Abstract: A variable light transmission device is disclosed, the variable light transmission device comprising two light transmissive electrode layer and a microcell layer having a plurality of microcells. Each of the plurality of microcells includes a first type of electrically charged pigment particles and a second type of electrically charged pigment particles, a charge control agent, and a non-polar liquid. Upon application of an electric field, the amount of light passing through the device can be modulated.

Abstract: The present invention relates to the fields of treating autoimmune diseases and molecular immunology, and specifically, to an anti-IL-17A antibody, a pharmaceutical composition thereof, and use thereof. More specifically, the present invention relates to a monoclonal antibody or an antigen binding fragment thereof, wherein a heavy chain variable region of the monoclonal antibody comprises: HCDR1-HCDR3 with amino acid sequences set forth in SEQ ID NOs: 31-33 respectively, or HCDR1-HCDR3 with amino acid sequences set forth in SEQ ID NOs: 37-39 respectively, and a light chain variable region of the monoclonal antibody comprises: LCDR1-LCDR3 with amino acid sequences set forth in SEQ ID NO: 34, KVS, and SEQ ID NO: 36, respectively, or LCDR1-LCDR3 with amino acid sequences set forth in SEQ ID NO: 40, LVS, and SEQ ID NO: 42, respectively.

Abstract: An anti-CTLA4 (cytotoxic T lymphocyte associated antigen4) and anti-PD-1 (programmed cell death 1) bifunctional antibody. a pharmaceutical composition thereof and use thereof. Particularly, the anti-CLTA4 and anti-PD-1 bifunctional antibody comprises a first protein functional domain that targets PD-1 and a second protein functional domain that targets CTLA-4. The bifunctional antibody can bind to CTLA-4 and PD-1 specifically, relieve immunosuppression of CTLA4 and PD-1 on an organism specifically, activate T lymphocytes, and thus has good application prospects.

Abstract: The present disclosure relates to a system and method for generating Computer-Aided Design (CAD) models from natural language descriptions utilizing Large Language Models (LLMs). A universal text-based representation of CAD models is provided, encoding complete Boundary Representation (B-Rep) information. A pre-trained LLM is fine-tuned using a dataset comprising paired natural language descriptions of CAD model creation processes and corresponding universal text-based representations. The fine-tuned LLM converts natural language descriptions into the universal text-based representations, which are subsequently converted into CAD models. The system incorporates solver-based grounding to ensure geometric and topological accuracy and employs Reinforcement Learning from Human Feedback (RLHF) to refine model alignment with expert-defined best practices.

Abstract: The present invention relates to an anti-PCSK9 antibody preparation and use thereof in medicine. The preparation contains an anti-PCSK9 antibody and a buffer solution. The anti-PCSK9 antibody preparation can effectively inhibit the aggregation of the anti-PCSK9 antibody, thereby preventing the degradation of an antibody product and obtaining a stable injectable pharmaceutical preparation.

Abstract: A pharmaceutical composition comprising an anti-CTLA4-anti-PD-1 bispecific antibody, comprising an anti-CTLA4-anti-PD-1 bispecific antibody, gemcitabine, and optionally paclitaxel (e.g., albumin-bound paclitaxel). The pharmaceutical composition has a good anti-tumor effect.

Abstract: The present disclosure provides a head-mounted device, including: a host; and a wearing apparatus connected to the host, wherein an acoustical device and a wire harness are disposed in the wearing apparatus, and the wire harness is configured to supply power to the host. The wearing apparatus further includes a spacer layer which is between the acoustical device and the wire harness, and the spacer layer is a high magnetic permeability material layer.

Abstract: A variable light transmission device is disclosed and a method of manufacture of the same. The variable light transmission device comprises two light transmissive electrodes and a microcell layer having a plurality of microcells, each microcell comprising a protrusion structure and a channel, and including an electrophoretic medium. The opacity of the device is controlled by an applied electric field.

Abstract: A method for reducing metal gate corrosion defects is provided. A thicker second hard mask layer is formed at the chamfer on top edge of the isolation layer between the PMOS and NMOS regions, wherein the chamfer sloping toward the NMOS region, as the deposition process creates a thicker layer around step corners. By precisely controlling the etching thickness during subsequent steps, the second hard mask layer in flat regions is removed, while the second hard mask layer at the chamfer is only partially removed, so the remaining second hard mask layer at the chamfer protects the chamfer, reducing the risk of wet cleaning solution penetrating into the metal gate during subsequent wet cleaning of the groove. The present invention addresses corrosion defects caused by chemical reactions between wet cleaning solutions and metal materials such as aluminum, significantly enhancing the performance and reliability of the semiconductor structure.

Abstract: A switchable light modulator includes an electrophoretic medium for use in a window of an enclosure (e.g., a greenhouse or other building or a vehicle) for light attenuation and heat management. The electrophoretic medium can be driven among a plurality of optical states including: (a) a first set of optical states for reducing transmittance of thermal radiation from incident sunlight through the switchable light modulator into the enclosure, (b) a second set of optical states for promoting transmittance of thermal radiation from the incident sunlight through the switchable light modulator into the enclosure, and (c) a third set of optical states for reducing transmittance of thermal radiation out of the enclosure during nighttime operation.

Abstract: An HKMG device and a method for manufacturing same. By separately forming the first groove in the PMOS region and the second groove in the NMOS region, depositing the first filling layer in the PMOS region and the second filling layer in the NMOS region, then removing the first and second filling layers through a combination of dry and wet etching and filling the grooves with metal material to respectively form the PMOS and NMOS metal gates, this method allows for precise control over etching depth and range, preventing interface damage to the PMOS region; it eliminates chamfer formation at the junction, prevents wet etching solutions from penetrating the PMOS metal gate, and resolves corrosion defects caused by chemical reactions; furthermore, the PMOS and NMOS work function metal layers are formed stepwise, with chemical mechanical polishing ensuring a uniform surface, significantly enhancing the performance and reliability of the HKMG device.

Abstract: A method for forming a shared contact hole and a semiconductor structure is provided. First, the first hard mask layer is formed on the region where the shared contact hole needs to be formed on the gate structures. Then, the step-by-step etching process ensures that the etching endpoint stops on the first hard mask layer and the second hard mask layer during the etching of the first interlayer dielectric layer, thereby preventing over-etching of the metal gate and the generation of by-products. Subsequently, the first hard mask layer and the second hard mask layer are completely etched to expose portions of the active regions and the metal gate to finally form a shared contact hole. The conductive layer formed in the shared contact hole ensures sufficient contact between the active regions and the metal gate, ultimately improving the yield and reliability of the semiconductor device.

Abstract: Provided are an anti-CD47 monoclonal antibody and a use thereof, secreted by the hybridoma cell line with the deposit number CCTCC NO: C2018135.

Abstract: Chemical reactions are expedited by exploiting contact electrification at curved microscale interfaces between water and a hydrophobic medium. The hydrophobic medium can be a solid, liquid, or gas. The microscale-interfaces can be surfaces of water droplets in contact with a hydrophobic medium, such as a gas, liquid, or solid, or they can be surfaces of gas microbubbles in contact with water alone or with water containing solid or liquid hydrophobic particles.

Abstract: An ant-TIGIT antibody, and a pharmaceutical composition and the use thereof. The present invention relates to an anti-TIGIT antibody or an antigen-binding fragment thereof, wherein a heavy chain variable region of the antibody comprises HCDR1-HCDR3 having amino acid sequences as shown in SEQ ID NOs: 3-5, respectively; and a light chain variable region of the antibody comprises LCDR1-LCDR3 having amino acid sequences as shown in SEQ ID NOs: 8-10, respectively. The antibody can effectively bind to TIGIT and has the potential for use in tumor prevention and treatment.

Abstract: The present invention relates to an antibody for treating or preventing autoimmune diseases. The antibody of the present invention comprises a heavy chain variable region set forth in SEQ ID NO:1 or SEQ ID NO:24 and a light chain variable region set forth in SEQ ID NO:6, SEQ ID NO:11, SEQ ID NO:13, SEQ ID NO:15, SEQ ID NO:17 or SEQ ID NO:25.

Abstract: A variable light transmission device is disclosed, the variable light transmission device comprising two light transmissive electrode layer and a microcell layer having a plurality of microcells. Each of the plurality of microcells includes a first type of electrically charged pigment particles and a second type of electrically charged pigment particles, a charge control agent, and a non-polar liquid. Upon application of an electric field, the amount of light passing through the device can be modulated.

Abstract: A method, apparatus, non-transitory computer readable medium, and system for obtaining a query comprising a document request. A language generation model is configured to retrieve a first document based on the query and generate an expanded query based on the first document using a knowledge graph that connects the first document to a second document. A third document is retrieved based on the expanded query in response to the query.

Abstract: The present invention relates to the fields of treating autoimmune diseases and molecular immunology, and specifically, to an anti-IL-17A antibody, a pharmaceutical composition thereof, and use thereof. The present invention relates to a monoclonal antibody or an antigen binding fragment thereof, wherein a heavy chain variable region of the monoclonal antibody comprises: HCDR1-HCDR3 with amino acid sequences set forth in SEQ ID NOs: 31-33 respectively, or HCDR1-HCDR3 with amino acid sequences set forth in SEQ ID NOs: 37-39 respectively, and a light chain variable region of the monoclonal antibody comprises: LCDR1-LCDR3 with amino acid sequences set forth in SEQ ID NOs: 34-36 respectively, or LCDR1-LCDR3 with amino acid sequences set forth in SEQ ID NOs: 40-42 respectively. Monoclonal antibodies of the present invention can specifically antagonize the binding of IL-17A to a ligand and inhibit activation of fibroblasts by IL-17A.

Abstract: A backlight brightness adjustment circuit and a control method therefor, and a device are provided. The circuit comprises: a control end of a first switch component is connected to an output of an AND gate circuit, one end of the first switch component is connected to one end of a first resistor, and the other end of the first switch component is connected to ground; the other end of the first resistor is connected to a first input of a voltage comparator, one end of a second switch component, and one end of a second resistor, and the other end of the second resistor is connected to the ground. Stepless adjustment of the backlight brightness is achieved and the backlight brightness adjustment experience is improved.