Patents by Inventor Yuhpyng L. Chen

Yuhpyng L. Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imidazole compounds for the treatment of neurological disorders
    Patent number: 7781435
    Abstract: The present invention relates to compounds of Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of Formula I.
    Type: Grant
    Filed: September 20, 2006
    Date of Patent: August 24, 2010
    Assignee: Pfizer Inc
    Inventors: Michael A. Brodney, Karen J. Coffman, Edward F. Kleinman, Brian T. O'Neill, Yuhpyng L. Chen
  • IMIDAZOLE COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
    Publication number: 20100184737
    Abstract: The present invention relates to compounds of Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of Formula I.
    Type: Application
    Filed: March 12, 2010
    Publication date: July 22, 2010
    Applicant: Pfizer Inc
    Inventors: Michael A. Brodney, Karen J. Coffman, Edward F. Kleinman, Brian T. O'Neill, Yuhpyng L. Chen
  • Pyrazole compounds for treatment of neurodegenerative disorders
    Patent number: 7521464
    Abstract: The invention provides compounds of Formula I: wherein R1, R2, R3, R4, R6, R7, R8 and A are as defined. Compounds of formula I have activity inhibiting production of A?-peptide. The invention also provides pharmaceutical compositions and methods for treating diseases, for example Alzheimer's disease, in mammals comprising compounds of Formula I.
    Type: Grant
    Filed: July 2, 2007
    Date of Patent: April 21, 2009
    Assignee: Pfizer Inc.
    Inventors: Yuhpyng L. Chen, Spiros Liras, Robert L. Rosati, Martin P. Allen
  • Pyrazole-amine compounds for the treatment of neurodegenerative disorders
    Patent number: 7468386
    Abstract: The present invention relates to compounds of the Formula wherein R1, R3, R4, R5, R6, R7 and R8 are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods of treating disorders and diseases, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Grant
    Filed: July 5, 2007
    Date of Patent: December 23, 2008
    Assignee: Pfizer Inc.
    Inventors: Yuhpyng L. Chen, Lei Zhang
  • COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
    Publication number: 20080249094
    Abstract: The present invention relates to compounds of the Formula wherein R3, R5, R7, U, X, Y and Z are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. This invention also relates to pharmaceutical compositions and methods of treating diseases, for example, neurodegenerative diseases, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Application
    Filed: June 18, 2008
    Publication date: October 9, 2008
    Inventor: Yuhpyng L. Chen
  • THIAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
    Publication number: 20080207712
    Abstract: The present invention relates to compounds of the Formula I wherein R1, R3, R4, R5, R6 and R7 are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods of treating disorders and diseases, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Application
    Filed: May 1, 2008
    Publication date: August 28, 2008
    Inventors: Yuhpyng L. Chen, Lei Zhang
  • Compounds for the treatment of neurodegenerative disorders
    Patent number: 7408068
    Abstract: The present invention relates to compounds of the Formula wherein R3, R5, R7, U, X, Y and Z are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. This invention also relates to pharmaceutical compositions and methods of treating diseases, for example, neurodegenerative diseases, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Grant
    Filed: July 17, 2007
    Date of Patent: August 5, 2008
    Assignee: Pfizer Inc.
    Inventor: Yuhpyng L. Chen
  • Thiazole-amine compounds for the treatment of neurodegenerative disorders
    Patent number: 7384968
    Abstract: The present invention relates to compounds of the Formula I wherein R1, R3, R4, R5, R6 and R7 are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods of treating disorders and diseases, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: June 10, 2008
    Assignee: Pfizer Inc.
    Inventor: Yuhpyng L. Chen
  • Compounds for the treatment of neurodegenerative disorders
    Patent number: 7253195
    Abstract: The present invention relates to compounds of the Formula wherein R3, R5, R7, U, X, Y and Z are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. This invention also relates to pharmaceutical compositions and methods of treating diseases, for example, neurodegenerative diseases, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Grant
    Filed: August 20, 2004
    Date of Patent: August 7, 2007
    Assignee: Pfizer Inc
    Inventor: Yuhpyng L. Chen
  • Pyrazole-amine compounds for the treatment of neurodegenerative disorders
    Patent number: 7244757
    Abstract: The present invention relates to compounds of the Formula wherein R1, R3, R4, R5, R6, R7 and R8 are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods of treating disorders and diseases, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: July 17, 2007
    Assignee: Pfizer Inc
    Inventors: Yuhpyng L. Chen, Lei Zhang
  • Pyrazole compounds for treatment of neurodegenerative disorders
    Patent number: 7238721
    Abstract: The invention provides compounds of Formula I: wherein R1, R2, R3, R4, R6, R7, R8, and A are as defined. Compounds of formula I have activity inhibiting production of A?-peptide. The invention also provides pharmaceutical compositions and methods for treating diseases, for example Alzheimer's disease, in mammals comprising compounds of Formula I.
    Type: Grant
    Filed: October 7, 2003
    Date of Patent: July 3, 2007
    Assignee: Pfizer Inc
    Inventors: Yuhpyng L. Chen, Spiros Liras, Robert L. Rosati, Martin P. Allen
  • Thiadiazole-amine compounds for the treatment of neurodegenerative disorders
    Patent number: 7232820
    Abstract: The present invention relates to compounds of the Formula I wherein R1, R3, R5, R7, X, Y and U are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods of treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: June 19, 2007
    Assignee: Pfizer Inc
    Inventor: Yuhpyng L. Chen
  • Isoxazole-and isothiazole-amine compounds for the treatment of neurodegenerative disorders
    Patent number: 7220865
    Abstract: The present invention relates to compounds of the Formula I wherein R1, R3, R5, R6, R7, X and Y are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods of treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: May 22, 2007
    Assignee: Pfizer Inc
    Inventors: Yuhpyng L Chen, Lei Zhang
  • Corticotropin releasing factor antagonists
    Patent number: 7125880
    Abstract: Corticotropin-releasing factor (CRF) antagonists having the formulae wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 and R17 are as defined in the application, and processes for preparing them. These compounds and their pharmaceutically acceptable salts are useful in the treatment disorders including CNS and stress-related disorders.
    Type: Grant
    Filed: May 30, 2000
    Date of Patent: October 24, 2006
    Assignee: Pfizer Inc.
    Inventor: Yuhpyng L. Chen
  • Oxazole compounds for the treatment of neurodegenerative disorders
    Patent number: 7112599
    Abstract: The present invention relates to compounds of the Formula wherein R3, R5, R6, R7, and Z, and other variables enumerated under one or more of R3, R5, R6, R7, and Z, are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. This invention also relates to pharmaceutical compositions and methods of treating diseases, for example, neurodegenerative diseases, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Grant
    Filed: August 5, 2004
    Date of Patent: September 26, 2006
    Assignee: Pfizer Inc.
    Inventor: Yuhpyng L. Chen
  • Corticotropin releasing factor antagonists
    Patent number: 7067664
    Abstract: Corticotropin-releasing factor (CRF) antagonists having the formulae wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 and R17 are as defined in the application, and processes for preparing them. These compounds and their pharmaceutically acceptable salts are useful in the treatment disorders including CNS and stress-related disorders.
    Type: Grant
    Filed: May 30, 2000
    Date of Patent: June 27, 2006
    Assignees: Pfizer Inc., Pfizer Products Inc.
    Inventor: Yuhpyng L. Chen
  • Substituted heterocyclic derivatives
    Patent number: 6992188
    Abstract: Corticotropin-releasing factor (CRF) antagonists having the formula wherein the dashed lines, A, B, D E, F, Z, G, R3, and R5 having the definitions set forth in the specification pharmaceutical compositions containing them.
    Type: Grant
    Filed: December 6, 1996
    Date of Patent: January 31, 2006
    Assignee: Pfizer, Inc.
    Inventor: Yuhpyng L. Chen
  • Corticotropin releasing factor antagonists
    Patent number: 6956047
    Abstract: Corticotropin-releasing factor (CRF) antagonists having the formulae wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 and R17 are as defined in the application, and processes for preparing them. These compounds and their pharmaceutically acceptable salts are useful in the treatment disorders including CNS and stress-related disorders.
    Type: Grant
    Filed: May 30, 2000
    Date of Patent: October 18, 2005
    Assignee: Pfizer Inc.
    Inventor: Yuhpyng L. Chen
  • Substituted 6,5-hetero-bicyclic derivatives
    Patent number: 6900217
    Abstract: This invention relates to compounds of the formula wherein A, B, D, E, K, T, G, R3 and R5 are defined as in the specification, and to the pharmaceutically acceptable salts of such compounds.
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: May 31, 2005
    Assignee: Pfizer Inc
    Inventor: Yuhpyng L. Chen
  • Substituted6,6-hetero-bicyclicderivatives
    Patent number: 6875769
    Abstract: This invention relates to compounds of the formula wherein A, B, D, E, K, G, R3 and R5 are defined as in the specification, and to the pharmaceutically acceptable salts of such compounds.
    Type: Grant
    Filed: January 6, 2003
    Date of Patent: April 5, 2005
    Assignee: Pfizer Inc.
    Inventor: Yuhpyng L. Chen