Abstract: The present application disclosures a double production line and a rapid prefabrication process of a segmental beam. The double production line including two production machine and a track system provided on the construction ground; the production machine includes a fixed end mold, two side molds, a bottom mold trolley, a middle internal mold trolley and two side internal mold trolley; two side molds are positioned on two sides of the fixed end mold respectively, the fixed end mold and two side molds together define a pouring position with an end opening, two openings of the pouring position are arranged facing each other; the track system includes a transverse track and a longitudinal track communicated with each other, two pouring positions are both positioned in the extension path of the transverse track, and the longitudinal track is positioned between two pouring positions.

Abstract: The present disclosure provides a self-ligating bracket, a double-wing spacing adjustable bracket and a dental appliance. The self-ligating bracket includes: a bracket base plate; a first end of a first elastic support is connected to the bracket base plate; a bracket body is a hollow structure, a second end of the first elastic support is connected to a distal end of the bracket body, and the distal end of the bracket body is provided with a gap and the distal end of the bracket body is expanded radially by the second end of the first elastic support; and a position-limited member is movable in an axial direction of the bracket body, and the position-limited member is sleeved on an outside of the bracket body for overcoming expansive force provided by the elastic supports and making the bracket body contract along a radial direction.

Abstract: The present invention provides preparation of a semicarbazide-sensitive amine oxidase inhibitor and use thereof. In particular, disclosed in the present invention are a compound as represented by formula I, or a stereoisomer or a racemate or a pharmaceutically acceptable salt of the compound. Also disclosed in the present invention is that the compound can inhibit semicarbazide-sensitive amine oxidase.

Abstract: Methods of inhibiting platelet activation and aggregation using antibodies or peptide vaccines having binding specificity for the ? subunit of the (Na++K+)-ATPase are provided, along with methods for inhibiting or preventing or treating thrombosis in a subject using such antibodies.

Abstract: A synergistic disposal method of hazardous waste incineration residues and solid wastes, ceramsite and an application thereof, all belonging to the field of resources and environment. The disposal method includes the following steps: mixing of the hazardous waste incineration residues and solid wastes, granulation and dehydration of the resulting mixture and calcination to obtain ceramsite. In the preparation of ceramsite by the synergistic disposal of hazardous waste incineration residues and solid wastes as the raw materials, dioxin and organic matters in the hazardous waste incineration residues and solid wastes are decomposed, meanwhile the contained heavy metals are reduced and solidified, solving the disposal problem of hazardous waste incineration residues and solid wastes, saving a lot of land for landfills, decreasing the cost for comprehensive disposal, not producing new hazardous wastes, and reducing the burden of ecological environment.

Abstract: Embodiments of the present disclosure provide techniques for efficiently and accurately performing propagation of search-head specific configuration customizations across multiple individual configuration files of search heads of a cluster for a consistent user experience. The cluster of search heads may be synchronized such that the search heads operate to receive the configuration or knowledge object customizations from one or more clients from a central or lead search head. To reduce the amount of data that is transferred during propagation, the list of configuration or knowledge object customizations maintained in each search head is filtered from the list of the lead search head until a divergence point is determined. Once determined and communicated to the lead search head, the lead search head sends the configuration and knowledge object customization data that is absent from the internal list of the member search head.

Abstract: Methods of preventing and treating type-1 diabetes and its complications using peptide vaccines to generate endogenous specific antibody activators that bind to the (Na++K+)-ATPase.

Abstract: Embodiments of the present disclosure provide techniques for efficiently and accurately performing propagation of search-head specific configuration customizations across multiple individual configuration files of search heads of a cluster for a consistent user experience. The cluster of search heads may be synchronized such that the search heads operate to receive the configuration or knowledge object customizations from one or more clients from a central or lead search head. To reduce the amount of data that is transferred during propagation, the list of configuration or knowledge object customizations maintained in each search head is filtered from the list of the lead search head until a divergence point is determined. Once determined and communicated to the lead search head, the lead search head sends the configuration and knowledge object customization data that is absent from the internal list of the member search head.

Abstract: A class of five-membered fused with six-membered heterocyclic compounds represented by formula I and a pharmaceutical composition, preparation, and an application thereof are disclosed. These compounds have TRK kinase inhibitory activity and can treat diseases related to TRK dysfunction.

Abstract: The present invention discloses a large-scale model testing system of a floating offshore wind power generation device, and a method for manufacturing the large-scale model testing system. The large-scale model testing system comprises a floating wind power generation device model, model response measurement systems and environmental parameter measurement systems. The floating wind power generation device model comprises a floating foundation and a tower, wherein a wind turbine is connected to the top of the tower. A plurality of anchoring devices is connected to the side surface of the floating foundation. Each model response measurement system comprises an IMU unit, a wind turbine monitoring unit and an anchoring tension measurement unit. Each environmental parameter measurement system comprises a buoy-type wave height meter, a wind speed and direction meter and a flow velocity and direction meter.

Abstract: Methods of preventing and treating type-1 diabetes and its complications using antibody activators that bind to the (Na++K+)-ATPase.

Abstract: Provided are a preparation of semicarbazide-sensitive amine oxidase inhibitor and the use thereof. In particular, disclosed are a compound as shown in formula I, or a stereoisomer or racemate or pharmaceutically acceptable salt thereof. Also disclosed is that the above-mentioned compound can inhibit semicarbazide-sensitive amine oxidase.

Abstract: The present invention discloses the preparation and application of heterocyclic compound having immunoregulatory function. Specifically, the present invention discloses a compound having a structure according to Formula I, wherein the definition of each group is as described in the specification. The invention also provides the use of the compounds in regulating immunity and inhibiting PD-1/PD-L1.

Abstract: Provided are a preparation and applications of a six-membered fused with six-membered heterocyclic compound, specifically, provided in the present invention is a compound as represented by formula I as follows, where the definitions of the groups are as described in the description. The compound has TRK kinase inhibiting activity and can serve as a pharmaceutical composition for treating TRK dysfunction-related diseases.

Abstract: Embodiments of the present disclosure disclose an event execution method, device, and system. The method includes: obtaining first event result information obtained by executing a first event by a first application client logged in on a mobile terminal by using a first account, the first event result information indicating an account resource to be deducted; displaying the first event result information on a screen of a processing device; and requesting to execute a second event by using the processing device, the second event being used for deducting an amount of resource from a second account associated with the first account.

Abstract: Methods, systems, and computer programs are presented for improving search speed and quality using differential indexing. One method includes an operation for building a first index for a database, the first index being for first tokens resulting from normalizing words in input data. Further, the method includes building a second index for the database, the second index being for second tokens comprising words of the input data eliminated from the first index during the normalizing. The method further includes operations for receiving a raw query for a search of the database, and for generating a search query based on tokens of the raw query. The search query comprises a combined search of the first index and the second index. A search is performed based on the search query, and results of the search are returned for presentation on a display.

Abstract: Provided are a JAK kinase inhibitor, preparation and use thereof. In particular, provided is a compound of Formula I, wherein each group is as described in the specification. The compound has an excellent JAK inhibitory activity, and therefore can be used to prepare pharmaceutical compositions for the treatment of cancer and other diseases related to JAK activity.

Abstract: Antibodies binding to sites on the alpha-subunit of the (Na++K+)-ATPase increase cardiac contraction of both ventricular myocytes and mouse heart. In particular, antibodies binding to the RSATEEEPPNDD (SEQ ID NO: 1) or DVEDSYGQQWTYEQR (SEQ ID NO: 2) peptides (or isoforms/derivatives thereof) of the alpha-subunit of the (Na++K+)-ATPase, have been found to be highly inotropic. Both the antibodies and the peptides are important for the treatment of human heart failure and other contractile disorders.

Abstract: Provided are an aromatic compound having immunoregulatory effect, a preparation method thereof, and a use of the same in regulating immune responses or inhibiting PD-1/PD-L1.

Abstract: Methods, systems, and computer programs are presented for improving search speed and quality using differential indexing. One method includes an operation for building a first index for a database, the first index being for first tokens resulting from normalizing words in input data. Further, the method includes building a second index for the database, the second index being for second tokens comprising words of the input data eliminated from the first index during the normalizing. The method further includes operations for receiving a raw query for a search of the database, and for generating a search query based on tokens of the raw query. The search query comprises a combined search of the first index and the second index. A search is performed based on the search query, and results of the search are returned for presentation on a display.