Abstract: In one aspect, the present disclosure provides GlcNAc-Asn analogs of the formula (I): wherein the variables are as defined herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of using the compounds disclosed herein. Additionally, the present disclosure also provides methods of treating cancer comprising inhibiting NGLY1.

Abstract: A non-contact body temperature measurement device includes a thermal imager, an anemometer and a processing unit. The thermal imager is provided to capture thermal images. The anemometer is provided to measure wind speed and output a wind speed signal. The processing unit is provided to process the thermal images according to the wind speed signal and remove the thermal image showing great variation in temperature between two consecutive frames. Consequently, an accurate body temperature can be measured through the processed thermal images.

Abstract: Certain embodiments are directed to modified or variant Cas9 proteins, and/or methods of using the same.

Abstract: Disclosed are methods for manufacturing liquid crystal devices including at least two liquid crystal layers and at least one interstitial substrate separating the liquid crystal layers. Methods for processing, assembling, and singulating liquid crystal devices are also disclosed.

Abstract: A method for obtaining enrichment information and a controller are provided. The method includes: querying, by an enrichment information handling circuit, whether a database stores a first enrichment information corresponding to a user device in response to the enrichment information handling circuit receiving a first creation request associated with the user device from an application; triggering, by the enrichment information handling circuit, the application to subscribe to the database for enrichment information corresponding to the user device in response to determining that the database stores the first enrichment information corresponding to the user device; and pushing, by the database, second enrichment information to the application in response to presence of the second enrichment information corresponding to the user device in the database.

Abstract: The present disclosure provides a decellularized extracellular matrix, the preparation process and uses thereof. The decellularized extracellular matrix of the present disclosure is derived from a three-dimensional cell spheroid, and the decellularized extracellular matrix has a three-dimensional spherical structure. The decellularized extracellular matrix of the present disclosure can be used to prepare a biomedical material scaffold for promoting tissue regeneration and repair.

Abstract: In one aspect, the present disclosure provides GlcNAc-Asn analogs of the formula (I): wherein the variables are as defined herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of using the compounds disclosed herein. Additionally, the present disclosure also provides methods of treating cancer comprising inhibiting NGLY1.

Abstract: Certain embodiments are directed to modified or variant Cas9 proteins, and/or methods of using the same.

Abstract: A suction floor mat includes a main body formed by a plurality of upper and lower support ribs arranged in a criss-cross pattern, a plurality of suction cups disposed at the bottom surface of the main body, a vertical opening formed between adjacent upper and lower support ribs, a groove formed at the bottom surface of each lower support rib, and a connecting structure disposed separately at two adjacent edges of the main body for connecting another adjacent suction floor mat.

Abstract: A ventilating pad with buffer and elastic support is formed by connecting an underlying layer, a middle layer and a surface layer with one another, characterized in that the underlying layer is disposed under the middle layer, and the middle layer is disposed under the surface layer, and the middle layer comprises a plurality of elastic protrusions protruded from the top of the middle layer, and the surface layer is attached flatly with the middle layer and along the direction of the elastic protrusion of the middle layer, and a gap is formed between two adjacent elastic protrusions, such that a downwardly concave air passage is formed between the adjacent elastic protrusions, such that the application of the ventilating pad will not cause sweltering or discomfort.

Abstract: A method for manufacturing a power socket is disclosed as that the power socket has at least two metal pins and an insulating seat member, wherein one end of each of the integrally-formed metal pin is defined as a solid round-column shaped contact section and the other end thereof is defined as a flat terminal section, the terminal section and the contact section are integrally formed in one piece.

Abstract: An apparatus is adapted for controlling a lamp unit mounted on an automobile body, and includes a housing for housing input and output rods, a deceleration unit and a transmission piece. The deceleration unit includes a planet gear connected to an eccentric engaging end portion of the input rod, meshing with a ring gear fixed in the housing, and connected to the transmission piece and an angle indicating unit sleeved on the input rod. The output rod has a coupling end portion coupled to the lamp unit, and a rack meshing with a center gear portion of the transmission piece. When the input rod rotates, the transmission piece and the angle indicating unit are driven to rotate in response to movement of the planet gear such that the output rod is movable in response to rotation of the transmission piece, thereby driving movement of the lamp unit relative to the automobile body.

Abstract: An apparatus is adapted for controlling a lamp unit mounted on an automobile body, and includes a housing for housing input and output rods, and a transmission gear. The transmission gear meshes with a worm segment of the input rod such that the transmission gear is driven by the worm segment to rotate in response to rotation of the input rod. The output rod has a coupling end portion coupled to the lamp unit, and a rack segment meshing with the transmission gear such that the output rod is movable relative to the housing in response to rotation of the transmission gear, thereby driving movement of the lamp unit relative to the automobile body.

Abstract: An apparatus is adapted for controlling a lamp unit mounted on an automobile body, and includes a housing for housing input and output rods, a deceleration unit and a transmission piece. The deceleration unit includes a planet gear connected to an eccentric engaging end portion of the input rod, meshing with a ring gear fixed in the housing, and connected to the transmission piece. The output rod has a coupling end portion extending out of the housing and coupled to the lamp unit, and a rack meshing with a center gear portion of the transmission piece. When an operating end portion of the input rod rotates, the transmission piece is driven to rotate in response to movement of the planet gear with the engaging end portion of the input rod such that the output rod is movable in response to rotation of the transmission piece, thereby driving movement of the lamp unit relative to the automobile body.

Abstract: A lighting device includes a secondary lamp casing having an inner ring portion connected to a peripheral portion of a primary lamp casing, an outer ring portion surrounding the inner ring portion, and an annular reflector wall extending between the ring portions. The reflector wall has at least one source mounting section having a reflecting surface with angularly spaced apart ends, an intermediate part between the spaced apart ends, and two sets of curved surface segments. The curved surface segments in each set are interconnected in sequence from the intermediate part to a respective one of the spaced apart ends, and are different paraboloid segments that have coaxial focal axes. A primary light source is mounted to and extends into the primary lamp casing. A secondary light source is disposed at the intermediate part of the source mounting section.