Abstract: The present disclosure provides an extended reality device and a control method thereof. The extended reality device includes: a front part and a rear part; the front part comprising: a display module, configured to display extended reality image; the rear part comprising: a system controller connected to the display module and configured to control operation of the display module; a battery connected to the system controller and configured to supply power to each electrical device. Through the above solution, transferring the system controller and the battery to the rear part setting, so that the weight of the front part of the extended reality device is significantly reduced, the thickness of the front part is significantly reduced, the weight of the rear part and the front part can be balanced, there is no bias when user wears the extended reality device, which improves the user's wearing comfort.

Abstract: Provided are griseofulvin 4 position etherified derivatives and their application thereof. The chemical structures of the griseofulvin 4 position etherified derivatives are drawn in a formula I below. The application of these derivatives includes using the griseofulvin 4 position etherified derivatives as preventive or direct antifungal agents against phytopathogenic fungi.

Abstract: Various arrangements of smart home devices are presented herein. A chassis assembly of a smart home device may define one or more compartments. The chassis assembly may include a plurality of cover fasteners. A rotatable cover assembly may be present and configured to be removably attached with the plurality of cover fasteners to the chassis assembly in any rotational orientation and to at least partially cover a front of the chassis assembly. While the rotatable cover is removably attached with the plurality of cover fasteners, the rotatable cover assembly is configured to block access to the one or more compartments defined by the chassis assembly.

Abstract: An individual serving size food dispenser includes a casing defining an interior volume configured for receipt of bulk food. An opening of the casing is positioned proximate a bottom portion of the interior volume. An auger is disposed within the interior volume of the casing. The auger includes a first flighting portion and a second flighting portion. The first and second flighting portions are wound in opposite directions. An auger motor is coupled to the auger such that the auger motor is operable to rotate the auger within the interior volume of the casing. A door assembly is positioned proximate the opening of the casing. The door assembly is configured for selectively opening to dispense bulk food from the opening of the casing.

Abstract: A display substrate is provided, including: a base substrate including at least pixel and hole areas; sub-pixels arranged on the base substrate and in the pixel area; a hole in the hole area; a first barrier dam between the sub-pixels and the hole and at least partially surrounding the hole; a functional film layer, an organic material layer and an encapsulating structure sequentially arranged on the display substrate in a direction away from the base substrate, an orthographic projection of the organic material layer on the base substrate falling within the pixel area, the organic material layer including at least one film layer; and a filling structure, at least a portion of which is arranged between the hole and the first barrier dam. The filling structure and the at least one film layer of the organic material layer are in the same layer and include the same material.

Abstract: In a spinning-drawing-winding device and a combined machine for industrial bio-based polyamide, according to a traveling direction of a tow, two adjacent rotational directions among a rotational direction of the tow winding through the first pair of drawing hot rollers, a rotational direction of the tow winding through the second pair of drawing hot rollers, a rotational direction of the tow winding through the third pair of drawing hot rollers, a rotational direction of the tow winding through the fourth pair of drawing hot rollers are in opposite to spin an industrial bio-based polyamide filament of 55 dtex-2222 dtex.

Abstract: The present disclosure provides a greenhouse gas emission reduction method for a heavy metal contaminated soil, falling within the technical field of emission reduction of greenhouse gas nitrous oxide. Specifically, hydroxyapatite (HAP) is added to a soil to effectively reduce the emission of nitrous oxide in the soil, and at the same time, the treatment of heavy metal contamination is realized, which is very suitable for the promotion and use of nitrous oxide emission reduction in the contaminated soil.

Abstract: A method for live streaming recommended content from a content request includes live streaming a first content from a first user side, activating a live reaction at the first user side, and providing the content request at a second user side when the live reaction is enabled. The method also includes determining a second content, sending the content request indicating the second content, and receiving a confirmation at the second user side indicating the content request being sent. The method further includes receiving, at the first user side, the content request sent from the second user side, approving the content request at the first user side, and after the content request is approved, live streaming from the first user side, the second content corresponding to the content request.

Abstract: The present disclosure relates to a spheroidizing-annealed steel for the ball screw having high strength and resistance to low temperatures, wherein the chemical composition of the steel in mass percentage is: C: 0.40-0.70%, Si: 1.20-1.80%, Mn: 1.00-1.60%, Cr: 0.80-1.20%, S: ?0.025%, P?0.025%, Ni: 0.10-0.60%, Cu: 0.30-0.80%, Mo: 0.10-0.40%, Al?0.05%, Ca?0.0010%, Ti?0.003%, O?0.0010%, As?0.04%, Sn?0.03%, Sb?0.005%, Pb?0.002%, the balance is Fe and unavoidable impurities. In microstructure of the steel, cementite exists in a spheroidized state with a diameter of 0.1-0.5 ?m, preferably 0.3-0.5 ?m, a spheroidizing rate is 95% or more, and the rest is ferrite.

Abstract: Methods and compositions are provided for generating F0 fertile XY female animals. The methods and compositions involve making XY pluripotent or totipotent animal cells, in vitro cell cultures, or embryos that are capable of producing a fertile female XY animal in an F0 generation. Such cells, embryos, and animals can be made by silencing a region of the Y chromosome. Optionally, the cells can also be cultured in feminizing medium such as a low-osmolality medium and/or can be modified to decrease the level and/or activity of an Sry protein. Methods and compositions are also provided for silencing a region of the Y chromosome in an XY pluripotent or totipotent animal cell, or in vitro cell cultures, embryos, or animals derived therefrom, by maintaining an XY pluripotent or totipotent animal cell in a feminizing medium.

Abstract: An imaging lens including a first lens group, a second lens group, and an aperture stop disposed between the first lens group and the second lens group is provided. The first lens group includes at least one and at most three lenses with refractive powers, and the second lens group has a positive refractive power and includes at least two and at most three lenses with a refractive powers. The imaging lens satisfies conditions of 2 mm<LT<20 mm and 0.8<D1/LT<1.4, where D1 is a lens diameter of the lens closest to the object side, and LT is distance along the optical axis between two outermost lens surfaces at opposite ends of the first lens group and the second lens group.

Abstract: Methods and systems for CRISPR positive selection are described. CRISPR positive selection uses DNA sequencing to identify genes that their perturbation by CRISPR guide RNAs is correlated to the phenotype. In some aspects, disclosed are genome-wide CRISPR/Cas9 screening methods to identify genetic modifiers. Also disclosed are the apparatuses used for performing the methods.

Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: Technologies are provided for alignment of spatial transcriptome slides of biological tissue. The alignment of images and the coordinates of spots within transcriptome profiles of the biological tissue can utilize an alignment model that can be machine-learned and can receive both a displaced image to be aligned and a reference image as inputs. The alignment model may learn a diffeomorphic transformation between those images. Such a transformation can be readily applied to the alignment of the displaced image and to the alignment of the displaced coordinates of spots within the transcriptome profiles of transcriptome. In some cases, transcriptome data can be analyzed and cast in an image-like format, and can then be utilized as supplementary input to the alignment model. The alignment model can be trained in a tissue agnostic manner, such as by using synthetic images.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer.

Abstract: The present invention relates to the field of medical biology, and discloses a single domain antibody and derivative proteins thereof against CTLA4. In particular, the present invention discloses a CTLA4 binding protein and the use thereof, especially the use for treating and/or preventing CTLA4 relevant diseases such as tumor.

Abstract: The technology of this application relates to a flow characteristic extraction method and apparatus, and belongs to the field of network technologies. The method includes a network device that determines a burst parameter of a burst traffic segment of a received first packet flow, and determines a burst parameter of the first packet flow based on the burst parameter of the burst traffic segment of the first packet flow. The first packet flow is an elephant flow, the burst traffic segment indicates a burst degree of traffic within one period of time, the burst parameter of the burst traffic segment is a parameter used to describe the burst traffic segment, and the burst parameter of the first packet flow is a parameter used to describe at least one burst traffic segment included in the first packet flow.

Abstract: Cas-protein-ready tau biosensor cells, CRISPR/Cas synergistic activation mediator (SAM)-ready tau biosensor cells, and methods of making and using such cells to screen for genetic vulnerability associated with tau aggregation are provided.

Abstract: Latency on the miss path to a cache level in a CPU module is reduced by predicting when a cache miss is likely. Main memory is directly accessed in parallel with the access to the cache level in the CPU module based on the prediction that a cache miss is likely in the cache level.