Patents by Inventor Yuan-Hao Liu
Yuan-Hao Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12238850Abstract: A neutron capture therapy system and a target material for a particle beam generation apparatus, the heat dissipation performance of a target material might be improved. A neutron capture therapy system includes a neutron generation apparatus and a beam shaping body, the neutron generation apparatus includes an accelerator and a target material, and a charged particle beam generated by means of acceleration of the accelerator acts with the target material to generate a neutron beam. The target material includes an active layer, an anti-foaming layer, a heat dissipation layer and a heat conduction layer, the active layer acts with a charged particle beam to generate a neutron beam; the anti-foaming layer suppresses foaming caused by the charged particle beam; the heat dissipation layer directly and rapidly conducts to the heat conduction layer, heat deposited on the active layer, and discharges by means of a cooling medium.Type: GrantFiled: January 16, 2024Date of Patent: February 25, 2025Assignee: NEUBORON THERAPY SYSTEM LTD.Inventors: Yuan-hao Liu, Chun-ting Lin
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Patent number: 12194316Abstract: A neutron capture therapy system and a target for a particle beam generating device, which may improve the heat dissipation performance of the target, reduce blistering and extend the service life of the target. The neutron capture therapy system includes a neutron generating device and a beam shaping assembly. The neutron generating device includes an accelerator and a target, and a charged particle beam generated by acceleration of the accelerator interacts with the target to generate a neutron beam. The target includes an acting layer, a backing layer and a heat dissipating structure, the acting layer interacts with the charged particle beam to generate the neutron beam, the backing layer supports the action layer, and the heat dissipating structure includes a tubular member composed of tubes arranged side by side.Type: GrantFiled: December 1, 2021Date of Patent: January 14, 2025Assignee: NEUBORON MEDTECH LTD.Inventors: Yuan-Hao Liu, Wei-Lin Chen
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Publication number: 20240431014Abstract: A neutron capture therapy system and a target material for a particle beam generation apparatus, the heat dissipation performance of a target material might be improved. A neutron capture therapy system includes a neutron generation apparatus and a beam shaping body, the neutron generation apparatus includes an accelerator and a target material, and a charged particle beam generated by means of acceleration of the accelerator acts with the target material to generate a neutron beam. The target material includes an active layer, an anti-foaming layer, a heat dissipation layer and a heat conduction layer, the active layer acts with a charged particle beam to generate a neutron beam; the anti-foaming layer suppresses foaming caused by the charged particle beam; the heat dissipation layer directly and rapidly conducts to the heat conduction layer, heat deposited on the active layer, and discharges by means of a cooling medium.Type: ApplicationFiled: August 13, 2024Publication date: December 26, 2024Inventors: Yuan-hao LIU, Chun-ting LIN
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Patent number: 12167953Abstract: An animal irradiation system includes a radioactive source and an irradiation fixing apparatus having irradiated bodies. The radioactive source includes a beam outlet having a first central axis. Radioactive rays generated by the radioactive source exit from the beam outlet and irradiate the irradiated bodies. The radioactive rays define a main axis around the first central axis. The irradiation fixing apparatus includes a box body, which is divided into multiple accommodating chambers around a second central axis. Each accommodating chamber accommodates an irradiated body. Multiple first irradiation holes corresponding to the accommodating chambers are formed on the box body. The radioactive rays pass through the first irradiation holes and then irradiate the irradiated bodies. A maximum distance from an inner wall of each first irradiation hole to the first central axis is less than a minimum distance from an inner wall of the beam outlet to the first central axis.Type: GrantFiled: October 27, 2022Date of Patent: December 17, 2024Assignee: NEUBORON MEDTECH LTD.Inventors: Dong-chun Wang, Yuan-hao Liu, Hong-feng Ji, Fa-zhi Yan
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Publication number: 20240325789Abstract: A radiation exposure system includes a radiation generation device, a control device, a simulation positioning chamber, an irradiation chamber, as well as same first and second placement platforms that are respectively arranged in the simulation positioning chamber and the irradiation chamber, and same first and second placement platforms positioning devices that support the first and second placement platforms. An irradiated object has the same position on the first and second placement platforms. A simulated positioning position of the first placement platform is determined in the simulation positioning chamber by means of the first placement platform positioning device. The second placement platform positioning device is controlled by the irradiation indoor control device to move the second placement platform to the simulated positioning position and determine the irradiation position of the second placement platform.Type: ApplicationFiled: June 12, 2024Publication date: October 3, 2024Inventors: Qiu-Ping GONG, Yuan-hao Liu
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Publication number: 20240261598Abstract: A neutron capture therapy system, comprising a charged particle beam generation portion, a beam transmission portion, and a neutron beam generation portion. The neutron beam generation portion comprises a target; the target interacts with a charged particle beam generated by the charged particle beam generation portion to generate a neutron beam; the neutron capture therapy system further comprises a charged particle beam generation chamber and a target replacement chamber; the charged particle beam generation chamber at least partially accommodates the charged particle beam generation portion and the beam transmission portion; the target replacement chamber is used for installing the target. By providing the target replacement chamber to install the target, the environment in the target replacement chamber can be set, so that the oxidation or nitridation of the target during an installation process is avoided, the operation is simple, and the cost is low.Type: ApplicationFiled: March 26, 2024Publication date: August 8, 2024Inventors: Yuan-Hao LIU, Chun-Ting LIN
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Publication number: 20240252842Abstract: A neutron dose measurement method and apparatus. The neutron dose measurement method comprises: determining a unit to be corrected that corresponds to a dose monitoring system (S10); on the basis of the number of rays emitted, after neutron activation, by a nonmetal unit to be activated, and the unit to corrected that corresponds to the dose monitoring system, determining a first correction factor (S20); and correcting the dose monitoring system on the basis of the first correction factor, so as to determine a real-time neutron dose of a patient (S30). By means of the present application, a first correction factor is determined to correct the sensitivity of a system, so as to determine a real-time neutron dose of a patient, so as to prevent a measurement error caused by a sensitivity reduction or a position change in the dose monitoring system, thereby improving the accuracy of a measurement result.Type: ApplicationFiled: March 22, 2024Publication date: August 1, 2024Inventors: Chao WANG, Yuan-hao Liu
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Publication number: 20240172354Abstract: A neutron capture therapy system and a target material for a particle beam generation apparatus, the heat dissipation performance of a target material might be improved. A neutron capture therapy system includes a neutron generation apparatus and a beam shaping body, the neutron generation apparatus includes an accelerator and a target material, and a charged particle beam generated by means of acceleration of the accelerator acts with the target material to generate a neutron beam. The target material includes an active layer, an anti-foaming layer, a heat dissipation layer and a heat conduction layer, the active layer acts with a charged particle beam to generate a neutron beam; the anti-foaming layer suppresses foaming caused by the charged particle beam; the heat dissipation layer directly and rapidly conducts to the heat conduction layer, heat deposited on the active layer, and discharges by means of a cooling medium.Type: ApplicationFiled: January 16, 2024Publication date: May 23, 2024Inventors: Yuan-hao LIU, Chun-ting Lin
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Patent number: 11986679Abstract: A neutron capture therapy system includes a neutron generation device for generating a neutron beam, an irradiation room for irradiating an irradiated body with the neutron beam and a placement table that is accommodated in the irradiation room and is adapted to support the irradiated body. The placement table includes a placement member for supporting a patient, an adjustment device for adjusting a spatial position of the placement member, a driving rod connected between the adjustment device and the placement member and a first shielding member covering the adjustment device. The first shielding member prevents the adjustment device from being radiated by radioactive rays. The adjustment device is disposed in the first shielding member that is basically sealed, thereby greatly reducing radiation damage to the adjustment device by neutrons and gamma rays and prolonging the service life of the adjustment device.Type: GrantFiled: November 4, 2020Date of Patent: May 21, 2024Assignee: NEUBORON THERAPY SYSTEM LTD.Inventor: Yuan-Hao Liu
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Publication number: 20230372740Abstract: A neutron-capture therapy system includes a charged particle beam generation unit, a beam transmission unit and a neutron beam generation unit. The charged particle beam generation unit includes an ion source and an accelerator. The accelerator accelerates charged particles generated by the ion source, so as to obtain a charged particle beam of the required energy. The neutron beam generation unit includes a target, a beam shaping body and a collimator. The charged particle beam irradiates onto the target through the beam transmission unit to generate neutrons, which sequentially pass through the beam shaping body and the collimator to form a neutron beam for therapy. The neutron-capture therapy system is accommodated in a concrete building including an irradiation room, an accelerator chamber and a beam transmission chamber. The neutron beam generation unit is at least partially accommodated in a partition wall of the irradiation chamber and the beam transmission chamber.Type: ApplicationFiled: August 4, 2023Publication date: November 23, 2023Inventors: Yuan-Hao LIU, Wei-Hua LU, Qiu=Ping GONG, Hao-lei XU
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Publication number: 20230277874Abstract: A neutron capture therapy device and a corresponding correction method for a neutron capture therapy device. The neutron capture therapy device comprises a neutron dose measurement apparatus (21) and a correction system (3) for correcting the neutron dose measurement apparatus (21), wherein the neutron dose measurement apparatus (21) comprises a detector (211) used to receive neutrons and output electrical signals, a signal processing unit (212) used to process the electrical signals output from the detector (211) and convert the electrical signals into pulse signals, and a counter (213) used to count the pulse signals output from the signal processing unit (212) to obtain a count rate.Type: ApplicationFiled: May 12, 2023Publication date: September 7, 2023Inventors: Chao WANG, Yuan-hao LIU
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Publication number: 20230277872Abstract: A neutron capture therapy system includes a neutron beam generating unit, an irradiation room configured to irradiate an irradiated body with a neutron beam, a preparation room configured to implement preparation work required to irradiate the irradiated body with the neutron beam, and an auxiliary positioner disposed in the irradiation room and/or the preparation room. The irradiation room includes a first shielding wall, a collimator is disposed on the first shielding wall for emitting the neutron beam, the neutron beam is emitted from the collimator and defines a neutron beam axis. The auxiliary positioner includes a laser emitter that emits a laser beam to position the irradiated body. Wherein the position of the laser emitter is selectable. Therefore, the irradiated body can be positioned in any case to implement precise irradiation.Type: ApplicationFiled: January 18, 2023Publication date: September 7, 2023Inventor: Yuan-hao LIU
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Publication number: 20230211186Abstract: A neutron capture therapy apparatus includes a neutron beam irradiation system, a detection system and a monitoring system. The neutron beam irradiation system is configured for generating a neutron beam. The detection system is configured for detecting real-time irradiation parameters during a neutron beam irradiation therapy process. The monitoring system is configured for controlling the whole neutron beam irradiation process and includes an input part for inputting preset irradiation parameters, a determination part for determining whether the irradiation parameters need to be corrected and a correction part for correcting some of the irradiation parameters when the determination part determines that the irradiation parameters need to be corrected. When the ratio of the real-time neutron dose detected by the detection system to a preset neutron dose is greater than or equal to a preset value, the determination part of the monitoring system determines that the irradiation parameters need to be corrected.Type: ApplicationFiled: December 29, 2022Publication date: July 6, 2023Inventors: Yuan-Hao LIU, Yong-Yin HUANG
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Publication number: 20230166126Abstract: Disclosed are a neutron dose detection apparatus and a neutron capture therapy device. The neutron dose detection apparatus includes at least two counting rate channels and a counting rate channel selection unit used for selecting one of the at least one counting rate channels. The counting rate channel includes a detector used for detecting neutrons and outputting a signal, a signal processing unit used for processing the signal output by the detector, and a counter used for counting the signal output by the signal processing unit.Type: ApplicationFiled: December 29, 2022Publication date: June 1, 2023Inventors: Yuan-Hao LIU, Chao WANG
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Publication number: 20230137634Abstract: Disclosed are a neutron dose measurement apparatus and a neutron capturing treatment device. The neutron dose measurement apparatus includes a measurement unit for receiving neutrons and outputting signals, a signal processing unit for processing the signals output from the measurement unit, a counter for counting the signals output from the signal processing unit to obtain a count rate, and a count rate correction unit for correcting the count rate.Type: ApplicationFiled: December 29, 2022Publication date: May 4, 2023Inventors: Yuan-Hao LIU, Chao Wang
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Publication number: 20230139037Abstract: Disclosed are a neutron capture therapy apparatus and an operation method of a monitoring system thereof. The neutron capture therapy apparatus includes a neutron beam irradiation system, a measurement system and a monitoring system. The neutron beam irradiation system is used for generating a neutron beam suitable for carrying out neutron irradiation therapy on a sick body, the measurement system is used for measuring real-time irradiation parameters during a neutron beam irradiation therapy process, and the monitoring system is used for controlling the whole neutron beam irradiation process. The monitoring system includes an input section for inputting preset irradiation parameters, a storage section for storing the irradiation parameters, a modification section for modifying some of the irradiation parameters in the storage section, and a display section for displaying the irradiation parameters in real time.Type: ApplicationFiled: December 29, 2022Publication date: May 4, 2023Inventors: Yuan-Hao LIU, Yong-Yin Huang
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Publication number: 20230126701Abstract: A neutron capture treatment device includes a neutron beam irradiation system, a detection system, and a correction system, the neutron beam irradiation system being used for producing neutron beams, the detection system being used for detecting irradiation parameters during the neutron beam irradiation treatment, and the correction system being used for correcting a preset neutron dosage; the accuracy of the neutron beam dosage irradiated to a sick body is thereby ensured at the source.Type: ApplicationFiled: December 16, 2022Publication date: April 27, 2023Inventors: Yuan-hao LIU, Wei-lin CHEN
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Publication number: 20230124008Abstract: Disclosed is a neutron capture therapy apparatus. The neutron capture therapy apparatus is used for irradiating a neutron beam with a preset neutron dose to an object to be irradiated. The neutron beam enters the object and undergoes a nuclear reaction with boron in the object. The neutron capture therapy apparatus includes a correction system for correcting the preset neutron dose.Type: ApplicationFiled: December 16, 2022Publication date: April 20, 2023Inventors: Yuan-hao LIU, Wei-lin CHEN
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Publication number: 20230111904Abstract: Disclosed are a neutron capture therapy device and an operation method of a monitoring system. The neutron capture therapy device includes a neutron beam irradiation system, a detection system and the monitoring system. The neutron beam irradiation system generates a neutron beam for performing neutron irradiation therapy on a sick body. The detection system is used for detecting irradiation parameters during a neutron beam irradiation therapy, and the monitoring system is used for controlling the whole neutron beam irradiation process. The monitoring system includes a storage part for storing the irradiation parameters, a control part for executing a therapy plan according to the irradiation parameters stored in the storage part, and a correction part for correcting part of the irradiation parameters stored in the storage part. The disclosure improves the accuracy of the dosage of the neutron beam for irradiating the sick body.Type: ApplicationFiled: December 14, 2022Publication date: April 13, 2023Inventors: Yuan-hao LIU, Wei-lin Chen
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Patent number: 11590360Abstract: A process for analyzing elements and mass ratios of elements of a tissue includes approximating the tissue having unknown elements and mass ratios of the unknown elements thereof using the data of the medical image corresponding to a tissue having known elements and mass ratios of the known elements thereof. A method for establishing a geometric model based on a medical image includes: reading data of the medical image; defining a type of a tissue according to a conversion relationship between the data of the medical image and tissue types or according to the process; determining a quantity of tissue clusters of the tissue; defining a tissue density of the tissue by a conversion relationship between the data of the medical image and density values; establishing a 3D coding matrix with information about the tissue and the density; and generating the geometric model.Type: GrantFiled: June 13, 2019Date of Patent: February 28, 2023Assignee: NEUBORON MEDTECH LTD.Inventors: Yuan-Hao Liu, Ming-Chen Hsiao