Patents by Inventor Yuan Xu

Yuan Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AZAINDAZOLE COMPOUNDS AND METHODS OF USE
    Publication number: 20160296517
    Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
    Type: Application
    Filed: February 23, 2016
    Publication date: October 13, 2016
    Inventors: Penglie ZHANG, Andrew M. K. Pennell, John J. Kim Wright, Wei Chen, Manmohan R. Leleti, Yandong Li, Lianfa Li, Yuan Xu, Mark M. Gleason, Yibin Zeng, Kevin Lloyd Greenman
  • Hybrid-guided block copolymer assembly
    Patent number: 9460747
    Abstract: A method for nano-patterning includes imprinting features in a resist with an imprint mold to form one or more topographic surface patterns on the imprinted resist. A block copolymer (“BCP”) material is deposited on the imprinted resist, wherein a molecular dimension L0 of the BCP material correlates by an integer multiple to a spacing dimension of the one or more topographic surface patterns on the imprinted resist. The deposited BCP is annealed and at least a portion of the annealed BCP is removed, forming a template having discrete domains.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: October 4, 2016
    Assignee: Seagate Technology LLC
    Inventors: Yuan Xu, Kim Y. Lee, David S. Kuo, Koichi Wago, Wei Hu
  • Contact lenses made with HEMA-compatible polysiloxane macromers
    Patent number: 9453110
    Abstract: Optically clear silicone hydrogel contact lenses are described that comprise a polymeric lens body that is the reaction product of a polymerizable composition comprising at least 25 wt. % of at least one hydroxyalkyl methacrylate; and at least 20 wt. % of at least one HEMA-compatible bifunctional polysiloxane comprising at least 6 siloxane groups and having an HLB value of at least 5 and/or a hydroxyl group content of at least 1 wt. %.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: September 27, 2016
    Assignee: CooperVision International Holding Company, LP
    Inventors: Hiroyuki Ueyama, Charlie Chen, Yuan Xu, Yuwen Liu, Ying Zheng, Paul Richardson, Prasad Dande
  • Method of producing a positive inotropic effect using an antibody that binds sodium potassium atpase
    Patent number: 9416159
    Abstract: Activation sites on the alpha subunit of sodium potassium ATPase have been discovered. It has also been discovered that certain antibodies that bind to the alpha subunit of sodium potassium ATPase dramatically increase enzyme activity. There has never before been a report of precise activation sites or drug interaction sites for sodium potassium ATPase. Certain methods have also been discovered for treating or preventing diseases associated with low sodium potassium ATPase activity by administering antibodies, antibody fragments and small molecules that bind to the activation sites on the alpha subunit of sodium potassium ATPase.
    Type: Grant
    Filed: April 4, 2013
    Date of Patent: August 16, 2016
    Inventor: Kai Yuan Xu
  • Methods and apparatus for imaging with magnetic induction
    Patent number: 9411033
    Abstract: An apparatus includes a magnetic energy source to provide a magnetic signal and a detector to detect an acoustic energy signal from a sample stimulated by the magnetic energy signal. A method includes applying a magnetic signal to a biological sample, detecting an acoustic signal from the sample, and processing the acoustic signal to determine the electrical impedance distribution of the sample, and identify disease in the biological sample. A method includes applying a magnetic signal to a sample, detecting a magnetic or electrical signal within the sample, and processing the magnetic or electrical signal to reconstruct electrical impedance distribution of the sample.
    Type: Grant
    Filed: May 10, 2006
    Date of Patent: August 9, 2016
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Bin He, Yuan Xu, Xu Li
  • Activation of sodium potassium ATPase
    Patent number: 9409949
    Abstract: Activation sites on the alpha subunit of sodium potassium ATPase have been discovered. It has also been discovered that certain antibodies that bind to the alpha subunit of sodium potassium ATPase dramatically increase enzyme activity. There has never before been a report of precise activation sites or drug interaction sites for sodium potassium ATPase. Certain methods have also been discovered for treating or preventing diseases associated with low sodium potassium ATPase activity by administering antibodies, antibody fragments and small molecules that bind to the activation sites on the alpha subunit of sodium potassium ATPase.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: August 9, 2016
    Inventor: Kai Yuan Xu
  • OMNIDIRECTIONAL BROADBAND ANTENNAS
    Publication number: 20160226145
    Abstract: Disclosed are exemplary embodiments of omnidirectional broadband antennas. In an exemplary embodiment, an antenna generally includes a ground element, an antenna element, and an annular patch element. The antenna element may be electrically isolated from the ground element. The antenna element may include at least one portion that is substantially conical, substantially pyramidal, and/or that tapers in a longitudinal direction. The annular patch element is electrically grounded to the ground element. The annular patch element surrounds at least a portion of the antenna element and is parasitically coupled to the antenna element.
    Type: Application
    Filed: April 12, 2016
    Publication date: August 4, 2016
    Inventors: Yuan Xu, Athanasios Petropoulos, Shawn Wayne Johnson
  • Inotropic Antibodies and Therapeutic Uses Thereof
    Publication number: 20160199468
    Abstract: Antibodies binding to sites on the alpha-subunit of the (Na++K+)-ATPase increase cardiac contraction of both ventricular myocytes and mouse heart. In particular, antibodies binding to the RSATEEEPPNDD (SEQ ID NO: 1) or DVEDSYGQQTYEQR (SEQ ID NO: 2) peptides (or isoforms/derivatives thereof) of the alpha-subunit of the (Na++K+)-ATPase, have been found to be highly inotropic. Both the antibodies and the peptides are important for the treatment of human heart failure and other contractile disorders.
    Type: Application
    Filed: March 7, 2016
    Publication date: July 14, 2016
    Inventor: Kai Yuan Xu
  • Contact Lenses Made With HEMA-Compatible Polysiloxane Macromers
    Publication number: 20160185914
    Abstract: Optically clear silicone hydrogel contact lenses are described that comprise a polymeric lens body that is the reaction product of a polymerizable composition comprising at least 25 wt. % of at least one hydroxyalkyl methacrylate; and at least 20 wt. % of at least one HEMA-compatible bifunctional polysiloxane comprising at least 6 siloxane groups and having an HLB value of at least 5 and/or a hydroxyl group content of at least 1 wt. %.
    Type: Application
    Filed: March 10, 2016
    Publication date: June 30, 2016
    Applicant: CooperVision International Holding Company, LP
    Inventors: Hiroyuki Ueyama, Charlie Chen, Yuan Xu, Yuwen Liu, Ying Zheng, Paul Richardson, Prasad Dande
  • Method for Adjusting Window Display Position, and Terminal
    Publication number: 20160162169
    Abstract: A method for adjusting a window display position, and a terminal. The method for adjusting a window display position in the present disclosure includes displaying a window in a first position of a terminal screen; acquiring a rotational angular acceleration and/or a rotating angle of a terminal; determining a change of a rotation direction of the terminal according to the rotational angular acceleration and/or the rotating angle; and adjusting, according to a rotational change direction of the terminal, the window to be displayed in a second position of the screen. In the embodiments of the present disclosure, a function of dynamically adjusting a window display position according to a change of a rotation direction of a terminal is implemented. After the adjustment, a user operation is more convenient.
    Type: Application
    Filed: June 6, 2014
    Publication date: June 9, 2016
    Inventor: Yuan Xu
  • CMOS input buffer circuit
    Patent number: 9337834
    Abstract: A high-linearity CMOS input buffer circuit is provided for neutralizing non-linearity of follower circuits' transconductance and output impedance resulting from input signals' variation. In doing so, the linearity of CMOS input buffer is improved. The buffer circuit includes a CMOS input follower circuit, a linearity improvement circuit of follower transistor, a current source load, and a linearity improvement circuit of load impedance. The buffer circuit is fabricated in standard CMOS process, featuring low cost, simplicity and strong linearity at high frequency. It has wide applications in analog and hybrid analog-digital CMOS ICs requiring high linearity input buffer.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: May 10, 2016
    Assignee: CHINA ELECTRONIC TECHNOLOGY CORPORATION, 24TH RESEARCH INSTITUTE
    Inventors: Xi Chen, Gang-Yi Hu, Xue-Liang Xu, Xing-Fa Huang, Liang Li, Xiao-Feng Shen, Ming-Yuan Xu, Lei Zhang, Yan Wang, Rong-Ke Ye, You-Hua Wang, Xu Huang, Jiao-Xue Li
  • Contact lenses made with HEMA-compatible polysiloxane macromers
    Patent number: 9322959
    Abstract: Optically clear silicone hydrogel contact lenses are described that comprise a polymeric lens body that is the reaction product of a polymerizable composition comprising at least 25 wt. % of at least one hydroxyalkyl methacrylate; and at least 20 wt. % of at least one HEMA-compatible bifunctional polysiloxane comprising at least 6 siloxane groups and having an HLB value of at least 5 and/or a hydroxyl group content of at least 1 wt. %.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: April 26, 2016
    Assignee: CooperVision International Holding Company, LP
    Inventors: Hiroyuki Ueyama, Charlie Chen, Yuan Xu, Yuwen Liu, Ying Zheng, Paul Richardson, Prasad Dande
  • Azaindazole compounds and methods of use
    Patent number: 9296740
    Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: March 29, 2016
    Assignee: ChemoCentryx, Inc.
    Inventors: Penglie Zhang, Andrew M. K. Pennell, John J. Kim Wright, Wei Chen, Manmohan R. Leleti, Yandong Li, Lianfa Li, Yuan Xu, Mark M. Gleason, Yibin Zeng, Kevin Lloyd Greenman
  • Silicone hydrogel contact lenses
    Patent number: 9296159
    Abstract: Silicone hydrogel contact lenses that are derived from a polymerizable composition including at least one siloxane monomer and at least one hydrophobic ethylene glycol methyl ether methacrylate-containing monomer, or at least one hydrophilic vinyl ether-containing monomer, or both, wherein, when the at least one hydrophobic ethylene glycol methyl ether methacrylate-containing monomer is present in the polymerizable composition, it is present in an amount of from 1 to 20 unit parts by weight, and when the at least one hydrophilic vinyl ether-containing monomer is present in the polymerizable composition, it is present in an amount of from 1 to 20 unit parts by weight, are described. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: March 29, 2016
    Assignee: CooperVision International Holding Company, LP
    Inventors: Ying Zheng, Yuan Xu, Junhao Ge, Charles A. Francis, Yuan Sun, Yuwen Liu, Charlie Chen, Ye Hong, Hongjin Qiu, Li Yao, Arthur Back
  • Sodium Pump Antibody Agonists And Methods Of Treating Heart Disease Using The Same
    Publication number: 20160083463
    Abstract: Antibodies that are agonists of sodium pump (Na+/K+ ATPase; NKA) activity are provided. In particular, antibodies that specifically bind epitopes on the beta-1 (?1) subunit of NKA are disclosed. These antibodies have the ability to increase the activity of the catalytic alpha subunit of NKA upon ?1 subunit binding. Due to their activity, the antibodies also have the ability to trigger a positive inotropic effect in cardiac tissues (i.e., increase cardiac contraction). The present invention thus includes, but is not limited to, NKA ?1 subunit peptide epitopes, antibodies that specifically bind the epitopes, methods of agonizing NKA activity through administration of the peptides or the antibodies, and methods of treating and/or preventing heart disease through administration of the peptides or the antibodies.
    Type: Application
    Filed: December 7, 2015
    Publication date: March 24, 2016
    Inventor: Kai Yuan Xu
  • Inotropic antibodies and therapeutic uses thereof
    Patent number: 9279020
    Abstract: Antibodies binding to sites on the alpha-subunit of the (Na++K+)-ATPase increase cardiac contraction of both ventricular myocytes and mouse heart. In particular, antibodies binding to the RSATEEEPPNDD (SEQ ID NO: 1) or DVEDSYGQQWTYEQR (SEQ ID NO: 2) peptides (or isoforms/derivatives thereof) of the alpha-subunit of the (Na++K+)-ATPase, have been found to be highly inotropic. Both the antibodies and the peptides are important for the treatment of human heart failure and other contractile disorders.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: March 8, 2016
    Inventor: Kai Yuan Xu
  • Synthetic Aperture Imaging Methods And Systems
    Publication number: 20160061950
    Abstract: The invention generally relates to the field of synthetic aperture imaging. In particular, the invention relates to systems and methods for generating synthetic transmit aperture (“STA”) signals and processing synthetic aperture imaging (“SAI”) signals for improved signal-to-noise ratio (“SNR”) and spatial resolution. This generally relates to a method to improve the signal-noise-ratio (SNR) of array signals by both encoding the transmission from multiple array elements with waveform modifications and time delays and encoding the receivers into output channels and decoding the measured signals at the selected output channels to estimate the equivalent received signals of a receiver as if only one transmitting element were fired individually in each transmission event. SAI techniques are subsequently applied to the equivalent SAI signals to obtain improved images.
    Type: Application
    Filed: August 31, 2015
    Publication date: March 3, 2016
    Inventors: Yuan XU, Michael C. KOLIOS, Ping GONG, Ying LI
  • Service processing method, a baseband processor chip and a terminal
    Patent number: 9271132
    Abstract: A service processing method, a baseband processor chip and a terminal are disclosed in embodiments of this invention, wherein the service processing method comprises: in response to a need for processing a CS domain service by a terminal, identifying whether PS domain data that is being received/transmitted in a PS domain service currently processed by the terminal is critical data for maintaining the QoS level of the PS domain service; in response to that the PS domain data being received/transmitted is not critical data, suspending the processing of the PS domain service and processing the CS domain service. The embodiment of this invention enables a terminal of Class B to process a CS domain service during the process of receiving/transmitting PS domain data.
    Type: Grant
    Filed: August 12, 2011
    Date of Patent: February 23, 2016
    Assignee: Spreadtrum Communications (Shanghai) Co., LTD
    Inventors: Zhi Zhang, Jiwu Liu, Xianliang Chen, Xichun Gao, Yuan Xu, Wenbo Lu, Ma Zhang, Yingping Hu
  • Sodium pump antibody agonists and methods of treating heart disease using the same
    Patent number: 9238695
    Abstract: Antibodies that are agonists of sodium pump (Na+/K+ ATPase; NKA) activity are provided. In particular, antibodies that specifically bind epitopes on the beta-1 (?1) subunit of NKA are disclosed. These antibodies have the ability to increase the activity of the catalytic alpha subunit of NKA upon ?1 subunit binding. Due to their activity, the antibodies also have the ability to trigger a positive inotropic effect in cardiac tissues (i.e., increase cardiac contraction). The present invention thus includes, but is not limited to, NKA ?1 subunit peptide epitopes, antibodies that specifically bind the epitopes, methods of agonizing NKA activity through administration of the peptides or the antibodies, and methods of treating and/or preventing heart disease through administration of the peptides or the antibodies.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: January 19, 2016
    Inventor: Kai Yuan Xu
  • Silicone hydrogel contact lenses
    Patent number: 9217813
    Abstract: Silicone hydrogel contact lenses are formed from the reaction product of a polymerizable composition comprising at least one acrylate-containing siloxane monomer, at least one hydrophilic vinyl-containing monomer, and at least one vinyl-containing cross-linking agent. The contact lenses have ophthalmically-acceptable ionoflux values and surface wettability, and can be manufactured without the use of volatile organic solvents.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: December 22, 2015
    Assignee: CooperVision International Holding Company, LP
    Inventors: Yuwen Liu, Junhao Ge, Charlie Chen, Yuan Xu, Li Yao, Arthur Back, Charles A. Francis