Abstract: The present application relates to the fields of tumor treatment and molecular immunology, and specifically, to an anti-VEGFA/PD-1 bifunctional antibody, a pharmaceutical composition thereof and use thereof. Specifically, the anti-VEGFA/PD-1 bifunctional antibody comprises a first protein functional region targeting VEGFA and a second protein functional region targeting PD-1. The bifunctional antibody can specifically bind to VEGFA and PD-1, specifically relieve immunosuppression of VEGFA and PD-1 in an organism, and inhibit tumor-induced angiogenesis, thus having good application prospect.

Abstract: A media server receives an audio stream of a conference speaker and an audio stream interpreted based on the audio stream, sends the interpreted audio stream to an artificial intelligence (AI) device to identify a language of the interpreted audio stream, and forwards the interpreted audio stream to a corresponding terminal based on an identification result.

Abstract: Provided are an anti-PCSK9 antibody and a use thereof preferably for the treatment of hypercholesterolemia.

Abstract: A high-performance multilayer film for packaging, the structure being: BL/TIE/PO1/POX/PO3, obtained once by multilayer coextrusion and biaxial stretching, wherein: the total thickness of the multilayer film is 8 to 100 micrometers; the absolute value of the difference of the solubility parameters between the PO1 and PO3 layer materials is ?0.1 and ?0.5, and the absolute value of the difference of the cohesive energy density is ?3, and ?5; the solubility parameter and cohesive energy density of the POX bridge material are based on one of the PO1 and PO3 layer materials, and it's transitioned to the other in a gradient way; the absolute value of the difference of the solubility parameters between adjacent layers from the PO1 layer to the POX bridge and the PO3 layer is ?0.1 (J·cm?3)1/2, and the absolute value of the difference of the cohesive energy density is ?3 J/cm3).

Abstract: The present invention relates to an anti-human interleukin-4-receptor A antibody, a pharmaceutical composition or a kit comprising the antibody, and use thereof.

Abstract: The present invention discloses a monoclonal antibody against nerve growth factor, and an encoding gene and use thereof. The monoclonal antibody against nerve growth factor of the present invention comprises heavy chains comprising a heavy chain constant region and a heavy chain variable region, and light chains comprising a light chain constant region and a light chain variable region. The heavy chain variable region comprises three complementarity determining regions HCDR1, HCDR2 and HCDR3, and the light chain variable region comprises three complementarity determining regions LCDR1, LCDR2 and LCDR3.

Abstract: Mesogenic compounds having a structure of Formula (I), (II) or (III): where A, B, X1, L, TG, m, and n are defined as in claim 1. Compositions containing these compounds, articles made from these polymerized and prepolymerized compositions, and methods of estimating the elastic constants and anchoring constants of a liquid crystal materials and mapping topological defect structures in liquid crystals using these compounds.

Abstract: Provided in the present invention are an anti-CD73 antibody and the use thereof. Specifically, a heavy chain variable region of the antibody contains HCDR1 to HCDR3 having amino acid sequences as shown in SEQ ID NOs: 15-17, respectively. Furthermore, a light chain variable region of the antibody contains LCDR1 to LCDR3 having amino acid sequences as shown in SEQ ID NOs: 18-20, respectively.

Abstract: Provided are an anti-CD73-anti-PD-1 bispecific antibody, a pharmaceutical composition thereof and a use thereof.

Abstract: The invention provides an adaptive manifold probability distribution-based bearing fault diagnosis method, including constructing transferable domains and transfer tasks; converting a data sample in each transfer task into frequency domain data via Fourier transform, inputting the frequency domain data into a GFK algorithm model, and calculating a manifold feature representation matrix related to a bearing fault in each transfer task by using the GFK algorithm model; calculating a cosine distance between centers of a target domain and a source domain in each transfer task according to a manifold feature representation, and defining a target function of in-domain classifier learning; then solving the target function, to obtain a probability distribution matrix of the target domain; and selecting a label corresponding to the largest probability value corresponding to each data sample in the target domain from the probability distribution matrix as a predicted label of the data sample in the target domain.

Abstract: The present invention relates to a method of insulating a motor, comprising: providing a impregnating resin; heating up the motor windings with electricity to 100-120° C., and potting the motor windings with the impregnating resin for 2-5 min at that temperature; heating up the motor windings with electricity to 140-160° C., and trickling the impregnating resin for 3-8 min for insulation; heating up the motor windings with electricity to 165-175° C., and curing for 15-45 min. The method of insulating a motor provided by the present invention has a higher resin filling level and a higher resin utilization rate, as well as faster curing speed.

Abstract: Provided is an ATF oil and corona-resistant enameled wire for electric vehicle motors, belonging to the insulating materials field. The ATF oil and corona-resistant enameled wire for electric vehicle motors comprises a copper conductor and an insulating layer, wherein said insulating layer from inside to outside is composed of ATF oil and corona-resistant protective film, corona-resistant PAI film, ATF oil and corona-resistant protective film, corona-resistant PAI film, ATF oil and corona-resistant protective film. The ATF oil and corona resistant enameled wire of this disclosure is suitable for the preparation of oil-cooled electric vehicle motor loose winding coil due to the advantages of good manufacturability, excellent ATF oil and corona resistance, and low manufacturing cost.

Abstract: The present invention belongs to the fields of tumor therapy and molecular immunology, and provides an anti-CTLA4 monoclonal antibody or antigen binding fragment thereof, a pharmaceutical composition thereof and use thereof. The monoclonal antibody of the present invention can block the binding of CLTA4 to B7, relieve the immunosuppression on the body by CTLA4, and activate T lymphocytes.

Abstract: The present application provides a metal gate structure of a high-voltage device and a method for making the same, forming a dummy gate on the gate oxide layer, wherein the dummy gate is composed of a plurality of polysilicon structures spaced apart from each other; forming a protective layer on sidewalls of the plurality of polysilicon structures and on the gate oxide layer between the polysilicon structures; performing covering with an insulating layer to fill a region between the polysilicon structures, wherein the filled region forms an insulating structure; removing the polysilicon structure to form a groove; forming a metal layer, wherein the metal layer covers the insulating structure and fills the groove; and polishing the surface of the metal layer, wherein the insulating structure, the protective layer, and the metal layer form a metal gate with a planarized surface.

Abstract: Disclosed are a corona-resistant enameled round wire and preparation method therefor. The corona-resistant enameled round wire is suitable for electric vehicle motors and comprises a copper conductor and an insulating layer, wherein the insulating layer clads the copper conductor and comprises, in sequence from inside to outside, a corona-resistant polyamideimide coating, a corona-resistant special resin coating, a corona-resistant polyimide coating, a corona-resistant modified silicone resin coating, and a corona-resistant polyamideimide coating.

Abstract: An anti-CTLA4 (cytotoxic T lymphocyte associated antigen 4) and anti-PD-1 (programmed cell death 1) bifunctional antibody. a pharmaceutical composition thereof and use thereof. Particularly, the anti-CLTA4 and anti-PD-1 bifunctional antibody comprises a first protein functional domain that targets PD-1 and a second protein functional domain that targets CTLA-4. The bifunctional antibody can bind to CTLA-4 and PD-1 specifically, relieve immunosuppression of CTLA4 and PD-1 on an organism specifically, activate T lymphocytes, and thus has good application prospects.

Abstract: Photocurable compositions that combine redox-active semiconducting organic polymers with photocurable organic molecules are provided. Upon exposure to radiation, the photocurable compositions form ion-permeable, electrically conductive crosslinked organic films that can be used as conducting channels in n-channel or p-channel organic electrochemical transistors, including vertical organic electrochemical transistors (vOECTs). The vOECTs can be incorporated in complementary electronic circuits.

Abstract: Provided are an anti-VEGFA-anti-PD-1 bispecific antibody and a use thereof. Specifically, the anti-VEGFA-anti-PD-1 bispecific antibody comprises: a PD-1-targeted first protein functional region and a VEGFA-targeted second protein functional region. According to an EU numbering system, mutation occurs at two positions of positions 234 and 235 of a heavy chain constant region of the immunoglobulin contained in the bispecific antibody, and after the mutation, an affinity constant of the bispecific antibody with Fc?RI, Fc?RIIa, Fc?RIIIa, and/or C1q is decreased compared to that before the mutation. The bispecific antibody can specifically bind to VEGFA and PD-1, specifically relieve immunosuppression of VEGFA and PD-1 on an organism, and inhibit tumor-induced angiogenesis, and thus has good application prospects.

Abstract: A degradable EVOH high-barrier composite film, characterized in that the materials of various layers in the composite film all obtain approximately-consistent biodegradability by introducing biomass, and the additive amount of the additive master batch in the materials of each layer is controlled within the range of 0.3-15% of the total mass of the materials of the corresponding layer; the hydrophilic activity of the hydrophilic groups in the additive master batch should be greater than or equal to that of the hydrophilic groups in the materials of each layer; by adding the additive master batch, the mole ratios of the hydrophilic groups to carbon atoms of the materials of various layers tend to be consistent, namely, the bioactivities tend to be consistent, so that the degradation rates of the materials of various layers in the composite film tend to be consistent.

Abstract: The invention provides an adaptive manifold probability distribution-based bearing fault diagnosis method, including constructing transferable domains and transfer tasks; converting a data sample in each transfer task into frequency domain data via Fourier transform, inputting the frequency domain data into a GFK algorithm model, and calculating a manifold feature representation matrix related to a bearing fault in each transfer task by using the GFK algorithm model; calculating a cosine distance between centers of a target domain and a source domain in each transfer task according to a manifold feature representation, and defining a target function of in-domain classifier learning; then solving the target function, to obtain a probability distribution matrix of the target domain; and selecting a label corresponding to the largest probability value corresponding to each data sample in the target domain from the probability distribution matrix as a predicted label of the data sample in the target domain.