Patents by Inventor Young-Tae Chang

Young-Tae Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090061031
    Abstract: The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPAR?2, LPL and ?P2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual.
    Type: Application
    Filed: July 9, 2007
    Publication date: March 5, 2009
    Inventors: Sylvia Lee-Huang, Paul L. Huang, Philip Lin Huang, Dawei Zhang, John Z.H. Zhang, Young Tae Chang, Jae Wook Lee, Ju Bao, Yongtao Sun
  • Publication number: 20080160521
    Abstract: The present invention is directed toward benzimidazolium dye compounds of formula (I) as follows: wherein, n is an integer from 2-10, m is an integer from 2-10, X1 and X2 are independently a halogen, Q is H or a resin, and R is (aromatic)o-(linker)p-with the linker being saturated or unsaturated C1-C5 hydrocarbons, each aromatic independently being a substituted or unsubstituted aromatic or heteroaromatic, o being 1 or 2, and p being 0 or 1. Methods of making and using these compounds are also disclosed.
    Type: Application
    Filed: July 18, 2007
    Publication date: July 3, 2008
    Applicant: NEW YORK UNIVERSITY
    Inventors: Young-Tae CHANG, Shenliang WANG
  • Patent number: 7384388
    Abstract: A combinatorial library of solid-state fluorescent dyes is prepared by reacting an aldehyde with a solid-supported pyridinium salt having a linker.
    Type: Grant
    Filed: April 13, 2005
    Date of Patent: June 10, 2008
    Assignee: New York University
    Inventor: Young-Tae Chang
  • Publication number: 20080124751
    Abstract: The present invention relates to a rosamine derivative compound, as described herein, having the following structure: Also disclosed are methods of making such compounds and for using them for detection and imaging.
    Type: Application
    Filed: September 11, 2007
    Publication date: May 29, 2008
    Applicant: NEW YORK UNIVERSITY
    Inventors: Young-Tae Chang, Young-Hoon Ahn
  • Publication number: 20080119373
    Abstract: An efficient molecular evolution system was obtained by combining two novel approaches in the field, intramolecular acyl migration for DCL generation and boronic acid as a selector. 1,4-Di-O-benzoyl chiro-inositol in acetonitrile with DBU as a base generated a reversible equilibrium of 9 regioisomers. Only 3,4-di-O-benzoyl chiro-inositol, containing two sets of cis-diols, is most favored toward binding with phenyl boronic acid, and its percentage of the DCL composition was amplified by up to 82%.
    Type: Application
    Filed: October 1, 2004
    Publication date: May 22, 2008
    Applicant: New York University
    Inventor: Young-Tae Chang
  • Publication number: 20080064037
    Abstract: The present invention is directed to fluorescent compounds and methods of making said compounds that selectively bind to cellular RNA. The fluorescent compounds of the present invention are useful for live cell imaging applications.
    Type: Application
    Filed: March 1, 2007
    Publication date: March 13, 2008
    Applicant: NEW YORK UNIVERSITY
    Inventors: Young-Tae CHANG, Qian LI, Gustavo ROSANIA
  • Patent number: 7338428
    Abstract: A combinatorial library of fluorescent compounds useful as organelle-specific probes are produced by reacting an aldehyde with a 2- or 4-methylpyridinium salt.
    Type: Grant
    Filed: July 1, 2004
    Date of Patent: March 4, 2008
    Assignee: New York University
    Inventors: Young-Tae Chang, Gustavo Rosania
  • Publication number: 20060293325
    Abstract: The present invention relates to a compound having the formula where Z is an amine, alcohol, or thiol-containing group, and Y is an alkyl-containing amine. Methods of producing such compounds and using them to treat patients with diabetes and obesity are also disclosed. The present invention also relates to treating such conditions with GADPH inhibitors and screening compounds useful for treating such conditions by using GADPH inhibitors. Compounds can also be screened for their effectiveness in modulating diabetes and obesity with a C. elegans strain.
    Type: Application
    Filed: June 20, 2006
    Publication date: December 28, 2006
    Applicant: New York University
    Inventors: Young-Tae Chang, Fabio Piano
  • Patent number: 7115737
    Abstract: Two methods are used to produce diaryl trisubstituted triazines. In the first method, cyanuric chloride is first reacted with a 4-alkoxybenzylamine. The product of this reaction is then reacted with a resin-bound amine, such as 4-alkoxybenzylamine, to ensure that the final compound will be bound to a resin. The product of this reaction is then reacted with boronic acid to produce a trisubstituted diaryl triazine. In the second method, cyanuric chloride is reacted with a benzenealkanethiol. The product of this reaction is then reacted with a resin-bound amine, such as 4-alkoxybenzylamine, to ensure that the final compound will be bound to a resin. The product of this reaction is then reacted with m-CPBA to form a sulfone, which is then reacted with a 4-alkoxybenzylamine to form the desired trisubstituted biaryltriazine.
    Type: Grant
    Filed: May 4, 2004
    Date of Patent: October 3, 2006
    Assignee: New York University
    Inventor: Young-Tae Chang
  • Patent number: 7060752
    Abstract: Nitrophenol resins based upon various support materials. The nitrophenol resins are prepared by amide bond formation between a hydroxyl nitro benzoic acid and an aminoalkyl polymer support.
    Type: Grant
    Filed: October 28, 2003
    Date of Patent: June 13, 2006
    Assignee: New York University
    Inventors: Young-Tae Chang, Jaw Wook Lee
  • Publication number: 20050227293
    Abstract: A combinatorial library of solid-state fluorescent dyes is prepared by reacting an aldehyde with a solid-supported pyridinium salt having a linker.
    Type: Application
    Filed: April 13, 2005
    Publication date: October 13, 2005
    Applicant: New York University
    Inventor: Young-Tae Chang
  • Publication number: 20050054006
    Abstract: A combinatorial library of fluorescent compounds useful as organelle-specific probes are produced by reacting an aldehyde with a 2- or 4-methylpyridinium salt.
    Type: Application
    Filed: July 1, 2004
    Publication date: March 10, 2005
    Applicant: New York University
    Inventors: Young-Tae Chang, Gustavo Rosania
  • Publication number: 20050019831
    Abstract: A novel tagged triazine library is provided in which three building blocks are prepared separately and assembled orthogonally to yield 1536 highly pure compounds. Each library compound contains a variety of a triethyleneglycol (TG) linker at one of the diversity sites of the triazine scaffold.
    Type: Application
    Filed: May 5, 2004
    Publication date: January 27, 2005
    Applicant: NEW YORK UNIVERSITY
    Inventor: Young-Tae Chang
  • Publication number: 20040265252
    Abstract: Trisubstituted triazine compounds are screened for pigment stimulating ability or pigment inhibiting ability. Compounds which bind ATPase increase melanin in the skin or hair. Compounds found to be active are used for screening for other active compounds. Active compounds are used for increasing melanin in the skin or hair, or for decreasing melanin in the skin or hair.
    Type: Application
    Filed: April 12, 2004
    Publication date: December 30, 2004
    Applicant: New York University
    Inventors: Seth Orlow, Young-Tae Chang
  • Publication number: 20040225125
    Abstract: Two methods are used to produce diaryl trisubstituted triazines. In the first method, cyanuric chloride is first reacted with a 4-alkoxybenzylamine. The product of this reaction is then reacted with a resin-bound amine, such as 4-alkoxybenzylamine, to ensure that the final compound will be bound to a resin. The product of this reaction is then reacted with boronic acid to produce a trisubstituted diaryl triazine. In the second method, cyanuric chloride is reacted with a benzenealkanethiol. The product of this reaction is then reacted with a resin-bound amine, such as 4-alkoxybenzylamine, to ensure that the final compound will be bound to a resin. The product of this reaction is then reacted with m-CPBA to form a sulfone, which is then reacted with a 4-alkoxybenzylamine to form the desired trisubstituted biaryltriazine.
    Type: Application
    Filed: May 4, 2004
    Publication date: November 11, 2004
    Applicant: NEW YORK UNIVERSITY
    Inventor: Young-Tae Chang
  • Publication number: 20040122009
    Abstract: Trisubstituted triazines can be synthesized from cyanuric chloride. These compounds are useful anti-tubulin agents for treating cancer and proliferative diseases.
    Type: Application
    Filed: June 20, 2003
    Publication date: June 24, 2004
    Applicant: New York University
    Inventors: Young-Tae Chang, Alexander Schier, Ho-Sang Moon, Eric Jacobson, Puja Parikh
  • Publication number: 20040087726
    Abstract: Nitrophenol resins based upon various support materials. The nitrophenol resins are prepared by amide bond formation between a hydroxyl nitro benzoic acid and an aminoalkyl polymer support.
    Type: Application
    Filed: October 28, 2003
    Publication date: May 6, 2004
    Applicant: NEW YORK UNIVERSITY
    Inventors: Young-Tae Chang, Jaw Wook Lee
  • Publication number: 20030166002
    Abstract: Triazine linkers can be used as universal small molecule chips for functional proteomics and sensors. These compounds are prepared by making a first building block by adding a first amine by reductive amination of triazine, making a second building block by adding a second amine to cyanuric chloride, and combining the first and second building blocks by aminating the first building block onto one of the chloride positions of the second building block.
    Type: Application
    Filed: October 9, 2002
    Publication date: September 4, 2003
    Inventors: Young-Tae Chang, Ho-Sang Moon, Sonya M. Khersonsky