Abstract: Technologies are provided for alignment of spatial transcriptome slides of biological tissue. The alignment of images and the coordinates of spots within transcriptome profiles of the biological tissue can utilize an alignment model that can be machine-learned and can receive both a displaced image to be aligned and a reference image as inputs. The alignment model may learn a diffeomorphic transformation between those images. Such a transformation can be readily applied to the alignment of the displaced image and to the alignment of the displaced coordinates of spots within the transcriptome profiles of transcriptome. In some cases, transcriptome data can be analyzed and cast in an image-like format, and can then be utilized as supplementary input to the alignment model. The alignment model can be trained in a tissue agnostic manner, such as by using synthetic images.

Abstract: The memory device includes a plurality of memory cells, which include a first set of memory cells and a second set of memory cells. A controller is in communication with the memory cells. The controller is configured to, in a first programming pass and then a second programming pass, program the memory cells of the first and second sets to respective final threshold voltages associated with a plurality of programmed data states. The controller is further configured to, in the first programming pass, verify the first set of memory cells at a first set of checkpoint data states and verify the second set of memory cells at a second set of checkpoint data states that is different than the first set of checkpoint data states.

Abstract: A sample processing apparatus (100) and a use method therefor. The sample processing apparatus (100) comprises a uniform mixing mechanism (130) and a magnetic attraction mechanism (140). The sample processing apparatus (100) further comprises at least one of a sample tube (110) and a reaction tube (120). The uniform mixing mechanism (130) is configured to perform uniform mixing processing on a biological sample in the sample tube (110) and/or a biological sample in the reaction tube (120). The magnetic attraction mechanism (140) comprises a magnet (141). The magnet (141) can move relative to the sample tube (110) and/or the reaction tube (120), so as to perform magnetic attraction processing on the biological sample in the sample tube (110) and/or the biological sample in the reaction tube (120).

Abstract: An automatic extraction device and a use method therefor. The automatic extraction device comprises a sample processing apparatus (100), a portal frame (200), a consumable assembly (300), and a pipetting apparatus (400). The sample processing apparatus (100) comprises a uniform mixing mechanism (130) and a magnetic attraction mechanism (140), which are respectively used for performing uniform mixing processing and magnetic attraction processing on a biological sample. The portal frame (200) comprises a base (201) and a moving beam (202) capable of moving relative to the base (201). The sample processing apparatus (100) and the consumable assembly (300) are provided on the base (201). The pipetting apparatus (400) is provided on the moving beam (202) for implementing a pipetting operation between the consumable assembly (300) and the sample processing apparatus (100).

Abstract: Embodiments of the present disclosure relate to a method, device and computer readable storage medium of scene text detection. In the method, a first visual representation of a first image is generated with an image encoding process. A first textual representation of a first text unit in the first image is generated with a text encoding process based on a first plurality of symbols obtained by masking a first symbol of a plurality of symbols in the first text unit. A first prediction of the masked first symbol is determined with a decoding process based on the first visual and textual representations. At least the image encoding process is updating according to at least a first training objective to increase at least similarity of the first prediction and the masked first symbol.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer.

Abstract: A display substrate and a display device are disclosed. In the display substrate, a plurality of openings include a plurality of opening groups, the plurality of opening groups include a plurality of opening group rows, each of the opening groups includes a first opening and a second opening, the plurality of opening group rows includes a first opening group row and a second opening group row, the spacer is located between the first opening of the first opening group row and the second opening of the second opening group row, an orthographic projection of the first opening includes a first long edge, and an orthographic projection of the second opening includes a second long edge, the first long edge is parallel to the second long edge, an extension line of the first long edge is misaligned from an extension line of the second long edge.

Abstract: A method for live streaming recommended content from a content request includes live streaming a first content from a first user side, activating a live reaction at the first user side, and providing the content request at a second user side when the live reaction is enabled. The method also includes determining a second content, sending the content request indicating the second content, and receiving a confirmation at the second user side indicating the content request being sent. The method further includes receiving, at the first user side, the content request sent from the second user side, approving the content request at the first user side, and after the content request is approved, live streaming from the first user side, the second content corresponding to the content request.

Abstract: The present invention relates to the field of medical biology, and discloses a single domain antibody and derivative proteins thereof against CTLA4. In particular, the present invention discloses a CTLA4 binding protein and the use thereof, especially the use for treating and/or preventing CTLA4 relevant diseases such as tumor.

Abstract: The technology of this application relates to a flow characteristic extraction method and apparatus, and belongs to the field of network technologies. The method includes a network device that determines a burst parameter of a burst traffic segment of a received first packet flow, and determines a burst parameter of the first packet flow based on the burst parameter of the burst traffic segment of the first packet flow. The first packet flow is an elephant flow, the burst traffic segment indicates a burst degree of traffic within one period of time, the burst parameter of the burst traffic segment is a parameter used to describe the burst traffic segment, and the burst parameter of the first packet flow is a parameter used to describe at least one burst traffic segment included in the first packet flow.

Abstract: Cas-protein-ready tau biosensor cells, CRISPR/Cas synergistic activation mediator (SAM)-ready tau biosensor cells, and methods of making and using such cells to screen for genetic vulnerability associated with tau aggregation are provided.

Abstract: Latency on the miss path to a cache level in a CPU module is reduced by predicting when a cache miss is likely. Main memory is directly accessed in parallel with the access to the cache level in the CPU module based on the prediction that a cache miss is likely in the cache level.

Abstract: Methods and systems for CRISPR positive selection are described. CRISPR positive selection uses DNA sequencing to identify genes that their perturbation by CRISPR guide RNAs is correlated to the phenotype. In some aspects, disclosed are genome-wide CRISPR/Cas9 screening methods to identify genetic modifiers. Also disclosed are the apparatuses used for performing the methods.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer.

Abstract: Embodiments described herein provide a Conformal Predictor (CP) that reduces the number of likely target class labels CP. Specifically, the CP provides a model agnostic framework to generate a label set, instead of a single label prediction, within a pre-defined error rate. The CP employs a fast base classifier which may be used to filter out unlikely labels from the target label set, and thus restrict the number of probable target class labels while ensuring the candidate class labels set meets the pre-defined error rate.

Abstract: Cas-protein-ready tau bio sensor cells, CRISPR/Cas synergistic activation mediator (SAM)-ready tau biosensor cells, and methods of making and using such cells to screen for genetic vulnerability associated with tau aggregation are provided.

Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: The present application provides tricyclic pyridone compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: A foldable grip is provided on the back panel of a mobile device to enable comfortable and secure holding of the device even during extended use. The grip structure has two main parts, a base that is integrally connected to the panel, and a grip element that is mounted to the base. The grip element moves from a resting position that is flat and flush with the panel of the mobile device to a deployed position in which at least a portion of the grip element folds and curves away from the base to provide a curved surface for a user’s hand to engage.