed position thereof, and an unlatched position, unlocking the cartridge door from the injector housing, thereby enabling movement of the cartridge door toward the open position. The latching mechanism is oriented in the unlatched position when the cartridge door is empty and the latching mechanism is configured to move to the latched position solely when a cartridge is present in the cartridge door and the cartridge door is subsequently moved to the fully closed position thereof.

Abstract: An injector includes an injector housing and a cartridge door movably mounted to the injector housing between a fully closed position and an open position. A latching mechanism is movable between a latched position, locking the cartridge door to the injector housing in the fully closed position thereof, and an unlatched position, unlocking the cartridge door from the injector housing, thereby enabling movement of the cartridge door toward the open position. The latching mechanism is oriented in the unlatched position when the cartridge door is empty and the latching mechanism is configured to move to the latched position solely when a cartridge is present in the cartridge door and the cartridge door is subsequently moved to the fully closed position thereof.

Abstract: A modular drive train is selectively securable within a wearable injector. The drive train includes a chassis and a telescoping driving assembly mounted within the chassis. The driving assembly includes a first shaft rotatable relative to the chassis, and a second shaft connected with the first shaft and axially movable relative thereto. Rotation of the first shaft axially drives the second shaft. The chassis includes one of a bearing and an elastically expandable collar projecting axially forward into the chassis from a rear end thereof, and the first shaft includes the other of the bearing and the elastically expandable collar projecting axially rearwardly from a rear end thereof. The collar is configured to elastically snap over an interference element of the bearing, whereby engagement of the collar with the bearing axially secures the first shaft to the chassis and permits rotation of the first shaft about the bearing.

Abstract: An assembly of a drug delivery system, comprising: a first component; a second component which is configured to move linearly with respect to the first component; and, a resistance element configured to resist linear movement during transport of the first component with respect to the second component in a closed transport configuration but which is adapted to be overcome during nominal operation of the drug delivery system.

Abstract: A bone connection system for attaching a surgical robot having its base mounted in the vicinity of a patient, to a bone of the patient. The system incorporates a switchable bone connection unit attached between the bone and a support element of the robot. This unit has a locked state in which the bone is attached essentially rigidly to the support element, and a released state in which the bone can move relative to the support element. The unit comprises a force sensor for determining the force exerted between the bone and the support element of the robot, and a position sensor for measuring the position of the bone relative to the support element of said robot. The unit switches from its locked state to its released state when the force exceeds a predetermined level, selected to ensure that the bone can move without detaching any bone connection elements.

Abstract: An independent mounting module is receivable within a housing of an injector configured to dispense a substance from a cartridge insertable into the housing through an injection needle of the injector. The mounting module includes a first mount and a second mount. The first mount is configured to receive a driving assembly engageable with the cartridge to expel the substance therefrom. The first mount is selectively securable to the injector housing and has a cantilevered mounting arm extending therefrom. The second mount is configured to receive an actuator operatively connectable with the driving assembly. The second mount is attached to the cantilevered mounting arm and suspended therefrom, thereby being supported by the cantilevered mounting arm.

Abstract: An injector includes a body, an injection needle movably mounted to the body and a pathway within the body sized for receiving either of a first cartridge or a differently dimensioned second cartridge therein. The pathway includes a coupler mounted at a distal end that is engageable with the first cartridge or the second cartridge for to fluidly connect with the injection needle. At least two adapter collars are mounted within the pathway. A first adapter collar is configured to receive either one of the two cartridges therethrough upon insertion into the pathway, and configured to engage a portion of the first cartridge to stabilize the first cartridge within the pathway. A second adapter collar is also configured to receive either one of the two cartridges therethrough upon insertion into the pathway, but configured to engage a portion of the second cartridge to stabilize the second cartridge within the pathway.

Abstract: A method of planning the correction of spinal deformations of a subject, by performing segmentation on a three dimensional image of the subject's spine in its erect neutral position, such that the positions and orientations of the vertebrae in a region of interest are characterized. Parameters relating to the alignment and position of the vertebrae are derived from the segmentation, followed by determining whether the parameters fall within an acceptable range desired for the spine of the subject. If not within the acceptable range, an alignment optimization is performed on the vertebrae to bring the parameters within the acceptable range, to reduce the spinal deformations of the subject's spine. The alignment optimization is performed by taking into consideration limitations arising from the dynamic range of motion of the vertebrae as determined by analyzing images of the subject's spine, while the subject is in positions of maximum bending.

Abstract: An electronic injector including a needle insertion assembly configured to move a needle in an insertion direction from a first needle position where the needle is above the surface of a patient's skin to a second needle position where the needle pierces the patient's skin. The injector further includes a member mechanically coupled to the needle and configured to move when the needle. The injector further includes an optical detector having a generally planar detection surface and configured to detect movement of the member based on a change in a transverse projection of the member onto the detection surface and output a signal based on the change in the transverse projection. Additional, a processor is configured to determine the position of the needle based on the output signal, and the transverse projection of the member changes when the needle moves.

Abstract: A method comprising: receiving an image of a scene, segmenting the image into a plurality of segments, obtaining at least one depth sample from each of at least some of the segments, and with respect to each of the at least some of the segments, assigning a value of the depth sample to each pixel in the segment, to create a depth image of the image.

Abstract: An injector includes a housing and an activation button assembly movably mounted thereto and translatable from an unactuated position to an actuated position. A cartridge door is configured to receive therein a cartridge containing a substance to be dispensed, and is movably mounted to the injector housing between open and closed positions. A deflectable interference member is mounted within the injector housing and, in a resting position, blocks movement of the activation button assembly from the unactuated to the actuated position thereof. The activation button assembly is configured to activate the injector when in the actuated position, and is movable from the unactuated position to the actuated position solely upon deflection of the interference element out of the resting position thereof. The cartridge door, when in the closed position thereof and having the cartridge received therein, deflects the interference element out of the resting position thereof.

Abstract: An injector has a cartridge door movable between a fully closed position and a fully open position. A power supply is employed to power at least one power-operated component of the injector. A power supply circuit electrically connects the power supply with the at least one power-operated component. An electrically insulated arm is movable from a first state, in which the electrically insulated arm electrically disconnects the power supply from the circuit, to a second state, in which the electrically insulated arm connects the power supply with the circuit to provide power to the at least one power-operated component. The insulated arm is coupled to the cartridge door and initially positioned in the first state thereof in the fully closed position of the cartridge door, whereby movement of the cartridge door out of the fully closed position toward the fully open position moves the arm to the second state thereof.

Abstract: A bone connection system for attaching a surgical robot having its base mounted in the vicinity of a patient, to a bone of the patient. The system incorporates a switchable bone connection unit attached between the bone and a support element of the robot. This unit has a locked state in which the bone is attached essentially rigidly to the support element, and a released state in which the bone can move relative to the support element. The unit comprises a force sensor for determining the force exerted between the bone and the support element of the robot, and a position sensor for measuring the position of the bone relative to the support element of said robot. The unit switches from its locked state to its released state when the force exceeds a predetermined level, selected to ensure that the bone can move without detaching any bone connection elements.

Abstract: A method of planning the correction of spinal deformations of a subject, by performing segmentation on a three dimensional image of the subject's spine in its erect neutral position, such that the positions and orientations of the vertebrae in a region of interest are characterized. Parameters relating to the alignment and position of the vertebrae are derived from the segmentation, followed by determining whether the parameters fall within an acceptable range desired for the spine of the subject. If not within the acceptable range, an alignment optimization is performed on the vertebrae to bring the parameters within the acceptable range, to reduce the spinal deformations of the subject's spine. The alignment optimization is performed by taking into consideration limitations arising from the dynamic range of motion of the vertebrae as determined by analyzing images of the subject's spine, while the subject is in positions of maximum bending.

Abstract: A cartridge interface assembly drives a stopper in a drug reservoir or a drug delivery device. An anti-rotational guide optionally moves along an axis of a cavity of the reservoir. The anti-rotational guide is optionally slidably anti-rotationally coupled to a housing of the drug delivery device. A telescoping plunger driver may include a proximal shaft and distal shaft that telescope by relative rotation. The distal shaft is optionally slidably anti-rotationally coupled to the anti-rotational guide. The shafts are optionally oriented along said axis. In some embodiments, rotating the proximal shaft with respect to the anti-rotational guide moves the guide along said axis with respect to the housing and moves the distal shaft along the axis with respect to the anti-rotational guide.

Abstract: An injector includes an injector housing, an activation button assembly movably mounted to the injector housing and operatively connected to the injection needle, and a cartridge door movably mounted to the injector housing between an open position and a closed position. A deflectable interference member engaging the rear end flange of the cartridge has a resting position configured to limit an insertion depth of a cartridge into an interior channel of the cartridge door to a sealed position, wherein the cartridge piercing needle does not fully penetrate a pierceable septum of the cartridge. The cartridge door includes an interior channel having a cartridge mounted therein. The cartridge includes a substance to be dispensed. The substance includes an anti-C5 antibody or antigen binding fragment thereof, and optionally further includes a recombinant human hyaluronidase enzyme. A method of treating a complement associated condition using an injector thereof.