Abstract: The present invention relates to the field of medical biology, and discloses a single domain antibody and derivative proteins thereof against CTLA4. In particular, the present invention discloses a CTLA4 binding protein and the use thereof, especially the use for treating and/or preventing CTLA4 relevant diseases such as tumor.

Abstract: The present invention belongs to the technical field of machining of fiber-reinforced composites, and relates to a method for measuring distribution of a thrust force during drilling of a unidirectional composite along with a fiber cutting angle. The method includes: cutting the surface a composite sample piece to form a groove; drilling on an existing experimental platform for measuring a thrust force during drilling, where a through hole obtained through the drilling is required to intersect with the groove; obtaining a curve of the thrust force during drilling, comparing the curve with a conventional curve of the thrust force to find a mutation point, and determining the mutation point, namely a fiber cutting angle at the groove; and calculating fluctuation periods of the thrust force according to machining parameters to reckon the distribution of the thrust force along with the fiber cutting angle in all the periods.

Abstract: This disclosure relates to methods for deconvolving bulk or spatial RNA-sequencing data, computer readable medium storing processor-executable instructions adapted to deconvolve bulk or spatial RNA-sequencing data, and systems for deconvolving bulk or spatial RNA-sequencing data to characterize cell type compositions.

Abstract: Methods and compositions are provided for generating F0 fertile XY female animals. The methods and compositions involve making XY pluripotent or totipotent animal cells, in vitro cell cultures, or embryos that are capable of producing a fertile female XY animal in an F0 generation. Such cells, embryos, and animals can be made by silencing a region of the Y chromosome. Optionally, the cells can also be cultured in feminizing medium such as a low-osmolality medium and/or can be modified to decrease the level and/or activity of an Sry protein. Methods and compositions are also provided for silencing a region of the Y chromosome in an XY pluripotent or totipotent animal cell, or in vitro cell cultures, embryos, or animals derived therefrom, by maintaining an XY pluripotent or totipotent animal cell in a feminizing medium.

Abstract: The disclosure provides methods and image processing devices for image super resolution, image enhancement, and convolutional neural network (CNN) model training. The method for image super resolution includes the following steps. An original image is received, and a feature map is extracted from the original image. The original image is segmented into original patches. Each of the original patches is classified respectively into one of patch clusters according to the feature map. The original patches are processed respectively by different pre-trained CNN models according to the belonging patch clusters to obtain predicted patches. A predicted image is generated based on the predicted patches.

Abstract: Systems, methods, and apparatuses relating to memory interface circuit allocation in a configurable spatial accelerator are described. In one embodiment, a configurable spatial accelerator (CSA) includes a plurality of processing elements; a plurality of request address file (RAF) circuits, and a circuit switched interconnect network between the plurality of processing elements and the RAF circuits. As a dataflow architecture, embodiments of CSA have a unique memory architecture where memory accesses are decoupled into an explicit request and response phase allowing pipelining through memory. Certain embodiments herein provide for an improved memory sub-system design via the improvements to allocation discussed herein.

Abstract: Methods and compositions are provided for generating F0 fertile XY female animals. The methods and compositions involve making XY pluripotent or totipotent animal cells, in vitro cell cultures, or embryos that are capable of producing a fertile female XY animal in an F0 generation. Such cells, embryos, and animals can be made by silencing a region of the Y chromosome. Optionally, the cells can also be cultured in feminizing medium such as a low-osmolality medium and/or can be modified to decrease the level and/or activity of an Sry protein. Methods and compositions are also provided for silencing a region of the Y chromosome in an XY pluripotent or totipotent animal cell, or in vitro cell cultures, embryos, or animals derived therefrom, by maintaining an XY pluripotent or totipotent animal cell in a feminizing medium.

Abstract: This document describes devices and systems related to gaming-systems and gaming-system accessories. In an aspect, a display mount for mounting a mobile device having a display and a housing on a game controller is described. The display mount includes a mobile device holder configured for releasable connection to the mobile device, a controller receiver configured for releasable connection with the game controller, and an upright for spacing the mobile device holder apart from the controller receiver.

Abstract: This document describes devices and systems related to gaming-systems and gaming-system accessories. In an aspect, a display mount for mounting a mobile device having a display and a housing on a game controller is described. The display mount includes a mobile device holder configured for releasable connection to the mobile device, a controller receiver configured for releasable connection with the game controller, and an upright for spacing the mobile device holder apart from the controller receiver.

Abstract: A kind of sawtooth structure with reversed cutting function and its drill series are presented in this invention. This invention is suitable for drilling low-damage holes on carbon fiber reinforced polymers (CFRP). The sawtooth structure is comprised of sawteeth and grooves located on the cutting edges of drill. And the sawtooth structure is helically arranged with a specific helix angle around the axis of the drill. It can be classified as the left-hand helix sawtooth structure and the right-hand helix sawtooth structure based on the helix angle value. The bottom edges of the left-hand helix sawtooth structure are the cutting edges, and the rake angles are positive; while the top edges of the right-hand helix sawtooth are the cutting edge with the positive rake angles. The sawtooth structure can be applied to various drilling tools, which proves to be universal. And it can effectively reduce delamination at both hole entrance and hole exit as well as burrs defects.

Abstract: The present invention relates to the identification of certain biomarkers for use in identifying patients who have, or are likely to develop an IL-33 mediated disease or disorder and who are more likely to respond to therapy with an IL-33 antagonist. The invention also relates to methods of treatment of an IL-33-mediated disease or disorder in a patient by administering an IL-33 antagonist to the patient in need thereof and monitoring the effectiveness of therapy using the biomarkers described herein. Also provided are methods for decreasing the level of at least one biomarker in a subject suffering from an IL-33-mediated disease or disorder, and methods for treating such diseases or disorders according to the expression levels of one or more biomarkers. The methods of the present invention comprise administering to a subject in need thereof a pharmaceutical composition comprising an interleukin-33 antagonist.

Abstract: The present disclosure discloses a method and an apparatus for point cloud registration. The method includes: segmenting a source point cloud and a destination point cloud respectively into different categories of attribute features based on semantic; segmenting the source point cloud and the destination point cloud into a plurality of grids based on the attribute features; calculating a current similarity between the source point cloud and the destination point cloud based on the plurality of grids; determining whether the current similarity and a current iterative number satisfy a preset condition; when the current similarity and the current iterative number satisfy the preset condition, performing a registration on the source point cloud and the destination point cloud to obtain a registered result; and based on the registered result, adjusting a position of the source point cloud, updating the current iterative number.

Abstract: Systems, methods, and apparatuses relating to memory interface circuit allocation in a configurable spatial accelerator are described. In one embodiment, a configurable spatial accelerator (CSA) includes a plurality of processing elements; a plurality of request address file (RAF) circuits, and a circuit switched interconnect network between the plurality of processing elements and the RAF circuits. As a dataflow architecture, embodiments of CSA have a unique memory architecture where memory accesses are decoupled into an explicit request and response phase allowing pipelining through memory. Certain embodiments herein provide for an improved memory sub-system design via the improvements to allocation discussed herein.

Abstract: Methods and systems for CRISPR positive selection are described. CRISPR positive selection uses DNA sequencing to identify genes that their perturbation by CRISPR guide RNAs is correlated to the phenotype.

Abstract: Cas-protein-ready tau bio sensor cells, CRISPR/Cas synergistic activation mediator (SAM)-ready tau biosensor cells, and methods of making and using such cells to screen for genetic vulnerability associated with tau aggregation are provided.

Abstract: A vertical-edge double-step sawtooth cutter for preparing high-quality holes of composite material and thereof hybrid stack structure, and has three parts which are a major cutting edge region A, a minor cutting edge region B and a shank region C. The minor cutting edge region B comprises a step vertical-edge region D and a sawtooth cutting region E. This has the step structure and the sawtooth structure which is distributed in the first step, has a recutting function at the inlet and a reverse cutting function at the outlet in the direction opposite to the main cutting motion. The cutter has the vertical edge structure distributed in the second step, and the angle of the second step is a negative value, thereby realizing chip breaking and crushing, reducing scratch to the upper-layer composite material and metal hole walls.

Abstract: Systems, apparatuses and methods may provide for technology that determines a plurality of memory operations associated with a data-flow graph that represents a computer code, where a spatial architecture executes the data-flow graph and the spatial architecture includes a plurality of memory controllers, randomly assigns one or more of the plurality of memory operations to one or more of the plurality of memory controllers to generate a first allocation of the plurality of memory operations to the memory controllers, and determines that the first allocation is to be stored as a permanent memory allocation based on a first performance metric associated with the first allocation.

Abstract: A scanning-type optical antenna is provided, which includes a housing, a fine-tune mirror, a light signal emitter, a light signal receiver, a scanning light receiver and a rotational mechanism. The housing includes a window. The scanning light receiver disposed on the housing receives an input sector scanning light from a target antenna to generate plural light speckles. The rotational mechanism mounts the housing and adjusts the deflection angle between the housing and the target antenna according to the light speckles. The fine-tune mirror is disposed outside the housing and corresponding to the window. The light signal emitter inside the housing transmits an output signal light to the target antenna after being reflected by the fine-tune mirror through the window. The input signal light of the target antenna is transmitted to the light signal receiver inside the housing after being reflected by the fine-tune mirror and passing through the window.

Abstract: A scanning-type optical antenna is provided, which includes a housing, a fine-tune mirror, a light signal emitter, a light signal receiver, a scanning light receiver and a rotational mechanism. The housing includes a window. The scanning light receiver disposed on the housing receives an input sector scanning light from a target antenna to generate plural light speckles. The rotational mechanism mounts the housing and adjusts the deflection angle between the housing and the target antenna according to the light speckles. The fine-tune mirror is disposed outside the housing and corresponding to the window. The light signal emitter inside the housing transmits an output signal light to the target antenna after being reflected by the fine-tune mirror through the window. The input signal light of the target antenna is transmitted to the light signal receiver inside the housing after being reflected by the fine-tune mirror and passing through the window.