Abstract: The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising a heparan N-sulfatase (HNS) protein, salt, and a polysorbate surfactant for the treatment of Sanfilippo Syndrome Type A.

Abstract: A process for producing methane or methanol includes combining a hydrogenation catalyst, hydrogen, and CO2 with a condensed phase solution comprising an amine under conditions effective to form methane or methanol, and water. A process for coproduction of methanol and a glycol includes combining an epoxide, a hydrogenation catalyst, hydrogen, and CO2 with a condensed phase solution comprising an amine under conditions effective to form methanol and a glycol.

Abstract: Provided are a hooked probe, a method for ligating a nucleic acid and a method for constructing a sequencing library. The hooked probe comprises a target specific area and a hooked area ligated thereto; the target specific area comprises a sequence complementarily paired with at least part of the single chain of the nucleic acid fragment to be ligated; the hooked area comprises a sequence unpaired with the nucleic acid fragment; the end of the hooked area is a ligatable end; and the ligatable end can ligate the end of the single chain of the nucleic acid fragment.

Abstract: Provided are an adaptor element in a bubble shape, a method of constructing a sequencing library with such an adapter element. The adaptor element is a hybrid formed with a long-chain nucleic acid A and a short-chain nucleic acid B. The hybrid is in the bubble shape with paired regions at two terminals and a non-paired region in the middle.

Abstract: A driver device for opening and closing a vehicle door, comprising an electric motor and a planetary gear gearbox, wherein the electric motor comprises an electric motor output shaft, and the planetary gear gearbox comprises a gearbox input shaft coaxially connected to the electric motor output shaft, and a gearbox output shaft coaxially connected to an end of a door shaft of the vehicle door to provide the door shaft with a torque required to open and close the vehicle door. Compared with vehicle door opening and closing functions in the prior art, the driver device can be installed by utilizing the space at the door shaft of the vehicle door, without affecting the integrity of the door body of the vehicle door. Furthermore, a vehicle door comprising the aforesaid driver device is further provided.

Abstract: A method and apparatus for measuring an angular resolution of a multi-beam lidar. The method includes: acquiring, when a checkerboard calibration plate is scanned by a multi-beam lidar, an image of the checkerboard calibration plate photographed by a camera; identifying a checkerboard in the image, and determining a physical length characterized by a unit pixel of the image based on shape and length information of each checker in the checkerboard calibration plate; determining a center light spot and a light spot pair in the image; determining an angle between a laser beam corresponding to each light spot of the light spot pair and a laser beam corresponding to the center light spot based on the physical length characterized by the unit pixel, the center light spot and the light spot pair; and determining the angular resolution of the multi-beam lidar based on the determined angle.

Abstract: Provided are a vesicular adaptor and a single-chain cyclic library constructed by using the adaptor. The library can be used for RNA sequencing and other sequencing platforms dependent on a single-stranded cyclic library, and has the advantage of high throughput sequencing, high accuracy and simple operations.

Abstract: A process for producing methanol includes combining a hydrogenation catalyst, hydrogen, and CO2 with a condensed phase solution comprising an amine under conditions effective to form methanol and water. A process for coproduction of methanol and a glycol includes combining an epoxide, a hydrogenation catalyst, hydrogen, and CO2 with a condensed phase solution comprising an amine under conditions effective to form methanol and a glycol.

Abstract: Provided are an adaptor element in a bubble shape, a method of constructing a sequencing library with such an adapter element. The adaptor element is a hybrid formed with a long-chain nucleic acid A and a short-chain nucleic acid B. The hybrid is in the bubble shape with paired regions at two terminals and a non-paired region in the middle.

Abstract: A process for producing methanol includes combining a hydrogenation catalyst, hydrogen, and CO2 with a condensed phase solution comprising an amine under conditions effective to form methanol and water. A process for coproduction of methanol and a glycol includes combining an epoxide, a hydrogenation catalyst, hydrogen, and CO2 with a condensed phase solution comprising an amine under conditions effective to form methanol and a glycol.

Abstract: A transparent film is used with a projector which emits a projected light. The transparent film includes a transparent substrate; a light-scattering layer disposed at an upstream position of the transparent substrate with respect to the projected light, and including a plurality of microstructures configured to scatter the projected light; and a light-blocking layer disposed at an upstream position of the light-scattering layer with respect to the projected light, and including a plurality of separate light-blocking units, which are configured to partially block the projected light and partially allow the projected light to reach the light-scattering layer.

Abstract: The present application discloses a topological insulator structure including an insulating substrate, a topological insulator quantum well film, and an insulating protective layer. The topological insulator quantum well film and the insulating protective layer are orderly stacked on a surface of the insulating substrate, forming a heterojunction structure. The insulating protective layer is selected from the group consisting of the wurtzite-structured CdSe, the sphalerite-structured ZnTe, the sphalerite-structured CdSe, the sphalerite-structured CdTe, the sphalerite-structured HgSe, the sphalerite-structured HgTe, and combinations thereof. The present application also discloses a method for making the topological insulator structure.

Abstract: The present application discloses a double-channel topological insulator structure includes an insulating substrate, a first topological insulator quantum well film, an insulating interlayer, and a second topological insulator quantum well film. The first topological insulator quantum well film, the insulating interlayer, and the second topological insulator quantum well film are orderly stacked on a surface of the insulating substrate. The first and second topological insulator quantum well films are separated by the insulating interlayer. The present application also discloses a method for making the double-channel topological insulator structure and a method for generating quantum spin Hall effect.

Abstract: The present application discloses a multi-channel topological insulator structure, including an insulating substrate, multiple topological insulator quantum well films, and multiple insulating interlayers. The topological insulator quantum well films and the insulating interlayers are alternately stacked on a surface of the insulating substrate. Two adjacent topological insulator quantum well films are separated by one insulating interlayer. The present application also discloses a method for making the multi-channel topological insulator structure and an electrical device.

Abstract: The present disclosure discloses an integrated device for millisecond-level gas phase catalytic cracking reaction and separation, comprising: a horizontal inertial cyclone separator, a horizontal inertial cyclone separator feed tube, a pyrolysis vapour inlet, a regenerated catalyst inlet, a horizontal inertial cyclone separator central tube, a cracked vapour outlet, a catalyst outlet tube, a spent catalyst silo, a first loop-seal, a riser regenerator, a settling tank, a gas-solid separator, and a second loop-seal.

Abstract: The invention provides a method of biomass grading pyrolysis gasification in a circulating fluidized bed comprising: feeding biomass into the lower-middle part of a carrying fluidized bed, mixing with high temperature synthesis gas and heat carrier from a turbulent fluidized bed, heating the biomass to carry out a pyrolysis reaction, and carrying the pyrolysis product upward; subjecting the cracked oil and gas to a gaseous phase catalytic cracking in an upper-middle part of the carrying fluidized bed, cracking the tar into methane, ethane and the like; subjecting the heat carrier, semi-coke and fuel gas after the reaction to the multi-stage of gas-solid separation, a large particle carrier and semi-coke following a first-level separation are used as the fuel gas cracking catalyst and the filter material for filtering and removing dust, and enter into a moving bed filter to separate out an ultra-fine ash and subsequently return to the turbulent fluidized bed so as to perform gasification reaction, the ultra-fi

Abstract: The invention provides a method of biomass grading pyrolysis gasification in a circulating fluidized bed comprising: feeding biomass into the lower-middle part of a carrying fluidized bed, mixing with high temperature synthesis gas and heat carrier from a turbulent fluidized bed, heating the biomass to carry out a pyrolysis reaction, and carrying the pyrolysis product upward; subjecting the cracked oil and gas to a gaseous phase catalytic cracking in an upper-middle part of the carrying fluidized bed, cracking the tar into methane, ethane and the like; subjecting the heat carrier, semi-coke and fuel gas after the reaction to the multi-stage of gas-solid separation, a large particle carrier and semi-coke following a first-level separation are used as the fuel gas cracking catalyst and the filter material for filtering and removing dust, and enter into a moving bed filter to separate out an ultra-fine ash and subsequently return to the turbulent fluidized bed so as to perform gasification reaction, the ultra-fi

Abstract: A gasification co-generation process of coal powder in a Y-type entrained flow bed, comprising: spraying coal water slurry or coal powder, gasification agent and water vapor into a gasification furnace through a top nozzle and a plurality of side nozzles for performing combustion and gasification with a residence time of 10 s or more; chilling the resulting slag with water, and subjecting the chilled slag to a dry method slagging to obtain gasification slag used as cement clinker; discharging the produced crude syngas carrying fine ash from the Y-type entrained flow bed to perform ash-slag separation.

Abstract: A transparent film is used with a projector which emits a projected light. The transparent film includes a transparent substrate; a light-scattering layer disposed at an upstream position of the transparent substrate with respect to the projected light, and including a plurality of microstructures configured to scatter the projected light; and a light-blocking layer disposed at an upstream position of the light-scattering layer with respect to the projected light, and including a plurality of separate light-blocking units, which are configured to partially block the projected light and partially allow the projected light to reach the light-scattering layer.

Abstract: The present disclosure discloses an integrated device for millisecond-level gas phase catalytic cracking reaction and separation, comprising: a horizontal inertial cyclone separator, a horizontal inertial cyclone separator feed tube, a pyrolysis vapour inlet, a regenerated catalyst inlet, a horizontal inertial cyclone separator central tube, a cracked vapour outlet, a catalyst outlet tube, a spent catalyst silo, a first loop-seal, a riser regenerator, a settling tank, a gas-solid separator, and a second loop-seal.