Patents by Inventor Yue Xu

Yue Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8772202
    Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: July 8, 2014
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: David R. Rank, Jeffrey Wegener, Jonas Korlach, Daniel Roitman, Yue Xu, John Lyle, Stephen Turner, Paul Peluso, Geoff Otto, Ronald L. Cicero
  • Publication number: 20140127752
    Abstract: A composition and method of cleaving a target DNA and isolating a DNA sequence of interest, directed by a targeting oligonucleotide (“ON”) including a DNA binding agent (stable or unstable), is disclosed. The targeting ON binds to the target DNA before or during DNA cleavage. After cleavage, the isolation of the DNA fragment of interest is facilitated by the affinity tag on the targeting ON or an affinity tag attached using either ligation or polymerase extension method.
    Type: Application
    Filed: November 7, 2013
    Publication date: May 8, 2014
    Inventors: Zhaohui Zhou, Yue Xu, Qun Shan
  • Patent number: 8691573
    Abstract: The present invention relates compounds for stabilizing cells and methods of their use.
    Type: Grant
    Filed: December 3, 2009
    Date of Patent: April 8, 2014
    Assignee: The Scripps Research Institute
    Inventors: Yue Xu, Sheng Ding
  • Patent number: 8604409
    Abstract: The present invention relates to a photosensitive detector with a composite dielectric gate MOSFET structure and its signal readout method. The MOSFET structure detector is formed on a p-type semiconductor substrate. N-type semiconductor regions locate on the two sides of the top part of the p-type semiconductor substrate to form a source and a drain. An underlying dielectric layer, a photo-electron storage layer, a top dielectric layer, and a control gate are stacked on the substrate in sequence. The top insulating dielectric layer can prevent the photoelectrons stored in the photo-electron storage layer from leaking into the control gate. The source and the drain are floating when photoelectrons are collected and injected into the photoelectron storing layer to be held therein. There is a transparent or semi-transparent window for detecting incident light forming on the substrate or gate surface.
    Type: Grant
    Filed: February 10, 2010
    Date of Patent: December 10, 2013
    Assignees: Nanjing University
    Inventors: Feng Yan, Rong Zhang, Yi Shi, Lin Pu, Yue Xu, Fuwei Wu, Xiaofeng Bo, Haoguang Xia
  • Publication number: 20130155768
    Abstract: A localized trapping multi-level memory cell operating method includes the following steps. First, a localized trapping memory cell with the initial threshold voltage of ˜2.5V is provided. Next, an erasing operation is performed to obtain a negative threshold level which has the uniform distribution along the channel region. Taking into account the over-erasure issue in the erasing course, a programming operation is performed to precisely adjust the threshold voltage to a predetermined level of ?2V˜?1V. Then, with the negative voltage as a new initial state, corresponding programming operation is performed and electrons are locally injected the storage layer. By controlling the quantity of injected electrons, the MLC storage is achieved.
    Type: Application
    Filed: December 15, 2011
    Publication date: June 20, 2013
    Applicant: NANJING UNIVERSITY
    Inventors: YUE XU, FENG YAN, LING PU, XIAOLI JI
  • Patent number: 8462556
    Abstract: A localized trapping multi-level memory cell operating method includes the following steps. First, a localized trapping memory cell with the initial threshold voltage of approximately 2.5V is provided. Next, an erasing operation is performed to obtain a negative threshold level having uniform charge distribution along the channel region. Taking into account the over-erasure issue in the erasing operation, a programming operation is performed to precisely adjust the threshold voltage to a predetermined level of ?2V to ?1V. Then, with this negative voltage as a new initial state, a corresponding programming operation is performed and electrons are locally injected into the storage layer. By controlling the quantity of injected electrons, the MLC storage is achieved.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: June 11, 2013
    Assignee: Nanjing University
    Inventors: Yue Xu, Feng Yan, Ling Pu, Xiaoli Ji
  • Publication number: 20120302459
    Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
    Type: Application
    Filed: June 4, 2012
    Publication date: November 29, 2012
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: David R. Rank, Jeffrey Wegener, Jonas Korlach, Daniel Roitman, Yue Xu, John Lyle, Stephen Turner, Paul Peluso, Geoff Otto, Ron Cicero
  • Patent number: 8193123
    Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: June 5, 2012
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: David R. Rank, Jeffery Wegener, Jonas Korlach, Daniel Roitman, Yue Xu, John Lyle, Stephen Turner, Paul Peluso, Geoff Otto, Ron Cicero
  • Publication number: 20110294761
    Abstract: The present invention relates compounds for stabilizing cells and methods of their use.
    Type: Application
    Filed: December 3, 2009
    Publication date: December 1, 2011
    Applicant: The Scripps Research Institute
    Inventors: Yue Xu, Sheng Ding
  • Patent number: 8058031
    Abstract: Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and various analyses based thereon, including DNA sequencing, single base identification, hybridization assays and others.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: November 15, 2011
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Yue Xu, Jeffrey Wegener, Arek Bibillo
  • Patent number: 8044201
    Abstract: The present invention relates compounds for stabilizing cells and methods of their use.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: October 25, 2011
    Assignee: The Scripps Research Institute
    Inventors: Yue Xu, Sheng Ding
  • Publication number: 20110224233
    Abstract: The present invention relates compounds for stabilizing cells and methods of their use.
    Type: Application
    Filed: June 1, 2011
    Publication date: September 15, 2011
    Applicant: The Scripps Research Institute
    Inventors: Yue Xu, Sheng Ding
  • Publication number: 20110215227
    Abstract: The present invention relates to a photosensitive detector with a composite dielectric gate MOSFET structure and its signal readout method. The MOSFET structure detector is formed on a p-type semiconductor substrate. N-type semiconductor regions locate on the two sides of the top part of the p-type semiconductor substrate to form a source and a drain. An underlying dielectric layer, a photo-electron storage layer, a top dielectric layer, and a control gate are stacked on the substrate in sequence. The top insulating dielectric layer can prevent the photoelectrons stored in the photo-electron storage layer from leaking into the control gate. The source and the drain are floating when photoelectrons are collected and injected into the photoelectron storing layer to be held therein. There is a transparent or semi-transparent window for detecting incident light forming on the substrate or gate surface.
    Type: Application
    Filed: February 10, 2010
    Publication date: September 8, 2011
    Applicants: NANJING UNIVERSITY
    Inventors: Feng Yan, Rong Zhang, Yi Shi, Lin Pu, Yue Xu, Fuwei Wu, Xiaofeng Bo, Haoguang Xia
  • Publication number: 20110059450
    Abstract: Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and various analyses based thereon, including DNA sequencing, single base identification, hybridization assays and others.
    Type: Application
    Filed: July 9, 2010
    Publication date: March 10, 2011
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: Yue Xu, Jeffrey Wegener, Arek Bibillo
  • Patent number: 7777013
    Abstract: Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and various analyses based thereon, including DNA sequencing, single base identification, hybridization assays and others.
    Type: Grant
    Filed: May 15, 2008
    Date of Patent: August 17, 2010
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Yue Xu, Jeffrey Wegener, Arek Bibillo
  • Publication number: 20100196443
    Abstract: A dietary supplement or animal feed includes at least one Cordyceps species or extract thereof. The dietary supplement and/or animal feed is preferably for oviparous animals and in particular for the production of eggs.
    Type: Application
    Filed: July 4, 2008
    Publication date: August 5, 2010
    Applicant: A P NUTRIPHARM PTE. LTD.
    Inventor: Yue Xu
  • Publication number: 20090018324
    Abstract: Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and various analyses based thereon, including DNA sequencing, single base identification, hybridization assays and others.
    Type: Application
    Filed: May 15, 2008
    Publication date: January 15, 2009
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: Yue Xu, Jeffrey Wegener, Arek Bibillo
  • Patent number: 7405281
    Abstract: Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and various analyses based thereon, including DNA sequencing, single base identification, hybridization assays and others.
    Type: Grant
    Filed: September 29, 2005
    Date of Patent: July 29, 2008
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Yue Xu, Jeffrey Wegener, Arek Bibillo
  • Publication number: 20080176769
    Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
    Type: Application
    Filed: October 26, 2007
    Publication date: July 24, 2008
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: David R. Rank, Jeffery Wegener, Jonas Korlach, Daniel Roitman, Yue Xu, John Lyle, Stephen Turner, Paul Peluso, Geoff Otto
  • Publication number: 20080153100
    Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
    Type: Application
    Filed: October 31, 2007
    Publication date: June 26, 2008
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: David Rank, Jonas Korlach, Yue Xu, Stephen Turner, Jeffery Wegener, Daniel Roitman, John Lyle