Patents by Inventor Yu Xia

Yu Xia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PDL-1 antibody, pharmaceutical composition thereof, and uses thereof
    Patent number: 10465014
    Abstract: The present invention belongs to the field of tumor therapy and molecular immunology, and relates to a PDL-1 antibody, a pharmaceutical composition thereof and use thereof. In particular, the present invention relates to a PDL-1 monoclonal antibody or an antigen-binding fragment thereof, wherein the monoclonal antibody has a heavy chain variable region comprising CDRs as set forth in SEQ ID NOs: 15-17; and/or has a light chain variable region comprising CDRs as set forth in SEQ ID NOs: 18-20. The monoclonal antibody of the present invention can bind to PDL-1 specifically, and specifically remove immunosuppressive function of PDL-1 and activate T lymphocytes.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: November 5, 2019
    Assignee: SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.
    Inventors: Baiyong Li, Tongtong Xue, Yu Xia, Zhongmin Maxwell Wang, Liang Xiao, Lichun Wang, Jingyi Wang
  • MONOCLONAL ANTIBODY AGAINST PD-1 AND APPLICATION THEREOF
    Publication number: 20190330347
    Abstract: Provided is a monoclonal antibody against programmed death-1 (PD-1) or applications thereof, where the monoclonal antibody against PD-1 comprises a neonatal Fc Receptor (FcRn)-binding site having an amino acid sequence of SEQ ID NO: 5.
    Type: Application
    Filed: July 12, 2019
    Publication date: October 31, 2019
    Inventors: Faming ZHANG, Gan XI, Ying HUANG, Yu XIA, Baiyong LI, Zhongmin Maxwell WANG
  • ANTI-PD1 MONOCLONAL ANTIBODY, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF
    Publication number: 20190321466
    Abstract: An anti-PD1 (programmed cell death 1) monoclonal antibody or an antigen-binding fragment thereof, a pharmaceutical composition thereof and use thereof. The heavy chain variable region of the monoclonal antibody comprises CDRs (complementary determining region) of amino acid sequences as shown in SEQ ID NO:9-11; and/or the light chain variable region of the monoclonal antibody comprises CDRs of amino acid sequences as shown in SEQ ID NO: 12-14. The monoclonal antibody can bind to PD1 specifically, relieve immunosuppression of PD1 on an organism specifically and activate T lymphocytes.
    Type: Application
    Filed: August 22, 2017
    Publication date: October 24, 2019
    Inventors: Baiyong LI, Yu XIA, Zhongmin Maxwell WANG, Peng ZHANG
  • Anti-CTLA4 monoclonal antibody or its antigen binding fragments, pharmaceutical compositions and uses
    Patent number: 10449251
    Abstract: The present invention belongs to the fields of tumor therapy and molecular immunology, and provides an anti-CTLA4 monoclonal antibody or antigen binding fragment thereof, a pharmaceutical composition thereof and use thereof. The monoclonal antibody of the present invention can block the binding of CTLA4 to B7, relieve the immunosuppression on the body by CTLA4, and activate T lymphocytes.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: October 22, 2019
    Assignee: AKESO BIOPHARMA, INC.
    Inventors: Baiyong Li, Yu Xia, Zhongmin Wang, Peng Zhang, Xinghua Pang
  • ANTI-CTLA4 AND ANTI-PD-1 BIFUNCTIONAL ANTIBODY, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF
    Publication number: 20190185569
    Abstract: An anti-CTLA4 (cytotoxic T lymphocyte associated antigen 4) and anti-PD-1 (programmed cell death 1) bifunctional antibody. a pharmaceutical composition thereof and use thereof. Particularly, the anti-CLTA4 and anti-PD-1 bifunctional antibody comprises a first protein functional domain that targets PD-1 and a second protein functional domain that targets CTLA-4. The bifunctional antibody can bind to CTLA-4 and PD-1 specifically, relieve immunosuppression of CTLA4 and PD-1 on an organism specifically, activate T lymphocytes, and thus has good application prospects.
    Type: Application
    Filed: August 22, 2017
    Publication date: June 20, 2019
    Inventors: Baiyong LI, Yu XIA, Zhongmin Maxwell WANG, Peng ZHANG
  • ANTI-CTLA4 ANTIBODIES
    Publication number: 20190177414
    Abstract: The present invention belongs to the fields of tumor therapy and molecular immunology. The present invention relates to an anti-CTLA4 antibody, pharmaceutical composition and use thereof. The anti-CTLA4 antibody of the present invention can specifically bind CTLA4, and can very effectively block the binding of CLTA4 to B7.
    Type: Application
    Filed: August 21, 2017
    Publication date: June 13, 2019
    Applicant: Akeso Biopharma, Inc.
    Inventors: Baiyong LI, Yu XIA, Peng ZHANG, Xinghua PANG, Zhongmin WANG
  • Semiconductor Package Structure and Semiconductor Package Structure Fabricating Method
    Publication number: 20190181108
    Abstract: A semiconductor package structure includes a connection pad disposed on a semiconductor component. A protective layer includes a first non-conductive material, a first part, and a second part. The first part covers the semiconductor component except the connection pad, a surface of the first part is at a first height, the second part covers a periphery of the connection pad, a surface of the second part is at a second height, the first height is less than the second height, a middle part of the connection pad is exposed, and the first part and the second part are connected at an edge of the connection pad.
    Type: Application
    Filed: February 19, 2019
    Publication date: June 13, 2019
    Inventors: Cheng Ting Chen, Sheng Chieh Chang, Yu Xia
  • SOFTWARE ASSET MANAGEMENT
    Publication number: 20190163456
    Abstract: Systems and methods are disclosed for provisioning software in computing networks. For example, methods may include invoking one or more discovery probes; retrieving software usage data based at least on the one or more discovery probes; determining software usage predictions based on the software usage data; allocating, based on the software usage predictions, per user software entitlements and per device software entitlements to obtain an allocation of software entitlements; and invoking installation or uninstallation of software responsive to the allocation of software entitlements.
    Type: Application
    Filed: November 16, 2018
    Publication date: May 30, 2019
    Inventors: Apolak Borthakur, Manish Srivastava, Yu Xia
  • ELECTRONIC DEVICE BASED ON TWO-DIMENSIONAL SEMICONDUCTOR AND METHOD FOR MANUFACTURING ELECTRONIC DEVICE
    Publication number: 20190139835
    Abstract: In embodiments of the present disclosure, an ambient medium of a two-dimensional semiconductor is doped or an ambient medium of a semiconductor is locally filled with a solid material, to form a filled region, and an electronic device based on the two-dimensional semiconductor is implemented by means of a doping effect of the doped region or the filled region on a characteristic of the two-dimensional semiconductor. In the embodiments of the present disclosure, doping the two-dimensional semiconductor is not directly processing the two-dimensional semiconductor. Therefore, damage caused to the two-dimensional semiconductor in a doping process and device performance deterioration caused accordingly can be effectively reduced, and stability of device performance after doping is improved.
    Type: Application
    Filed: January 3, 2019
    Publication date: May 9, 2019
    Inventors: Wen Yang, Riqing Zhang, Yu Xia
  • Anti-PD-1 monoclonal antibody
    Publication number: 20190040138
    Abstract: Proposed is an anti-PD-1 monoclonal antibody or an antigen binding fragment thereof, comprising a heavy chain variable region having at least one of the amino acid sequences listed below: (1) the amino acid sequence shown in SEQ ID NO: 1; (2) the amino acid sequence shown in SEQ ID NO: 3; (3) the amino acid sequence shown in SEQ ID NO: 5; and (4) an amino acid sequence having more than one conservative amino acid mutation compared with (1)-(3).
    Type: Application
    Filed: September 28, 2018
    Publication date: February 7, 2019
    Inventors: Yu Xia, Baiyong Li, Zhongmin Maxwell Wang, Faming Zhang, Gan Xi, Ying Huang
  • Phase-inverted clock generation circuit and register
    Patent number: 10164613
    Abstract: A phase-inverted clock generation circuit is provided, where sources of a first PMOS and a second PMOS are connected to a power source, drains of the first PMOS and the second PMOS are connected to a source of a third PMOS, and a drain of the third PMOS is connected to a drain of a third NMOS; and the drain of the third PMOS is connected to a drain of a second NMOS, a source of the second NMOS is connected to a drain of a first NMOS, and a source of the first NMOS and a source of the third NMOS.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: December 25, 2018
    Assignee: Huawei Technologies Co., Ltd
    Inventors: Qi Chen, Jianfu Zhong, Qiuling Zeng, Yu Xia
  • Systems and Methods for Detecting Current Transformer Ultrasaturation to Enhance Relay Security and Dependability
    Publication number: 20180364290
    Abstract: Methods and systems to prevent relay misoperation and enhance relay dependability during ultrasaturation is disclosed. An ultrasaturation detection system may identify an ultrasaturation condition by comparing a differential current to a first and second derivative of the differential current. When an ultrasaturation condition is determined to be present, the ultrasaturation detection system may provide parameters to a relay to prevent misoperation and enhance relay dependability.
    Type: Application
    Filed: June 14, 2017
    Publication date: December 20, 2018
    Applicant: Schweitzer Engineering Laboratories, Inc.
    Inventor: Yu Xia
  • Software asset management
    Patent number: 10152314
    Abstract: Systems and methods are disclosed for provisioning software in computing networks. For example, methods may include invoking one or more discovery probes; retrieving software usage data based at least on the one or more discovery probes; determining software usage predictions based on the software usage data; allocating, based on the software usage predictions, per user software entitlements and per device software entitlements to obtain an allocation of software entitlements; and invoking installation or uninstallation of software responsive to the allocation of software entitlements.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: December 11, 2018
    Assignee: ServiceNow, Inc.
    Inventors: Apolak Borthakur, Manish Srivastava, Yu Xia
  • SOFTWARE ASSET MANAGEMENT
    Publication number: 20180321927
    Abstract: Systems and methods are disclosed for provisioning software in computing networks. For example, methods may include invoking one or more discovery probes; retrieving software usage data based at least on the one or more discovery probes; determining software usage predictions based on the software usage data; allocating, based on the software usage predictions, per user software entitlements and per device software entitlements to obtain an allocation of software entitlements; and invoking installation or uninstallation of software responsive to the allocation of software entitlements.
    Type: Application
    Filed: May 5, 2017
    Publication date: November 8, 2018
    Inventors: Apolak Borthakur, Manish Srivastava, Yu Xia
  • FUZZY MATCHING FOR COMPUTING RESOURCES
    Publication number: 20180322189
    Abstract: Systems and methods are disclosed for normalizing strings to identify computing resources and improve performance and utilization of computing resources. For example, methods may include determining a comparison length based on lengths of strings in a set of strings; padding a first string from the set of strings to the comparison length to obtain a padded string; receiving a second string; determining a distance between the second string and the padded string; and identifying a match between the first string and the second string based on the distance.
    Type: Application
    Filed: May 3, 2017
    Publication date: November 8, 2018
    Inventor: Yu Xia
  • SOFTWARE ASSET MANAGEMENT
    Publication number: 20180321928
    Abstract: Systems and methods are disclosed for provisioning software in computing networks. For example, methods may include invoking one or more discovery probes; retrieving software usage data based at least on the one or more discovery probes; determining software usage predictions based on the software usage data; allocating, based on the software usage predictions, per user software entitlements and per device software entitlements to obtain an allocation of software entitlements; and invoking installation or uninstallation of software responsive to the allocation of software entitlements.
    Type: Application
    Filed: March 29, 2018
    Publication date: November 8, 2018
    Inventors: Apolak Borthakur, Manish Srivastava, Yu Xia
  • COMPUTING RESOURCE IDENTIFICATION
    Publication number: 20180324198
    Abstract: Systems and methods are disclosed for computing network operations. For example, methods may include identifying one or more partial matches between a value associated with a configuration item and a value associated with one or more computing resource types from a set of computing resource types; forming a search query based on the one or more partial matches; invoking a search of one or more information sources using the search query to obtain ranked search results; selecting one computing resource type from the set of computing resource types based on a ranking of the search results; and updating the configuration item to associate the configuration item with the selected computing resource type.
    Type: Application
    Filed: May 3, 2017
    Publication date: November 8, 2018
    Inventors: Apolak Borthakur, Manish Srivastava, Yu Xia
  • PDL-1 ANTIBODY, PHARMACEUTICAL COMPOSITION THEREOF, AND USES THEREOF
    Publication number: 20180305464
    Abstract: The present invention belongs to the field of tumor therapy and molecular immunology, and relates to a PDL-1 antibody, a pharmaceutical composition thereof and use thereof. In particular, the present invention relates to a PDL-1 monoclonal antibody or an antigen-binding fragment thereof, wherein the monoclonal antibody has a heavy chain variable region comprising CDRs as set forth in SEQ ID NOs: 15-17; and/or has a light chain variable region comprising CDRs as set forth in SEQ ID NOs: 18-20. The monoclonal antibody of the present invention can bind to PDL-1 specifically, and specifically remove immunosuppressive function of PDL-1 and activate T lymphocytes.
    Type: Application
    Filed: March 2, 2017
    Publication date: October 25, 2018
    Inventors: Baiyong Li, Tongtong Xue, Yu Xia, Zhongmin Maxwell Wang, Liang Xiao, Lichun Wang, Jingyi Wang
  • METHODS FOR ANALYZING A TISSUE SAMPLE
    Publication number: 20180294148
    Abstract: The invention generally relates to methods for analyzing a tissue sample. In certain aspects, the invention provides methods that involve obtaining a tissue sample including an unsaturated compound, conducting a radical reaction on the tissue sample that targets a carbon-carbon double bond within the unsaturated compound to thereby produce a plurality of compound isomers, subjecting the plurality of compound isomers to mass spectrometry analysis to identify a location of the carbon-carbon double bond within the unsaturated compound, and quantifying the plurality of compound isomers in order to distinguish normal tissue from diseased tissue.
    Type: Application
    Filed: May 27, 2016
    Publication date: October 11, 2018
    Inventors: Zheng Ouyang, Yu Xia, Xiaoxiao Ma
  • DIRECT MAPPING OF LOCAL DIRECTOR FIELD OF NEMATIC LIQUID CRYSTALS AT THE NANOSCALE
    Publication number: 20180244995
    Abstract: The present disclosure is directed to mesogenic compounds having a structure of Formula (I), (II) or (III): where A, B, X1, L, TG, m, and n are defined herein, and compositions containing these compounds, as well as articles made from such polymerized and prepolymerized compositions and methods of estimating the elastic constants and anchoring constants of a liquid crystal materials and mapping topological defect structures in liquid crystals using these compounds.
    Type: Application
    Filed: February 18, 2016
    Publication date: August 30, 2018
    Inventors: Yu XIA, Randall D. KAMIEN, Shu YANG, Francesca SERRA, Kathleen J. Stebe