Abstract: A method for reducing metal gate corrosion defects is provided. A thicker second hard mask layer is formed at the chamfer on top edge of the isolation layer between the PMOS and NMOS regions, wherein the chamfer sloping toward the NMOS region, as the deposition process creates a thicker layer around step corners. By precisely controlling the etching thickness during subsequent steps, the second hard mask layer in flat regions is removed, while the second hard mask layer at the chamfer is only partially removed, so the remaining second hard mask layer at the chamfer protects the chamfer, reducing the risk of wet cleaning solution penetrating into the metal gate during subsequent wet cleaning of the groove. The present invention addresses corrosion defects caused by chemical reactions between wet cleaning solutions and metal materials such as aluminum, significantly enhancing the performance and reliability of the semiconductor structure.

Abstract: A switchable light modulator includes an electrophoretic medium for use in a window of an enclosure (e.g., a greenhouse or other building or a vehicle) for light attenuation and heat management. The electrophoretic medium can be driven among a plurality of optical states including: (a) a first set of optical states for reducing transmittance of thermal radiation from incident sunlight through the switchable light modulator into the enclosure, (b) a second set of optical states for promoting transmittance of thermal radiation from the incident sunlight through the switchable light modulator into the enclosure, and (c) a third set of optical states for reducing transmittance of thermal radiation out of the enclosure during nighttime operation.

Abstract: An HKMG device and a method for manufacturing same. By separately forming the first groove in the PMOS region and the second groove in the NMOS region, depositing the first filling layer in the PMOS region and the second filling layer in the NMOS region, then removing the first and second filling layers through a combination of dry and wet etching and filling the grooves with metal material to respectively form the PMOS and NMOS metal gates, this method allows for precise control over etching depth and range, preventing interface damage to the PMOS region; it eliminates chamfer formation at the junction, prevents wet etching solutions from penetrating the PMOS metal gate, and resolves corrosion defects caused by chemical reactions; furthermore, the PMOS and NMOS work function metal layers are formed stepwise, with chemical mechanical polishing ensuring a uniform surface, significantly enhancing the performance and reliability of the HKMG device.

Abstract: A method for forming a shared contact hole and a semiconductor structure is provided. First, the first hard mask layer is formed on the region where the shared contact hole needs to be formed on the gate structures. Then, the step-by-step etching process ensures that the etching endpoint stops on the first hard mask layer and the second hard mask layer during the etching of the first interlayer dielectric layer, thereby preventing over-etching of the metal gate and the generation of by-products. Subsequently, the first hard mask layer and the second hard mask layer are completely etched to expose portions of the active regions and the metal gate to finally form a shared contact hole. The conductive layer formed in the shared contact hole ensures sufficient contact between the active regions and the metal gate, ultimately improving the yield and reliability of the semiconductor device.

Abstract: Provided are an anti-CD47 monoclonal antibody and a use thereof, secreted by the hybridoma cell line with the deposit number CCTCC NO: C2018135.

Abstract: Chemical reactions are expedited by exploiting contact electrification at curved microscale interfaces between water and a hydrophobic medium. The hydrophobic medium can be a solid, liquid, or gas. The microscale-interfaces can be surfaces of water droplets in contact with a hydrophobic medium, such as a gas, liquid, or solid, or they can be surfaces of gas microbubbles in contact with water alone or with water containing solid or liquid hydrophobic particles.

Abstract: An ant-TIGIT antibody, and a pharmaceutical composition and the use thereof. The present invention relates to an anti-TIGIT antibody or an antigen-binding fragment thereof, wherein a heavy chain variable region of the antibody comprises HCDR1-HCDR3 having amino acid sequences as shown in SEQ ID NOs: 3-5, respectively; and a light chain variable region of the antibody comprises LCDR1-LCDR3 having amino acid sequences as shown in SEQ ID NOs: 8-10, respectively. The antibody can effectively bind to TIGIT and has the potential for use in tumor prevention and treatment.

Abstract: The present invention relates to an antibody for treating or preventing autoimmune diseases. The antibody of the present invention comprises a heavy chain variable region set forth in SEQ ID NO:1 or SEQ ID NO:24 and a light chain variable region set forth in SEQ ID NO:6, SEQ ID NO:11, SEQ ID NO:13, SEQ ID NO:15, SEQ ID NO:17 or SEQ ID NO:25.

Abstract: A variable light transmission device is disclosed, the variable light transmission device comprising two light transmissive electrode layer and a microcell layer having a plurality of microcells. Each of the plurality of microcells includes a first type of electrically charged pigment particles and a second type of electrically charged pigment particles, a charge control agent, and a non-polar liquid. Upon application of an electric field, the amount of light passing through the device can be modulated.

Abstract: A method, apparatus, non-transitory computer readable medium, and system for obtaining a query comprising a document request. A language generation model is configured to retrieve a first document based on the query and generate an expanded query based on the first document using a knowledge graph that connects the first document to a second document. A third document is retrieved based on the expanded query in response to the query.

Abstract: The present invention relates to the fields of treating autoimmune diseases and molecular immunology, and specifically, to an anti-IL-17A antibody, a pharmaceutical composition thereof, and use thereof. The present invention relates to a monoclonal antibody or an antigen binding fragment thereof, wherein a heavy chain variable region of the monoclonal antibody comprises: HCDR1-HCDR3 with amino acid sequences set forth in SEQ ID NOs: 31-33 respectively, or HCDR1-HCDR3 with amino acid sequences set forth in SEQ ID NOs: 37-39 respectively, and a light chain variable region of the monoclonal antibody comprises: LCDR1-LCDR3 with amino acid sequences set forth in SEQ ID NOs: 34-36 respectively, or LCDR1-LCDR3 with amino acid sequences set forth in SEQ ID NOs: 40-42 respectively. Monoclonal antibodies of the present invention can specifically antagonize the binding of IL-17A to a ligand and inhibit activation of fibroblasts by IL-17A.

Abstract: A backlight brightness adjustment circuit and a control method therefor, and a device are provided. The circuit comprises: a control end of a first switch component is connected to an output of an AND gate circuit, one end of the first switch component is connected to one end of a first resistor, and the other end of the first switch component is connected to ground; the other end of the first resistor is connected to a first input of a voltage comparator, one end of a second switch component, and one end of a second resistor, and the other end of the second resistor is connected to the ground. Stepless adjustment of the backlight brightness is achieved and the backlight brightness adjustment experience is improved.

Abstract: The present invention belongs to the fields of tumor therapy and molecular immunology, and provides an anti-CTLA4 monoclonal antibody or antigen binding fragment thereof, a pharmaceutical composition thereof and use thereof. The monoclonal antibody of the present invention can block the binding of CLTA4 to B7, relieve the immunosuppression on the body by CTLA4, and activate T lymphocytes.

Abstract: An intelligence processing unit (IPU) includes a memory, a grid processing circuit, and a convolution computation circuit. The memory is configured to store a part of a first input data of a deformable convolution operation, a part of a bias of the deformable convolution operation, a part of a weight of the deformable convolution operation, and a part of a grid, where the grid is transformed from an offset of the deformable convolution operation. The grid processing circuit is configured to perform a grid-sample operation to generate a second input data based on the first input data and the grid. The convolution computation circuit is configured to perform a convolution operation on the second input data, the weight, and the bias to generate an output data. The output data is substantially equal to the result of the deformable convolution operation.

Abstract: A method for online monitoring of gel strength changes during surimi thermal processing based on hyperspectral imaging includes following steps: raw hyperspectral data of surimi samples during a heating process is acquired, and gel strength of the surimi samples is measured; the raw hyperspectral data is preprocessed; a dataset is constructed based on preprocessed raw hyperspectral data and the gel strength; a partial least squares (PLS) model is trained and validated using the dataset to obtain a gel strength prediction model; and the gel strength prediction model is utilized to monitor changes in gel strength during surimi thermal processing.

Abstract: The present application provides a therapeutic combination of a quinoline derivative and an antibody, which comprises an immune checkpoint inhibitor and a tyrosine kinase inhibitor, wherein the tyrosine kinase inhibitor is a compound of formula I or a pharmaceutically acceptable salt thereof. The therapeutic combination in the present application shows good activity against lung tumor and liver tumor.

Abstract: The present disclosure provides an extended reality device and a control method thereof. The extended reality device includes: a front part and a rear part; the front part comprising: a display module, configured to display extended reality image; the rear part comprising: a system controller connected to the display module and configured to control operation of the display module; a battery connected to the system controller and configured to supply power to each electrical device. Through the above solution, transferring the system controller and the battery to the rear part setting, so that the weight of the front part of the extended reality device is significantly reduced, the thickness of the front part is significantly reduced, the weight of the rear part and the front part can be balanced, there is no bias when user wears the extended reality device, which improves the user's wearing comfort.

Abstract: Provided is an antibody for the treatment or prevention of autoimmune diseases, comprising a heavy chain variable region represented by SEQ ID NO: 1 or SEQ ID NO: 24, and a light chain variable region represented by SEQ ID NO: 6, SEQ ID NO: 11, SEQ ID NO: 13, SEQ ID NO: 15, SEQ ID NO: 17, or SEQ ID NO: 25.

Abstract: This disclosure relates to a context enforcement system that efficiently and securely protects tenant context information that travels across microservices in a multi-tenant distributed cloud computing system and protects against data leaks that often occur in conventional microservice management systems. For example, the context enforcement system ensures secure external and internal communications and context isolation by providing various shared library functions to microservices of a multi-tenant distributed cloud computing system. Additionally, the shared library provided by the context enforcement system improves the efficiency of the multi-tenant distributed cloud computing system by allowing microservices to focus on target operations rather than also maintaining and performing additional redundant functions.

Abstract: Disclosed is a method for manufacturing a zeroth interlayer dielectric, including: step 1: providing a semiconductor substrate subjected to a process of forming a contact etch stop layer; step 2: performing a first deposition process using a HARP process, to form a first oxide layer fully filling a spacing region; step 3: polishing the first oxide layer using a first chemical mechanical polishing process; step 4: performing wet etch to lower a top surface of the first oxide layer and form a first groove at the top of the spacing region; step 5: performing a second deposition process using an HDP CVD process, to form a second oxide layer fully filling the first groove; and step 6: polishing the second oxide layer using a second chemical mechanical polishing process, which is stopped on a surface of a first gate material layer of a first gate structure.