Abstract: A method for measuring radiation intensity includes measuring the radiation intensity received by the protein in a radiation field based on degree of protein degradation in the radiation field, wherein the degree of degradation is a ratio of the molecular weight of the protein before and after irradiation. The measuring method is simple in operation, small in number of steps, small in error, and capable of measuring radiation doses of various radiation fields or even mixed radiation fields. Use of a biological dosimeter for measuring the radiation intensity by the method in a neutron capture therapy system can not only assess radiation contamination in the irradiation chamber, but also evaluate the neutron dose.

Abstract: The present disclosure discloses a boron neutron capture therapy system comprising: a boron neutron capture therapy device and an ?-amino acid-like boron trifluoride compound having a structure shown as formula (I) below: Wherein: R is selected from hydrogen, methyl, isopropyl, 1-methylpropyl, 2-methylpropyl, hydroxymethyl, 1-hydroxyethyl, benzyl or hydroxybenzyl; M is H or metal atom. The energy generated from the action of the neutron beam generated by the boron neutron capture therapy device on the ?-amino acid-like boron trifluoride compound destroys tumor cell DNA. In another aspect, the present disclosure discloses a use of an ?-amino acid-like boron trifluoride compound in the preparation of a medicament for tumor therapy.

Abstract: A neutron capture therapy system and a target for a particle beam generating device, which may improve the heat dissipation performance of the target, reduce blistering and extend the service life of the target. The neutron capture therapy system includes a neutron generating device and a beam shaping assembly. The neutron generating device includes an accelerator and a target, and a charged particle beam generated by acceleration of the accelerator interacts with the target to generate a neutron beam. The target includes an acting layer, a backing layer and a heat dissipating layer, the acting layer interacts with the charged particle beam to generate the neutron beam, the base layer supports the action layer, and the heat dissipating layer includes a tubular member composed of tubes arranged side by side.

Abstract: A beam shaping assembly (10) used in a neutron capture system and capable of changing an irradiation range of a neutron beam. The beam shaping assembly includes: a beam inlet (11), a target (12), a moderator (13) adjoining the target (12), a reflector (14) surrounding the moderator (13), a thermal neutron absorber (15) adjoining the moderator (13), a radiation shield (16) arranged inside the beam shaping assembly (10), and a beam outlet (17). The beam shaping assembly (10) further includes replacement components (21, 22) that can be attached to and detached from the beam shaping assembly (10) to change the irradiation range of the neutron beam.

Abstract: A process for analyzing elements and mass ratios of elements of a tissue includes approximating the tissue having unknown elements and mass ratios of the unknown elements thereof using the data of the medical image corresponding to a tissue having known elements and mass ratios of the known elements thereof. A method for establishing a geometric model based on a medical image includes: reading data of the medical image; defining a type of a tissue according to a conversion relationship between the data of the medical image and tissue types or according to the process; determining a quantity of tissue clusters of the tissue; defining a tissue density of the tissue by a conversion relationship between the data of the medical image and density values; establishing a 3D coding matrix with information about the tissue and the density; and generating the geometric model.

Abstract: In one aspect, a method for establishing a smooth geometric model based on data of a medical image includes: inputting or reading the data of the medical image; establishing a three-dimensional medical image voxel model based on the data of the medical image; smoothing the three-dimensional medical image voxel model; and establishing a three-dimensional voxel phantom tissue model based on the smoothed three-dimensional medical image voxel model. In another aspect, a method for establishing a smooth geometric model based on data of a medical image includes: inputting or reading the data of the medical image; establishing a three-dimensional voxel phantom tissue model based on the data of the medical image; and smoothing the three-dimensional voxel phantom tissue model.

Abstract: Disclosed is a beam shaping assembly, including a beam inlet; a target, wherein the target has nuclear reaction with the incident proton beam; a moderator adjoining to the target, wherein the neutrons are moderated by the moderator to epithermal neutrons; a reflector surrounding the moderator, and leads the deflected neutrons back to the moderator to enhance the epithermal neutron beam intensity; and a cooling system, wherein the cooling system comprises a first cooling part for cooling target, a second cooling part and a third cooling part connecting with the first cooling part and extending in a direction parallel to the axis of the accelerating tube respectively, the first cooling part connects with the target in a face to face manner, the cooling medium is inputted into the first cooling part from the second cooling part and is outputted from first cooling part through the third cooling part.

Abstract: A neutron capture therapy system and a target for a particle beam generating device, which may improve the heat dissipation performance of the target, reduce blistering and extend the service life of the target. The neutron capture therapy system includes a neutron generating device and a beam shaping assembly. The neutron generating device includes an accelerator and a target, and a charged particle beam generated by acceleration of the accelerator interacts with the target to generate a neutron beam. The target includes an acting layer, a backing layer and a heat dissipating layer, the acting layer interacts with the charged particle beam to generate the neutron beam, the base layer supports the action layer, and the heat dissipating layer includes a tubular member composed of tubes arranged side by side.

Abstract: The present disclosure provides a neutron capture therapy system. The neutron capture therapy system includes an accelerator, the accelerator generates a charged particle beam; a neutron generator, the neutron generator generates a neutron beam after being irradiated by the charged particle beam; a beam shaping assembly, the beam shaping assembly includes a moderator and a reflector surrounds around the outer periphery of the moderator, the moderator moderates the neutrons generated by the neutron generator to a preset spectrum, and the reflector leads the deflected neutrons back to increase the neutron intensity within the preset spectrum; and a collimator, the collimator concentrates the neutrons generated by the neutron generator; the spectrum of the neutron beam is changed by changing the spectrum of the charged particle beam.

Abstract: A beam shaping assembly for neutron capture therapy includes a beam inlet, a target having nuclear reaction with an incident proton beam from the beam inlet to produce neutrons forming a neutron beam, a moderator adjoining to the target, a reflector surrounding the moderator, a thermal neutron absorber adjoining to the moderator, a radiation shield arranged inside the beam shaping assembly and a beam outlet. The material of the moderator is subjected to a powder sintering process using a powder sintering device so as to change powders or a power compact into blocks. The reflector leads the neutrons deviated from the main axis back. The thermal neutron absorber is used for absorbing thermal neutrons so as to avoid overdosing in superficial normal tissue during therapy. The radiation shield is used for shielding leaking neutrons and photons so as to reduce dose of the normal tissue not exposed to irradiation.

Abstract: A medical image-based radiation shielding device and method thereof, which may form a targeted and highly accurate radiation shielding according to individual differences in patients, such as tumor location and size, thereby reduce or avoid radiation from a irradiation apparatus to normal tissues of patients. The shielding device includes a medical image scanning means for scanning an irradiated site of an irradiated subject and outputting medical image voxel data, a data processing and three-dimensional modeling means for establishing a three-dimensional phantom tissue model according to the medical image voxel data and establishing a three-dimensional shield model according to the three-dimensional phantom tissue model; a shield located between the irradiation apparatus and the irradiated site, wherein the shield is formed by printing the three-dimensional shield model data input to a 3D printer.

Abstract: Provided is a compound for specifically binding to amyloid ?-protein. The compound has thereon a nuclide with a large thermal neutron capture cross section and the compound is capable of specifically binding to the amyloid ?-protein. The property of the compound allows it to be used in conjunction with a neutron capture therapy device to eliminate amyloid ?-protein. Similarly, when the compound is labelled with radioactive element 11C, the compound can also be used in conjunction with PET/CT for determining the part of the brain where amyloid ?-protein is deposited, for diagnosing Alzheimer's disease. Also disclosed is a preparation process for the compound. The beneficial effect of the present disclosure is to make the therapy and diagnosis of Alzheimer's disease more targeted by providing the compound for specifically binding to amyloid ?-protein.

Abstract: Provided is a compound for specifically binding to amyloid ?-protein. The compound has thereon a nuclide with a large thermal neutron capture cross section and the compound is capable of specifically binding to the amyloid ?-protein. The property of the compound allows it to be used in conjunction with a neutron capture therapy device to eliminate amyloid ?-protein. Similarly, when the compound is labelled with radioactive element 11C, the compound can also be used in conjunction with PET/CT for determining the part of the brain where amyloid ?-protein is deposited, for diagnosing Alzheimer's disease. Also disclosed is a preparation process for the compound. The beneficial effect of the present disclosure is to make the therapy and diagnosis of Alzheimer's disease more targeted by providing the compound for specifically binding to amyloid ?-protein.

Abstract: The present disclosure provides a neutron capture therapy system for eliminating amyloid ?-protein deposition plaque, comprising a neutron capture therapy device and a 10B-containing compound capable of specifically binding to amyloid ?-protein deposition plaque, and the energy generated when the neutron beam generated by the neutron capture therapy device irradiates on the 10B element can destroy the structure of the amyloid ?-protein deposition plaque. The beneficial effects of the present disclosure are targeted and highly effective destruction of amyloid ?-protein deposition plaque.

Abstract: Abeam shaping assembly for neutron capture therapy includes a beam inlet, a target having nuclear reaction with an incident proton beam from the beam inlet to produce neutrons forming a neutron beam defining a main axis, a moderator adjoining to the target, a reflector surrounding the moderator, a thermal neutron absorber adjoining to the moderator, a radiation shield arranged inside the beam shaping assembly and a beam outlet. The neutrons are moderated to epithermal neutron energies. The reflector leads the neutrons deviated from the main axis back, and a gap channel is arranged between the moderator and the reflector. The thermal neutron absorber is used for absorbing thermal neutrons so as to avoid overdosing in superficial normal tissue during therapy. The radiation shield is used for shielding leaking neutrons and photons so as to reduce dose of the normal tissue not exposed to irradiation.

Abstract: A neutron capture therapy system capable of eliminating amyloid ?-protein includes a neutron capture therapy device and a compound capable of specifically binding to the amyloid ?-protein having a nuclide with a large thermal neutron capture cross section. The neutron capture therapy device includes a neutron source, a beam shaping assembly and a collimator, the neutrons released by the neutron source pass through the beam shaping assembly and are slowed into a neutron beam within a certain energy range. The neutron beam irradiates the compound, and the energy generated by the reaction thereof can destroy the structure of the amyloid ?-protein. The neutron capture therapy system can specifically eliminate the amyloid ?-protein, and reduce the damage to the tissues surrounding the amyloid ?-protein.

Abstract: A neutron moderation material for use in a BNCT beam shaping assembly. The neutron moderation material comprises three elements, i.e., Mg, Al, and F, wherein the mass fraction of the Mg element is 3.5%-37.1%, the mass fraction of the Al element is 5%-90.4%, and the mass fraction of the F element is 5.8%-67.2%; the sum of the weights of the Mg, Al, and F elements is 100% of the total weight of the neutron moderation material. The neutron moderation material may be doped with a small amount of 6Li-containing substances, and the addition of the 6Li-containing substances effectively decreases the content of ?-rays in epithermal neutron beams.

Abstract: A radiation detection system and method for a neutron capture therapy system, which may increase the accuracy of neutron beam irradiation dose of the neutron capture therapy system and find out a fault position in time. The neutron capture therapy system includes a charged particle beam, a charged particle beam inlet allowing the charged particle beam to pass through, a neutron beam generating unit which may generate a neutron beam after a nuclear reaction occurs between the neutron beam generating unit and the charged particle beam, a beam shaping assembly for adjusting the flux and the quality of the neutron beam generated by the neutron beam generating unit, and a beam outlet adjacent to the beam shaping assembly, the radiation detection system includes a radiation detection device for real-time detection of ? rays instantly emitted under neutron beam irradiation.

Abstract: A beam shaping assembly for neutron capture therapy includes a beam inlet, a target having nuclear reaction with an incident proton beam from the beam inlet to produce neutrons forming a neutron beam defining a main axis, a moderator adjoining to the target, a reflector surrounding the moderator, a thermal neutron absorber adjoining to the moderator, a radiation shield arranged inside the beam shaping assembly and a beam outlet. The neutrons are moderated to epithermal neutron energies. The reflector leads the neutrons deviated from the main axis back, and a gap channel is arranged between the moderator and the reflector. The thermal neutron absorber is used for absorbing thermal neutrons so as to avoid overdosing in superficial normal tissue during therapy. The radiation shield is used for shielding leaking neutrons and photons so as to reduce dose of the normal tissue not exposed to irradiation.

Abstract: Disclosed is a beam shaping assembly, including a beam inlet; a target, wherein the target has nuclear reaction with the incident proton beam; a moderator adjoining to the target, wherein the neutrons are moderated by the moderator to epithermal neutrons; a reflector surrounding the moderator, and leads the deflected neutrons back to the moderator to enhance the epithermal neutron beam intensity; and a cooling system, wherein the cooling system comprises a first cooling part for cooling target, a second cooling part and a third cooling part connecting with the first cooling part and extending in a direction parallel to the axis of the accelerating tube respectively, the first cooling part connects with the target in a face to face manner, the cooling medium is inputted into the first cooling part from the second cooling part and is outputted from first cooling part through the third cooling part.