Abstract: A pharmaceutical composition comprising an anti-TIGIT antibody or an antigen-binding fragment thereof, and an anti-CTLA4-anti-PD-1 bispecific antibody or an antigen-binding fragment thereof. Specifically, a heavy chain variable region of the antibody contains HCDR1-HCDR3 having amino acid sequences as shown in SEQ ID NOs: 3-5, respectively, and a light chain variable region contains LCDR1-LCDR3 having amino acid sequences as shown in SEQ ID NOs: 8-10, respectively.

Abstract: A method of performing a matrix multiplication operation based on a convolution operation includes the following steps: (A) reading a first data from a first storage device and storing the first data in a second storage device; (B) reading a second data from the first storage device and storing the second data in the second storage device; (C) performing the convolution operation on the first data and the second data to obtain a first result; and (D) storing the first result in the first storage device. The first result is equal to a second result obtained by performing the matrix multiplication operation on the first data and the second data.

Abstract: A rotary body dynamic balance detection and correction device, comprising a detection assembly and a machining correction assembly. The detection assembly is configured to detect the amount of unbalance of a rotary body. The machining correction assembly is configured to machine an outer peripheral face of the rotary body to form a correction hole, so that the value of the amount of unbalance of the machined rotary body does not exceed the value of a preset maximum amount of unbalance. The rotary body dynamic balance detection and correction device can effectively correct the amount of unbalance of the rotary body, reduce the degree of unbalance of the rotary body, and avoid excessive lateral vibration generated when the rotary body rotates at a high speed. A rotary body dynamic balance detection and correction method and a numerical control tool holder are also provided.

Abstract: Various embodiments of the teachings herein include a method for optimizing operation of a transformer substation with transformers connected or disconnected by switches. The method may include: acquiring a current load of each transformer, and predicting loads for each in various operating modes in some time periods based on current loads; calculating transformer costs for each time period based on predicted loads including transformer losses and operation costs; calculating switch costs based on purchase cost and service life for a switch corresponding to each transformer; and calculating a total cost in a total time period using the transformer costs and the switch costs, optimizing the total cost to obtain optimization parameters, and operating the transformer substation according to the optimization parameters, the total time period consisting of the plurality of time periods.

Abstract: The present disclosure provides an extended reality device and a control method thereof. The extended reality device includes: a front part and a rear part; the front part comprising: a display module, configured to display extended reality image; the rear part comprising: a system controller connected to the display module and configured to control operation of the display module; a battery connected to the system controller and configured to supply power to each electrical device. Through the above solution, transferring the system controller and the battery to the rear part setting, so that the weight of the front part of the extended reality device is significantly reduced, the thickness of the front part is significantly reduced, the weight of the rear part and the front part can be balanced, there is no bias when user wears the extended reality device, which improves the user's wearing comfort.

Abstract: An anti-PDl (programmed cell death 1) monoclonal antibody or an antigen-binding fragment thereof, a pharmaceutical composition thereof and use thereof. The heavy chain variable region of the monoclonal antibody comprises CDRs (complementary determining region) of amino acid sequences as shown in SEQ ID NO:9-11; and/or the light chain variable region of the monoclonal antibody comprises CDRs of amino acid sequences as shown in SEQ ID NO: 12-14. The monoclonal antibody can bind to PDl specifically, relieve immunosuppression of PDl on an organism specifically and activate T lymphocytes.

Abstract: Techniques are provided for a camera control system with reduced power consumption. A system implementing the techniques according to an embodiment includes a scene change tracker configured to quantify a level of change between current and previous image frames provided by the camera. The system also includes a general purpose processor to generate camera control parameters using a first processing algorithm, based on the current and previous image frames, if the level of change exceeds a threshold. The system further includes an image signal processor to generate the camera control parameters using a second processing algorithm, based on the current and previous image frames, if the level of change is less than or equal to the threshold. The image signal processor consumes less power than the general purpose processor and the second processing algorithm is less computationally complex than the first processing algorithm.

Abstract: This application provides an integrated circuit device and a preparation method thereof, and relates to the field of semiconductor technologies. An isolation section for suppressing a leakage current path of two adjacent transistors may be formed by using a simple process. The integrated circuit device includes a substrate and a fin protruding from the substrate. The integrated circuit device further includes two adjacent transistors. The two adjacent transistors use two spaced segments on the fin as respective channels of the two adjacent transistors. A part that is of the fin and that is located between the two spaced segments is processed to obtain an isolation section. The isolation section is used to suppress current transfer between the two channels of the two adjacent transistors.

Abstract: A method, system, and article provide unified automatic white balancing for multi-image processing.

Abstract: Multi-state switchability is highly desirable in optoelectronic devices. For liquid crystal (LC) based devices, the stability of any configuration is achieved through a balance between imposed interactions and the LC's orientational elasticity. In most cases, the latter acts to resist deformation. By combining surface topography and chemical patterning, provided here are the effects of saddle-splay orientational elasticity, a property that, despite being intrinsic to all LCs, is routinely suppressed. Utilizing theory and continuum elastic calculations, provided here are example conditions for which, even using generic, achiral LC materials, spontaneously broken surface symmetries develop. Also provided are multi-stable devices in which a weak, but directional, applied field switches between spontaneously-polar surface state domains. The disclosed approach is useful in low-field and fast-switching optoelectronic devices, beyond those attainable by current technologies.

Abstract: A variable light transmission device is disclosed, the variable light transmission device comprising two light transmissive electrode layer and a microcell layer having a plurality of microcells. Each of the plurality of microcells includes a first type of electrically charged pigment particles and a second type of electrically charged pigment particles, a charge control agent, and a non-polar liquid. Upon application of an electric field, the amount of light passing through the device can be modulated.

Abstract: The present disclosure relates to an anti-CD73 antibody and application thereof in treating diseases caused by coronavirus infection. Specifically, a heavy chain variable region of the antibody contains amino acid sequences such as HCDR1-HCDR3 as shown in SEQ ID NOs:15-17; and the light chain variable region of the antibody contains amino acid sequences such as LCDR1-LCDR3 as shown in SEQ ID NOs: 18-20.

Abstract: A variable light transmission device is disclosed and a method of manufacture of the same. The variable light transmission device comprises two light transmissive electrodes and a microcell layer having a plurality of microcells, each microcell comprising a protrusion structure and a channel, and including an electrophoretic medium. The opacity of the device is controlled by an applied electric field.

Abstract: A variable light transmission device is disclosed and a method of operation of the same. The method of operation of a variable light transmission device comprises the step of (a) providing a variable light transmission device comprising a microcell layer having a plurality of microcells, each microcell comprising a protrusion structure and a channel, and including an electrophoretic medium, (b) applying a first electric field across the microcell layer to an open optical state, and (c) applying a second electric field across the microcell layer to an closed optical state, the closed optical state having lower percent light transmission than the open optical state.

Abstract: The present invention relates to a bispecific antibody against CTLA4 and PD-1, wherein the antibody is used for treating tumors, is administered in combination with an anti-VEGFR2 monoclonal antibody or an anti-VEGF monoclonal antibody, and comprises a first protein functional region targeting PD-1 and a second protein functional region targeting CTLA4, the first protein functional region being an immunoglobulin and the second protein functional region being a single-chain antibody, or the first protein functional region being a single-chain antibody and the second protein functional region being an immunoglobulin.

Abstract: Provided are antibodies or antigen binding fragments thereof, which can bind to human IL-1?, block the binding of IL-1? to receptors thereof and thereby down regulate the activity of IL-1?, and can be used to prepare drugs for the treatment of immune diseases mediated by IL-1? overexpression such as arthritis, osteoporosis, and tumor necrosis factor receptor-associated periodic syndrome.

Abstract: The present invention belongs to the field of tumor treatment and molecular immunology, and specifically relates to a therapeutic combination and use thereof. Specifically, the therapeutic combination comprises an anti-CTLA4-anti-PD-1 bispecific antibody and an anti-PD-1-anti-VEGFA bispecific antibody. The therapeutic combination of the present invention can effectively treat or prevent a tumor and has good application prospects.

Abstract: A reshaping method for metal product includes acquiring position data information of a workpiece; converting the position data information into coordinate information, and fitting the coordinate information to obtain a surface contour curve of the workpiece; comparing the surface contour curve with a standard contour curve to generate a comparison result; obtaining reshaping information of the workpiece based on the comparison result; and controlling the reshaping system to reshape the workpiece. The disclosure acquires position data information of the workpiece by measuring, converts the position data information into coordinate information, fits the coordinate information to obtain the surface contour curve of the workpiece, compares the surface contour curve with the standard contour curve to obtain deformation situation, and reshapes the workpiece according to the reshaping information based on the deformation situation, which improves efficiency of workpiece reshaping and reducing labor costs.