Abstract: A method, apparatus, non-transitory computer readable medium, and system for obtaining a query comprising a document request. A language generation model is configured to retrieve a first document based on the query and generate an expanded query based on the first document using a knowledge graph that connects the first document to a second document. A third document is retrieved based on the expanded query in response to the query.

Abstract: The present invention relates to the fields of treating autoimmune diseases and molecular immunology, and specifically, to an anti-IL-17A antibody, a pharmaceutical composition thereof, and use thereof. The present invention relates to a monoclonal antibody or an antigen binding fragment thereof, wherein a heavy chain variable region of the monoclonal antibody comprises: HCDR1-HCDR3 with amino acid sequences set forth in SEQ ID NOs: 31-33 respectively, or HCDR1-HCDR3 with amino acid sequences set forth in SEQ ID NOs: 37-39 respectively, and a light chain variable region of the monoclonal antibody comprises: LCDR1-LCDR3 with amino acid sequences set forth in SEQ ID NOs: 34-36 respectively, or LCDR1-LCDR3 with amino acid sequences set forth in SEQ ID NOs: 40-42 respectively. Monoclonal antibodies of the present invention can specifically antagonize the binding of IL-17A to a ligand and inhibit activation of fibroblasts by IL-17A.

Abstract: A backlight brightness adjustment circuit and a control method therefor, and a device are provided. The circuit comprises: a control end of a first switch component is connected to an output of an AND gate circuit, one end of the first switch component is connected to one end of a first resistor, and the other end of the first switch component is connected to ground; the other end of the first resistor is connected to a first input of a voltage comparator, one end of a second switch component, and one end of a second resistor, and the other end of the second resistor is connected to the ground. Stepless adjustment of the backlight brightness is achieved and the backlight brightness adjustment experience is improved.

Abstract: The present invention belongs to the fields of tumor therapy and molecular immunology, and provides an anti-CTLA4 monoclonal antibody or antigen binding fragment thereof, a pharmaceutical composition thereof and use thereof. The monoclonal antibody of the present invention can block the binding of CLTA4 to B7, relieve the immunosuppression on the body by CTLA4, and activate T lymphocytes.

Abstract: An intelligence processing unit (IPU) includes a memory, a grid processing circuit, and a convolution computation circuit. The memory is configured to store a part of a first input data of a deformable convolution operation, a part of a bias of the deformable convolution operation, a part of a weight of the deformable convolution operation, and a part of a grid, where the grid is transformed from an offset of the deformable convolution operation. The grid processing circuit is configured to perform a grid-sample operation to generate a second input data based on the first input data and the grid. The convolution computation circuit is configured to perform a convolution operation on the second input data, the weight, and the bias to generate an output data. The output data is substantially equal to the result of the deformable convolution operation.

Abstract: A method for online monitoring of gel strength changes during surimi thermal processing based on hyperspectral imaging includes following steps: raw hyperspectral data of surimi samples during a heating process is acquired, and gel strength of the surimi samples is measured; the raw hyperspectral data is preprocessed; a dataset is constructed based on preprocessed raw hyperspectral data and the gel strength; a partial least squares (PLS) model is trained and validated using the dataset to obtain a gel strength prediction model; and the gel strength prediction model is utilized to monitor changes in gel strength during surimi thermal processing.

Abstract: The present application provides a therapeutic combination of a quinoline derivative and an antibody, which comprises an immune checkpoint inhibitor and a tyrosine kinase inhibitor, wherein the tyrosine kinase inhibitor is a compound of formula I or a pharmaceutically acceptable salt thereof. The therapeutic combination in the present application shows good activity against lung tumor and liver tumor.

Abstract: The present disclosure provides an extended reality device and a control method thereof. The extended reality device includes: a front part and a rear part; the front part comprising: a display module, configured to display extended reality image; the rear part comprising: a system controller connected to the display module and configured to control operation of the display module; a battery connected to the system controller and configured to supply power to each electrical device. Through the above solution, transferring the system controller and the battery to the rear part setting, so that the weight of the front part of the extended reality device is significantly reduced, the thickness of the front part is significantly reduced, the weight of the rear part and the front part can be balanced, there is no bias when user wears the extended reality device, which improves the user's wearing comfort.

Abstract: Provided is an antibody for the treatment or prevention of autoimmune diseases, comprising a heavy chain variable region represented by SEQ ID NO: 1 or SEQ ID NO: 24, and a light chain variable region represented by SEQ ID NO: 6, SEQ ID NO: 11, SEQ ID NO: 13, SEQ ID NO: 15, SEQ ID NO: 17, or SEQ ID NO: 25.

Abstract: This disclosure relates to a context enforcement system that efficiently and securely protects tenant context information that travels across microservices in a multi-tenant distributed cloud computing system and protects against data leaks that often occur in conventional microservice management systems. For example, the context enforcement system ensures secure external and internal communications and context isolation by providing various shared library functions to microservices of a multi-tenant distributed cloud computing system. Additionally, the shared library provided by the context enforcement system improves the efficiency of the multi-tenant distributed cloud computing system by allowing microservices to focus on target operations rather than also maintaining and performing additional redundant functions.

Abstract: Disclosed is a method for manufacturing a zeroth interlayer dielectric, including: step 1: providing a semiconductor substrate subjected to a process of forming a contact etch stop layer; step 2: performing a first deposition process using a HARP process, to form a first oxide layer fully filling a spacing region; step 3: polishing the first oxide layer using a first chemical mechanical polishing process; step 4: performing wet etch to lower a top surface of the first oxide layer and form a first groove at the top of the spacing region; step 5: performing a second deposition process using an HDP CVD process, to form a second oxide layer fully filling the first groove; and step 6: polishing the second oxide layer using a second chemical mechanical polishing process, which is stopped on a surface of a first gate material layer of a first gate structure.

Abstract: The present disclosure provides an accident warning method, apparatus, storage medium, controller, and vehicle. According to the accident warning method proposed by the present disclosure, in response to detecting that the host vehicle has been involved in a traffic accident, accident warning information corresponding to the traffic accident is generated, wherein the accident warning information comprises the accident location associated with the traffic accident. The accident warning information is sent to a navigation server, such that the navigation server sends the accident warning information to vehicles to be warned that are about to pass through the accident location. In this way, vehicles approaching the accident location can be warned in advance when a traffic accident occurs, thereby improving driving safety.

Abstract: A method for regulating and controlling an ultrasonic cutting speed of an outer paraboloid of a honeycomb material is provided. The method includes: regulating and controlling an ultrasonic cutting speed of an outer end face of a honeycomb blank, an ultrasonic cutting speed of an outer paraboloid of the honeycomb blank in a roughing stage, an ultrasonic cutting speed of the outer paraboloid of the honeycomb blank in a first finishing stage, an ultrasonic cutting speed of the outer paraboloid of the honeycomb blank in a second finishing stage, and an ultrasonic cutting speed of an outer peripheral face of the honeycomb blank. The ultrasonic cutting method according to the present disclosure in which the ultrasonic cutting speed V is kept constant can improve the machining quality of parts with the outer paraboloid of the honeycomb material and ensure the service life of a sharp knife.

Abstract: The present invention belongs to the field of immunology, and relates to an anti-IL-1? antibody and pharmaceutical composition thereof and use of the same. Specifically, the present invention relates to an anti-IL-1? antibody or an antigen-binding fragment thereof, wherein a heavy chain variable region of the antibody comprises HCDR1-HCDR3 with amino acid sequences set forth in SEQ ID NO: 17-SEQ ID NO: 19, respectively; and a light chain variable region of the antibody comprises LCDR1-LCDR3 set forth in SEQ ID NO: 20-SEQ ID NO: 22, respectively. The antibody disclosed herein can effectively bind to human IL-1?, block the binding of IL-1? to a receptor IL-1R1 thereof, and inhibit the activation of downstream signaling pathways of IL-1?; having the potential of being used for preparing a medicament for preventing and treating autoimmune diseases, cryopyrin-associated periodic syndromes in children and adults, systemic juvenile idiopathic arthritis, gouty arthritis, cardiovascular diseases or tumors.

Abstract: The present application provides a metal gate structure of a high-voltage device and a method for making the same, forming a dummy gate on the gate oxide layer, wherein the dummy gate is composed of a plurality of polysilicon structures spaced apart from each other; forming a protective layer on sidewalls of the plurality of polysilicon structures and on the gate oxide layer between the polysilicon structures; performing covering with an insulating layer to fill a region between the polysilicon structures, wherein the filled region forms an insulating structure; removing the polysilicon structure to form a groove; forming a metal layer, wherein the metal layer covers the insulating structure and fills the groove; and polishing the surface of the metal layer, wherein the insulating structure, the protective layer, and the metal layer form a metal gate with a planarized surface.

Abstract: Methods, apparatus, systems, and articles of manufacture are disclosed to automatically process an image based on a detection of a face mask. An example article of manufacture include instructions that, when executed, cause programmable circuitry to at least: map a characteristic of an upper area of a face of a person in an image to a color plot including a face skin tone cone; map a characteristic of a lower area of the face to the color plot; and identify a presence or an absence of a face mask based on the respective positions of the characteristic of the upper area and the characteristic of the lower area relative to the skin tone cone.

Abstract: A media server receives an audio stream of a conference speaker and an audio stream interpreted based on the audio stream, sends the interpreted audio stream to an artificial intelligence (AI) device to identify a language of the interpreted audio stream, and forwards the interpreted audio stream to a corresponding terminal based on an identification result.

Abstract: A variable light transmission device is disclosed that mitigates negative aperture diffraction effects and shows good switching speed between the open and the closed optical states. The device comprises a microcell layer disposed between two light transmissive electrode layers, the microcell layer having a plurality of microcells, each microcell including an electrophoretic medium, each microcell comprising a protrusion structure, the protrusion structure having one or more wells.

Abstract: A variable light transmission device is disclosed that mitigates negative aperture diffraction effects and shows good switching speed between the open and the closed optical states. The device comprises a microcell layer disposed between two light transmissive electrode layers, the microcell layer having a plurality of microcells, each microcell including an electrophoretic medium, and each microcell comprising a channel, a protrusion structure, the protrusion structure comprising a conoid geometric solid.

Abstract: A variable light transmission device is disclosed that mitigates negative aperture diffraction effects and shows good switching speed between the open and the closed optical states. The device comprises a microcell layer disposed between two light transmissive electrode layers, the microcell layer having a plurality of microcells, each microcell including an electrophoretic medium. And each microcell comprises a protrusion structure and a channel.