Patents by Inventor Yuling Liu

Yuling Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12202488
    Abstract: The present application relates to the technical field of vehicle controlling technology, and provides a method and a device for gradient calculating. The method for gradient calculating includes: acquiring current operating parameters of the vehicle, wherein the current operating parameters include a current longitudinal acceleration, a current lateral acceleration, a current vehicle acceleration, and a current vehicle speed; determining a first influence value of the current lateral acceleration on the current longitudinal acceleration according to the current lateral acceleration and the current vehicle speed; determining a second influence value of the current vehicle acceleration on the current longitudinal acceleration according to the current vehicle acceleration and the current vehicle speed; correcting the current longitudinal acceleration according to the first influence value and the second influence value; and determining the gradient value based on the corrected current longitudinal acceleration.
    Type: Grant
    Filed: October 14, 2020
    Date of Patent: January 21, 2025
    Assignee: Great Wall Motor Company Limited
    Inventors: Dexiang Zhou, Yuling Liu, Jian Zhang, Xu Shi
  • Publication number: 20250018000
    Abstract: The invention discloses a use of a mulberry (Morus alba L.) extract, including a method for treating ulcerative colitis, a method for preventing ulcerative colitis, and a method for reduction in Disease Activity Index, DAI. The use is application of a mulberry extract to the preparation of a product for treating and/or preventing ulcerative colitis. The invention experimentally demonstrated that positive drug group, SZ-A-1, SZ-A-2, SZ-A-3, SZ-A-4 and SZ-A-5 (pretreatment) could each significantly inhibit colonic atrophy in UC model mice, and the effects in SZ-A-2, SZ-A-3 and SZ-A-4 groups are comparable to that in positive drug group, with SZ-A-5 (pretreatment) achieving a superior effect to the positive drug. The mulberry extract of the invention, as a component derived from natural plants, has unique advantages of small toxic and side effects, mild and lasting actions etc.
    Type: Application
    Filed: September 30, 2024
    Publication date: January 16, 2025
    Applicants: BEIJING WEHAND-BIO PHARMACEUTICAL CO., LTD, GUANGXI WEHAND-BIO PHARMACEUTICAL CO., LTD
    Inventors: Yuling LIU, Jun YE, Dongdong LIU, Hongliang WANG, Mo WANG, Renjie LI, Yanfang YANG
  • Publication number: 20240408162
    Abstract: The present invention discloses applications of extracts from Morus alba L. Disclosed by the present invention is a use of extracts from Morus alba L. in the preparation of a product for alleviating, preventing and/or treating a hepatobiliary disease. The present invention demonstrated experimentally that extracts from Morus alba L. have effects of reducing hepatic lipid content and alleviating hepatic fibrosis in NAFLD mice gavaged with extracts from Morus alba L., thereby alleviating high-fat diet-induced fatty liver without toxic and side effects on liver and kidney. The drug of the present invention exerts multi-target pharmacological effects through multi-components, and specifically can regulate the hepatic lipid content by regulating the synthesis and oxidation of fatty acids, and can also affect hepatic fibrosis, which is more conducive to the treatment of a non-alcoholic fatty liver disease.
    Type: Application
    Filed: August 14, 2024
    Publication date: December 12, 2024
    Inventors: Yuling LIU, Yanmin CHEN, Zhihua LIU, Xiangyang ZHU, Tingting WANG, Yuanyuan LIU, Chunfang LIAN, Qianwen SUN, Lili GAO, Yuanyuan ZOU, Hongzhen YANG, Yiqun JIN
  • Publication number: 20240156889
    Abstract: The present disclosure relates a method for reducing animal weight, comprising administering to a patient in need thereof a therapeutically or prophylactically effective amount of a mulberry extract. The mulberry extract comprises: 3% to 99% of an alkaloid, 0.2% to 70% of a polysaccharide, 0% to 50% of an amino acid, 0% to 10% of flavone, and 0% to 25% of other components. The mulberry extract of the present disclosure can be used for controlling weight gain, and has a good therapeutic effect on type 2 diabetes with obesity.
    Type: Application
    Filed: March 11, 2022
    Publication date: May 16, 2024
    Inventors: Yuling LIU, Yanmin CHEN, Zhihua LIU, Xiangyang ZHU, Yiqun JIN, Hongzhen YANG, Tingting WANG, Yuanyuan LIU, Zhufang SHEN, Shuainan LIU, Quan LIU, Chunfang LIAN, Qianwen SUN, Yuanyuan ZOU, Caina LI, Lei LEI, Hui CAO
  • Patent number: 11779041
    Abstract: A plant extraction method includes the following steps: 1) preparation of a crude plant extraction solution; 2) separation of the crude extraction solution through a cation resin and an optional anion resin to obtain a collection solution; 3) concentration of the collection solution obtained in step 2); 4) alcohol precipitation of the concentration solution obtained in step 3); and optionally, step 5) concentration and drying. The method can effectively reduce the content of heavy metals in an extract, and reduce the amount of ethanol used in extraction, thereby improving the product quality and lowering the production cost, and the efficiency and safety of industrial production are improved. The extract obtained by this method can be used to prepare drugs for lowering blood lipid, treating abnormal glucose tolerance, treating diseases related to abnormal blood glucose, or regulating intestinal flora, and can be processed into food products, health-care products or drinks.
    Type: Grant
    Filed: August 20, 2020
    Date of Patent: October 10, 2023
    Assignees: BEIJING WEHAND-BIO PHARMACEUTICAL CO., LTD, GUANGXI WEHAND-BIO PHARMACEUTICAL CO., LTD
    Inventors: Yuling Liu, Xiangyang Zhu, Yiqun Jin, Zhihua Liu, Jundong Yang
  • Patent number: 11771660
    Abstract: A flavonoid polyphenol drug self-emulsifying composition based on a flavonoid polyphenol drug-phospholipid complex being used as an intermediate, the composition comprising a flavonoid polyphenol drug-phospholipid complex, an oil phase, an emulsifier and a co-emulsifier, the flavonoid polyphenol drug comprising one or more selected from baicalein, proanthocyanidin, quercetin, curcumin and resveratrol. The described self-emulsifying composition has the beneficial effects of good stability, a high amount of drug loading, high bioavailability, and so on.
    Type: Grant
    Filed: April 8, 2020
    Date of Patent: October 3, 2023
    Assignees: BEIJING WEHAND-BIO PHARMACEUTICAL CO., LTD., INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCE & PEKING UNION MEDICAL COLLEGE
    Inventors: Yuling Liu, Hengfeng Liao, Yue Gao, Wujun Dong, Zhihua Liu, Bangyuan Wang, Yun Zhang, Yu Feng, Junzhuo Zhou, Lu Liu, Jun Ye, Yanfang Yang, Xuejun Xia
  • Publication number: 20220324455
    Abstract: The present application relates to the technical field of vehicle controlling technology, and provides a method and a device for gradient calculating. The method for gradient calculating includes: acquiring current operating parameters of the vehicle, wherein the current operating parameters include a current longitudinal acceleration, a current lateral acceleration, a current vehicle acceleration, and a current vehicle speed; determining a first influence value of the current lateral acceleration on the current longitudinal acceleration according to the current lateral acceleration and the current vehicle speed; determining a second influence value of the current vehicle acceleration on the current longitudinal acceleration according to the current vehicle acceleration and the current vehicle speed; correcting the current longitudinal acceleration according to the first influence value and the second influence value; and determining the gradient value based on the corrected current longitudinal acceleration.
    Type: Application
    Filed: October 14, 2020
    Publication date: October 13, 2022
    Inventors: Dexiang Zhou, Yuling Liu, Jian Zhang, Xu Shi
  • Publication number: 20220273014
    Abstract: A plant extraction method includes the following steps: 1) preparation of a crude plant extraction solution; 2) separation of the crude extraction solution through a cation resin and an optional anion resin to obtain a collection solution; 3) concentration of the collection solution obtained in step 2); 4) alcohol precipitation of the concentration solution obtained in step 3); and optionally, step 5) concentration and drying. The method can effectively reduce the content of heavy metals in an extract, and reduce the amount of ethanol used in extraction, thereby improving the product quality and lowering the production cost, and the efficiency and safety of industrial production are improved. The extract obtained by this method can be used to prepare drugs for lowering blood lipid, treating abnormal glucose tolerance, treating diseases related to abnormal blood glucose, or regulating intestinal flora, and can be processed into food products, health-care products or drinks.
    Type: Application
    Filed: August 20, 2020
    Publication date: September 1, 2022
    Applicants: BEIJING WEHAND-BIO PHARMACEUTICAL CO., LTD, GUANGXI WEHAND-BIO PHARMACEUTICAL CO., LTD
    Inventors: Yuling LIU, Xiangyang ZHU, Yiqun JIN, Zhihua LIU, Jundong YANG
  • Publication number: 20220168237
    Abstract: A flavonoid polyphenol drug self-emulsifying composition based on a flavonoid polyphenol drug-phospholipid complex being used as an intermediate, the composition comprising a flavonoid polyphenol drug-phospholipid complex, an oil phase, an emulsifier and a co-emulsifier, the flavonoid polyphenol drug comprising one or more selected from baicalein, proanthocyanidin, quercetin, curcumin and resveratrol. The described self-emulsifying composition has the beneficial effects of good stability, a high amount of drug loading, high bioavailability, and so on.
    Type: Application
    Filed: April 8, 2020
    Publication date: June 2, 2022
    Inventors: Yuling LIU, Hengfeng LIAO, Yue GAO, Wujun DONG, Zhihua LIU, Bangyuan WANG, Yun ZHANG, Yu FENG, Junzhuo ZHOU, Lu LIU, Jun YE, Yanfang YANG, Xuejun XIA
  • Publication number: 20210037854
    Abstract: An egg rich in nutrients of ?-linolenic acid and DHA, a breeding method of laying hens and a feed additive are provided. Laying hens are fed with a feed additive rich in ?-linolenic acid, after the feed additive are digested and absorbed by the laying hens, a part of the ?-linolenic acid is enriched in the egg yolk, and another part of the ?-linolenic acid is used as a precursor which is metabolized to be DHA by laying hen's biochemical process and thereby partially enriched in the egg yolk. Therefore, the contents of these two nutrients in eggs are greatly increased and reach their respective healthy supply levels, consumers can obtain stable and sufficient nutrition supply from the eggs. The invention can effectively solve a current situation of too low ?-linolenic acid and DHA contents in ordinary eggs while maintaining the nature of eggs as a consumer product.
    Type: Application
    Filed: April 30, 2020
    Publication date: February 11, 2021
    Inventors: XINGSHI TAO, GuoPan Gao, YuLing Liu
  • Publication number: 20200272591
    Abstract: A port circuit, method for supplying power for an electronic device via a port circuit and electronic device. The port circuit includes: power supply pins configured to connect power lines of an external device and power lines of an electronic device provided with the port circuit; data pins configured to connect data lines of the external device and data lines of the electronic device; and first switch configured to switch between switching on and turning off, so that a path for performing data exchange by the electronic device and the external device is switched on or turned off. With the method for supplying power for an electronic device via a port circuit and the electronic device, whether the electronic device exchanges data with the external device via the data pins of the port circuit is controlled by providing a switch at the port circuit, thereby guaranteeing information security of the electronic device.
    Type: Application
    Filed: December 15, 2017
    Publication date: August 27, 2020
    Inventors: Yaofeng SHI, Xiaoxia SUN, Haoyu LI, Yuling LIU
  • Patent number: 10611852
    Abstract: Provided are an insulin-lipid complex, a preparation method thereof, and a formulation thereof. The insulin-lipid complex is prepared by compounding insulin and a lipid material in an organic solvent system containing a low boiling point acid, and drying. The mass ratio of insulin to the lipid material is 1:3˜1:20. An oil solution of the insulin-lipid complex and vesicles containing insulin are further provided.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: April 7, 2020
    Assignee: INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES
    Inventors: Yuling Liu, Cuiping Zhou, Zhihui Song, Lin Li, Hongliang Wang, Xuejun Xia, Renyun Wang, Wujun Dong, Dujia Jin
  • Publication number: 20180171031
    Abstract: Provided are an insulin-lipid complex, a preparation method thereof, and a formulation thereof. The insulin-lipid complex is prepared by compounding insulin and a lipid material in an organic solvent system containing a low boiling point acid, and drying. The mass ratio of insulin to the lipid material is 1:3-1:20. An oil solution of the insulin-lipid complex and vesicles containing insulin are further provided.
    Type: Application
    Filed: February 13, 2018
    Publication date: June 21, 2018
    Inventors: Yuling LIU, Cuiping ZHOU, Zhihui SONG, Lin LI, Hongliang WANG, Xuejun XIA, Renyun WANG, Wujun DONG, Dujia JIN
  • Patent number: 9066960
    Abstract: The present invention relates to an effective fraction of alkaloids and the effective fraction is prepared from mulberry twig and its active ingredients are a composition of alkaloids. Determined by HPLC, the percentage of the total alkaloids are 50% or more by weight in the effective fraction and the percentage of the compound 1-deoxynojirimycin is 30% or more by weight in the total alkaloids. The effective fraction of the invention is prepared as the following steps: the mulberry twig is extracted by solvents, and the extract is precipitated by alcohol precipitation or flocculation to remove the impurities, and then concentrated, purified by resin chromatography. The present invention also relates to a pharmaceutical composition containing the said effective fraction of alkaloids and to the use of the effective fraction of alkaloids according to claim 1-4 in preparing hypoglycemic agents.
    Type: Grant
    Filed: August 22, 2007
    Date of Patent: June 30, 2015
    Assignee: INSTITUTE OF MATARIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES
    Inventors: Yuling Liu, Zhufang Shen, Zhen Chen, Renyun Wang, Xuejun Xia, Yueteng Chen, Quan Liu, Sujuan Sun, Mingzhi Xie
  • Patent number: 8921229
    Abstract: A method of polishing copper wiring surfaces of in ultra large scale integrated circuit, the method including: a) preparing a polishing solution including between 35 and 80 w. % of a nano SiO2 abrasive, between 12 and 60 w. % of deionized water, between 1 and 3 w. % of an oxidant, between 1 and 4 w. % of an active agent, and between 0.5 and 1.5 w. % of a chelating agent; and b) polishing using the polishing solution under following conditions: between 2 and 5 kPa pressure; between 20 and 50° C.; between 120 and 250 mL/min slurry flow rate; and at between 30 and 60 rpm/min rotational speed.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: December 30, 2014
    Inventors: Yuling Liu, Xiaoyan Liu, Jun Tian
  • Patent number: 8912134
    Abstract: A method of cleaning copper material surfaces in ultra large scale integrated circuits after polishing, the method including: a) mixing and stirring between 1 and 4 wt. % of a surfactant, between 0.5 and 3 wt. % of a chelating agent, between 0.1 and 5 wt. % of a corrosion inhibitor, and deionized water, to yield a water soluble cleaning solution with pH value of between 7.4 and 8.2; and b) washing the copper material surfaces using the cleaning solution after alkaline chemical-mechanical polishing under following conditions: between 2000 and 3000 Pa of pressure; between 1000 and 5000 mL/min of flow rate; and at least between 0.5 and 2 min of washing time.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: December 16, 2014
    Assignee: Hebei University of Technology
    Inventors: Yuling Liu, Xiaoyan Liu, Na Liu, Yangang He
  • Publication number: 20130338064
    Abstract: Provided are an insulin-lipid complex, a preparation method thereof, and a formulation thereof. The insulin-lipid complex is prepared by compounding insulin and a lipid material in an organic solvent system containing a low boiling point acid, and drying. The mass ratio of insulin to the lipid material is 1:3˜1:20. An oil solution of the insulin-lipid complex and vesicles containing insulin are further provided.
    Type: Application
    Filed: July 14, 2011
    Publication date: December 19, 2013
    Applicant: Institute of Materia Medica, Chinese Academy of Medical Sciences
    Inventors: Yuling Liu, Cuiping Zhou, Zhihui Song, Lin Li, Hongliang Wang, Xuejun Xia, Renyun Wang, Wujun Dong, Dujia Jin
  • Publication number: 20130150335
    Abstract: A paclitaxel/steroid complex comprising paclitaxel and steroid is disclosed. The molar ratio of paclitaxel to steroid is 1:0.2˜4, preferably 1:0.25˜2. A process for the preparation thereof and the use thereof in the manufacture of submicron emulsion, dry emulsion, self-microemulsifying system are also disclosed.
    Type: Application
    Filed: October 28, 2010
    Publication date: June 13, 2013
    Applicant: Institute of Mataria Medica, Chinese Academy of Medical Sciences
    Inventors: Yuling Liu, Xuejun Xia, Ruifang Guo, Pengxiao Zhang, Cuiping Zhou, Renyun Wang, Dujia Jin
  • Publication number: 20120318293
    Abstract: A method of cleaning wafer surfaces after polishing aluminum wirings by means of a polishing disc in ultra large scale integrated circuits, the method including: a) mixing and stirring deionized water, between 0.5 and 5 wt. % of a surfactant, between 0.1 and 5 wt. % of an FA/O II chelating agent, and between 0.01 and 5 wt. % of an FA/O II corrosion inhibitor, to yield a neutral aqueous cleaning solution; and b) after a chemical-mechanical polishing treatment for aluminum wirings, directly washing wafer surfaces with the neutral aqueous cleaning solution without lifting the polishing disc.
    Type: Application
    Filed: August 29, 2012
    Publication date: December 20, 2012
    Inventors: Yuling LIU, Jianwei ZHOU, Yi HU
  • Publication number: 20120321780
    Abstract: A method of preventing oxidation of multilayer wirings in ultra large scale integrated circuits after alkaline polishing, the method including: a) mixing between 0.5 and 1 wt. % of a surfactant, between 0.05 and 0.5 wt. % of a chelating agent, between 1 and 10 wt. % of a corrosion inhibitor, and deionized water, and stirring to yield a water soluble antioxidant solution with pH value of between 6.8 and 7.5; and b) washing the multilayer wirings in the ultra large scale integrated circuits using the antioxidant solution after alkaline CMP under following conditions: between 1000 and 2000 Pa pressure; between 2000 and 5000 mL/min flow rate; and at least between 0.5 and 1 min washing time.
    Type: Application
    Filed: August 23, 2012
    Publication date: December 20, 2012
    Inventors: Yuling LIU, Xiaoyan LIU, Jun TIAN